632,913 results match your criteria blood pressure

Palmitoleic Acid Protects against Hypertension by Inhibiting NF-κB-Mediated Inflammation.

Mol Nutr Food Res 2021 Apr 17:e2001025. Epub 2021 Apr 17.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Scope: The role of palmitoleic acid (POA) in hypertension or blood pressure remains uncertain. We aim to investigate the epidemiological association between circulating POA and primary hypertension in humans, and subsequently evaluate the effects of exogenous POA on blood pressure and aortic remodeling in spontaneously hypertensive rats (SHRs).

Methods And Results: We conducted a case-control study of 349 hypertensive and 1396 normotensive children and adolescents, and found hypertensive cases showed significant lower erythrocyte phospholipid POA than normotensive controls (P < 0. Read More

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Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study.

Bone 2021 Apr 14:115960. Epub 2021 Apr 14.

Women's Health and Perinatalogy Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Gynecology and Obstetrics, University Hospital of North Norway, Tromsø, Norway; Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway. Electronic address:

Purpose: Patients with end-stage kidney disease have an increased fracture risk. Whether mild to moderate reductions in kidney function is associated with increased fracture risk is uncertain. Results from previous studies may be confounded by muscle mass because of the use of creatinine-based estimates of the glomerular filtration rate (eGFRcre). Read More

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Determinants of cardiac structure in frail and sarcopenic elderly adults.

Exp Gerontol 2021 Apr 14:111351. Epub 2021 Apr 14.

Department of Medicine and Surgery, University Medical School of Parma, Parma, Italy; University-Hospital of Parma, Parma, Italy; Geriatric Clinic Unit, University-Hospital of Parma, Parma, Italy.

Background: Cardiac structure and function change with age. The higher prevalence of left ventricular hypertrophy (LVH) with concentric remodeling is indicative of a typical geometric pattern of aging associated with a higher cardiovascular (CV) risk and diseases. The recent associations found between low left ventricular and skeletal mass in older patients with frailty and sarcopenia have raised great interest in investigating cardiac characteristics and determinants of left ventricular mass (LVM) in this population. Read More

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Cigarette smoke exposure causes systemic and autonomic cardiocirculatory changes in rats depending on the daily exposure dose.

Life Sci 2021 Apr 14:119498. Epub 2021 Apr 14.

Medical School, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:

Aims: To evaluate the systemic changes and autonomic cardiocirculatory control of awaken rats chronically exposed to the cigarette smoke (CS) of 1 or 2 cigarettes/day.

Main Methods: Rats were exposed to clean air (control) or cigarette smoke of 1 (CS1) or 2 (CS2) cigarettes/animal/day for 30 days. Then, arterial pressure (AP) and heart rate (HR) were recorded in conscious rats to assess spontaneous baroreflex sensitivity and HR and AP variabilities. Read More

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Maternal Health Outcomes and Male Partner Involvement Among HIV Infected Women in Rural South Africa.

Matern Child Health J 2021 Apr 17. Epub 2021 Apr 17.

HIV/AIDS, STIs, & TB Research Programme, Human Sciences Research Council, 134 Pretorius Street, Pretoria, 0001, South Africa.

Introduction: This study aimed to investigate the association between Male Partner Involvement (MPI) and maternal health outcomes among women attending Prevention of Mother-to-Child Transmission of HIV (PMTCT) services in rural South Africa. The association between Male Partner Participation in the main study (MPP) and maternal health outcomes among these women was also investigated.

Methods: The study utilized data collected from 535 HIV infected women in a randomized controlled trial between 2015 and 2016. Read More

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Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement.

Michael Dandel

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

German Centre for Heart and Circulatory Research (DZHK) Partner Site, Berlin, Berlin, Germany.

Due to the SARS-CoV-2 infection-related severe pulmonary tissue damages associated with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of heart-lung interactions becomes crucial for the development and progression of right ventricular (RV) dysfunction. The high resistance in the pulmonary circulation, as a result of small vessel thrombosis and hypoxemia, is the major cause of right heart failure associated with a particularly high mortality in severe COVID-19. Timely identification of patients at high risk for RV failure, optimization of mechanical ventilation to limit its adverse effects on RV preload and afterload, avoidance of medication-related increase in the pulmonary vascular resistance, and the use of extracorporeal membrane oxygenation in refractory respiratory failure with hemodynamic instability, before RV failure develops, can improve patient survival. Read More

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Skin microvascular function and renal hemodynamics in overweight patients with type 2 diabetes: a cross-sectional study.

Microcirculation 2021 Apr 17:e12700. Epub 2021 Apr 17.

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Center, location VUMC, Amsterdam, The Netherlands.

Objective: Diabetic kidney disease is a microvascular complication of diabetes Here we assessed the association between skin microvascular function and renal hemodynamic function in a cohort of well-phenotyped adults with type 2 diabetes (T2D).

Methods: We included 81 overweight/obese adults (age: 62±8 years; BMI: 32±4 kg/m ) with well-controlled T2D and no renal impairment. Skin microvascular function was assessed by nailfold capillary density in rest and after arterial occlusion (i. Read More

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Impact of intravenous antihypertensives on outcomes among hospitalized patients.

Am J Hypertens 2021 Apr 17. Epub 2021 Apr 17.

HCA Healthcare / USF Morsani College of Medicine GME: Largo Medical Center, Largo, FL USA.

Background: Many hospitalized patients with acute elevations in blood pressure are treated with intravenous (IV) antihypertensive medications without evidence of benefit. This study investigated the effects of IV as-needed (PRN) antihypertensives on blood pressure, hospital length of stay, and mortality.

Methods: We included hospitalized patients with an order for an IV PRN antihypertensive medication. Read More

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Efficacy and Safety of Phentermine/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

Obesity (Silver Spring) 2021 Apr 16. Epub 2021 Apr 16.

Geriatrics Department of Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Objective: The study objective was to examine the association between phentermine/topiramate therapy and weight loss and adverse events in adults with overweight or obesity by meta-analysis and systematic review.

Methods: Medical Subject Headings and free-text terms were selected to search for eligible trials in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase up to April 18, 2020. The quality of randomized controlled trials was evaluated by the Cochrane risk-of-bias tool. Read More

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The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.

Cell Mol Neurobiol 2021 Apr 16. Epub 2021 Apr 16.

Department of Pharmacology of the School of Medicine of Ribeirão Preto, University of São Paulo, Ave. Bandeirantes, São Paulo, Ribeirão Preto, 3900-14049-900, Brazil.

The renin-angiotensin system (RAS) is involved in cardiovascular and hydroelectrolytic control, being associated with the development of hypertension. The restraint stress (RS) model is an aversive situation, which promotes a sustained increase in blood pressure and heart rate, and stimulation of the hypothalamic-pituitary-adrenal axis. Stress leads to an increase of angiotensin-II contents both in the circulation and the central nervous system (CNS), as well as an increased expression of AT-1 receptors in CNS structures related to stress. Read More

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Sustained high blood pressure and 24-h ambulatory blood pressure monitoring in Tanzanian adolescents.

Sci Rep 2021 Apr 16;11(1):8397. Epub 2021 Apr 16.

Mwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania.

Estimates for prevalence of high blood pressure (BP) among adolescents in Africa vary widely and few studies, if any, have documented the results of the recommended stepwise BP screening. In this cross-sectional study in Tanzania, we aimed to estimate prevalence of sustained high BP in 3 public secondary schools using the American Academy of Pediatrics BP screening strategy. On Day 1, one screening automated office BP (AOBP) measurement (Step 1) was followed by two more AOBP measurements (Step 2). Read More

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Mesenteric Tear Can Be Caused by Abdominal Counter-Pressure Applied During Colonoscopy.

Am J Case Rep 2021 Apr 17;22:e928889. Epub 2021 Apr 17.

5G Law Firm, PLLC, Woodward, OK, USA.

BACKGROUND We report the case of a patient undergoing a colonoscopy during which pressure applied on the abdomen by a nurse assisting in the procedure caused an extraluminal mesenteric tear. Mesenteric tears can be life-threating and need to be managed appropriately. This is the first case reported in the literature describing abdominal counter-pressure applied in the endoscopic procedure room as the cause of traumatic bowel injury. Read More

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Acute Blood Pressure Effects in Older Adults with Hypertension After Different Modalities of Exercise: An Experimental Study.

J Aging Phys Act 2021 Apr 15:1-7. Epub 2021 Apr 15.

This study investigated the acute blood pressure (BP) effects of different exercise modalities in older adults with hypertension. Sixty volunteers were randomly assigned (n = 15/group) into different exercise protocols: resistance, bike, water-based exercise (WE), and a control session-all for ∼45 min. Clinic BP measurements were taken before, immediately after, and 15 and 30 min after protocols. Read More

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Pulse arrival time, a novel sleep cardiovascular marker: the multi-ethnic study of atherosclerosis.

Thorax 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: Pulse arrival time (PAT) is commonly used to estimate blood pressure response. We hypothesised that PAT response to obstructive respiratory events would be associated with increased cardiovascular risk in people with obstructive sleep apnoea.

Methods: PAT, defined as the time interval between electrocardiography R wave and pulse arrival by photoplethysmography, was measured in the Multi-Ethnic Study of Atherosclerosis Sleep study participants. Read More

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Emergency TAVI in cardiogenic shock and cardiorenal syndrome secondary to severe bicuspid aortic stenosis.

BMJ Case Rep 2021 Apr 16;14(4). Epub 2021 Apr 16.

Cardiology, St James Hospital, Dublin, Ireland.

A 78-year man with severe aortic stenosis awaiting elective surgical aortic valve replacement presented with worsening New York Heart Association IV shortness of breath. Despite appropriate heart failure treatment, he deteriorated and developed cardiogenic shock and cardiorenal syndrome which progressed despite inotropic support. A non-contrast-gated CT coronary angiogram was arranged in light of acute renal failure which revealed a bicuspid aortic valve. Read More

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Impact of obstructive sleep apnea and intermittent hypoxia on blood rheology - a translational study.

Eur Respir J 2021 Apr 16. Epub 2021 Apr 16.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Rationale: Hemorheological alterations are reported in obstructive sleep apnea (OSA) and reversed with continuous positive airway pressure (CPAP), observations potentially explained by intermittent hypoxia (IH)-induced oxidative stress.

Objective: To investigate whether IH causes hemorheological alterations oxidative stress.

Methods: Wistar rats were exposed to normoxia (n=7) or IH (n=8) for 14 days. Read More

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CD52/GPI- T-Cells Are Enriched for Alloreactive Specificity and Predict Acute Graft-Versus-Host-Disease After Stem Cell Transplantation.

Transplant Cell Ther 2021 Feb 25. Epub 2021 Feb 25.

Institute of Immunology and Immunotherapy, College of Medical and Dental Studies, University of Birmingham and Birmingham Health Partners, Birmingham, United Kingdom; Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust and Birmingham Health Partners, Birmingham, United Kingdom.

Alemtuzumab is a CD52-specific lympho-depleting antibody. CD52- T cells emerge under alemtuzumab selection pressure. We sought to investigate the phenotype and function of the CD52- T cell fraction and related their presence to clinical outcome. Read More

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February 2021

[Blood pressure measurement campaign (May Measurement Month) from community pharmacies in 2018: analysis of screening in Spain].

Hipertens Riesgo Vasc 2021 Apr 13. Epub 2021 Apr 13.

Instituto de Investigación 12 de octubre, Madrid, España.

Introduction: Within the international project May Measurement Month, in Spain, the community pharmacy is where the greatest number of measurements are carried out and where the population can be made aware of the importance of regular blood pressure measurement.

Objectiv: To ascertain the situation of the Spanish population's blood pressure and dissemination of the importance of its regular measurement through the community pharmacies.

Methods: Cross-sectional descriptive study carried out in Spanish community pharmacies during the month of May 2018, among pharmacy users of legal age. Read More

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Warning signals of elevated prediabetes prevalence in the modern Iranian urban population.

Prim Care Diabetes 2021 Apr 13. Epub 2021 Apr 13.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Research Center for the Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: We sought to estimate the prevalence of diabetes mellitus (DM) and pre-DM and their associated factors among a sample of the Iranian urban population between 2017 and 2019.

Methods: The present investigation is a sub-study on the HAMRAH cohort study, a longitudinal population-based cohort study to assess the 10-year risk of cardiovascular diseases and their related risk factors in the adult population of the Iranian capital, Tehran. Via a multistage cluster randomized sampling method, 2123 adults aged between 30 and 75 years who had no history of cardiovascular diseases were selected for the study. Read More

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Weight loss and metabolic outcomes in women with or without polycystic ovarian syndrome after Roux-en-Y gastric bypass: A case-matched study.

Surgeon 2021 Apr 13. Epub 2021 Apr 13.

The University of Manchester, Oxford Road, Manchester, M13 9PL, UK; Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK. Electronic address:

Background And Objectives: Weight loss is the mainstay of management for women with polycystic ovarian syndrome (PCOS). However, lifestyle and dietary modifications, and gastric banding have generally poor long-term efficacy. We aimed to investigate whether gastric bypass is equally efficacious in women with or without PCOS. Read More

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[Cognitive impairment in patients with cardiovascular risk: DECOG study].

Semergen 2021 Apr 13. Epub 2021 Apr 13.

Medicina Familiar y Comunitaria, Centro de Salud Ciudad Rodrigo. Coordinador Grupo de Trabajo de Neurología de Semergen, Salamanca, España.

Objective: To evaluate the correlation between cardiovascular risk factors (CRF) and mild cognitive impairment (MCI) in the primary care setting.

Materials And Methods: Observational, cross-sectional and multicenter study conducted in the setting of primary care. Information regarding demographic variables, CRF, comorbidities, and cognitive impairment determined by Mini-Mental State Examination (MMSE) score was collected. Read More

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Impact of heat stress on broilers with varying body weights: Elucidating their interactive role through physiological signatures.

J Therm Biol 2021 Apr 20;97:102840. Epub 2021 Jan 20.

Division of Avian Genetics and Breeding, ICAR-Central Avian Research Institute, Izatnagar, 243122, Uttar Pradesh, India.

Physiological determinants of different body weight (BW) broiler chickens under heat stressed conditions were investigated to compare the performance at market age considering medium body weight group as standard. At 5 weeks, broilers were categorized randomly into 3 treatments (N = 24 per group) as high (HBW) (>1050 g), medium (MBW) (900-1050 g) and low (LBW) (<900 g) followed by simultaneous exposure to normal and heat stress (HS) conditions at 40 ± 1 °C and 45 ± 5% RH for 4 h/day for a period of 7 days (D) and sample collection was employed at D0, D3 and D7. Physiological and stress responses, haematological and biochemical profile, intestinal gross and histological aspects were estimated using standard protocols. Read More

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Core temperature circadian rhythm across aging in Spontaneously Hypertensive Rats.

J Therm Biol 2021 Apr 23;97:102807. Epub 2021 Feb 23.

Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brazil. Electronic address:

The purpose of this study was to evaluate the circadian rhythm of core temperature (T) across aging in Spontaneously Hypertensive Rats (SHR) with comparison to the two rat strains often used as their normotensive control animals, namely, Wistar (WIS) and Wistar Kyoto (WKY).

Methods: WIS, WKY and SHR rats were subdivided into three different groups according their age: WIS16, WIS48, WIS72, WKY16, WKY48, WKY72, SHR16, SHR48 and SHR72 weeks-old. Body mass and blood pressure were periodically measured along the experiments. Read More

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Malignant hyperthermia when dantrolene is not readily available.

Xiaodan Gong

BMC Anesthesiol 2021 Apr 16;21(1):119. Epub 2021 Apr 16.

Department of Cardiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charité University Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Malignant hyperthermia is a rare but life-threatening pharmacogenetic muscle disorder characterized by abnormal hypermetabolic reactions and commonly triggered in susceptible individuals by volatile anesthetics or succinylcholine, or both. Unfortunately, the specific medicine dantrolene is not readily available in many countries including China. The aim of this study was to find the characteristics of malignant hyperthermia under the situation that dantrolene is not readily available. Read More

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Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin.

Auton Neurosci 2021 Apr 7;233:102809. Epub 2021 Apr 7.

Department of Physical Therapy, School of Health & Human Sciences; and (2)Departments of Dermatology and Anatomy, Cell Biology, & Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA. Electronic address:

Local neuronal circuits in non-glabrous skin drive the initial increase of the biphasic cutaneous vasodilation response to fast non-noxious heating. Voltage-sensitive Na (NaV) channel inhibition blocks the afferent limb of the non-glabrous forearm cutaneous axon reflex. Slow local heating does not engage this response. Read More

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Pulmonary infarction in acute pulmonary embolism.

Thromb Res 2021 Apr 1;202:162-169. Epub 2021 Apr 1.

Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Pulmonary infarction results from occlusion of the distal pulmonary arteries leading to ischemia, hemorrhage and ultimately necrosis of the lung parenchyma. It is most commonly caused by acute pulmonary embolism (PE), with a reported incidence of around 30%. Following an occlusion of the pulmonary artery, the bronchial arteries are recruited as primary source of perfusion of the pulmonary capillaries. Read More

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[Prevalence of Arterial Hypertension in a neonatal intensive care unit].

Rev Chil Pediatr 2020 Dec 8;91(6):891-898. Epub 2020 Oct 8.

Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: The prevalence of neonatal hypertension in neonatal intensive care units (NICU) ranges between 3 and 9%. However, there is no current data on Latin America.

Objective: To estimate the prevalence of neonatal hypertension and to assess its association with causes previously related to this condi tion. Read More

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December 2020

Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances.

Am J Respir Crit Care Med 2021 Apr 16. Epub 2021 Apr 16.

Columbia University Medical Center, 21611, New York, New York, United States.

The diagnosis and management of pulmonary arterial hypertension (PAH) includes several advances, such as broader recognition of extra-pulmonary vascular organ system involvement, validated point-of-care clinical assessment tools, and a focus on early-initiation of multiple pharmacotherapeutics in appropriate patients. Indeed, a principal goal in PAH today is early diagnosis for prompt initiation of treatment to achieve minimal symptom burden, optimize the patient's biochemical, hemodynamic, and functional profile, and limit adverse events. To accomplish this end, clinicians must be familiar with novel risk factors and the revised hemodynamic definition for PAH. Read More

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Targeting Adenosine Receptors in Neurological Diseases.

Cell Reprogram 2021 Apr;23(2):57-72

Department of Clinical Nutrition, NUR International University, Lahore, Pakistan.

Adenosine plays a significant role in neurotransmission process by controlling the blood pressure, while adenosine triphosphate (ATP) acts as a neuromodulator and neurotransmitter and by activation of P2 receptors, regulates the contractility of the heart. Adenosine signaling is essential in the process of regeneration by regulating proliferation, differentiation, and apoptosis of stem cells. In this review, we have selected neurological disorders (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and epilepsy) with clinical trials using antagonists and epigenetic tools targeting adenosine receptor as a therapeutic approach in the treatment of these disorders. Read More

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Trajectories of Blood Pressure Control a Year after Randomization and Incident Cardiovascular Outcomes in SPRINT.

Am J Hypertens 2021 Apr 16. Epub 2021 Apr 16.

Section of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

Background: While studies have assessed the association between blood pressure trajectories and cardiovascular disease (CVD) outcomes using observational data, few have assessed these associations using clinical trial data. We sought to identify systolic blood pressure (SBP) trajectories and to determine if these trajectory patterns carry inherent CVD risk, irrespective of baseline blood pressure.

Methods: SBP trajectories were identified using latent class group based modeling among a cohort of 8901Systolic Blood Pressure Intervention Trial (SPRINT) participants by incorporating SBP measures during the first 12 months of the trial post randomization. Read More

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