108,660 results match your criteria blood neutrophils


Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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The relationship between neutrophil-lymphocyte ratio and early renal fibrosis and renal prognosis in patients with lupus nephritis.

Am J Transl Res 2021 15;13(3):1710-1716. Epub 2021 Mar 15.

Department of Nephrology, China-Japan Friendship Hospital Beijing 100029, China.

Objective: To explore the relationship between neutrophil-lymphocyte ratio (NLR) and early renal fibrosis and renal prognosis in patients with lupus nephritis.

Methods: A total of 186 patients with lupus nephritis admitted to our hospital were enrolled and grouped according to the standard of "NLR=3.175". Read More

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Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells.

Front Genet 2021 25;12:634938. Epub 2021 Mar 25.

Department of Biology, Indian Institute of Science Education and Research, Pune, India.

Lipid species are known to have various biological functions owing to their structural differences, and each of them possesses a specific role to play depending upon their location and distribution in the cell. Some of these lipids interact with proteins on the cell membrane and acts as second messengers. The level of lipid mediators is generally maintained in the cell by feedback mechanisms; however, their improper degradation or enhanced production leads to their accumulation in the tumor microenvironment and disturbs the homeostasis of the cell. Read More

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Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity.

Cytokine 2021 Mar 31:155523. Epub 2021 Mar 31.

Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 86-027-67812888, China. Electronic address:

Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat to global public health. Elucidating its pathogenesis is essential to finding effective therapy. Read More

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Synovial fluid neutrophils in oligoarticular juvenile idiopathic arthritis have an altered phenotype and impaired effector functions.

Arthritis Res Ther 2021 Apr 9;23(1):109. Epub 2021 Apr 9.

Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

Background: Neutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil function at the site of inflammation in JIA and how local neutrophils contribute to disease pathogenesis. This study aimed to characterize the phenotype and function of synovial fluid neutrophils in oligoarticular JIA. Read More

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[Coronavirus disease 2019 in Northeastern Sichuan: clinical characteristics and treatment analysis of 59 cases].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):352-356

Department of Ultrasonography, Bazhong Central Hospital, Bazhong 636000, Sichuan, China. Corresponding author: Luo Shilin, Email:

Objective: To analyze the epidemiological, clinical characteristics and treatment of coronavirus disease 2019 (COVID-19) in Northeastern Sichuan, and summarize experience in time to provide reference for clinical diagnosis and treatment.

Methods: A retrospective study was conducted. Fifty-nine patients with COVID-19 admitted to Bazhong Central Hospital and Dazhou Central Hospital from January 27th to February 9th, 2020 were selected as the subjects. Read More

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THE IMPACT OF NEUTROPHIL-TOLYMPHOCYTE RATIO AND PLATELETTO- LYMPHOCYTE RATIO IN CAROTID ARTERY DISEASE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):45-51. Epub 2021 Apr 8.

Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal.

Introduction: Inflammation is a common underlying feature of atherosclerosis. Several inflammatory biomarkers have been reported to have prognostic value, in several areas, including in vascular surgery. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) may permit to identify patients at greater risk for cerebrovascular events, tailor patient management, improve preoperative status and possibly develop target anti-atherosclerotic therapy. Read More

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Does Parathyroidectomy Affect the Neutrophil/Lymphocyte Ratio, a Systemic Inflammatory Marker?

Cureus 2021 Mar 5;13(3):e13708. Epub 2021 Mar 5.

Department of General Surgery, Adiyaman University Faculty of Medicine, Adiyaman, TUR.

Introduction Primary hyperparathyroidism (PHPT) is an endocrinological disorder associated with increased systemic inflammation. This study aimed to examine the changes in the neutrophil/lymphocyte ratio (NLR), serum parathormone, serum corrected calcium, serum phosphate, and white blood cell (WBC) count ​​in patients with PHPT before and after parathyroidectomy. Methods A total of 37 patients who underwent successful parathyroidectomy for PHPT were included in the study. Read More

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Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2249-2255

National Institute of food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

Stevia rebaudiana Bertoni a non-caloric, safe and natural sweetener has been shown pharmaceutically important in the management of blood disorders. This study was designed to investigate hematology and safety of stevia aqueous extract through animal modeling. For this purpose, fifty albino rats were categorized into 5 groups and all the groups were received aqueous stevia extract at different dosage levels (200, 300, 400 and 500 ppm/kg b. Read More

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September 2020

Systemic immune-inflammation index predicts postoperative acute kidney injury in hepatocellular carcinoma patients after hepatectomy.

Medicine (Baltimore) 2021 Apr;100(14):e25335

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Abstract: The systemic immune-inflammation index (SII) is an independent prognostic predictor of hepatocellular carcinoma (HCC). The present investigation examined whether an association exists between preoperative SII value and postoperative acute kidney injury (pAKI) in HCC patients.The study included 479 hepatitis B virus (HBV)-associated HCC patients undergoing hepatectomy. Read More

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Hematological and CD4+ T- cell count reference interval for pregnant women attending antenatal care at Hawassa University Comprehensive Specialized Hospital, Hawassa Southern Ethiopia.

PLoS One 2021 8;16(4):e0249185. Epub 2021 Apr 8.

School of Medical Laboratory Science, College of Medicine and Health Science, Hawassa University, Hawassa, Sidama Region, Ethiopia.

Background: Pregnancy is a state characterized by physiological, hematological, and immunological changes. However, the reference intervals (RI) being used in clinical practice in Ethiopia are derived from non-local general populations. Therefore; this study was aimed to determine the reference interval of hematological and immunological profiles among healthy pregnant mothers attending Hawassa University Hospital. Read More

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Neutrophil Extracellular Traps in the Autoimmunity Context.

Front Med (Lausanne) 2021 22;8:614829. Epub 2021 Mar 22.

Laboratory of Molecular Nephrology, Scientific Institute for Research and Health Care, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

The formation of neutrophil extracellular traps (NETs) is a strategy utilized by neutrophils for capturing infective agents. Extracellular traps consist in a physical net made of DNA and intracellular proteins externalized from neutrophils, where bacteria and viruses are entrapped and killed by proteolysis. A complex series of events contributes to achieving NET formation: signaling from infectious triggers comes first, followed by decondensation of chromatin and extrusion of the nucleosome components (DNA, histones) from the nucleus and, after cell membrane breakdown, outside the cell. Read More

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Single Cell Transcriptome Data Analysis Defines the Heterogeneity of Peripheral Nerve Cells in Homeostasis and Regeneration.

Front Cell Neurosci 2021 22;15:624826. Epub 2021 Mar 22.

Faculty of Health, Peninsula Medical School, University of Plymouth, Plymouth, United Kingdom.

The advances in single-cell RNA sequencing technologies and the development of bioinformatics pipelines enable us to more accurately define the heterogeneity of cell types in a selected tissue. In this report, we re-analyzed recently published single-cell RNA sequencing data sets and provide a rationale to redefine the heterogeneity of cells in both intact and injured mouse peripheral nerves. Our analysis showed that, in both intact and injured peripheral nerves, cells could be functionally classified into four categories: Schwann cells, nerve fibroblasts, immune cells, and cells associated with blood vessels. Read More

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CLINICAL PATHOLOGY OF CAPTIVE ENDANGERED MAHOGANY GLIDERS () IN RESPONSE TO ENVIRONMENTAL CHANGE.

J Zoo Wildl Med 2021 Apr;52(1):268-275

University of Queensland, School of Veterinary Science, Gatton Campus, Gatton, Queensland 4343, Australia.

The impetus of this study was the imperative to establish blood biomarker values for clinically healthy mahogany gliders () in order to monitor the health status of eight captive individuals during their movement to a new facility. The study established ranges for 18 hematologic and 21 biochemical blood biomarkers for healthy individuals in a captive environment. The reported values are consistent with those published for other Australian glider and possum species. Read More

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Fcγ receptors on aging neutrophils.

J Appl Oral Sci 2021 31;29:e20200770. Epub 2021 Mar 31.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Bauru, SP, Brasil.

Objective: Neutrophils are key effector cells of the innate immune system. They recognize antigens through membrane receptors, which are expressed during their maturation and activation. Neutrophils express FcγRII (CD32), FcγRIII (CD16), and FcγRI (CD64) after being activated by different factors such as cytokines and bacterial products. Read More

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Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis.

Clin Transl Gastroenterol 2021 Apr 6;12(4):e00331. Epub 2021 Apr 6.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Introduction: DEFA1A3 encodes human neutrophil peptides (HNPs) 1-3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed. Read More

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Intrabone infusion for allogeneic umbilical cord blood transplantation in children.

Bone Marrow Transplant 2021 Apr 6. Epub 2021 Apr 6.

Cell Therapy and Transplant Program, Division of Hematology-Oncology, Ste-Justine University Hospital Center, Montreal, QC, Canada.

Umbilical cord blood transplantation (UCBT) has been used to treat malignant and non-malignant diseases. UCBT offers the advantages of easy procurement and acceptable partial HLA mismatches, but also shows delayed hematopoietic and immunological recoveries. We postulated that an intrabone (IB) infusion of cord blood could provide a faster short- and long-term engraftment in a pediatric population with malignant and non-malignant hematologic diseases. Read More

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Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study.

Pak J Pharm Sci 2020 Sep;33(5):1945-1953

Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan.

We determined anti-Parkinson's activity of M. chamomilla L. tea in chlorpromazine (CPZ) developed investigational animal model. Read More

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September 2020

Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice.

Am J Physiol Lung Cell Mol Physiol 2021 Apr 6. Epub 2021 Apr 6.

Cardiovascular Research Institute, University of California, San Francisco, United States.

Resolution of the acute respiratory distress syndrome (ARDS) from pneumonia requires repair of the injured lung endothelium and alveolar epithelium, removal of neutrophils from the distal airspaces of the lung, and clearance of the pathogen. Previous studies have demonstrated the importance of specialized pro-resolving mediators (SPMs) in the regulation of host responses during inflammation. Although ARDS is commonly caused by Streptococcus pneumoniae, the role of Lipoxin A4 (LXA4) and Resolvin D1 (RvD1) in pneumococcal pneumonia is not well understood. Read More

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IgG immune complexes may contribute to neutrophil activation in the course of severe COVID-19.

J Infect Dis 2021 Apr 2. Epub 2021 Apr 2.

INBIRS, Universidad de Buenos Aires (UBA)-CONICET, Buenos Aires, Argentina.

Severe COVID-19 is associated with an overactive inflammatory response mediated by macrophages. Here, we analyzed the phenotype and function of neutrophils in COVID-19 patients. We found that neutrophils from severe COVID-19 patients express high levels of CD11b and CD66b, spontaneously produce CXCL8 and CCL2 and show a strong association with platelets. Read More

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A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase.

Turk J Med Sci 2021 Apr 6. Epub 2021 Apr 6.

Background/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Read More

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Post-transplantation Cyclophosphamide, Tacrolimus and Low-Dose ATG as GVHD Prophylaxis for Allogeneic Peripheral Stem Cell Transplantation for Adult Patients With Lymphoid Malignancies: A Single Arm Phase II Study.

Front Med (Lausanne) 2021 18;8:630160. Epub 2021 Mar 18.

Shanghai Institute of Hematology, Department of Hematology, Blood & Marrow Transplantation Center, Collaborative Innovation Center of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The PT-Cy was considered as one of the mainstay protocol for graft verus host disease (GVHD) prophylaxis. Recent study demonstrated that PT-Cy combined with other immunosuppressants could further reduce the incidence of GVHD and improve the GVHD and relapse free survival (GRFS). In this prospective phase II study, we evaluated the effect of a new GVHD prophylaxis consist of PT-Cy combined with tacrolimus and low dose anti-thymoglobulin (ATG). Read More

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Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis.

Front Cell Infect Microbiol 2021 17;11:653228. Epub 2021 Mar 17.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Patients with sepsis commonly suffer from coagulation dysfunction and lead to the formation of thrombus. During the development of sepsis, neutrophils migrate from the circulating blood to infected tissues and mediate the formation of neutrophil extracellular traps (NETs) that kill pathogens. However, the overactivation of neutrophils can promote the formation of immunothrombosis and even cause disseminated intravascular coagulation (DIC), which damages microcirculation. Read More

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Phenotypic Changes in T Cell and Macrophage Subtypes in Perivascular Adipose Tissues Precede High-Fat Diet-Induced Hypertension.

Front Physiol 2021 17;12:616055. Epub 2021 Mar 17.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.

Perivascular adipose tissue (PVAT) may connect adiposity to hypertension because of its vasoactive functions and proximity to blood vessels. We hypothesized that immune cell changes in PVATs precede the development of high fat diet (HFD)-induced hypertension. Both sexes of Dahl S rat become equally hypertensive when fed a HFD. Read More

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Correlational analysis of the regulatory interplay between molecules and cellular components mediating angiogenesis in wound healing under normal and hyperglycemic conditions.

Clin Hemorheol Microcirc 2021 Apr 1. Epub 2021 Apr 1.

Bogomolets National Medical University, Kiev, Ukraine.

Aim: The aim of this study was to correlate the content of cells with regulatory molecules associated with angiogenesis in wound healing in a rat model of hyperglycemia. We hypothesize that blood neutrophils are the main VEGF source and can stimulate FLT-1 receptor expression, which is the perquisite for efficient neoangiogenesis.

Materials And Methods: Kinetic studies of the healing dynamics (3, 7, 14, 21 days) of burn wounds on the skin were conducted in white adult male rats. Read More

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A comparison study between the results of the Siemens ADVIA 120 analyzer and the manual method for differential leukocyte counts in sheep.

Vet Clin Pathol 2021 Apr 4. Epub 2021 Apr 4.

School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: The ADVIA 120 is a widely used hematology analyzer, which has not been previously validated for determining differential leukocyte counts in sheep.

Objectives: We aimed to compare differential leukocyte counts on the ADVIA 120 (A-Diff) with counts obtained using the manual method (M-Diff) in sheep.

Methods: Ethylenediaminetetraacetic acid-anticoagulated blood samples analyzed within 4 hours of collection were used. Read More

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Microbiota profiling in aging-associated inflammation and liver degeneration.

Int J Med Microbiol 2021 Mar 29;311(4):151500. Epub 2021 Mar 29.

Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria. Electronic address:

Background: The number of people above the age of 60 years is raising world-wide being associated with an increase in the prevalence of aging-associated impairments and even diseases. Recent studies suggest that aging is associated with alterations in bacterial endotoxin levels and that these changes may add to low-grade inflammation, the so-called 'inflammaging', and aging-associated liver degeneration. However, mechanisms involved, and especially, the interaction of intestinal microbiota and barrier in the development of aging-associated inflammation and liver degeneration have not been fully understood. Read More

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[Optimization of Mouse Model of Aplastic Anemia Induced by Pan T Lymphocytes Combined with Irradiation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):557-566

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020,

AbstractObjective: To establish an acquired aplastic anemia animal model for investigating the function of T lymphocyte and the pathogenesis and treatment of aplastic anemia(AA).

Methods: To establish the acquired aplastic anemia mouse model through the X-ray irradiation in combination with lymphocytes injection. AA Group: the purified Pan T lymphocytes from the spleen of C57BL/6J mice were enriched and injected to the mice through tail vein(5×10), the CB6F1 mice were exposed to 3,4 and 5 Gy X-ray irradiation; TBI Group: the CB6F1 mice were exposed to 3,4 and 5 Gy X-ray irradiation, and were injected with the same volume of PBS buffer; Control group: the CB6F1 mice were only injected with the same volume of PBS buffer. Read More

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[Effect of Etoposide on Elimination of Chronic Myeloid Leukemia Stem Cells by Imatinib in Vivo].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):395-402

School of Life Sciences and Biopharmaceutical,Guangzhou 510006, Guangdong Province, China,Guangdong Province Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou 510006, Guangdong Province, China,E-mail:

Objective: To investigate the effect of etoposide (ETO) on elimination of chronic myeloid leukemia (CML) stem cells by imatinib mesylate(IM) in vivo.

Methods: SCL-tTA/BCR-ABL mice were used as CML animal model. Flow cytometry was used to assess the effect of ETO alone or in combination with IM on the number of leukemia stem cell (LSC) in bone marrow and spleen, and peripheral blood neutrophils in CML mice and normal control FVB mice. Read More

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[Efficacy of Micro-Transplantation Consolidation Therapy for Patients with Acute Myeloid Leukemia after Complete Remission].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):316-321

Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China,Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China,E-mail:

Objective: To investigate the efficacy and safety of micro-transplantation in acute myeloid leukemia (AML).

Methods: The clinical data of 13 adult AML patients who received micro-transplantation as consolidation therapy from July 2014 to October 2019 was retrospectively analyzed, and the adverse reactions and efficacy of micro-transplantation were followed up.

Results: Eight patients received micro-transpantation were still in complete remission, 5 patients relapsed after micro-transplantation, 1 of them received umbilical cord blood micro-transplantation after remission by reinduction, and all of the 13 patients have survived till now. Read More

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