5,767 results match your criteria blood gondii


SAG3 Toxoplasma gondii cloning reveals unexpected fivefold infection in the blood of feral cats in the Mexican Caribbean.

BMC Vet Res 2022 Jan 14;18(1):33. Epub 2022 Jan 14.

Laboratorio de Inmunología Experimental, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Colonia Insurgentes-Cuicuilco, Delegación Coyoacán, Insurgentes Sur 3700C, Col. Insurgentes Cuicuilco, C.P. 04530, Ciudad de México, México.

Background: Currently, more than 300 genotypes of Toxoplasma gondii (T. gondii) have been described throughout the world, demonstrating its wide genetic diversity. The SAG3 locus is one of the genes included in the genotyping panel of this parasite. Read More

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January 2022

Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.

J Neuroinflammation 2022 Jan 13;19(1):17. Epub 2022 Jan 13.

Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Toxoplasma gondii (T. gondii) is a highly successful parasite being able to cross all biological barriers of the body, finally reaching the central nervous system (CNS). Previous studies have highlighted the critical involvement of the blood-brain barrier (BBB) during T. Read More

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January 2022

Comparative analysis of ketone body metabolism in BALB/c mice infected with Trypanosoma evansi and Toxoplasma gondii.

Res Vet Sci 2021 Dec 20;143:134-141. Epub 2021 Dec 20.

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, China; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

KBs (ketone bodies), i.e., acetoacetate, acetone, and (R)-3-Hydroxybutanoate, constitute the intermediate products of the incomplete oxidative degradation of fatty acids. Read More

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December 2021

First report on molecular epidemiology, seasonality and phylogeny of Toxoplasma gondii infecting goats from Khanewal district in Punjab, Pakistan.

Acta Trop 2022 Jan 6;228:106304. Epub 2022 Jan 6.

Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan. Electronic address:

Raising small ruminants is the main source of income for farmers in Pakistan. Economic losses caused by Toxoplasma gondii to small ruminants have been reported worldwide, however reports on molecular detection of T. gondii are lacking in Pakistan despite a large goat population. Read More

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January 2022

Primary Toxoplasma gondii infection-associated with hemophagocytic syndrome in a man with HIV infection: a case report.

BMC Infect Dis 2022 Jan 6;22(1):35. Epub 2022 Jan 6.

Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Background: Reactivation of latent Toxoplasma gondii (T. gondii) infection is more common than primary infection in patients with human immunodeficiency virus (HIV). We report a rare case of primary T. Read More

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January 2022

Dynamics of natural infection by Toxoplasma gondii in goat herds in the semiarid region of northeastern Brazil: transitional antibody observation.

Vet Res Commun 2022 Jan 5. Epub 2022 Jan 5.

Postgraduate Program in Animal Science, Federal University of Campina Grande (UFCG), Patos, Paraíba, Brazil.

This study aimed to describe the transmission of T. gondii in naturally infected goats in the semiarid region of northeastern Brazil, through evaluating the serological status of these animals from one to 12 months of age. Seven goat farms were selected. Read More

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January 2022

Sero-molecular survey on Toxoplasma gondii infection among drug addicted and non-addicted individuals: a case-control study.

BMC Infect Dis 2022 Jan 4;22(1):19. Epub 2022 Jan 4.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Up to now, epidemiological studies on the prevalence of Toxoplasma gondii infection among drug addicted individuals have been rarely performed. By designing an age and sex matched case-control study, we sought to determine the prevalence and associated factors with T. gondii infection in these population using serological and molecular techniques. Read More

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January 2022

Toxoplasma gondii infection in pet cats and their owners in northeastern China:an important public health concern.

BMC Vet Res 2022 Jan 3;18(1). Epub 2022 Jan 3.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, 130118, People's Republic of China.

Background: Limited information about Toxoplasma gondii infection in pet cats and their owners is available in China.

Methods: In this study, blood samples were randomly collected from 306 pet cats and 397 corresponding pet owners in Jilin province, northeastern China. Sera from the pet cats and the pet owners were tested for anti-T. Read More

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January 2022

Serosurvey and Molecular Detection of in Dogs in Rural Areas of Kazeroun District, Fars Province, Southern Iran.

J Parasitol Res 2021 15;2021:4499086. Epub 2021 Dec 15.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

is an intracellular protozoan parasite responsible for systemic disease in a wide range of warm-blooded animals. The current study is aimed at evaluating the prevalence of infection in dogs, using serological and molecular methods in rural areas in Kazeroun Township, Fars province, southern Iran. Blood samples were obtained from 60 clinically healthy dogs with an age range of 1 to 7 years in three rural areas of Fars province, southern Iran. Read More

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December 2021

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds.

Microorganisms 2021 Dec 18;9(12). Epub 2021 Dec 18.

Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.

Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites. Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs and cannot be eliminated as most of the other pig viruses can. Read More

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December 2021

Wild Rabbit Exposure to , , and Evidenced by Serum and Aqueous Humor Antibody Detection.

Microorganisms 2021 Dec 17;9(12). Epub 2021 Dec 17.

Department of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.

Wild rabbits () can be important sentinel species for the presence of zoonotic pathogens. Therefore, we collected blood samples from wild rabbits harvested by hunters during the hunting season 2019-2020 on the island of Lemnos, to determine exposure of wild rabbits to the zoonotic pathogens , , and , as well as aqueous humor to assess its diagnostic performance in terms of sensitivity, specificity, positive and negative likelihood ratios. Antibodies against these pathogens were detected by Indirect Immunofluorescence Antibody (IFA) assay. Read More

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December 2021

A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy.

J Infect Chemother 2021 Dec 17. Epub 2021 Dec 17.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan; Center for Recurrent Pregnancy Loss, Teine Keijinkai Hospital, 1-40, Maeda 1-jho, 12-chome, Teine-ku, Sapporo, 006-8555, Japan.

Introduction: The aims were to investigate the clinical characteristics of Toxoplasma gondii (T. gondii) immunoglobulin (Ig) M-positive mothers and to clarify the incidences of serum T. gondii IgM or blood T. Read More

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December 2021

Seroprevalence and risk factor investigation for the exposure of Toxoplasma gondii among veterinary personnel in Punjab, India.

Comp Immunol Microbiol Infect Dis 2021 Dec 14;80:101739. Epub 2021 Dec 14.

Centre for One Health, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab 141004, India; Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.

Toxoplasma gondii, a globally important food borne zoonotic parasite, infects most of the warm-blooded animals as well as people. Veterinarians and para vets are considered at risk of T. gondii exposure. Read More

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December 2021

MicroRNA-155 contributes to host immunity against Toxoplasma gondii.

Parasite 2021 15;28:83. Epub 2021 Dec 15.

Ningbo Women and Children's Hospital, Ningbo, Zhejiang, PR China.

Toxoplasma gondii is well known to infect almost all avian and mammalian species including humans, with worldwide distribution. This protozoan parasite can cause serious toxoplasmosis, posing with a risk to public health. The role of microRNAs in the pathogenesis of T. Read More

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December 2021

Soluble total antigen derived from Toxoplasma gondii RH strain prevents apoptosis, but induces anti-apoptosis in human monocyte cell line.

Folia Parasitol (Praha) 2021 Nov 23;68. Epub 2021 Nov 23.

Gastroenterology and Liver Diseases Research Centre, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran *Address for correspondence: Hamed Mirjalali, Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Arabi Street, 1985717413, Chamran Highway, Tehran, Iran. Email:

Apoptosis plays crucial role in the pathogenesis of toxoplasmosis, as it limits further development of the disease. The current study aimed to investigate the effects of different concentrations of soluble total antigen (STAg) of Toxoplasma gondii (Nicolle et Manceaux, 1908) on the apoptotic and anti-apoptotic pathways. PMA-activated THP-1 cell line was sensed by T. Read More

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November 2021

Spatial distribution and risk factors for sheep toxoplasmosis in Goiás, Brazilian Cerrado Region.

Vet Parasitol Reg Stud Reports 2021 Dec 27;26:100625. Epub 2021 Aug 27.

School of Veterinary and Zootechnics, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:

The present study aimed to evaluate the spatial distribution and risk factors for infection by Toxoplasma gondii in sheep in the state of Goiás, located in the central-western region of Brazil. Through the immunofluorescence antibody test (IFAT), the seroprevalence of anti-T. gondii antibodies was analyzed in 1000 blood serum samples obtained from sheep in all macro and micro regions of the state of Goiás. Read More

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December 2021

The Basal Complex Protein PfMORN1 Is Not Required for Asexual Replication of Plasmodium falciparum.

mSphere 2021 12 8;6(6):e0089521. Epub 2021 Dec 8.

Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.

Plasmodium falciparum, the Apicomplexan parasite that causes the most severe form of human malaria, divides via schizogony during the asexual blood stage of its life cycle. In this method of cell division, multiple daughter cells are generated from a single schizont by segmentation. During segmentation, the basal complex forms at the basal end of the nascent daughter parasites and likely facilitates cell shape and cytokinesis. Read More

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December 2021

Blood-brain barrier-restricted translocation of from cortical capillaries.

Elife 2021 12 8;10. Epub 2021 Dec 8.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

The cellular barriers of the central nervous system proficiently protect the brain parenchyma from infectious insults. Yet, the single-celled parasite commonly causes latent cerebral infection in humans and other vertebrates. Here, we addressed the role of the cerebral vasculature in the passage of to the brain parenchyma. Read More

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December 2021

Investigating the risk factors for seroprevalence and the correlation between CD4+ T-cell count and humoral antibody responses to Toxoplasma gondii infection amongst HIV patients in the Bamenda Health District, Cameroon.

PLoS One 2021 2;16(12):e0256947. Epub 2021 Dec 2.

Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Background: Toxoplasmosis is caused by an obligate intracellular tissue protozoan parasite, Toxoplasma gondii that infect humans and other warm-blooded animals. Transmission to humans is by eating raw or inadequately cooked infected meat or through ingestion of oocysts that cats have passed in faeces. Studies have shown life-threatening and substantial neurologic damage in immunocompromised patients; however, 80% of humans remain asymptomatic. Read More

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January 2022

Seroprevalence of , Rubella, Group A , CMV and HSV-1 in COVID-19 Patients with Vitamin D Deficiency.

Pak J Biol Sci 2021 Jan;24(11):1169-1174

<b>Background and Objective:</b> In recent years, respiratory tract viral infections have caused many pandemics that impact the whole world. To investigate the seropositivity of <i>Toxoplasma gondii</i>, rubella, CMV, HSV-1 and group A <i>Streptococcus</i> in recovered COVID-19 patients and correlate these findings with vitamin D levels. <b>Materials and Methods:</b> A total of 417 COVID-19 patients with diarrhoea were enrolled in this study. Read More

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January 2021

Comparison of real-time PCR and nested PCR for toxoplasmosis diagnosis in toxoplasmic retinochoroiditis patients.

BMC Infect Dis 2021 Nov 23;21(1):1180. Epub 2021 Nov 23.

Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Backgrounds: PCR is a proper technique that significantly improves toxoplasmosis diagnosis. However, a more sensitive technique is required. This study compared real-time PCR with nested PCR using B1, SAG-4, and MAG-1 bradyzoite genes to diagnose toxoplasmosis in toxoplasmic retinochoroiditis patients. Read More

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November 2021

The role of polyspecific T-cell exhaustion in severe outcomes for COVID-19 patients having latent pathogen infections such as Toxoplasmagondii.

Authors:
Kevin Roe

Microb Pathog 2021 Dec 20;161(Pt B):105299. Epub 2021 Nov 20.

San Jose, California, USA. Electronic address:

Various categories of coronavirus disease 19 (COVID-19) patients have exhibited major mortality rate differences and symptoms. Some papers have recently explained these differences in mortality rates and symptoms as a consequence of this virus infection acting in synergy with one or more latent pathogen infections in some patients. A latent pathogen infection likely to be involved in millions of these patients is the protozoan parasite Toxoplasma gondii, which infects approximately one third of the global human population. Read More

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December 2021

Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort.

Front Immunol 2021 4;12:727457. Epub 2021 Nov 4.

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

The burden of infections on an individual and public health is profound. Many observational studies have shown a link between infections and the pathogenesis of disease; however a greater understanding of the role of host genetics is essential. Children from the longitudinal birth cohort, the Avon Longitudinal Study of Parents and Children, had 14 antibodies measured in plasma at age 7: Alpha-casein protein, beta-casein protein, cytomegalovirus, Epstein-Barr virus, feline herpes virus, , herpes simplex virus 1, influenza virus subtype H1N1, influenza virus subtype H3N2, measles virus, , Theiler's virus, , and SAG1 protein domain, a surface antigen of measured for greater precision. Read More

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November 2021

High rate of feline immunodeficiency virus infection in cats in the Brazilian semiarid region: Occurrence, associated factors and coinfection with Toxoplasma gondii and feline leukemia virus.

Comp Immunol Microbiol Infect Dis 2021 Dec 7;79:101718. Epub 2021 Nov 7.

Laboratório de Imunologia e Doenças Infectocontagiosas. Departamento de Medicina Veterinária. Instituto Federal de Educação, Ciência e Tecnologia da Paraíba, IFPB, Sousa, Paraíba, Brasil.

To evaluate the occurrence of feline immunodeficiency virus (FIV) and factors associated with this and to demonstrate occurrences of coinfection with Toxoplasma gondii and feline leukemia virus (FeLV) in cats, a total of 103 blood samples were collected from owned cats, during home visits. To diagnose FIV and FeLV, immunochromatographic kit was used and serological diagnoses of T. gondii, the indirect immunofluorescence test was performed. Read More

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December 2021

[Development of a fluorescent recombinase-aided isothermal amplification-based nucleic acid assay for detection of ].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Oct;33(5):452-456

Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, China.

Objective: To develop a fluorescent recombinase-aided isothermal amplification (RAA)-based nucleic acid assay for detection of .

Methods: Specific primers and probes were designed targeting internal transcribed spacer 1 () gene for RAA assay, and a fluorescent RAA assay was developed for detection of following screening of primer pairs and optimization of primer and probe concentrations. The sensitivity of RAA assay for detection of was evaluated using recombinant plasmid containing gene sequences at different copies and genomic DNA at different concentrations as templates, and the specificity of RAA assay for detection of was evaluated using the genomic DNA of transfusion-transmitted parasites, including , , , , , , and . Read More

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October 2021

Postnatal ocular toxoplasmosis in immunocompetent patients.

J Infect Dev Ctries 2021 10 31;15(10):1515-1522. Epub 2021 Oct 31.

National Reference Laboratory for Toxoplasmosis, Institute for Medical Research, University of Belgrade, Belgrade, Serbia.

Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Read More

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October 2021

Detection of Acute and Chronic Infection among Women with History of Abortion in the Southwest of Iran.

J Parasitol Res 2021 2;2021:6693070. Epub 2021 Nov 2.

Research Center for Environmental Contaminants (RCEC), Abadan University of Medical Sciences, Abadan, Iran.

Background: () is one of the most common intracellular protozoan parasites, which can infect humans and a wide range of mammals and birds. The current study is aimed at investigating the occurrence of infection in women with a history of abortion in Khuzestan, Iran.

Materials And Methods: A total of 480 women with an abortion history, as well as 200 pregnant women with a normal delivery, were examined in this study. Read More

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November 2021

Detection of Specific IgG-Antibodies Against in the Serum and Milk of Domestic Donkeys During Lactation in China: A Potential Public Health Concern.

Front Cell Infect Microbiol 2021 21;11:760400. Epub 2021 Oct 21.

Technology Center, Changchun Customs, Changchun, China.

is a worldwide zoonotic protozoan. Donkeys are often susceptible to many pathological agents, acting as carriers of pathogens for other animal species and humans. However, data on the prevalence of in donkeys during lactation and on the status of antibodies against in donkey milk are lacking. Read More

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November 2021

Pathogens with potential impact on reproduction in captive and free-ranging European bison (Bison bonasus) in Poland - a serological survey.

BMC Vet Res 2021 Nov 4;17(1):345. Epub 2021 Nov 4.

Department of Food Hygiene and Public Health Protection, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 166, 02-787, Warsaw, Poland.

Background: The European bison is an endangered species, and as such it is extremely important to monitor herds for pathogens which can lead to reproductive failure. The aim of the present study was to determine the current prevalence of antibodies to pathogens known to potentially influence reproduction in European bison. Serum samples from 183 bison, originating from different parts of Poland, were tested using commercial ELISA tests for antibodies to Chlamydia spp. Read More

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November 2021

Foodborne Parasites Dominate Current Parasitic Infections in Hunan Province, China.

Front Cell Infect Microbiol 2021 14;11:774980. Epub 2021 Oct 14.

Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha, China.

Great progress has been made in the prevention and treatment of human parasitic diseases in China over the past six decades, but parasitic diseases are still one of the most serious public health problems in the world. The specific prevalence of parasitic diseases varies in different provinces due to their geographical environment and the dietary habits of people. In this study, a total of 4,428 patients suspected to have parasitic infection by clinicians or themselves from January 1, 2016, to December 31, 2020 were recommended to our laboratory for further testing. Read More

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November 2021