300,300 results match your criteria blood glucose

Clinical interpretation of the flash continuous glucose monitoring data out of range in type 2 diabetes: a real-world study.

Diabetes Res Clin Pract 2021 Jul 28:108989. Epub 2021 Jul 28.

Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510250, China. Electronic address:

Aims: Flash continuous glucose monitoring system (FCGM) reports nocturnal hypoglycemia with low accuracy in low blood glucose. In our study, we aimed to evaluate the accuracy and clinic profile of FCGM data out of range in T2DM.

Methods: FCGM data out of range were measured in T2DM patients at eight-time points of a day and compared with fingertip capillary blood glucose levels (REFs) as reference values. Read More

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Combined therapy of adenovirus vector mediated IGF-1 gene with anti-CD20 mAbs exerts potential beneficial role on type 1 diabetes in nonobese diabetic mice.

Life Sci 2021 Jul 28:119853. Epub 2021 Jul 28.

Department of Medical College, Shenzhen Polytechnic, Shenzhen 518055, Guangdong Province, PR China. Electronic address:

Aims: To assess the protective effects of combined treatment with anti-CD20 monoclonal antibody (mAb) and adenovirus mediated mouse insulin-like growth factor 1 (Adv-mIGF-1) gene on type 1 diabetes (T1D) in nonobese diabetic (NOD) mice at early stage.

Methods: To simultaneously restore the proportion of Th cells and block the interaction of B cells, NOD model mice were assigned to four groups which received PBS, Adv-mIGF-1 gene and anti-CD20 mAbs alone or combination, respectively. After 16 weeks of therapeutic intervention, blood samples and pancreatic tissues of mice were measured via the methods of ELISA, RT-PCR, western blotting, H&E staining, TUNEL and immunohistochemistry assays. Read More

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Feasibility study evaluating a veterinary point-of-care urine culture system for diagnosing septic peritonitis.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 31. Epub 2021 Jul 31.

Department of Microbiology & Immunology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Objective: To evaluate the use of a veterinary point-of-care urine culture system (POCUCS) for the diagnosis of septic peritonitis.

Design: Prospective feasibility study performed between August 2017 and April 2018.

Setting: Private referral hospital. Read More

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Effect of Curcumin on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials.

Adv Exp Med Biol 2021 ;1291:139-149

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition, which carries considerable morbidity and mortality. There is growing evidence that curcumin could modulate glucose homeostasis and improve vascular risk in patients with T2DM. The aim of this systematic review was to study the effect of curcumin on glycemic indices in patients with diabetes. Read More

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January 2021

Iterative principal component analysis method for improvised classification of breast cancer disease using blood sample analysis.

Med Biol Eng Comput 2021 Jul 31. Epub 2021 Jul 31.

Department of Information Science and Technology, College of Engineering, Anna University, Guindy, 600025, Chennai, India.

Breast cancer is the most common cancer in women occurring worldwide. Some of the procedures used to diagnose breast cancer are mammogram, breast ultrasound, biopsy, breast magnetic resonance imaging, and blood tests such as complete blood count. Detecting breast cancer at an early stage plays an important role in diagnostic and curative procedures. Read More

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Metformin stimulates intestinal glycolysis and lactate release: A single-dose study of metformin in patients with intrahepatic portosystemic stent.

Clin Pharmacol Ther 2021 Jul 31. Epub 2021 Jul 31.

Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200, Aarhus N, Denmark.

The pharmacodynamic effects of metformin remain elusive, but several lines of evidence suggest a critical role of direct effects in the gastrointestinal (GI) tract. We investigated if metformin stimulates intestinal glucose metabolism and lactate release in the prehepatic circulation. We included eight patients with transjugular intrahepatic portosytemic stent (TIPS) in an open label study. Read More

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Feasibility and application of trimetazidine in F-FDG PET myocardial metabolic imaging of diabetic mellitus patients with severe coronary artery disease: A prospective, self-controlled study.

J Nucl Cardiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.

Background: F-FDG PET myocardial metabolic imaging (MMI) is sometimes uninterpretable due to background activity from uncontrolled glucose homeostasis in diabetic mellitus (DM) patients. Trimetazidine is an oral medication that promotes the transformation of myocardial energy supply from free fatty acids to glucose. We aimed to investigate the feasibility and application of trimetazidine in F-FDG PET MMI of DM patients. Read More

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Distinct opposing associations of upper and lower body fat depots with metabolic and cardiovascular disease risk markers.

Int J Obes (Lond) 2021 Jul 30. Epub 2021 Jul 30.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.

Background: To examine the associations of total and regional adiposity with metabolic and cardiovascular disease (CVD) risk markers.

Methods: This cross-sectional study included 1080 (53.8% men, aged 39-44 years) individuals from South India. Read More

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Triglyceride glucose (TyG) index and the progression of liver fibrosis: A cross-sectional study.

Clin Nutr ESPEN 2021 Aug 7;44:483-487. Epub 2021 May 7.

Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Non-alcoholic fatty liver (NAFLD) is a multi-factorial liver disease and its incidence is globally rising. Little is known about the association between triglyceride glucose (TyG) index and liver fibrosis progression in NAFLD patients.

Aim: To examine the association of liver fibrosis with TyG index among patients with NAFLD in a sample of Iranian adults. Read More

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Correlation between vitamin D deficiency and fasting blood glucose levels in obese children.

Clin Nutr ESPEN 2021 Aug 2;44:200-203. Epub 2021 Jul 2.

Department of Pediatrics, Hasanuddin University's Faculty of Medicine, Makassar, 90245, Indonesia.

Background: This study aimed to determine the relationship between Deficiency of vitamin D and hyperglycemia in children with obesity.

Methods: This cross-sectional study was carried out between February and April of 2020. This study's subject population consisted of high school students aged 11 to 17 who were obese. Read More

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Implications of gender-based variabilities in bone mineral density and hemoglobin levels.

BMC Musculoskelet Disord 2021 Jul 30;22(1):645. Epub 2021 Jul 30.

School of Laboratory Medicine, Wannan Medical College, 22 West Wenchang Road, Wuhu, Anhui Province, 241002, People's Republic of China.

Background: Studies reported that there is a relationship between volumetric bone mineral density (vBMD) and hemoglobin (HGB) in sickle cell anemia, chronic obstructive pulmonary disease, inflammatory bowel disease, and chronic kidney disease, it is not clear whether this association exists in normal populations or different genders. In order to further clarify the relationship between vBMD and HGB, and provide the basis for the diagnosis of related diseases, this study was conducted in the physical examination population.

Methods: A cross-sectional study was conducted on a health check-up population from Wannan area of China from January to December 2018. Read More

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Ecological Momentary Assessment (EMA) of Positive and Negative Affect and Associations with Blood Glucose (BG) in Teens with Type 1 Diabetes (T1D).

J Diabetes Sci Technol 2021 Jul 30:19322968211035451. Epub 2021 Jul 30.

Harvard Medical School, Joslin Diabetes Center, Boston, MA, USA.

Background: Affect (i.e., emotions) can be associated with diabetes self-care and ambient glucose in teens with type 1 diabetes (T1D). Read More

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A new interventional home care model for COVID management: Virtual Covid IP.

Diabetes Metab Syndr 2021 Jul 23;15(5):102228. Epub 2021 Jul 23.

Department of Diabetology, Jothydev's Diabetes Research Centers, Kerala, India.

Aim: Amidst COVID-19 pandemic, the health care delivery in India faces major challenges owing to the overwhelming hospitals, exhausted healthcare workers, and shortage of crucial medical supplies such as ventilators and oxygen. The study aims to propose a novel successful interventional home care model, the Virtual COVID In-Patient (VCIP) care for effective COVID management.

Methods: The Covid-19 positive patients enrolled in VCIP were chosen for the study. Read More

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Characterization of PFOS toxicity on in-vivo and ex-vivo mouse pancreatic islets.

Environ Pollut 2021 Jul 26;289:117857. Epub 2021 Jul 26.

Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Considerable human data have shown that the exposure to perfluorooctane sulfonate (PFOS) correlates to the risk of metabolic diseases, however the underlying effects are not clearly elucidated. In this study, we investigated the impacts of PFOS treatment, using in-vivo, ex-vivo and in-vitro approaches, on pancreatic β-cell functions. Mice were oral-gavage with 1 and 5 μg PFOS/g body weight/day for 21 days. Read More

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FGF15/FGF19 alleviates insulin resistance and upregulates placental IRS1/GLUT expression in pregnant mice fed a high-fat diet.

Placenta 2021 Jul 15;112:81-88. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Introduction: This study aimed to evaluate whether FGF19 can alleviate insulin resistance and change the expression of placental IRS1/GLUTs.

Methods: Mice transgenic for Fgf15 (the murine homologue of human FGF19) were constructed, and human recombinant FGF19 was administered to pregnant high-fat diet mice. Then, glycolipid metabolism parameters and the weight of foetus and placenta were observed. Read More

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Design of intelligent diabetes mellitus detection system using hybrid feature selection based XGBoost classifier.

Comput Biol Med 2021 Jul 22;136:104664. Epub 2021 Jul 22.

Division of Instrumentation and Control Engineering, Netaji Subhas Institute of Technology, University of Delhi, New Delhi, India. Electronic address:

In this work, a non-invasive diabetes mellitus detection system is proposed based on the wristband photoplethysmography (PPG) signal and basic physiological parameters (PhyP) to enable easy detection of diabetes mellitus (DM). A dataset of 217 participants with diabetes, prediabetes and normal conditions is used to develop the system. The Mel frequency cepstral coefficients (MFCC) extracted from 5s PPG signal segments and the PhyP are used as input for the machine learning algorithms. Read More

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Prevalence of non-communicable diseases risk factors and their determinants: Results from STEPS survey 2019, Nepal.

PLoS One 2021 30;16(7):e0253605. Epub 2021 Jul 30.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Background: The World Health Organization (WHO) recommends ongoing surveillance of non-communicable diseases (NCDs) and their risk factors, using the WHO STEPwise approach to surveillance (STEPS). The aim of this study was to assess the distribution and determinants of NCD risk factors in Nepal, a low-income country, in which two-thirds (66%) of annual deaths are attributable to NCDs.

Methods: A nationally representative NCD risk factors STEPS survey (instrument version 3. Read More

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Inpatient Glycemic Control With Sliding Scale Insulin in Noncritical Patients With Type 2 Diabetes: Who Can Slide?

J Hosp Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Medicine, Emory University, Atlanta, Georgia.

Objective: Despite clinical guideline recommendations, sliding scale insulin (SSI) is widely used for the hospital management of patients with type 2 diabetes (T2D). We aimed to determine which patients with T2D can be appropriately managed with SSI in non-critical care settings.

Methods: We used electronic health records to assess inpatient glycemic control in medicine and surgical patients treated with SSI according to admission blood glucose (BG) concentration between June 2010 and June 2018. Read More

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The effect of sorghum consumption on markers of chronic disease: A systematic review.

Crit Rev Food Sci Nutr 2021 Jul 30:1-19. Epub 2021 Jul 30.

School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.

Sorghum requires fewer inputs for sustainable cultivation in harsh climates and has the potential to be utilized in modern food product innovations. Moreover, consumption of sorghum may elicit favorable health effects similar to other commonly consumed cereals, like wheat. Animal and human research exploring health effects of sorghum consumption indicates potential beneficial effects on blood glucose and lipid regulation, oxidative stress modulation, appetite regulation and weight management. Read More

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Effect of one-week administration of dipeptidyl peptidase-IV inhibitory peptides from chum salmon milt on postprandial blood glucose level: a randomised, placebo-controlled, double-blind, crossover, pilot clinical trial.

Food Funct 2021 Jul 30. Epub 2021 Jul 30.

Department of Medical Management and Informatics, Hokkaido Information University, 59-2, Nishi-nopporo, Ebetsu, Hokkaido, 069-8585, Japan.

Salmon milt peptide (SMP), an unused fish processing byproduct, exhibits strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV) and a suppressive effect on postprandial hyperglycaemia in Sprague-Dawley rats. Herein, we conducted a randomised, placebo-controlled, double-blind, crossover study of healthy Japanese subjects to investigate the effect of glucose loading on postprandial blood glucose levels after one week of administering continuous or single dose of 500 mg of SMP. The primary and secondary outcomes of reduced blood glucose and insulin levels were not met in the 14 subjects included in the analysis. Read More

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The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial.

Biomed Pharmacother 2021 Jul 10;141:111915. Epub 2021 Jul 10.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Based on a comprehensive search, we realized that the findings of the available literature are contradictory, and also limited data are available on Middle Eastern populations in terms of probiotic supplementation during the pregnancy. Therefore, the current double-blind, randomized, placebo-controlled clinical trial was carried out to investigate the effects of probiotic supplementation during pregnancy on the risk of gestational diabetes mellitus and also other maternal and neonatal outcomes.

Materials And Methods: The pregnant women were randomized to either received probiotic supplement (n = 271) or placebo (n = 271) from the first half of the second trimester (14 weeks of pregnancy) up to 24 weeks when pregnant women routinely evaluated regarding the GDM. Read More

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New progress in drugs treatment of diabetic kidney disease.

Biomed Pharmacother 2021 Jul 19;141:111918. Epub 2021 Jul 19.

Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but also the leading cause of the end-stage renal disease (ESRD). The occurrence and development of DKD have always been a serious clinical problem that leads to the increase of morbidity and mortality and the severe damage to the quality of life of human beings. Controlling blood glucose, blood pressure, blood lipids, and improving lifestyle can help slow the progress of DKD. Read More

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The Need for Sharps Waste Disposal Guidelines for Commercial Airports.

J Diabetes Sci Technol 2021 Jul 30:19322968211024268. Epub 2021 Jul 30.

Mills-Peninsula Medical Center, San Mateo, CA, USA.

Travelers frequently eat at an airport before their flight. Travelers with diabetes also frequently need to lance their fingertips to check a blood glucose concentration and/or inject themselves with insulin. These actions generate medical sharps waste. Read More

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[Analysis of the development of acute coronary syndrome during the COVID-19 pandemic].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Jun;29(Special Issue):603-606

Pirogov Russian National Research Medical University, 117997, Moscow, Russia.

The study compares two groups of patients with acute coronary syndrome, depending on the presence of COVID-19 in the anamnesis. The comparison groups analyzed the risk factors for cardiovascular diseases, including smoking, heredity, gender differences, age, diabetes, and obesity. The results of biochemical blood tests were analyzed. Read More

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Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk.

Mol Nutr Food Res 2021 Jul 30:e2001051. Epub 2021 Jul 30.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

Scope: Peanuts are widely consumed as a meal ingredient and a snack, and are commonly considered as a healthy food based on their nutrient profile. Peanut consumption has been associated with a lower risk of metabolic syndrome (MetS) in epidemiological studies. In this study, we aimed to investigate whether consuming peanuts affects the gut microbiota in adults with risk of metabolic syndrome and whether the intervention effect of peanuts is associated with gut microbiota composition. Read More

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Influence of pregnancy and non-fasting conditions on the plasma metabolome in a rat prenatal toxicity study.

Arch Toxicol 2021 Jul 30. Epub 2021 Jul 30.

Experimental Toxicology and Ecology, BASF SE, 67056, Ludwigshafen, Germany.

The current parameters for determining maternal toxicity (e.g. clinical signs, food consumption, body weight development) lack specificity and may underestimate the extent of effects of test compounds on the dams. Read More

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Ten things to know about ten cardiovascular disease risk factors.

Am J Prev Cardiol 2021 Mar 23;5:100149. Epub 2021 Jan 23.

CGH Medical Center, Sterling, IL USA.

Given rapid advancements in medical science, it is often challenging for the busy clinician to remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and maintain awareness of the latest guidelines applicable to cardiovascular disease (CVD) risk factors. The "American Society for Preventive Cardiology (ASPC) Top Ten CVD Risk Factors 2021 Update" is a summary document (updated yearly) regarding CVD risk factors. This "ASPC Top Ten CVD Risk Factors 2021 Update" summary document reflects the perspective of the section authors regarding ten things to know about ten sentinel CVD risk factors. Read More

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Risk factor control across the spectrum of cardiovascular risk: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Am J Prev Cardiol 2021 Mar 13;5:100147. Epub 2021 Jan 13.

Department of Hospital Medicine, San Francisco VA Medical Center, San Francisco, CA, USA.

Background: Presence of cardiovascular disease (CVD) risk factors (RFs) should prompt patients and their providers to work aggressively towards controlling those that are modifiable. The extent to which a greater CVD RF burden is related to CVD RF control in a contemporary and diverse Hispanic/Latino population is not well-understood.

Methods: Using multicenter community-based data from the Hispanic Community Health Study/Study of Latinos, we assessed the self-reported prevalence of hypertension, hypercholesterolemia, diabetes, and prevalent CVD (ischemic heart disease or stroke). Read More

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The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study.

Am J Prev Cardiol 2020 Dec 20;4:100097. Epub 2020 Oct 20.

Houston Methodist, Debakey Heart and Vascular Institute, Houston, TX, USA.

Background: Recent studies suggest that non-alcoholic fatty liver disease (NAFLD) in lean (BMI<25 ​kg/m) individuals presents a distinct phenotype. We sought to determine the cardiometabolic consequences of lean NAFLD in a population cohort of relatively young asymptomatic individuals who participated in a voluntary routine health promotion evaluation in Brazil.

Methods: We analyzed data in our population collected from 2004 to 2016. Read More

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December 2020

Blood pressure and cardiovascular diseases in Chinese adults with type 2 diabetes: A prospective cohort study.

Lancet Reg Health West Pac 2021 Feb 23;7:100085. Epub 2021 Jan 23.

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.

Background: Controversy persists about the relationship of blood pressure with cardiovascular diseases (CVD) in diabetes and associated disease burden. We assessed these associations among Chinese adults with type 2 diabetes (T2D).

Methods: In 2004-08, the China Kadoorie Biobank recruited >512,000 adults aged 30-79 years from 10 localities across China, including 26,315 with T2D (based on self-report or plasma glucose measurement) but no prior CVD, followed-up for ~9 years. Read More

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February 2021