563,312 results match your criteria blood flow

HEDOS - a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Division of Radiation Biophysics, Department of Radiation Oncology, , Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, UNITED STATES.

We have developed a time-dependent computational framework, HEDOS (HEmatological DOSe), to estimate dose to circulating blood cells from radiation therapy treatment fields for any treatment site. Two independent dynamic models were implemented in HEDOS: one describing the spatiotemporal distribution of blood particles (BPs) in organs and the second describing the time-dependent radiation field delivery. A whole-body blood flow network based on blood volumes and flow rates from ICRP Publication 89 was simulated to produce the spatiotemporal distribution of BPs in organs across the entire body using a discrete-time Markov process. Read More

View Article and Full-Text PDF

Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

View Article and Full-Text PDF

Personalized 0D-1D multiscale hemodynamic modeling and wave dynamics analysis of cerebral circulation for an elderly patient with dementia.

Int J Numer Method Biomed Eng 2021 Jul 22:e3510. Epub 2021 Jul 22.

Graduate School of Engineering, Chiba University, Chiba, Japan.

Senile dementia is associated with pronounced alterations in cerebral circulation. A fundamental understanding of intracranial hemodynamics and wave dynamics is essential for assessing dementia risk. Recent findings suggest that higher carotid artery wave intensity (WI) can predict future cognitive impairments in the elderly. Read More

View Article and Full-Text PDF

A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery.

Transfusion 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, MCL Academy, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Background: Patients undergoing cardiothoracic surgery are at substantial risk for blood transfusion. Increased awareness and patient blood management have resulted in a significant reduction over the past years. The next step is preoperative treatment of patients at high risk for packed red blood cells (RBC) transfusion, with the ultimate goal to eventually prevent RBC transfusion. Read More

View Article and Full-Text PDF

A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles.

J Physiol Biochem 2021 Jul 22. Epub 2021 Jul 22.

INRAE, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Université Clermont Auvergne, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.

The purpose of this study was to determine whether magnesium L-lactate is responsible for having a beneficial effect on the myocardium and the skeletal muscles and how this substrate acts at the molecular level. Twenty seven young male Wistar rats were supplied with a magnesium L-lactate (L) solution, a magnesium chloride (M) solution and/or water (W) as a vehicle for 10 weeks. The treated animals absorbed the L and M solutions as they wished since they also had free access to water. Read More

View Article and Full-Text PDF

Association of serum apolipoprotein B with retinal neurovascular structural alterations in patients with type 2 diabetes: an optical coherence tomography angiography study.

Acta Diabetol 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

Purpose: To investigate the association of serum apoB concentrations with retinal neurovascular structural alterations in type 2 diabetes patients without clinically visible retinopathy.

Methods: Eyes with no clinically visible diabetic retinopathy (DR) from diabetic patients with or without dyslipidemia were included. Changes in retinal neural structures, including the ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (RNFL) thicknesses, and microvascular metrics, including macular vessel density (VD) and perfusion density (PD) of the superficial capillary plexus, were measured with optical coherence tomography angiography (OCTA). Read More

View Article and Full-Text PDF

Non-Invasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals with Posttraumatic Stress Disorder.

Psychosom Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta GA Department of Medicine (Cardiology), Emory University School of Medicine, Atlanta, GA Atlanta VA Medical Center, Decatur, GA Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta GA Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.

Objective: Posttraumatic stress disorder (PTSD) is a disabling condition affecting a large segment of the population, however current treatment options have limitations. New interventions that target the neurobiological alterations underlying symptoms of PTSD could be highly beneficial. Transcutaneous cervical (neck) vagal nerve stimulation (tcVNS) has the potential to represent such an intervention. Read More

View Article and Full-Text PDF

Predicting outcome in higher-risk myelodysplastic syndrome patients treated with azacitidine.

Epigenomics 2021 Jul 22. Epub 2021 Jul 22.

Second Department of Internal Medicine & Research Unit Hematology Unit, University General Hospital Attikon, Rimini, 12462 Chaidari, Athens, Greece.

5-Azacitidine (5-AZA) is widely used for the treatment of higher-risk myelodysplastic syndromes. However, response and survival rates vary considerably, while indicated treatment duration remains undefined. For these reasons, factors determining response and survival are of major importance. Read More

View Article and Full-Text PDF

Brain perfusion magnetic resonance imaging using pseudocontinuous arterial spin labeling in 314 dogs and cats.

J Vet Intern Med 2021 Jul 22. Epub 2021 Jul 22.

Unit of Diagnostic Imaging, ADVETIA Veterinary Referral Hospital, Vélizy-Villacoublay, France.

Background: Arterial spin labeling (ASL) is a noninvasive brain perfusion magnetic resonance imaging (MRI) technique that has not been assessed in clinical veterinary medicine.

Hypothesis/objectives: To test the feasibility of ASL using a 1.5 Tesla scanner and provide recommendations for optimal quantification of cerebral blood flow (CBF) in dogs and cats. Read More

View Article and Full-Text PDF

Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background And Aims: This study aimed to investigate the impact of fish oil-based lipid emulsion (FO) on enterohepatic injuries and intestinal microbiota in piglets of total parenteral nutrition (TPN).

Methods: Newborn piglets were divided into three groups, including enteral diet (the controls), TPN with 100% FO and TPN with MCT/LCT-based lipid emulsion (MCT/LCT) for 14 days. Serum biochemical indicators, hepatic and intestinal histology, and expression of genes associated with inflammation, oxidative stress, and lipid metabolism were measured. Read More

View Article and Full-Text PDF

A valuable echocardiographic indicator for the optimal tightness of bilateral pulmonary artery banding.

Gen Thorac Cardiovasc Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatric Cardiac Surgery, Children's Medical Center, Gifu Prefectural General Medical Center, 4-6-1 Noishiki Gifu, Gifu, 500-8716, Japan.

Objectives: The optimal tightness of bilateral pulmonary artery banding (BPAB) is considered to balance not only systemic-to-pulmonary blood flow but also each pulmonary blood flow, which is still challenging. To achieve them, we adopt the end-diastolic velocity (EDV) to the peak systolic velocity (PSV) ratio at BPAB with intraoperative epicardial echocardiography. We evaluated the usefulness of the EDV to PSV ratio and the patient outcomes. Read More

View Article and Full-Text PDF

Two-Versus One-Stage Nipple-Sparing Mastectomy: Timing of Surgery Prevents Nipple Loss.

Ann Surg Oncol 2021 Jul 21. Epub 2021 Jul 21.

Section of Surgical Oncology, Department of Surgery, Stanford University School of Medicine Stanford, Stanford, CA, USA.

Background: Devascularization of the nipple-areola complex (NAC) before nipple-sparing mastectomy (NSM) enhances blood flow to the skin. This study analyzed the effect of the interval between stages in two-stage (2S) operations and compared the ischemic events with those of one-stage (1S) NSM.

Methods: Ischemic complications were defined as partial/reversible (PR) or full-thickness/irreversible (FI) skin necrosis of the NAC or flap. Read More

View Article and Full-Text PDF

microRNAs involved in psoriasis and cardiovascular diseases.

Vasc Biol 2021 3;3(1):R49-R68. Epub 2021 Jun 3.

Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Via Fosso del Cavaliere, Rome, Italy.

Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular disease (CVD), and cerebrovascular diseases (CeVD). Read More

View Article and Full-Text PDF

HLA Antibody Incompatible Renal Transplantation: Long-term Outcomes Similar to Deceased Donor Transplantation.

Transplant Direct 2021 Aug 19;7(8):e732. Epub 2021 Jul 19.

H&I Laboratory, NHS Blood and Transplant, Birmingham, United Kingdom.

Background: HLA incompatible renal transplantation still remains one of best therapeutic options for a subgroup of patients who are highly sensitized and difficult to match but not much is known about its long-term graft and patient survival.

Methods: One hundred thirty-four HLA incompatible renal transplantation patients from 2003 to 2018 with a median follow of 6.93 y were analyzed retrospectively to estimate patient and graft survivals. Read More

View Article and Full-Text PDF

Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma.

ERJ Open Res 2021 Jul 19;7(3). Epub 2021 Jul 19.

Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.

Background: Dysregulation of tumour necrosis factor-α (TNF-α) signalling is implicated in neutrophilic asthma. TNF-α signalling involves membrane-bound and soluble ligand (TNF-α) and receptors (TNFRs); however, little is known about how these proteins are altered in asthma. We hypothesised that intercompartment-, immune cell- and/or asthma inflammatory phenotype-dependent regulation could relate to TNF dysregulation in neutrophilic asthma. Read More

View Article and Full-Text PDF

White Matter Hyperintensity Volume and Location: Associations With WM Microstructure, Brain Iron, and Cerebral Perfusion.

Front Aging Neurosci 2021 5;13:617947. Epub 2021 Jul 5.

Department of Neuroscience, University of Kentucky, Lexington, KY, United States.

Cerebral white matter hyperintensities (WMHs) represent macrostructural brain damage associated with various etiologies. However, the relative contributions of various etiologies to WMH volume, as assessed via different neuroimaging measures, is not well-understood. Here, we explored associations between three potential early markers of white matter hyperintensity volume. Read More

View Article and Full-Text PDF

Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies.

Front Neurosci 2021 5;15:684926. Epub 2021 Jul 5.

College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Previous studies have identified altered brain changes in chronic pain patients, however, it remains unclear whether these changes are reversible. We summarized the neural and molecular changes in patients with chronic pain and employed a meta-analysis approach to quantify the changes. We included 75 studies and 11 of these 75 studies were included in the activation likelihood estimation (ALE) analysis. Read More

View Article and Full-Text PDF

Diabetic Retinopathy in the Aging Population: A Perspective of Pathogenesis and Treatment.

Clin Interv Aging 2021 15;16:1367-1378. Epub 2021 Jul 15.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.

The elderly population in the United States is projected to almost double by the year 2050. In addition, the numbers of diabetics are rising, along with its most common complication, diabetic retinopathy (DR). To effectively treat DR within the elderly population, it is essential first to consider the retinal changes that occur due to aging, such as decreased blood flow, retinal thinning, and microglial changes, and understand that these changes can render the retina more vulnerable to oxidative and ischemic damage. Read More

View Article and Full-Text PDF

Brain vulnerability and viability after ischaemia.

Nat Rev Neurosci 2021 Jul 21. Epub 2021 Jul 21.

Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.

The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into question the temporal limits within which the brain is capable of tolerating prolonged circulatory arrest. This Review assesses cell type-specific mechanisms of global cerebral ischaemia, and examines the circumstances in which the brain exhibits heightened resilience to injury. Read More

View Article and Full-Text PDF

Local IP receptor-mediated Ca signals compound to direct blood flow in brain capillaries.

Sci Adv 2021 Jul 21;7(30). Epub 2021 Jul 21.

Department of Pharmacology, University of Vermont, Burlington, VT, USA.

Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo imaging in anesthetized mice, we reveal that brain capillary endothelial cells control blood flow through a hierarchy of IP receptor-mediated Ca events, ranging from small, subsecond protoevents, reflecting Ca release through a small number of channels, to high-amplitude, sustained (up to ~1 min) compound events mediated by large clusters of channels. These frequent (~5000 events/s per microliter of cortex) Ca signals are driven by neuronal activity, which engages G protein-coupled receptor signaling, and are enhanced by Ca entry through TRPV4 channels. Read More

View Article and Full-Text PDF

Altered circulating CCR6and CXCR3 T cell subsets are associated with poor renal prognosis in MPO-ANCA-associated vasculitis.

Arthritis Res Ther 2021 Jul 21;23(1):194. Epub 2021 Jul 21.

Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Background: Effector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and are involved in the pathogenesis of ANCA-associated vasculitis (AAV). The diversity of effector memory T cells in chemokine receptor expression has been well studied in proteinase 3 (PR3)-AAV. However, few studies have been conducted in myeloperoxidase (MPO)-AAV. Read More

View Article and Full-Text PDF

First-in-Human Clinical Application of the Medyria TrackCath System in Endovascular Repair of Complex Aortic Aneurysms (ACCESS Trial): A Prospective Multicenter Single-Arm Clinical Trial.

J Endovasc Ther 2021 Jul 21:15266028211030536. Epub 2021 Jul 21.

Department of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany.

Purpose: The Medyria TrackCath Catheter (MedTCC) is an innovative, thermal convection-based blood flow velocity (BFV) tracking catheter that may be used during complex aortic endovascular procedures for identification and catheterization of target orifices. The ACCESS Trial analyzes the safety and performance of the MedTCC for targeted vessel catheterization to generally evaluate the feasibility of thermal convection-based BFV.

Materials And Methods: We performed a first-in-human, proof-of-concept, prospective single-arm multicenter clinical trial between March 2018 and February 2019 in patients who underwent endovascular aortic procedures at 4 high-volume centers. Read More

View Article and Full-Text PDF

[Relationship of operation manner and postoperative recurrence of hepatocellular carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Jun;43(6):635-637

Department of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.

Hepatocellular carcinoma (HCC) owns the high morbidity and mortality rates. Surgical resection is still the major pathway for the longer survival of HCC patients. Postoperative recurrence and metastasis have become the key impairment of prognosis of HCC patients. Read More

View Article and Full-Text PDF

Fetal Thoracic Circumference and Lung Volume and Their Relation to Fetal Size and Pulmonary Artery Blood Flow.

J Ultrasound Med 2021 Jul 21. Epub 2021 Jul 21.

Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo.

Objective: Research on early origins of lung disease suggests the need for studying the relationships of thoracic and lung size with fetal size and pulmonary circulation. The primary aim of this study is therefore to explore the associations between fetal thoracic circumference, lung volume, and fetal size. We also aim to assess if lung volume and thoracic circumference are associated with fetal pulmonary artery blood flow velocity measures. Read More

View Article and Full-Text PDF

Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.

J Gynecol Obstet Hum Reprod 2021 Jul 18:102198. Epub 2021 Jul 18.

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Objective: The proprotein convertase furin is known to be involved in the processing of pro-B-type natriuretic peptide (proBNP) and prorenin receptor (PRR), suggesting that it has a potential function in blood pressure regulation. We investigated the role of furin in the etiology of pre-eclampsia and its related disorder, unexplained fetal growth restriction (FGR) without hypertension.

Methods: We evaluated serum and placental furin levels in pre-eclampsia, FGR and uncomplicated pregnancy. Read More

View Article and Full-Text PDF

Assessment of heterogeneity in collective endothelial cell behavior with multicolor clonal cell tracking to predict arteriovenous remodeling.

Cell Rep 2021 Jul;36(3):109395

The David Richmond Laboratory for Cardiovascular Development, Gene Regulation and Editing, the Centenary Institute, Camperdown, 2006 NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, 2006 NSW, Australia. Electronic address:

Arteries and veins form in a stepwise process that combines vasculogenesis and sprouting angiogenesis. Despite extensive data on the mechanisms governing blood vessel assembly at the single-cell level, little is known about how collective cell migration contributes to the organization of the balanced distribution between arteries and veins. Here, we use an endothelial-specific zebrafish reporter, arteriobow, to label small cohorts of arterial cells and trace their progeny from early vasculogenesis throughout arteriovenous remodeling. Read More

View Article and Full-Text PDF

JKAP relates to disease risk, severity, and Th1 and Th17 differentiation in Parkinson's disease.

Ann Clin Transl Neurol 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, China.

Objective: JNK pathway-associated phosphatase (JKAP) is previously reported to regulate immune/inflammatory process via T-cell signaling, and closely involves in neurological diseases, while its implication in Parkinson's disease (PD) is unknown. Therefore, this study aimed to investigate the correlation of JKAP with Th1/Th2/Th17 cells and their clinical roles in PD patients, and then further explore the effect of JKAP on regulating CD4 T-cell differentiation in PD.

Methods: Totally 50 PD patients and 50 age-/gender-matched controls were enrolled. Read More

View Article and Full-Text PDF

lncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis.

Bioengineered 2021 Dec;12(1):4100-4110

Obstetrics Department, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Preeclampsia (PE) is a potentially fatal pregnancy complication; however, its pathogenesis remains unclear. Long non-coding RNAs (lncRNAs) are associated with occurrence and progression of PE. Therefore, this study aimed to explore the function of the lncRNA prospero homeobox 1-antisense RNA 1 (PROX1-AS1) and elucidate its underlying molecular mechanism of action. Read More

View Article and Full-Text PDF
December 2021

Characterization of the blood and neutrophil-specific microbiomes and exploration of potential bacterial biomarkers for sepsis in surgical patients.

Immun Inflamm Dis 2021 Jul 20. Epub 2021 Jul 20.

Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Introduction: Recent studies have demonstrated the presence of a circulating microbiome in the blood of healthy subjects and chronic inflammatory patients. However, our knowledge regarding the blood microbiome and its potential roles in surgical patients remains very limited. The objective of this study was to determine the blood microbial landscape in surgical patients and to explore its potential associations with postoperative sepsis. Read More

View Article and Full-Text PDF