632,949 results match your criteria blood examination

Primary anastomosis for complete bulbar urethral rupture with rectal laceration caused by straddle injury: A case report.

Int J Surg Case Rep 2021 Apr 1;82:105848. Epub 2021 Apr 1.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Electronic address:

Introduction: The initial management of urethral trauma remains disputed, and there are several suitable techniques, including delayed repair and suprapubic urinary diversion as well as primary endoscopic or open alignments. The treatment choice used depends on the rupture's location and length as well as the accompanying trauma.

Case Presentation: A 33-year-old male patient was referred to the department of emergency, with the chief complaint of inability to void experienced 1 day before being admitted, after falling from a height of approximately three meters. Read More

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High prevalence of SARS-CoV-2 infection in patients scheduled for digestive endoscopy after the peak of the first wave of the pandemic.

Gastroenterol Hepatol 2021 Apr 13. Epub 2021 Apr 13.

Servicio Digestivo ICS-Intitut d'Assistència Sanitària. Hospital Santa Caterina, Salt, Girona, Spain.

Healthcare professionals in endoscopy units have a possible risk of SARS-CoV-2 infection by different routes: inhalation of airborne droplets, aerosols, conjunctival contact and faecal-oral transmission.

Objective: To describe the detection of SARS-CoV-2 in a series of patients scheduled for digestive endoscopy at the Hospital Santa Caterina. Salt. Read More

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Occupational risk factors for airway obstruction in a population-based study in Northern Europe.

Am J Ind Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, University of Göteborg, Göteborg, Sweden.

Background: Airway obstruction is a key feature of asthma and chronic obstructive pulmonary diseases (COPD). Smoking habits and workplace exposures to vapors, gas, dusts, and fumes (VGDF) could cause or exacerbate airway obstruction. The aim of this study is to evaluate the risk of airway obstruction due to smoking and workplace exposure, and their interaction, in a large population-based study. Read More

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Pharmacokinetics of Single Dose Lidocaine and Epinephrine Following Iontophoresis of the Tympanic Membrane in a Double-Blinded Randomized Trial.

Otol Neurotol 2021 Apr 14. Epub 2021 Apr 14.

Tusker Medical, Inc., a subsidiary of Smith + Nephew, Menlo Park, California Ear Medical Group ENT Clinics of San Antonio, San Antonio, Texas.

Objective: To evaluate local and systemic safety of bilateral iontophoretic administration of lidocaine with epinephrine or lidocaine alone to the tympanic membrane (TM).

Study Design: A randomized, double-blind, two-arm study was conducted at a single center. Healthy adults were randomized to bilateral iontophoretic treatment with 2% lidocaine, 1:100,000 epinephrine, or 2% lidocaine (control). Read More

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No correlation between mean platelet volume and carotid artery thickness in patients with diabetes at intermediate or high risk for cardiovascular diseases.

Blood Coagul Fibrinolysis 2021 Apr 14. Epub 2021 Apr 14.

Department of Clinical Laboratory Department of Hematology, Chugoku Central Hospital, Fukuyama Department of Hematology, Okayama University Medical School, Okayama, Japan.

The number of patients with diabetes with a risk of cardiovascular diseases (CVDs) is increasing worldwide, leading to a higher demand for evaluating atherosclerosis. Recently, the mean platelet volume (MPV) available from complete blood count is gaining attention as a marker of underlying atherosclerotic lesions. In the current study, we examined whether MPV can predict carotid atherosclerosis in patients with diabetes at an intermediate or high risk for CVD. Read More

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Flecainide-induced myalgias and weakness: a rare adverse reaction.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA

Flecainide is a class 1C antiarrhythmic, which is known to cause several cardiac and non-cardiac adverse reactions. We report a case of a 62-year-old woman with atrial fibrillation who presented with generalised myalgias and intermittent chest heaviness after being started on flecainide. She had undergone her third cardiac ablation 1 week prior to presentation and was subsequently started on flecainide 150 mg two times per day. Read More

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[The association between blood homocysteine level and Chinese Healthy Eating Index in a suburb population of Shanghai].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):485-491

School of Public Health, Fudan University, Shanghai 200032, China.

To explore the relationship between the level of blood homocysteine (Hcy) and the total score of Chinese Healthy Eating Index (CHEI) and its item score. The subjects were recruited from the East China Natural Population Cohort Study, led by the School of Public Health in Fudan University, which was conducted in Zhongshan Community, Songjiang District of Shanghai from April to September 2017. By using the cluster random sampling method, 8 neighborhood committees were randomly selected from 18 neighborhood committees in Zhongshan community (Beimen, Baiyun, Dongwai, Huaqiao, Lantian village 1, Lantian village 2, Lantian village 4, and Lantian village 5). Read More

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Optical Coherence Tomography-Based Prevalence of Diabetic Macular Edema and its Associated Risk Factors in Urban South India: A Population-Based Study.

Ophthalmic Epidemiol 2021 Apr 15:1-7. Epub 2021 Apr 15.

Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

: To estimate the prevalence of optical coherence tomography (OCT)-defined diabetic macular oedema (DME) in urban South Indian population and to elucidate their associated risk factors. Of 911 participants from the Sankara Nethralaya Diabetic Retinopathy and Molecular Genetics Study-II (SN-DREAMS-), 759 who underwent OCT were analysed. The participants underwent a comprehensive examination and retinal photography following a standard protocol for diabetic retinopathy (DR) grading. Read More

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Prospective Observational Multisite Study of Handover in the Emergency Department: Theory versus Practice.

West J Emerg Med 2021 Jan 12;22(2):401-409. Epub 2021 Jan 12.

University Hospital Bonn, Department of Emergency Medicine, Bonn, Germany.

Introduction: The handover process in the emergency department (ED) is relevant for patient outcomes and lays the foundation for adequate patient care. The aim of this study was to examine the current prehospital to ED handover practice with regard to content, structure, and scope.

Methods: We carried out a prospective, multicenter observational study using a specifically developed checklist. Read More

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January 2021

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital.

Brain 2021 Apr 15. Epub 2021 Apr 15.

Department of Pathology and Cell Biology, Division of Neuropathology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, and the New York Presbyterian Hospital, New York, NY, 10032, USA.

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings of 41 consecutive patients with SARS-CoV-2 infections who died and underwent autopsy in our medical center. The mean age was 74 years (38-97 years), 27 patients (66%) were male and 34 (83%) were of Hispanic/Latinx ethnicity. Read More

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The effectiveness of home-based nursing intervention in the elderly with recurrent diabetic foot ulcers: A case report.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

Community Health Nursing Department, Faculty of Nursing, Universitas Indonesia, Depok.

Background: Inadequate glycemic control usually leads to peripheral neuropathy, vasculopathy, and foot deformities that leads to diabetic foot ulcer (DFU), and a 10-years history of diabetes and inadequate self-management increases the risk of reoccurring DFU. A home-based intervention program, which includes Diabetes Self-Management Education (DSME) and wound care is the most likely approach, to engage families and overcoming the barriers in self-care management. The aim of this study is to provide an overview on the effectiveness of home-based nursing intervention in the elderly patients with reoccurring diabetic foot ulcers. Read More

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Relationship between plasma 12,13-diHOME level and nonalcoholic fatty liver disease in patients with type 2 diabetes and obesity.

Minerva Endocrinol (Torino) 2021 Apr 15. Epub 2021 Apr 15.

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China -

Objective: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal of this study was to investigate whether the 12,13-diHOME was associated with related metabolic markers of nonalcoholic fatty liver disease (NAFLD) in a Chinese population with type 2 diabetes (T2DM) and obesity.

Methods: This cross-sectional study enrolled 202 subjects with T2DM. Read More

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Neurosteroid involvement in threatened preterm labour.

Endocrinol Diabetes Metab 2021 Apr 10;4(2):e00216. Epub 2020 Dec 10.

Sundsvalls Research Unit Department of Clinical Sciences, Obstetrics and Gynaecology Umeå University Sundsvall Sweden.

Introduction: The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABA receptor. Whether neurosteroid levels and the function of the GABA receptor are involved in the risk of preterm labour in pregnant women is unknown.

Methods: Pregnant women with ( = 16) or without ( = 20) threatened preterm labour (TPL) in gestational week 33 + 6 days to 37 + 0 days were studied prospectively with procedures including foetal heart rate monitoring, vaginal examination, ultrasound examination and blood tests to determine allopregnanolone, progesterone and oxytocin levels. Read More

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Case Report: Next-Generation Sequencing in Diagnosis of Pneumonia Due to and Cytomegalovirus in a Patient With HIV Infection.

Front Med (Lausanne) 2021 29;8:653294. Epub 2021 Mar 29.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Pulmonary infections remain a significant cause of morbidity and mortality in immunocompromised patients. The pathogens spectrum of pulmonary infection that can affect patients with human immunodeficiency virus (HIV) is wide such as bacterial, fungal, viral, parasitic organisms, and so on. The risk of multi-pathogenic pneumonia is higher in HIV-infected patients. Read More

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Employment of Artificial Intelligence Based on Routine Laboratory Results for the Early Diagnosis of Multiple Myeloma.

Front Oncol 2021 29;11:608191. Epub 2021 Mar 29.

Haematology Department of Shengjing Hospital, China Medical University, Shenyang, China.

Objective: In order to enhance the detection rate of multiple myeloma and execute an early and more precise disease management, an artificial intelligence assistant diagnosis system is developed.

Methods: 4,187 routine blood and biochemical examination records were collected from Shengjing Hospital affiliated to China Medical University from January 2010 to January 2020, which include 1,741 records of multiple myeloma (MM) and 2,446 records of non-myeloma (infectious diseases, rheumatic immune system diseases, hepatic diseases and renal diseases). The data set was split into training and test subsets with the ratio of 4:1 while connecting hemoglobin, serum creatinine, serum calcium, immunoglobulin (A, G and M), albumin, total protein, and the ratio of albumin to globulin data. Read More

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Examination of a blood-brain barrier targeting β-galactosidase-monoclonal antibody fusion protein in a murine model of GM1-gangliosidosis.

Mol Genet Metab Rep 2021 Jun 25;27:100748. Epub 2021 Mar 25.

Gene Therapy Center, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

GM1-gangliosidosis is a lysosomal disease resulting from a deficiency in the hydrolase β-galactosidase (β-gal) and subsequent accumulation of gangliosides, primarily in neuronal tissue, leading to progressive neurological deterioration and eventually early death. Lysosomal diseases with neurological involvement have limited non-invasive therapies due to the inability of lysosomal enzymes to cross the blood-brain barrier (BBB). A novel fusion enzyme, labeled mTfR-GLB1, was designed to act as a ferry across the BBB by fusing β-gal to the mouse monoclonal antibody against the mouse transferrin receptor and tested in a murine model of GM1-gangliosidosis (β-gal). Read More

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Perivascular macrophages create an intravascular niche for CD8 T cell localisation prior to the onset of fatal experimental cerebral malaria.

Clin Transl Immunology 2021 7;10(4):e1273. Epub 2021 Apr 7.

Centre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.

Objectives: The immunologic events that build up to the fatal neurological stage of experimental cerebral malaria (ECM) are incompletely understood. Here, we dissect immune cell behaviour occurring in the central nervous system (CNS) when ANKA (PbA)-infected mice show only minor clinical signs.

Methods: A 2-photon intravital microscopy (2P-IVM) brain imaging model was used to study the spatiotemporal context of early immunological events during ECM. Read More

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Relations Between Urinary Albumin Excretion and a Dietary Intake of Fruits in Patients With Type 2 Diabetes.

J Clin Med Res 2021 Mar 19;13(3):151-157. Epub 2021 Mar 19.

Department of Laboratory Medicine, The Jikei University Kashiwa Hospital, Chiba, Japan.

Background: It was reported that microalbuminuria and a decline in renal function were associated with cardiovascular disease (CVD) mortality and renal events and prognostic serious complications. Dietary factors and nutrients affecting microalbuminuria in type 2 diabetes remain unclear, and accordingly we conducted a cross-sectional study on the possible relevance of dietary factors to urinary albumin excretion in patients with type 2 diabetes.

Methods: Forty-two patients with type 2 diabetes participated in this study, and these subjects were categorized into patients without microalbuminuria group with urine albumin-to-creatinine ratio (ACR) of less than 30 mg/g Cr (n = 29) and a microalbuminuria group with ACR of 30 - 299 mg/g Cr (n = 13). Read More

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Moving toward targeting the right phenotype with the right platelet-rich plasma (PRP) formulation for knee osteoarthritis.

Ther Adv Musculoskelet Dis 2021 29;13:1759720X211004336. Epub 2021 Mar 29.

Department of Musculoskeletal Disorders, University of Salerno School of Medicine and Dentristry, Salerno, Italy.

Intra-articular injections of platelet-rich plasma (PRP) and other novel blood-derived products developed specifically for osteoarthritis (OA) can provide pain relief and potential benefits in disease progression. Meta-analyses show the clinical superiority of PRP compared with other intra-articular injections, but results are modest and the effect sizes are small. PRP injections in knee OA are performed indiscriminately, but the clinical response varies enormously between patients because of an array of mixed OA phenotypes. Read More

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Blood pressure and resting heart rate in 3-17-year-olds in Germany in 2003-2006 and 2014-2017.

J Hum Hypertens 2021 Apr 14. Epub 2021 Apr 14.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.

To track blood pressure (BP) and resting heart rate (RHR) in children and adolescents is important due to its associations with cardiovascular outcomes in the adulthood. Therefore, the aim of this study was to examine BP and RHR over a decade among children and adolescents living in Germany using national examination data. Cross-sectional data from 3- to 17-year-old national survey participants (KiGGS 2003-06, n = 14,701; KiGGS 2014-17, n = 3509) including standardized oscillometric BP and RHR were used for age- and sex-standardized analysis. Read More

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Acute heart failure: on the track of a rare disease.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Cardiology Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Eosinophilic granulomatosis with polyangiitis is an antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis with cardiac involvement in more than 60% of cases. Authors describe the case of a 48-year-old woman who presented with progressively worsening asthenia, dyspnoea and macular, non-painful, non-itchy cutaneous lesions. She had signs of congestion on clinical examination and a history of asthma and nasal polyps. Read More

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Confirming the factor structure and improving the screening function of the Medical Fear Survey - short in a Hungarian community sample.

Anxiety Stress Coping 2021 Apr 15:1-11. Epub 2021 Apr 15.

Institute of Psychology, University of Pécs, Pécs, Hungary.

Medical Fear Survey (MFS) was designed to assess the fear of medical treatments and related factors through five dimensions including fears of injections and blood draws, sharp objects, blood, mutilation, medical examination and physical symptoms. We analysed the factor structure and validity of a short version of MFS in Hungarian, on a large sample (2631 participants; 558 men, 2067 women) focusing on possible age and gender differences (aged  = 30.4,  = 13. Read More

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Bilateral pheochromocytoma revealed by acute abdominal pain in a child. A case report.

Pediatr Endocrinol Diabetes Metab 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatrics, University Hospital Farhat Hached, Sousse, Tunisia.

Pheochromocytoma is a rare tumor during childhood, originating from the chromafine tissue. The clinical presentation can be variable and assembling many other diseases. This tumor submits specific care problems. Read More

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Hepatic coccidiosis in Serrasalmus rhombeus Linnaeus, 1766 from the Amazon basin: morphological and histopathological aspects.

Rev Bras Parasitol Vet 2021 12;30(1):e026120. Epub 2021 Apr 12.

Universidade Federal Rural da Amazônia - UFRA Paragominas, Paragominas, PA, Brasil.

Calyptospora species are coccids that commonly cause liver infections in fish all around the world. This paper describes the morphology and histopathological characteristics of liver infection caused by Calyptospora sp. in black piranha Serrasalmus rhombeus, from the Capim River, in the municipality of Ipixuna do Pará, state of Pará (Brazil). Read More

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Establishing Normal Testicular F-FDG PET/CT SUVs.

AJR Am J Roentgenol 2021 Apr 14:1-7. Epub 2021 Apr 14.

Department of Radiology, Mayo Clinic, 200 First St, Rochester, MN 55905.

Knowledge of normal testicular F-FDG PET/CT (FDG PET/CT) SUVs is crucial for accurate examination interpretation. The objective of this study was to establish normal testicular SUV ranges among adult men receiving health care in North America. A retrospective review of an institutional electronic database identified adult men undergoing pretreatment clinical FDG PET/CT examinations from March 15, 2013, through March 15, 2018. Read More

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Superior antihypertensive and cardioprotective effects of chlorthalidone compared with hydrochlorothiazide.

Drugs Today (Barc) 2021 Apr;57(4):291-301

INTEGRIS Baptist Medical Center, Oklahoma City, Oklahoma, USA.

Diuretics are the most commonly used drugs for the treatment of hypertension, either alone or in combination with other antihypertensive drugs. Of all diuretics, hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) are the most commonly used, with HCTZ being the most widely prescribed diuretic. Recent studies have shown that CTD is a better diuretic with superior antihypertensive effectiveness and cardiovascular protection. Read More

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Wiad Lek 2021 ;74(1):98-101


Objective: The aim: To determine the peculiarities of changes in the homocysteine levels in the patients with chronic pancreatitis and type 2 diabetes blood serum depending on the vitamin status.

Patients And Methods: Materials and methods: We investigated 36 patients with chronic pancreatitis and type 2 diabetes, who were included in the first group of the patients examined; Group 2 consisted of 34 patients with chronic pancreatitis; and Group 3 of the patients examined consisted of 40 patients with type 2 diabetes.

Results: Results: All patients examined were diagnosed with type 2 diabetes mellitus of moderate severity. Read More

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Wiad Lek 2021 ;74(1):28-34


Objective: The aim: Improving perinatal outcomes in pregnant women at high risk of intrauterine infection by developing diagnostic criteria and algorithms for managing pregnancy and childbirth.

Patients And Methods: Materials and methods: The study of pregnancy and childbirth was conducted in 72 patients at high risk of IUI, which formed the main group. The control group consisted of 64 patients with a low infectious risk of IUI. Read More

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Satisfaction and genital perception after orchiectomy for prostate cancer: does the technique matter? A randomized trial.

Int Urol Nephrol 2021 Apr 13. Epub 2021 Apr 13.

Department of Urology, Christian Medical College and Hospital, Vellore, Tamil Nadu, 632004, India.

Objectives: Bilateral extracapsular or total orchiectomy (BEO) for prostate cancer is presumed to have psychological consequences after the surgery due to perception of an empty scrotum. Bilateral subcapsular orchiectomy (BSO) was designed to preserve perception of palpable testes. We compared the patients' satisfaction and genital perception following BEO and BSO. Read More

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Convalescent Plasma Use in the United States was inversely correlated with COVID-19 Mortality: Did Convalescent Plasma Hesitancy cost lives?

medRxiv 2021 Apr 10. Epub 2021 Apr 10.

The US Food and Drug Administration (FDA) authorized treatment of hospitalized COVID-19 patients with Convalescent Plasma (CCP) via the Expanded Access Program (EAP) and the Emergency Use Authorization (EUA), leading to the use of CCP in some 500,000 patients during the first year of the pandemic. We tracked the number of CCP units dispensed to hospitals by blood banking organizations and correlated that usage with hospital admission and mortality data over the course of the year. CCP usage per admission peaked after issuance of the EUA, with more than 40% of inpatients estimated to have received CCP between late September and early November 2020. Read More

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