200,105 results match your criteria blood count

[Harvest of Stem Cells from Umbilical Cord Blood: Relevance of Perinatal Factors for the Quality of Umbilical Cord Transplant Units].

Z Geburtshilfe Neonatol 2021 Sep 27. Epub 2021 Sep 27.

Klinik für Geburtshilfe und Schwangerschaftsmedizin, Frauenklinik, Universitätsspital Basel, Basel, Schweiz.

Introduction: Umbilical cord blood (UCB) contains hematopoietic stem cells with therapeutic potential and unique cellular properties. Due to the limited number of stem cells in the UCB (surrogate marker total nucleated cells, TNC), only one in five donations is suitable for transplantation. The aim of this study was to investigate whether predictive factors exist for a TNC count above the 99th percentile. Read More

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September 2021

The Role of C-Reactive Protein and White Blood Cell Count as a Diagnostic, Prognostic, and Monitoring Markers in Bacterial Orofacial Infections.

J Oral Maxillofac Surg 2021 Aug 27. Epub 2021 Aug 27.

Senior Resident, Maxillofacial Surgery, Iraqi Board for Medical Specialization, Iraq. Electronic address:

Purpose: 1) To assess the efficacy of C reactive protein (CRP) and white blood cell count (WBC) levels as a diagnostic, prognostic, and monitoring tools for determining the severity of bacterial orofacial infections, length of hospital stay (LOS), and the effectiveness of treatment. 2) To evaluate the sensitivity and specificity of CRP and WBC as an inflammatory markers in bacterial orofacial infections.

Methods: This prospective study included 30 patients. Read More

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Complete blood cell count-derived ratios can be useful biomarkers for neurological diseases.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211048264

Department of Health Sciences, University of Catanzaro "Magna Graecia," Catanzaro, Italy.

Complete blood cell count-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have recently shown to be highly sensitive biomarkers. Their usefulness has been proven as prognostic factors in several cancers, in the stratification of mortality in major cardiac events, as predictors and markers of infectious or inflammatory pathologies, and in many other conditions. Surprisingly, the study of these biomarkers in neurological diseases is somewhat limited. Read More

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September 2021

Social, epidemiological, and virological characteristics from Peruvian subjects living with HIV-1 / AIDS with different sexual risk behavior.

AIDS Res Hum Retroviruses 2021 Sep 25. Epub 2021 Sep 25.

Ponce School of Medicine, Microbiology, P.O. Box 7004, Ponce, PR, Puerto Rico, 00732;

HIV-1 genetic diversity and resistance profile might change according to the risky sexual behavior of the host. To show this, we recruited 134 individuals between the years 2015 to 2017 identified as Transgender Women Sex Workers (TWSW, n = 73) and Heterosexual Military Officers (HET-MO, n = 61). After obtaining informed consent, we collected a blood sample to perform the HIV genotyping, CD4 cell count, and viral load. Read More

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September 2021

The effects of gallic acid and metformin on male reproductive dysfunction in diabetic mice induced by methylglyoxal: An experimental study.

Int J Reprod Biomed 2021 Aug 9;19(8):715-724. Epub 2021 Sep 9.

Department of Anatomical Sciences, Faculty of Medicine, Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus is a disease that has reached a dangerous point. Today, nearly 500 million men and women around the world live with diabetes. Gallic acid (Gal) affects diabetes. Read More

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Evaluation of invasive ventilation (intubation) prognosis in patients with Covid-19 symptoms.

Int J Surg Open 2020 16;27:149-153. Epub 2020 Nov 16.

Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran.

Background: Coronavirus 2019 (COVID 19) has been reported as a pandemic by the world health organization. Increasing number of cases and associated mortality have demanded the need for clinical studies and researches.

Objective: The aim of this study is to evaluate intubation prognosis of the COVID 19 patients referred to Shahid Beheshti hospital in Qom city. Read More

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November 2020

Association Between White Blood Cells at Baseline and Treatment Failure of MTX for Ectopic Pregnancy.

Front Med (Lausanne) 2021 10;8:722963. Epub 2021 Sep 10.

Department of Gynecology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

The aim of this study was to evaluate white blood cell (WBC) count as a risk factor related to methotrexate (MTX) treatment failure in patients with ectopic pregnancy (EP). A total of 236 women diagnosed with EP and treated with a single dose of MTX were included. The exposure variable was WBC count at baseline, and the outcome was MTX treatment outcome. Read More

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September 2021

Dynamic profile and clinical implications of hematological and immunological parameters in COVID-19 patients. A retrospective study.

J Family Med Prim Care 2021 Jul 30;10(7):2518-2523. Epub 2021 Jul 30.

Senior Resident Department of Community Medicine, Private Practitioner, New Delhi, India.

Background: Ever since the World Health Organization (WHO) announced the SARS-CoV-2 or nCOVID-19 infection (a pandemic), continuous spread of the virus has been observed which has continuously seen to affect and kill multitudes of individuals all over the world. An understanding of the pathophysiology of this disease is necessary for an effective treatment. Laboratory investigations play an important role in the diagnosis as well as treatment of this infectious disease. Read More

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Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study.

Ann Glob Health 2021 9;87(1):89. Epub 2021 Sep 9.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: A major episode of lead poisoning caused by lead-adulterated opium occurred in Iran in 2016. Patients were removed from exposure and treated with chelating agents. A subset of those patients was evaluated in this follow-up study to evaluate treatment efficacy in relation to patient outcome. Read More

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September 2021

Blood leukocyte count as a systemic inflammatory biomarker associated with a more rapid spirometric decline in a large cohort of iron and steel industry workers.

Respir Res 2021 Sep 26;22(1):254. Epub 2021 Sep 26.

Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao, 266021, Shandong, China.

Objective: Iron and steel industry workers are exposed to high levels of inhalable dust particles that contain various elements, including metals, and cause occupational lung diseases. We aim to assess the relationship between occupational dust exposure, systemic inflammation, and spirometric decline in a cohort of Chinese iron and steel workers.

Methods: We studied 7513 workers who participated in a Health Surveillance program at Wugang Institute for Occupational Health between 2008 and 2017. Read More

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September 2021

Asymptomatic and sub-microscopic Plasmodium falciparum infection in children in the Mount Cameroon area: a cross-sectional study on altitudinal influence, haematological parameters and risk factors.

Malar J 2021 Sep 26;20(1):382. Epub 2021 Sep 26.

Department of Zoology and Animal Physiology, University of Buea, Buea, Cameroon.

Background: The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, the disease is still of public health concern. The objective of the study was to assess the burden of asymptomatic and sub-microscopic Plasmodium infection, altitudinal influence on it, their effect on haematological parameters as well as identify the risk factors of infection. Read More

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September 2021

Hematological profiles of visceral leishmaniasis patients before and after treatment of anti-leishmanial drugs at University of Gondar Hospital; Leishmania Research and Treatment Center Northwest, Ethiopia.

BMC Infect Dis 2021 Sep 26;21(1):1005. Epub 2021 Sep 26.

Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Visceral leshimaniasis is a parasitic disease characterized by systemic infection of phagocytic cells and an intense inflammatory response. The progression of the disease or treatment may have an effect on hematological parameters of these patients'. Thus, the current study sought to compare the hematological profiles of visceral leishmaniasis patients before and after treatment with anti-leishmaniasis drugs. Read More

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September 2021

Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome.

Ann Hematol 2021 Sep 25. Epub 2021 Sep 25.

Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.

The aims of this study were to determine the possible relationships between the levels of hemin, hemopexin, acid sphingomyelinase, nitrite/nitrate (NOx), and other parameters in patients with SCD and to assess whether they were associated with vaso-occlusive crises (VOCs) or acute chest syndrome (ACS). Patients with SCD (homozygous or sickle beta-thalassemia) who were confirmed to have VOC or ACS were included. Blood samples were obtained at admission, on the third day of hospitalization, and at steady state. Read More

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September 2021

Disrupts the Intestinal Structure and Immune Barrier Integrity in Rats.

Toxins (Basel) 2021 Sep 15;13(9). Epub 2021 Sep 15.

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

The aim of this study was to investigate the effects of on the intestines morphology and integrity in rat. Rats were randomly divided into two groups and were fed with 10 g/100 g body weight (BW) basal diet and 10 g/100 g BW experimental diet, which was a mixture of powder and basal diet in a 3:7 ratio. The feeding experiment lasted for 60 days. Read More

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September 2021

Effect of Feed Containing Larvae Immunized by Injection on the Growth and Immunity of Rainbow Trout ().

Insects 2021 Sep 7;12(9). Epub 2021 Sep 7.

Department of Integrative Biological Sciences and Industry, Sejong University, Seoul 05006, Korea.

We investigated the effects of a feed containing larvae injected with bacteria on the growth and immunity of . The feed was prepared by replacing fishmeal in feed with 25 and 50% nonimmunized (HIL25, HIL50) or immunized HIL (ImHIL25, ImHIL50), and its protein:fat:carbohydrate ratio was 45:15:18. ImHIL extracts showed inhibitory activity against fish pathogenic bacteria. Read More

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September 2021

A prospective study of inflammatory biomarkers and growth factors and risk of glioma in the UK Biobank.

Cancer Epidemiol 2021 Sep 24;75:102043. Epub 2021 Sep 24.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.

Purpose: The role of growth factors and inflammation in the onset of glioma is poorly understood, and conflicting reports of associations of circulating IGF-1 and inflammatory biomarkers with glioma risk exist in the literature. We examined associations between C-reactive protein (CRP), white blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), and insulin-like growth factor-1 (IGF-1) and glioma risk in the UK Biobank cohort.

Methods: Hazard ratios (HR) and 95% confidence intervals (CI) for glioma according to circulating biomarkers concentrations were calculated using Cox proportional hazards regression, adjusted for age, sex, race, and education. Read More

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September 2021

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury.

J Neuroinflammation 2021 Sep 25;18(1):221. Epub 2021 Sep 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary injury development; however, how systemic inflammatory mediators affect this is not fully understood. The aim of this study was to see how systemic inflammation affects markers of neuroinflammation, if this inflammatory response had a temporal correlation between compartments and how different compartments differ in cytokine composition.

Methods: TBI patients recruited to a previous randomised controlled trial studying the effects of the drug anakinra (Kineret®), a human recombinant interleukin-1 receptor antagonist (rhIL1ra), were used (n = 10 treatment arm, n = 10 control arm). Read More

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September 2021

A comparison of demographic, epidemiological and clinical characteristics of hospital influenza-related viral pneumonia patients.

BMC Infect Dis 2021 Sep 25;21(1):1002. Epub 2021 Sep 25.

State Key Laboratory for Diagnosis and Treatment of Infectious Disease, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, Zhejiang, People's Republic of China.

Background: Through the comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B)-related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia patients, find the different between them.

Methods: A retrospective study was conducted in hospitalized influenza-related viral pneumonia patients.

Results: Human influenza A-related patients in the 35-49-year-old group were more than those with B pneumonia patients (p = 0. Read More

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September 2021

Admission white blood cell count predicts post-discharge mortality in patients with acute aortic dissection: data from the MIMIC-III database.

BMC Cardiovasc Disord 2021 Sep 25;21(1):462. Epub 2021 Sep 25.

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Xiangya Rd 87, Changsha, 410008, Hunan, China.

Background: Inflammation underlies both the pathogenesis and prognosis in patients with acute aortic dissection (AAD). This study aimed to assess the association of ICU admission of white blood cell count (WBCc) with post-discharge mortality in these patients.

Methods: Clinical data were extracted from the MIMIC-III V1. Read More

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September 2021

Predictors and management of relapse to axicabtagene ciloleucel in patients with aggressive B-cell lymphoma.

Hematol Oncol Stem Cell Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Internal Medicine, Division Hematology-Oncology, Mayo Clinic, Phoenix, AZ, USA. Electronic address:

Objective/background: Despite the success of chimeric antigen receptor (CAR) T-cell therapy in patients with aggressive non-Hodgkin lymphoma (aNHL), some patients still fail treatment, and their prognosis is dismal.

Methods: We performed a retrospective study of aNHL patients treated with axicabtagene ciloleucel (axi-cel) at two Mayo Clinic centers between 2018 and 2020. We evaluated predictive factors, toxicities, and responses to salvage regimens after CAR T-cell therapy. Read More

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September 2021

Prevalence of Non-Adherence and Non-Compliance during Maintenance Therapy in Adults with Acute Lymphoblastic Leukemia and their Associations with Survival.

Eur J Haematol 2021 Sep 25. Epub 2021 Sep 25.

Pediatric Oncology Research Laboratory, Rigshospitalet, University of Copenhagen, Denmark.

Objectives: Explore patient adherence and physician compliance to protocol guidelines during maintenance therapy, including the association with survival in adults with acute lymphoblastic leukemia (ALL).

Methods: Blood counts, aminotransferase levels and prescribed 6-mercaptopurine (6MP)/methotrexate (MTX) doses were compared with the protocol guidelines to assess compliance. Non-adherence to the prescribed medication was confirmed in patients with unmeasurable 6MP metabolite levels and suspected in patients with low 6MP metabolites concurrent with aminotransferase and white blood cell count within normal ranges, while potential intermittent non-adherence was defined by >1. Read More

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September 2021

Hemoglobin and hematocrit levels are positively associated with blood pressure in children and adolescents 10 to 18 years old.

Sci Rep 2021 Sep 24;11(1):19052. Epub 2021 Sep 24.

Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.

To investigate the associations between hemoglobin (Hb) concentration and hematocrit (Hct), and blood pressure (BP) in children and adolescents. The study population consisted of 7950 subjects total (4229 boys and 3721 girls) aged 10-18 years who participated in the Korea National Health and Nutrition Examination Surveys conducted between 2007 and 2017. The prevalence of hypertension was 19. Read More

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September 2021

Reticulocyte Count: The Forgotten Factor in Transfusion Decisions for Extremely Low Birth Weight Infants.

Am J Perinatol 2021 Sep 24. Epub 2021 Sep 24.

Pediatrics/Neonatology, CHOP Newborn services at Virtua, Voorhees, United States.

Background: Extremely low birth weight (ELBW) infants often receive transfusions of packed red blood cells. Long-term outcomes of infants treated with liberal versus restricted transfusion criteria have been evaluated with conflicting results. Clinicians incorporate a reticulocyte count (RC) in their transfusion decisions. Read More

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September 2021

Prediction Model Performance With Different Imputation Strategies: A Simulation Study Using a North American ICU Registry.

Pediatr Crit Care Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Statistics, University of British Columbia, Vancouver, BC, Canada. Research Institute, BC Children's Hospital, Vancouver, BC, Canada. Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada. Department of Pediatrics, Division of Critical Care, University of British Columbia, Vancouver, BC, Canada.

Objectives: To evaluate the performance of pragmatic imputation approaches when estimating model coefficients using datasets with varying degrees of data missingness.

Design: Performance in predicting observed mortality in a registry dataset was evaluated using simulations of two simple logistic regression models with age-specific criteria for abnormal vital signs (mentation, systolic blood pressure, respiratory rate, WBC count, heart rate, and temperature). Starting with a dataset with complete information, increasing degrees of biased missingness of WBC and mentation were introduced, depending on the values of temperature and systolic blood pressure, respectively. Read More

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September 2021

Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. Electronic address:

Patients with locally advanced cervical cancer (LACC) treated with chemoradiation often experience hematologic toxicity (HT), as chemoradiation can induce bone marrow (BM) suppression. Studies on the relationship between BM dosimetric parameters and clinically significant HT might provide relevant indices for developing BM-sparing (BMS) radiotherapy techniques. This systematic review studied the relationship between bone marrow dose and HT in LACC-patients treated with primary cisplatin-based chemoradiation. Read More

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September 2021

A Phase 1b Trial of Prexasertib in Combination with Standard-of-Care Agents in Advanced or Metastatic Cancer.

Target Oncol 2021 Sep 24. Epub 2021 Sep 24.

Sarah Cannon Research Institute, Nashville, TN, USA.

Background: The checkpoint kinase 1 (CHK1) inhibitor prexasertib exhibited modest monotherapy antitumor activity in prior trials, suggesting that combination with chemotherapy or other targeted agents may be needed to maximize efficacy.

Objectives: The aim of this study was to determine the recommended phase II dose and schedule of prexasertib in combination with either cisplatin, cetuximab, pemetrexed, or 5-fluorouracil in patients with advanced and/or metastatic cancer, and to summarize preliminary antitumor activity of these combinations.

Patients And Methods: This phase Ib, nonrandomized, open-label study comprised dose-escalation phase(s) with multiple sub-arms evaluating different prexasertib-drug combinations: Part A, prexasertib + cisplatin (n = 63); Part B, prexasertib + cetuximab (n = 41); Part C, prexasertib + pemetrexed (n = 3); Part D, prexasertib + 5-fluorouracil (n =8). Read More

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September 2021

Calcitonin receptor-like (CALCRL) is a marker of stemness and an independent predictor of outcome in pediatric AML.

Blood Adv 2021 Sep 24. Epub 2021 Sep 24.

University Children's Hospital Münster, Muenster, Germany.

We have recently identified the G protein-coupled neuropeptide receptor Calcitonin receptor-like (CALCRL) as an independent prognostic biomarker and a therapeutic target in more than 1500 adult patients with acute myeloid leukemia (AML). Here, we confirmed CALCRL expression as a prognostic factor in a cohort of 284 pediatric patients with AML. High CALCRL expression was independently associated with event free survival (EFS) (hazard ratio [HR], 1. Read More

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September 2021

Risk Prediction of Nosocomial and Posthospital Discharge Infections in Alcohol-Associated Hepatitis.

Hepatol Commun 2021 Jul 28. Epub 2021 Jul 28.

Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN, USA.

Alcohol-associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%-40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. However, determining the risk and subsequent development of infection in patients with AAH remain challenging. Read More

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Efficacy of peripheral arterial access for peripheral blood stem cells collection.

J Clin Apher 2021 Sep 24. Epub 2021 Sep 24.

Department of Nursing, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Background: Transplantation of peripheral blood stem cells (PBSCs) mobilized by cytokines is increasingly applied to treat patients with hematologic diseases, such as lymphoma, multiple myeloma, leukemia, etc. Successful hematopoietic stem cell transplantation (HSCT) increasingly depends on the collection of hematopoietic stem cells (HSCs) from peripheral blood. Peripheral vein (PV) is the most common type of blood access. Read More

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September 2021