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Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

First Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Slovakia.

Objectives: There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Read More

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Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis.

Auton Neurosci 2021 May 27;234:102825. Epub 2021 May 27.

Department of Kinesiology, University of Connecticut, Storrs, CT, USA.

Changes in autonomic control have been suggested to mediate postexercise hypotension (PEH). We investigated through meta-analysis the after-effects of acute resistance exercise (RE) on blood pressure (BP) and autonomic activity in individuals with normal and elevated BP. Electronic databases were searched for trials including: adults; exclusive RE interventions; and BP and autonomic outcomes measured pre- and postintervention for at least 30 min. Read More

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Highly permselective uric acid detection using kidney cell membrane-functionalized enzymatic biosensors.

Biosens Bioelectron 2021 Jun 5;190:113411. Epub 2021 Jun 5.

School of Biomedical Engineering, Korea University, Seoul, 02841, South Korea; Interdisciplinary Program in Precision Public Health, Korea University, Seoul, 02841, South Korea. Electronic address:

Abnormal blood uric acid (UA) levels can lead to its crystallization in the joints, consequently resulting in gout. Accurate detection of UA in the blood is imperative for the early diagnosis of gout. However, electrochemical UA biosensors are vulnerable to antioxidants in the blood, limiting accurate UA detection. Read More

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Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men.

Growth Horm IGF Res 2021 Jun 6;59:101407. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175. Read More

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Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients.

J Infect Public Health 2021 May 27;14(7):845-851. Epub 2021 May 27.

Department of Epidemiology, Second Military Medical University, Shanghai 200433, China. Electronic address:

Background: Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. However, data concerning the epidemiological features, viral shedding, and antibody dynamics between asymptomatic SARS-CoV-2 carriers and COVID-19 patients remain controversial.

Methods: We enrolled 193 SARS-CoV-2 infected subjects in Ningbo and Zhoushan, Zhejiang, China, from January 21 to March 6, 2020. Read More

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Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

J Infect Public Health 2021 Apr 24;14(7):832-838. Epub 2021 Apr 24.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Read More

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Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study.

J Subst Abuse Treat 2021 Jun 3;130:108521. Epub 2021 Jun 3.

Humankind Charity, Inspiration House, Unit 22, Bowburn North Industrial Estate, Durham DH6 5PF, United Kingdom.

Background: Methadone use for the management of opioid dependency during pregnancy is commonplace. Methadone levels are altered during pregnancy due to changes in maternal physiology. Despite this, a paucity of data exist regarding the most appropriate optimal dosing regimens during pregnancy. Read More

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Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.

Environ Int 2021 Jun 9;155:106678. Epub 2021 Jun 9.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Ten years of nationally representative biomonitoring data collected between 2007 and 2017 are available from the Canadian Health Measures Survey (CHMS). These data establish baseline environmental chemical concentrations in the general population. Here we sought to evaluate temporal trends in environmental chemical exposures in the Canadian population by quantifying changes in biomarker concentrations measured in the first five two-year cycles of the CHMS. Read More

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OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males.

J Psychiatr Res 2021 May 23;140:221-227. Epub 2021 May 23.

Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy.

Objectives: This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males.

Methods: Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (M = 32.4 years, SD = 9. Read More

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Genome-wide DNA methylation patterns associated with general psychopathology in children.

J Psychiatr Res 2021 May 28;140:214-220. Epub 2021 May 28.

Department of Child and Adolescent Psychiatry/ Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Psychiatric symptoms are interrelated and found to be largely captured by a general psychopathology factor (GPF). Although epigenetic mechanisms, such as DNA methylation (DNAm), have been linked to individual psychiatric outcomes, associations with GPF remain unclear. Using data from 440 children aged 10 years participating in the Generation R Study, we examined the associations of DNAm with both general and specific (internalizing, externalizing) factors of psychopathology. Read More

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Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis.

J Psychiatr Res 2021 Jun 2;140:197-204. Epub 2021 Jun 2.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment is poorly understood. This study aims to elucidate the role of long non-coding RNAs (lncRNAs) expression and lncRNA-mRNA interaction networks, by analyzing lncRNA expression in whole blood samples of 400 middle and old aged monozygotic twins in association with cognitive function using both linear models and a generalized correlation coefficient (GCC) to capture the diverse patterns of correlation. Read More

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The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickens.

Poult Sci 2021 Apr 20;100(7):101203. Epub 2021 Apr 20.

Alzchem Trostberg GmbH, Dr.-Albert-Frank-Straße 32, 83308 Trostberg, Germany.

The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio between GAA and arginine for broiler diet formulation, the ratio being of how much arginine could be spared, or replaced by GAA. Guanidionoacetic acid, the precursor of creatine, can be synthesized de novo from the amino acids arginine and glycine, whereby 1 mol of arginine creates 1 mol of GAA; that is a weight:weight (w:w) ratio of 1.49:1 (arginine:GAA). Read More

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β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis.

Biochem Biophys Res Commun 2021 Jun 9;566:75-79. Epub 2021 Jun 9.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; School of Life Sciences, Shanghai University, Shanghai, China; Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Biochemistry, Medical College of Milwaukee, Wisconsin, USA. Electronic address:

Anti-angiogenesis serves as an effective tumor therapy approach. In a previous study, we found that β3-endonexin expressed in vascular endothelial cells was involved in promoting proliferation and angiogenesis partially by facilitating VEGF expression. However, it still remains unclear if β3-endonexin in vascular endothelial cells also employs other mechanisms in regulating angiogenesis. Read More

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Cross-sectional analysis of peripheral blood mononuclear cells in lymphopenic and non-lymphopenic relapsing-remitting multiple sclerosis patients treated with dimethyl fumarate.

Mult Scler Relat Disord 2021 May 7;52:103003. Epub 2021 May 7.

Division of Neurology, Department of Medicine, University of Alberta, Alberta Canada T6G 2M8, Edmonton, Canada. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is an autoimmune disorder of the central nervous system. Dimethyl Fumarate is a disease-modifying medication used to treat RRMS patients that can induce lymphopenia. We aimed to immunophenotype peripheral blood mononuclear cells (PBMC) in RRMS patients cross-sectionally and examine the characteristics and modifications of lymphopenia over time. Read More

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Antimicrobial activity and toxicological risk assessment of silver nanoparticles synthesized using an eco-friendly method with Gloeophyllum striatum.

J Hazard Mater 2021 Jun 4;418:126316. Epub 2021 Jun 4.

Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. Electronic address:

Recently, nanomaterials synthesized ecologically using microorganisms have attracted much interest. In the present study, the ability of Gloeophyllum striatum to synthesize silver nanoparticles is described for the first time. Nanoparticles were formed in an eco-friendly extracellular manner and characterized by UV-Vis, FT-IR, MADLS and SEM techniques. Read More

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Fabrication of a gradient hydrophobic surface with parallel ridges on pyrolytic carbon for artificial heart valves.

Colloids Surf B Biointerfaces 2021 Jun 2;205:111894. Epub 2021 Jun 2.

Jiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, China; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. Electronic address:

Effective surface modification to endow pyrolytic carbon (PYC) with long-term anti-thrombotic performance is highly demanded. In this work, a gradient hydrophobic surface on PYC was prepared by creating parallel ridges via the combination of laser etching technology and surface fluorosilanization. Scanning electron microscopy (SEM) observation confirms that the gradient hydrophobic surface is composed of a bare PYC region and four regions of parallel ridges with varying distances. Read More

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Frequency of surface bacterial contamination in family physicians' offices.

Infect Dis Now 2021 Jun 9. Epub 2021 Jun 9.

Équipe Mobile de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, 75014 Paris, France; Service de maladies infectieuses et tropicales, Hôpital Necker Enfants-Malades, Centre médicale de l'institut Pasteur, Université de Paris, Paris, France; Institut Micalis, UMR1319, Université Paris-Saclay, INRAe, AgroParisTech, Bactéries Pathogènes et Santé, Chatenay-Malabry, France.

Objectives: The environment is perceived as a potential source of healthcare-associated infections. While this infection source has been well studied in hospital settings, little data on the risk of contamination in general medical practice is available. We aimed to assess the frequency of environmental contamination in family practice (FP), and to describe pathogens isolated, at-risk surfaces, and factors associated with this contamination. Read More

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K channel blockers control glucagon secretion by distinct mechanisms: a direct stimulation of α-cells involving a [Ca] rise and an indirect inhibition mediated by somatostatin.

Mol Metab 2021 Jun 9:101268. Epub 2021 Jun 9.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Brussels, Belgium. Electronic address:

Objective: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by glucose by mechanisms implicating an inhibition of their ATP-sensitive K (K) channels, leading to an increase in [Ca] that triggers exocytosis. Drugs that close K channels, such as sulfonylureas, are used to stimulate insulin release in type 2 diabetic patients. Read More

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High-throughput rat immunoglobulin G N-glycosylation profiling revealed subclass-specific changes associated with chronic stress.

J Proteomics 2021 Jun 9:104293. Epub 2021 Jun 9.

Laboratory of Neurobiology, Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Immunoglobulin G (IgG) glycosylation corresponds well with immune system changes, so it can potentially be used as a biomarker for the consequences of chronic stress such as low-grade inflammation and enhanced immunosenescence in older animals. Here we present a high-throughput glycoproteomic workflow, including IgG enrichment, HILIC glycopeptide purification, and nano-LC-MS analysis of tryptic glycopeptides applied for the analysis of rat IgG. A cohort of 80 animals was exposed to seven stressors in a customized chronic stress protocol with blood and tissue sampling in three timepoints. Read More

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Inflammatory bowel disease in primary immunodeficiency disorders is a heterogeneous clinical entity requiring an individualized treatment strategy: A systematic review.

Autoimmun Rev 2021 Jun 9:102872. Epub 2021 Jun 9.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: To describe the prevalence, clinical presentation and current treatment regimens of inflammatory bowel disease (IBD) in patients with primary immunodeficiency disorders (PIDs).

Methods: A systematic review was conducted. The following databases were searched: MEDLINE, Embase, Web of Science, the Cochrane Library and Google Scholar. Read More

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Correlation between the prognosis of chronic hepatitis B treated with interferon and the gene polymorphism of CGRP and its receptor.

Infect Genet Evol 2021 Jun 9:104968. Epub 2021 Jun 9.

Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human health, Shi Jiazhuang, PR China. Electronic address:

Objective: To investigate the relationship of the polymorphism of two gene loci (CGRP rs155209 and RAMP1 rs3754701) with the prognosis of interferon therapy for chronic hepatitis B (CHB) by case-control study.

Materials And Methods: 317 CHB patients using interferon for the first time alone were collected in northern China and peripheral blood samples were obtained, the single-nucleotide polymorphisms (SNPs) in CGRP rs155209 and RAMP1 rs3754701 were genotyped by MALDI-TOF-MS. Univariate and multivariate logistic regression methods were used to assess the correlation between the prognosis of CHB treated with interferon and the gene polymorphism of CGRP rs155209 and RAMP1 rs3754701. Read More

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Effect of zinc depletion/repletion on intestinal iron absorption and iron status in Rats.

J Nutr Biochem 2021 Jun 9:108800. Epub 2021 Jun 9.

ICMR-National Institute of Nutrition, Hyderabad, India. Electronic address:

Iron and zinc deficiencies likely coexist in general population. We have previously demonstrated that zinc treatment induces while zinc deficiency inhibits iron absorption in intestinal cell culture models, but this needs to be tested in vivo. In the present study we assessed intestinal iron absorption, iron status (haemoglobin (Hb), red blood cell (RBC) number, plasma ferritin, transferrin receptor (TfR), hepcidin) and tissue iron levels in zinc depleted, replete and pair fed control rats. Read More

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Level of Maternal Respiratory Syncytial Virus (RSV) F Antibodies in Hospitalized Children and Correlates of Protection.

Int J Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Biomedical Research Center, Qatar University, Qatar; College of Health Sciences, Qatar University, Qatar. Electronic address:

Background: RSV is a major cause of lower respiratory infections among children, where no vaccine is available. The stabilized form of the fusion (F) protein, pre-F, is a leading vaccine candidate targeting different populations, including pregnant women. This study aimed to determine the magnitude and nature of RSV-directed maternal antibodies (matAbs) in hospitalized children with RSV infection. Read More

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TikTok browsing for anxiety relief in the preoperative period: a randomized clinical trial.

Complement Ther Med 2021 Jun 9:102749. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:

Objective: The purpose of this study was to determine the effect of browsing TikTok for 20 minutes on patients' preoperative anxiety.

Method: A randomized controlled trial was conducted at the Department of Anesthesiology of The First Affiliated Hospital, Zhejiang University School of Medicine from January 2021 to March 2021. The 80 patients were randomly divided into two groups. Read More

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Acupuncture as an adjunctive treatment for pain in hospitalized children with sickle cell disease.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington DC; Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital, Washington DC. Electronic address:

Context: Acute episodes of pain associated with sickle cell disease (SCD) account for over 100,000 hospitalizations and expenses of nearly 1 billion dollars annually in the United States. New treatment approaches are needed as the current opioid based therapy is often inadequate in controlling pain, resulting in prolonged inpatient stays and high rates of readmission.

Objectives: To evaluate acceptability of acupuncture as an adjunctive therapy and explore the impact of acupuncture on pain related outcomes in a population of youth with SCD hospitalized for management of acute pain. Read More

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Leojaponin inhibits NLRP3 inflammasome activation through restoration of autophagy via upregulating RAPTOR phosphorylation.

J Ethnopharmacol 2021 Jun 9:114322. Epub 2021 Jun 9.

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China. Electronic address:

Ethnopharmacological Relevance: Duan Teng Yimu decoction is a Chinese herbal medicine compound with proven therapeutic effects on inflammasome-related diseases, such as rheumatoid arthritis. This decoction consists of three Chinese herbal medicines, including Leonurus japonicus (L. japonicus), which promotes the blood circulation and exhibits detumescence activity, traditionally curing gynecologic and inflammasome diseases. Read More

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Unfolding the Apoptotic Mechanism of Antioxidant Enriched-Leaves of Tabebuia pallida (Lindl.) Miers in EAC Cells and Mouse Model.

J Ethnopharmacol 2021 Jun 9:114297. Epub 2021 Jun 9.

Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. Electronic address:

Ethnopharmacological Relevance: Tabebuia pallida (Lindl.) Miers (T. pallida) is a well-known native Caribbean medicinal plant. Read More

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Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

J Control Release 2021 Jun 9. Epub 2021 Jun 9.

Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan. Electronic address:

Claudin-5 (CLDN-5) is an essential component of the tight junction seal in the blood-brain barrier. Previously, we showed that CLDN-5 modulation in vitro via an anti-CLDN-5 monoclonal antibody (mAb) may be useful for increasing the permeability of the blood-brain barrier for drug delivery to the brain. Based on these findings, here we examined the safety and efficacy of the anti-CLDN-5 mAb in a non-human primate. Read More

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Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.

J Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Odense University Hospital, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background & Aims: Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking.

Methods: Prospective cohort study of patients with early, compensated alcohol-related liver disease. Read More

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