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Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers.

J Colloid Interface Sci 2021 Apr 20;599:313-325. Epub 2021 Apr 20.

Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Prague 2, Czech Republic. Electronic address:

Hydrophobic blocks of amphiphilic block copolymers often form glassy micellar cores at room temperature with a rigid structure that limits their applications as nanocapsules for targeted delivery. Nevertheless, we prepared and analyzed core/shell micelles with a soft core, formed by a self-assembled block copolymer consisting of a hydrophobic block and a polycation block, poly(lauryl acrylate)-block-poly(trimethyl-aminoethyl acrylate) (PLA-QPDMAEA), in aqueous solution. By light and small-angle neutron scattering, by transmission electron microscopy and by fluorescence spectroscopy, we showed that these core/shell micelles are spherical and cylindrical with a fluid-like PLA core and a positively charged outer shell and that they can encapsulate and release hydrophobic solutes. Read More

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Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.

Genetics 2019 Aug;212(4):1133-1145

Department of Microbiology and Molecular Genetics, University of California, Davis, California 95616.

Saccharomyces cerevisiae Srs2, in addition to its well-documented antirecombination activity, has been proposed to play a role in promoting synthesis-dependent strand annealing (SDSA). Here we report the identification and characterization of an SRS2 mutant with a single amino acid substitution (srs2-F891A) that specifically affects the Srs2 pro-SDSA function. This residue is located within the Srs2-Rad51 interaction domain and embedded within a protein sequence resembling a BRC repeat motif. Read More

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Obscure Involvement of MYC in Neurodegenerative Diseases and Neuronal Repair.

Mol Neurobiol 2021 May 5. Epub 2021 May 5.

Faculty of Special Education and Rehabilitation, University of Belgrade, Visokog Stevana 2, 11000, Belgrade, Serbia.

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Read More

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Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Fab-8 Boundary.

Genetics 2019 Nov;213(3):865-876

Department of Molecular Biology, Princeton University, New Jersey 08544.

Boundaries in the Drosophila bithorax complex (BX-C) enable the regulatory domains that drive parasegment-specific expression of the three Hox genes to function autonomously. The four regulatory domains (iab-5, iab-6, iab-7, and iab-8) that control the expression of the Abdominal-B (Abd-B) gene are located downstream of the transcription unit, and are delimited by the Mcp, Fab-6, Fab-7, and Fab-8 boundaries. These boundaries function to block cross talk between neighboring regulatory domains. Read More

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November 2019

Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models.

Genetics 2020 May;215(1):41-58

Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina.

Age-at-onset traits are of paramount importance in studies of age-related diseases and behavioral genetics. Cox mixed-effects models (CMEMs) are widely used when sample dependence is taken into account. However, the application of CMEMs in genome-wide association. Read More

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Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Post-Operative Delirium.

Geriatr Orthop Surg Rehabil 2021 16;12:21514593211004530. Epub 2021 Apr 16.

Department of Anaesthesiology, Queen Mary Hospital, Hong Kong.

Background: Delirium in elderly orthopaedic patients poses an enormous medical, social and financial burden to the healthcare system, and causes significant distress to patients and their caregivers. We examined whether a Multi-component Care Bundle (MCB) could reduce the incidence of post-operative delirium (POD) in fractured hip patients.

Methods: An observational study was conducted, analyzing 154 patients (mean age ± SD, 85 ± 7. Read More

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Dynamic Study of Oesophageal Function during Phonation: Simple but Effective.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-6. Epub 2021 May 5.

ENT Section, Department of Medical, Surgical and Advanced Technologies G.F. Ingrassia, University of Catania, Catania, Italy.

Secondary aphonia significantly affects the quality of life of the laryngectomy patient despite the excellent success of the operation. Vocal rehabilitation often does not achieve the desired results, given the innumerable prognostic variables. Tracheo-oesophageal speech is considered the standard gold method of voice restoration, but a possible spasm of pharyngo-oesophageal segment is the prominent cause of rehabilitation failure. Read More

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The Beta vulgaris-derived resistance gene Rz2 confers broad-spectrum resistance against soilborne sugar beet-infecting viruses from different families by recognizing triple gene block protein 1.

Mol Plant Pathol 2021 May 5. Epub 2021 May 5.

Institute of Sugar Beet Research, Göttingen, Germany.

Sugar beet cultivation is dependent on an effective control of beet necrotic yellow vein virus (BNYVV, family Benyviridae), which causes tremendous economic losses in sugar production. As the virus is transmitted by a soilborne protist, the use of resistant cultivars is currently the only way to control the disease. The Rz2 gene product belongs to a family of proteins conferring resistance towards diverse pathogens in plants. Read More

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Downsizing of Block Polymer-Templated Nanopores to One Nanometer via Hyper-Cross-Linking of High χ-Low Precursors.

ACS Nano 2021 May 5. Epub 2021 May 5.

Department of Chemistry, KAIST, Daejeon 34141, Korea.

Synthesizing nanoporous polymer from the block polymer template by selective removal of the sacrificial domain offers straightforward pore size control as a function of the degree of polymerization (). Downscaling pore size into the microporous regime (<2 nm) has been thermodynamically challenging, because the low drives the system to disorder and the small-sized pore is prone to collapse. Herein, we report that maximizing cross-linking density of a block polymer precursor with an increased interaction parameter (χ) can help successfully stabilize the structure bearing pore sizes of 1. Read More

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Thymidine decreases the DNA damage and apoptosis caused by tumor-treating fields in cancer cell lines.

Genes Genomics 2021 May 5. Epub 2021 May 5.

School of Biosystems and Biomedical Sciences, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Tumor-treating fields (TTFields) is an emerging non-invasive cancer-treatment modality using alternating electric fields with low intensities and an intermediate range of frequency. TTFields affects an extensive range of charged and polarizable cellular factors known to be involved in cell division. However, it causes side-effects, such as DNA damage and apoptosis, in healthy cells. Read More

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POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression.

Adipocyte 2021 Dec;10(1):251-263

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Excessive production of visceral adipose is a major risk factor of many diseases. Inhibiting the adipogenesis of mesenchymal stem cells (MSCs) will be an efficient way to block adipose production. We illuminated POU class 2 homeobox associating factor 1 (POU2AF1) may promote MSCs adipogenesis by histone deacetylases 1 (HDAC1) signalling. Read More

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December 2021

Continuous erector spinae plane block versus thoracic epidural analgesia in video-assisted thoracic surgery: a study protocol for a prospective randomized open label non-inferiority trial.

Trials 2021 May 4;22(1):321. Epub 2021 May 4.

Department of Anesthesiology and Pain Medicine, Catharina Hospital, Michelangelolaan 2, Eindhoven, 5623 EJ, The Netherlands.

Background: Thoracic epidural analgesia is considered the gold standard for pain relief in video-assisted thoracoscopic surgery. This neuraxial technique blocks pain sensation by injecting a local anesthetic agent in the epidural space near the spinal cord to block spinal nerve roots. Recently, the erector spinae plane block has been introduced as a practical alternative to the thoracic epidural. Read More

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Decision making under ambiguity and risk in adolescent-onset schizophrenia.

BMC Psychiatry 2021 05 4;21(1):230. Epub 2021 May 4.

Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China.

Objective: Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Read More

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1,3,4-Thiadiazoles Effectively Inhibit Proliferation of .

Cells 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.

Congenital and acquired toxoplasmosis caused by the food- and water-born parasite () is one of the most prevalent zoonotic infection of global importance. is an obligate intracellular parasite with limited capacity for extracellular survival, thus a successful, efficient and robust host cell invasion process is crucial for its survival, proliferation and transmission. In this study, we screened a series of novel 1,3,4-thiadiazole-2-halophenylamines functionalized at the C5 position with the imidazole ring (-) for their effects on host cell invasion and proliferation. Read More

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A Novel Method for COVID-19 Diagnosis Using Artificial Intelligence in Chest X-ray Images.

Healthcare (Basel) 2021 Apr 29;9(5). Epub 2021 Apr 29.

Electrical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 61441, Saudi Arabia.

The Coronavirus disease 2019 (COVID-19) is an infectious disease spreading rapidly and uncontrollably throughout the world. The critical challenge is the rapid detection of Coronavirus infected people. The available techniques being utilized are body-temperature measurement, along with anterior nasal swab analysis. Read More

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Quantitative EEG (QEEG) Analysis of Emotional Interaction between Abusers and Victims in Intimate Partner Violence: A Pilot Study.

Brain Sci 2021 Apr 29;11(5). Epub 2021 Apr 29.

Department of Community Health & Epidemiology, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.

Background: The perpetrators of intimate partner violence (IPV) and their victims have different emotional states. Abusers typically have problems associated with low self-esteem, low self-awareness, violence, anger, and communication, whereas victims experience mental distress and physical pain. The emotions surrounding IPV for both abuser and victim are key influences on their behavior and their relationship. Read More

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Reduced Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155.

Biomedicines 2021 Apr 30;9(5). Epub 2021 Apr 30.

Institute for Respiratory Health, Nedland 6009, WA, Australia.

The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and function are unknown. Suppressor of cytokine signaling (SOCS)1 and SOCS3 block STAT3, and low SOCS1 levels have been reported in IPF fibroblasts and shown to facilitate collagen production. Fibroblasts and lung tissue from IPF patients and controls were used to examine the mechanisms underlying SOCS1 down-regulation in IPF. Read More

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Main control factors affecting mechanical oil recovery efficiency in complex blocks identified using the improved k-means algorithm.

PLoS One 2021 4;16(5):e0248840. Epub 2021 May 4.

School of Mechanics Science & Engineering, Northeast Petroleum University, Daqing, Heilongjiang, China.

The system efficiency of pumping units in the middle and late stages of oil recovery is characterized by several factors, complex data and poor regulation. Further, the main control factors that affect system efficiency in different blocks vary greatly; therefore, it is necessary to obtain the block characteristics to effectively improve system efficiency. The k-means algorithm is simple and efficient, but it assumes that all factors have the same amount of influence on the output value. Read More

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The Clinical Efficacy of High-Voltage Long-Duration Pulsed Radiofrequency Treatment in Pudendal Neuralgia: A Retrospective Study.

Neuromodulation 2021 May 4. Epub 2021 May 4.

Department of Pain Medicine, the First Affiliated Hospital, China Medical University, Shenyang, China.

Background: Patients with pudendal neuralgia (PN) experience long-lasting chronic pain, hyperalgesia, and comorbid emotional disorders, such as depression and anxiety. Treatment via conventional pulsed radiofrequency (PRF) current carries a significantly high rate of failure.

Objective: To determine the safety and clinical efficacy of high-voltage, long-duration PRF application to the pudendal nerve in patients with PN. Read More

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Selection history modulates the limit of visual awareness in color perception.

Psychon Bull Rev 2021 May 4. Epub 2021 May 4.

School of Psychology, Speech and Hearing, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.

Among studies on the limit of conscious representation of color at a given instant, some have shown evidence of momentary awareness of only a single color, while others have not, leading to uncertainty about the factors that influence the limit. In two experiments, we explored the role of selection history, or recent experience with a trial, which is known to influence the representations of task stimuli and responses. Two color patches were briefly displayed either simultaneously or sequentially. Read More

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Effects of greater occipital nerve block with local anesthetic and triamcinolone for treatment of medication overuse headache: an open-label, parallel, randomized, controlled clinical trial.

Neurol Sci 2021 May 4. Epub 2021 May 4.

Isfahan Neurosciences Research Center, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Aim: There is a paucity of evidence and consensus on exactly how to carry out the detoxification process. To examine the effect of a greater occipital nerve block (GONB) in the detoxification process, we conducted an open-label, parallel, randomized, controlled clinical trial.

Materials And Methods: In order to conduct this study, 54 medication-overuse headache (MOH) patients were recruited and allocated randomly to group A (n = 27) or B (n = 27). Read More

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Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines.

J Am Vet Med Assoc 2021 May;258(10):1119-1129

Objective: To compare immune responses induced by 2 commercially available vaccines with a bovine herpesvirus type 1 (BHV1) component following intranasal (IN) administration to colostrum-fed calves.

Animals: 90 male Holstein calves (ages, 5 to 14 days).

Procedures: In a randomized complete block design, each calf received 2 mL (1 mL/nostril) of vaccine A (n = 30), vaccine B (30), or saline (0. Read More

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First Report of Fusarium ipomoeae Causing Peanut leaf Spot in China.

Plant Dis 2021 May 4. Epub 2021 May 4.

Shandong Peanut Research Institute , Plant Protect, No. 126 Wannianquan Road, Licang, Qingdao, Shandong, 266100, China, Qingdao, Shandong Province, China, 266100.

Peanut (Arachis hypogaea L.) is one of the most economically important crops as an important source of edible oil and protein. In August 2020, circular to oval-shaped brown leaf spots (2-6 mm in diameter) with well-defined borders surrounded by a yellow margin were observed on peanut plant leaves in Laixi City, Shandong Province, China. Read More

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Lipotoxicity suppresses the synthesis of growth hormone in pituitary somatotrophs via endoplasmic reticulum stress.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Lipotoxicity has been shown to cause dysfunction of many organs and tissues. However, it is unclear whether lipotoxicity is harmful to the somatotrophs, a kind of cell that synthesize growth hormone (GH) in the pituitary. In this study, we performed an epidemiological study, serum levels of triglyceride (TG) and GH showed a negative correlation, even after adjustment for potential confounders. Read More

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An investigation of the effects of dexmedetomidine and fentanyl as an adjuvant to ropivacaine on pain scores and hemodynamic changes following laparoscopic cholecystectomy.

Med Gas Res 2021 Jul-Sep;11(3):88-93

School of Health, Department of Epidemiology, Arak University of Medical Sciences, Arak, Iran.

Postoperative pain control is recognized as a challenging surgical issue receiving high priority in the healthcare system, and opioids are routinely prescribed for anesthesia and pain relief. This study aimed to investigate the effects of ropivacaine administered intraperitoneally alone or combined with dexmedetomidine or fentanyl on postoperative pain control following laparoscopic cholecystectomy. This randomized double-blind clinical trial recruited three equal-size block-randomized groups of patients (n = 138) scheduled for elective laparoscopic cholecystectomy at Valiasr Hospital, Arak, Iran, in 2019-2020 who received ropivacaine (40 mL/0. Read More

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Central pain modulatory mechanisms of attentional analgesia are preserved in fibromyalgia.

Pain 2021 May 1. Epub 2021 May 1.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD. Anaesthesia, Pain & Critical Care Sciences, Bristol Medical School, University Hospitals Bristol, Bristol, BS2 8HW. School of Psychological Science, University of Bristol, Bristol, BS8 1TU. University of East Anglia Brain Imaging Centre, School of Psychology, Lawrence Stenhouse Building, Chancellors Drive, NR4 7TJ, United Kingdom.

Abstract: Fibromyalgia is a prevalent pain condition that is associated with cognitive impairments including in attention, memory, and executive processing. It has been proposed that fibromyalgia may be caused by altered central pain processing characterised by a loss of endogenous pain modulation. We tested whether attentional analgesia, where cognitive engagement diminishes pain percept, was attenuated in fibromyalgia patients (n=20) compared to matched healthy controls (n=20). Read More

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An orally available PD-1/PD-L1 blocking peptide OPBP-1-loaded trimethyl chitosan hydrogel for cancer immunotherapy.

J Control Release 2021 Apr 30. Epub 2021 Apr 30.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Blockade of the immune checkpoint PD-1/PD-L1 with monoclonal antibodies demonstrated unprecedented clinical efficacies in many cancers. But the orally available low molecular weight inhibitors remain infancy. Compared to small molecules, peptide exhibits better selectivity and fewer side effects, but poor half-life and a big challenge to be orally administrated. Read More

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Specific Binding of Leptin to Red Blood Cells Delivers a Pancreatic Hormone and Stimulates ATP Release.

Mol Pharm 2021 May 3. Epub 2021 May 3.

Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan 48824, United States.

Since its discovery in 1994, leptin continues to have new potential physiological roles uncovered, including a role in the regulation of blood flow. Leptin's role in regulating blood flow is not completely understood. Red blood cell (RBC)-derived ATP is a recognized stimulus of blood flow, and multiple studies suggest that C-peptide, a hormone secreted in equimolar amounts with insulin from the pancreatic β-cells, can stimulate that release when delivered by albumin and in combination with Zn. Read More

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Efficacy of paravertebral block in "Fast-tracking" pediatric cardiac surgery - Experiences from a tertiary care center.

Ann Card Anaesth 2021 Jan-Mar;24(1):24-29

Department of Cardiothoracic Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Introduction: Fast tracking plays a crucial role in reducing perioperative morbidity and financial burden by facilitating early extubation and discharge from hospital. Paravertebral block (PVB) is becoming more popular in paediatric surgeries as an alternative to epidural and caudal analgesia. There is scarcity of data regarding the efficacy and safety of PVB in paediatric cardiac surgery. Read More

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Post mastectomy pain syndrome after preoperative stellate ganglion block: a randomized controlled trial.

Minerva Anestesiol 2021 May 3. Epub 2021 May 3.

Anesthesia and Pain Medicine Department, National Cancer Institute, Cairo, Egypt -

Background: This study investigated the effect of preoperative ultrasound (US) guided stellate ganglion block (SGB) with bupivacaine on the frequency of post mastectomy pain syndrome (PMPS).

Methods: Eighty patients scheduled for mastectomy with axillary dissection for breast cancer were included in this randomized controlled trial. Patients were randomized into two equal groups: Group A received US guided SGB one hour before surgery using five mL of 0. Read More

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