283,573 results match your criteria block


FPSN-FNCC: an accurate and fast motion tracking algorithm in 3D ultrasound for image guided interventions.

Phys Med Biol 2021 May 11. Epub 2021 May 11.

Insititute of Biomedical Engineering, Tsinghua University, Shenzhen International Graduate School, Shenzhen, Shenzhen, GuangDong, CHINA.

Uncertain motions of target caused by breath, heartbeat and body drift of patient can increase the target locating error during image guided interventions, and that may cause additional surgery trauma. The surgery navigation system with accurate motion tracking is important for improving the operation accuracy and reducing trauma. In this work, we propose an accurate and fast tracking algorithm in three-dimension (3D) ultrasound (US) sequences for US guided surgery to achieve moving object tracking. Read More

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Hepatic hilar and celiac plexus nerve blocks as analgesia for doxorubicin-eluting bead embolization procedures for hepatocellular carcinoma: A non-blinded randomized clinical trial.

J Vasc Interv Radiol 2021 May 8. Epub 2021 May 8.

Department of Radiodiagnosis, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Purpose: To investigate whether hepatic hilar and celiac plexus nerve blocks provide safe and effective analgesia to patients undergoing doxorubicin-eluting embolics embolization for hepatocellular carcinoma MATERIALS AND METHODS: In this prospective, randomized trial, 92 patients undergoing drug-eluting embolics transarterial chemoembolization (TACE) for hepatocellular carcinoma were enrolled. The control group received standard intraprocedural local anesthetic, intraarterial lidocaine, and intravenous analgesia; the study group (HHCB) underwent hepatic hilar and celiac plexus nerve blockade in addition. Intraarterial lidocaine, intravenous and postprocedural oral narcotics and antiemetics requirements, pain, patient satisfaction, adverse events, and hospital stay were compared. Read More

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Plastrum testudinis extract suppresses osteoclast differentiation via the NF-κB signaling pathway and ameliorates senile osteoporosis.

J Ethnopharmacol 2021 May 8:114195. Epub 2021 May 8.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: Plastrum testudinis (PT) is a kind of single traditional Chinese medicine that can tonify kidney and strengthen bone. Plastrum testudinis extract (PTE) has been approved to promote the osteogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. However, the mechanism by which PTE reduces osteoclast differentiation has not yet been reported. Read More

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Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.

Cell 2021 Apr 24. Epub 2021 Apr 24.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address:

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by binding of the viral Spike protein to host receptor angiotensin-converting enzyme 2 (ACE2), followed by fusion of viral and host membranes. Although antibodies that block this interaction are in emergency use as early coronavirus disease 2019 (COVID-19) therapies, the precise determinants of neutralization potency remain unknown. We discovered a series of antibodies that potently block ACE2 binding but exhibit divergent neutralization efficacy against the live virus. Read More

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Predictors of permanent pacemaker requirement after cardiac surgery for infective endocarditis.

Eur Heart J Acute Cardiovasc Care 2021 May;10(3):329-334

Department of Cardiovascular Medicine, Cleveland Clinic, USA.

Background: Infectious endocarditis is often complicated by conduction abnormalities at the time of presentation. Cardiac surgery is the treatment of choice for many infectious endocarditis patients, but carries an additional risk of persistent postoperative conduction abnormality. We sought to define the incidence and clinical predictors of significant postoperative conduction abnormalities necessitating permanent pacemaker implantation after cardiac surgery for infectious endocarditis. Read More

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Quality Enhancement of Compressed Vibrotactile Signals using Recurrent Neural Networks and Residual Learning.

IEEE Trans Haptics 2021 May 11;PP. Epub 2021 May 11.

We present a neural network-based compression artifact removal technique for vibrotactile signals. The proposed decoder-side quality enhancement approach is based on recurrent neural networks (RNNs) and the principle of residual learning. We use a total of 8 nonlinear RNN layers trained to first estimate the difference between the original and the compressed signal. Read More

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SSR markers and seed quality traits revealed genetic diversity in durum wheat (Triticum durum Desf.).

Mol Biol Rep 2021 May 11. Epub 2021 May 11.

Faculty of Sciences of Tunis, Laboratory of Biodiversity, Biotechnologies and Climate Change (LR11/ES09), University of Tunis El-Manar, 2092, Tunis, Tunisia.

Genetic diversity and differences among durum-wheat cultivars evolved in various regions of the world are important for sustainable production in the current climate change scenario. Information regarding genetic differences was also important for the correct choice of parental material for the selection of high quality cultivars. Two elite and six obsolete cultivars of durum-wheat were characterized with 25-simple sequence repeats (SSR) markers. Read More

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Detection of liver cirrhosis in standard T2-weighted MRI using deep transfer learning.

Eur Radiol 2021 May 11. Epub 2021 May 11.

Department of Diagnostic and Interventional Radiology, Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn (Universitätsklinikum Bonn), Venusberg-Campus 1, 53127, Bonn, Germany.

Objectives: To investigate the diagnostic performance of deep transfer learning (DTL) to detect liver cirrhosis from clinical MRI.

Methods: The dataset for this retrospective analysis consisted of 713 (343 female) patients who underwent liver MRI between 2017 and 2019. In total, 553 of these subjects had a confirmed diagnosis of liver cirrhosis, while the remainder had no history of liver disease. Read More

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Association between Paravertebral Block and Pain Score at the Time of Hospital Discharge in Oncoplastic Breast Surgery: A Retrospective Cohort Study.

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Departments of Anesthesiology and Perioperative Medicine and Surgery, Tufts Medical Center; and Tufts University School of Medicine.

Background: Using nonopioid analgesics may decrease the risk of patients chronically using opioids postoperatively. The authors evaluated the relationship between paravertebral block and pain score at the time of hospital discharge.

Methods: The authors performed a retrospective cohort study of 89 women with American Society of Anesthesiologists Physical Status I to III undergoing oncoplastic breast surgery with 20 to 50 percent breast tissue removal and immediate contralateral reconstruction between August of 2015 and August of 2018. Read More

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A Comprehensive Review of State Vision Screening Mandates for Schoolchildren in the United States.

Optom Vis Sci 2021 May 7. Epub 2021 May 7.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland Prevent Blindness, Chicago, Illinois Illinois College of Optometry, Chicago, Illinois Massachusetts Eye and Ear, Glaucoma Center of Excellence, Harvard Medical School, Boston, Massachusetts Berman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland

Significance: Methods and frequency of vision screenings for school-aged children vary widely by state, and there has been no recent comparative analysis of state requirements. This analysis underscores the need for developing evidence-based criteria for vision screening in school-aged children across the United States.

Purpose: The purpose of this study was to conduct an updated comprehensive analysis of vision screening requirements for school-aged children in the United States. Read More

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Case Report: Role of Anterior Segment Optical Coherence Tomography in Late-onset Capsular Block Syndrome.

Optom Vis Sci 2021 May 7. Epub 2021 May 7.

FISABIO Oftalmología Médica, Valencia, Spain

Significance: We report the use of anterior segment optical coherence tomography (AS-OCT) as a valuable tool for capsular block syndrome diagnosis and follow-up.

Purpose: The purposes of this study are to report a case of late-onset capsular block syndrome or lacteocrumenasia and to describe differential diagnosis with other more common phacoemulsification complications such as intraocular lens (IOL) or posterior capsule opacification.

Case Report: We report the case of a 56-year-old man with a clinical history of cataract surgery in his left eye. Read More

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Intrasacral Meningocele Complicating Caudal Analgesia in a 6-Year-Old Child After 3 Previous Uneventful Caudals: A Case Report.

A A Pract 2021 May 10;15(5):e01457. Epub 2021 May 10.

Urology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana.

A 6-year-old male undergoing bilateral hydrocelectomy was to receive caudal analgesia after induction of general anesthesia. After insertion of the caudal needle, cerebrospinal fluid was unexpectedly aspirated and the caudal was abandoned. The surgeon performed bilateral ilioinguinal nerve blocks just before incision. Read More

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Intrapatient Tumor Heterogeneity in IHC Interpretation Using PD-L1 IHC 22C3 pharmDx.

Appl Immunohistochem Mol Morphol 2021 May 12. Epub 2021 May 12.

Agilent Technologies Inc., R&D Agilent Technologies Inc., Histopathology, Carpinteria, CA.

Tumor heterogeneity may impact immunohistochemical (IHC) interpretation, thus potentially affecting decision making by treating oncologists for cancer patient management. Programmed cell death ligand-1 (PD-L1) IHC 22C3 pharmDx is a companion diagnostic used as an aid in identifying patient eligibility for treatment with pembrolizumab (KEYTRUDA). This study aims to investigate tumor heterogeneity impact on IHC staining when evaluating PD-L1 expression using PD-L1 IHC 22C3 pharmDx. Read More

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SVLR: Genome Structural Variant Detection Using Long-Read Sequencing Data.

J Comput Biol 2021 May 10. Epub 2021 May 10.

School of Computer Science and Technology, Shandong University, Qindao, China.

Genome structural variants (SVs) have great impacts on human phenotype and diversity, and have been linked to numerous diseases. Long-read sequencing technologies arise to make it possible to find SVs of as long as 10,000 nucleotides. Thus, long read-based SV detection has been drawing attention of many recent research projects, and many tools have been developed for long reads to detect SVs recently. Read More

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Efophylins A and B, Two -Asymmetric Macrodiolide Immunosuppressants from .

J Nat Prod 2021 May 11. Epub 2021 May 11.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

Genomics-inspired isolation led to the identification of two new natural congeneric -asymmetric macrodiolide immunosuppressants, named efophylins A () and B (), from DSM 4137. Their structures were elucidated by spectroscopic and computational methods and were in agreement with biosynthetic predictions from the efophylin gene cluster. Compound exhibited potent immunosuppressive activity and demonstrated to inhibit the activation of the NFAT and block NFAT dephosphorylation . Read More

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Nitrogen Fixation via Splitting into Nitrido Complexes.

Chem Rev 2021 May 11. Epub 2021 May 11.

Institut für Anorganische Chemie, Universität Göttingen, Tammannstrasse 4, D-37077 Göttingen, Germany.

The large carbon footprint of the Haber-Bosch process, which provides ammonia for fertilizers but also the feedstock for all nitrogenous commercial products, has fueled the quest for alternative synthetic strategies to nitrogen fixation. Owing to the extraordinarily strong N≡N triple bond, the key step of the Haber-Bosch reaction, i.e. Read More

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The prognostic significance of electrocardiography findings in patients with coronavirus disease 2019: A retrospective study.

Clin Cardiol 2021 May 11. Epub 2021 May 11.

Department of Cardiology, Intervention Cardiology Center, Wuhan No.1 Hospital, No.215 Zhongshan Avenue, QiaoKou District, Wuhan, China.

Background: Coronavirus disease 2019 (COVID-19) has reached a pandemic level. Cardiac injury is not uncommon among COVID-19 patients. We sought to describe the electrocardiographic characteristics and to identify the prognostic significance of electrocardiography (ECG) findings of patients with COVID-19. Read More

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In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases.

Elife 2021 May 11;10. Epub 2021 May 11.

Department of Biology, Washington University in St. Louis, St. Louis, United States.

Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondrial (HCCS) and bacterial (CcsBA) cytochrome c synthases. We employ apocytochrome c and peptide analogs containing CXXCH as substrates, examining recognition determinants, thioether attachment, and subsequent release and folding of cytochrome c. Read More

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ACE2-Based Decoy Receptors for SARS Coronavirus 2.

Proteins 2021 May 10. Epub 2021 May 10.

Center for Biophysics and Quantitative Biology, University of Illinois, Urbana, IL, USA.

SARS-CoV-2 is neutralized by proteins that block receptor-binding sites on spikes that project from the viral envelope. In particular, substantial research investment has advanced monoclonal antibody therapies to the clinic where they have shown partial efficacy in reducing viral burden and hospitalization. An alternative is to use the host entry receptor, ACE2, as a soluble decoy that broadly blocks SARS-associated coronaviruses with limited potential for viral escape. Read More

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Multimodal treatment including lumbar facet joint denervation for severe low back pain in patients with neuromuscular disorders.

Neurol Sci 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: Severe low back pain (LBP) is an occasional complaint in patients with neuromuscular disorders (NMDs). Accurate diagnosis and treatment are required to manage LBP; however, the precise pathophysiology differs for each patient. This study aimed to evaluate the efficacy of lumbar facet joint denervation (FJD) and adjunctive modalities in the treatment of LBP in patients with NMD-associated kyphoscoliosis. Read More

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Quantitative helix handedness bias through a single H CH stereochemical differentiation.

Chem Commun (Camb) 2021 May 11. Epub 2021 May 11.

Department of Pharmacy and Center for Integrated Protein Science, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, München 81377, Germany.

A novel chiral aromatic δ-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation. Read More

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Is pudendal nerve entrapment a potential cause for weak ejaculation?

Int J Impot Res 2021 May 10. Epub 2021 May 10.

Department of Urology, Wallonie Picarde Hospital, Tournai, Belgium.

Ejaculatory dysfunction is one of the most common complaints of patients with sexual disorders. While it encompasses several ejaculatory disorders, weak ejaculation is seldom described in the literature. Since the pudendal nerve is the main nerve of ejaculation, we aim to hypothesize that pudendal nerve entrapment could be a cause of weak ejaculation, and that pudendal nerve release could contribute to the improvement of the ejaculatory stream. Read More

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Relationship of contact angle of spray solution on leaf surfaces with weed control.

Sci Rep 2021 May 10;11(1):9886. Epub 2021 May 10.

Department of Plant Production, School of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal, 14884-900, Brazil.

The weeds are important in agricultural and livestock areas because these plants can cause several damages, especially in the yield. The herbicide pulverization for weed control is the most used, but the efficiency of the control can be dependent the several factors, for example, the correct chose the herbicide and the mixture or not with adjuvant. This study aimed to evaluate the contact angle of herbicide solution droplets associated with adjuvant when deposited on the leaf surface of different weed species and their relationship with chemical control. Read More

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Semi-conducting 2D rectangles with tunable length via uniaxial living crystallization-driven self-assembly of homopolymer.

Nat Commun 2021 May 10;12(1):2602. Epub 2021 May 10.

Department of Chemistry, Seoul National University, Seoul, 08826, Korea.

Semi-conducting two-dimensional (2D) nanoobjects, prepared by self-assembly of conjugated polymers, are promising materials for optoelectronic applications. However, no examples of self-assembled semi-conducting 2D nanosheets whose lengths and aspect ratios are controlled at the same time have been reported. Herein, we successfully prepared uniform semi-conducting 2D sheets using a conjugated poly(cyclopentenylene vinylene) homopolymer and its block copolymer by blending and heating. Read More

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DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling.

Stem Cell Res Ther 2021 May 10;12(1):281. Epub 2021 May 10.

Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

Background: Maintaining the stability and maturation of blood vessels is of paramount importance for the vessels to carry out their physiological function. Smooth muscle cells (SMCs), pericytes, and mesenchymal stem cells (MSCs) are involved in the maturation process of the newly formed vessels. The aim of this study was to investigate whether transforming growth factor beta 1 (TGF-β1) treatment could enhance pericyte-like properties of dental pulp stem cells (DPSCs) and how TGF-β1-treated DPSCs for 7 days (T-DPSCs) stabilize the newly formed blood vessels. Read More

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On forecasting the community-level COVID-19 cases from the concentration of SARS-CoV-2 in wastewater.

Sci Total Environ 2021 Apr 30;786:147451. Epub 2021 Apr 30.

Department of Wastewater Treatment, Borough of Indiana, Indiana, PA, USA.

The building of an effective wastewater-based epidemiological model that can translate SARS-CoV-2 concentrations in wastewater to the prevalence of virus shedders within a community is a significant challenge for wastewater surveillance. The objectives of this study were to investigate the association between SARS-CoV-2 wastewater concentrations and the COVID-19 cases at the community-level and to assess how SARS-CoV-2 wastewater concentrations should be integrated into a wastewater-based epidemiological statistical model that can provide reliable forecasts for the number of COVID-19 infections and the evolution over time as well. Weekly variations on the SARS-CoV-2 wastewater concentrations and COVID-19 cases from April 29, 2020 through February 17, 2021 were obtained in Borough of Indiana, PA. Read More

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Tumstatin attenuates the promotion effect of IL-17 secreted by Th17 cells on the stemness maintenance of glioma cells.

Pathol Res Pract 2021 May 5;223:153463. Epub 2021 May 5.

Department of Neurosurgery, Beilun District People's Hospital of Ningbo City, Ningbo, Zhejiang, 315800, China. Electronic address:

The presence and clinical significance of IL-17 and IL-17-expressing cells have been studied for several cancers, although their correlation with tumor development remains controversial. Peripheral blood was collected from healthy donors and glioma patients to isolate peripheral blood mononuclear cells (PBMCs). The percentage of IL-17-expressing cells and the production of inflammatory cytokines in PBMCs and tissues were measured. Read More

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Klippel-Feil syndrome cases from Slovakia.

Int J Paleopathol 2021 May 7;33:188-195. Epub 2021 May 7.

Archaeological Institute of the Slovak Academy of Sciences, Akademická 2, 949 21 Nitra, Slovakia. Electronic address:

Objective: This study analyzes two probable cases of Klippel-Feil syndrome (KFS) from the region of modern Slovakia and provides an overview of possible cases reported in 'grey' literature.

Materials: Two adult skeletons with probable KFS from Vráble-Veľké Lehemby and Radoľa-Koscelisko.

Methods: Macroscopic analysis was performed using standard osteological methods. Read More

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Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission.

Int J Biochem Cell Biol 2021 May 7:106003. Epub 2021 May 7.

Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address:

Background: CD137 signaling is an essential factor in cell fate and atherosclerosis. An increase in the number of apoptotic macrophages accelerates atherosclerotic development involving mitochondrial dynamics.However, the role of CD137 signaling in macrophage apoptosis and changes in mitochondria has not been demonstrated clearly. Read More

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Sudden unexpected improvement in the atrioventricular conduction. What is the mechanism?

Indian Pacing Electrophysiol J 2021 May 7. Epub 2021 May 7.

Department of Cardiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:

The 12-lead electrocardiogram (ECG) of a 79-year-old male patient with recurrent pre-syncope showed irregular sinus rhythm with constant PR interval and left bundle branch block (LBBB) with intermittently blocked P waves. The beat following the blocked P wave had a narrower QRS with shorter PR interval. The phenomenon of bilateral bundle branch block explains sudden improvement in the atrioventricular conduction. Read More

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