2,339 results match your criteria bleeding accounted


Age-Specific Rates and Time-Courses of Gastrointestinal and Nongastrointestinal Complications Associated With Screening/Surveillance Colonoscopy.

Am J Gastroenterol 2021 Oct 25. Epub 2021 Oct 25.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Introduction: The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.

Methods: We performed a multistate population-based study using changepoint analysis to determine the rates and timing of serious gastrointestinal and nongastrointestinal adverse events associated with screening/surveillance colonoscopy, including analyses by age (45 to <55, 55 to <65, 65 to <75, and ≥75 years). Among 4. Read More

View Article and Full-Text PDF
October 2021

A retrospective study of maternal near miss in the Critical Maternal Care Center in Suqian City, Jiangsu Province, China: A single-center study.

Health Sci Rep 2021 Dec 14;4(4):e407. Epub 2021 Oct 14.

Department of Obstetrics and Gynecology, Suqian Hospital of Nanjing Drum Tower Hospital Group The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian Critical Maternal Care Center in Suqian City Jiangsu Province China.

Background And Aims: Through a retrospective study of maternal near miss (MNM) cases treated by the Suqian Critical Maternal Care Center in Suqian City, Jiangsu Province, we summarized the most common diseases that caused MNM, treatment measures, and short-term prognosis in this region. The purpose of the research is to improve the clinical evidence of maternal health care in the region.

Methods: The study is a retrospective descriptive study. Read More

View Article and Full-Text PDF
December 2021

Cost Implications of Using Carbetocin Injection to Prevent Postpartum Hemorrhage in a Greater Toronto Area Hospital.

J Obstet Gynaecol Can 2021 Oct 14. Epub 2021 Oct 14.

Patient Access Solutions Inc., 219 Dufferin Street, Toronto, Ontario, M6K 3J1. Electronic address:

Objective: Recent World Health Organization (WHO) recommendations regarding uterotonics for the prevention of postpartum hemorrhage (PPH) state that carbetocin should be considered a first-line prophylactic agent for all births where its cost is comparable to other effective uterotonics. This study evaluated whether a room temperature stable formulation of carbetocin met this recommendation in a Canadian urban hospital setting.

Methods: A decision tree model was developed to assess the financial implications of replacing oxytocin with carbetocin as a first-line prophylactic agent for PPH prevention in a Greater Toronto Area (GTA) hospital. Read More

View Article and Full-Text PDF
October 2021

Prevalence of bleeding and thrombosis in critically ill patients with chronic liver disease.

Thromb Haemost 2021 Oct 12. Epub 2021 Oct 12.

Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland.

Introduction: Haemorrhage and venous thromboembolism (VTE) are recognised complications of chronic liver disease (CLD), but their prevalence and risk factors in critically ill patients is uncertain.

Patients And Methods: We studied a retrospective cohort of patients with CLD non-electively admitted to a specialist intensive care unit determining the prevalence and timing of major bleeding and VTE (early, present on admission/diagnosed within 48h; later diagnosed >48h post ICU admission). Associations with baseline clinical and laboratory characteristics, multi-organ failure (MOF), blood product administration and mortality were explored. Read More

View Article and Full-Text PDF
October 2021

[Clinical Characteristics, Prognostic Factors and Misdiagnosis of Bone Marrow Necrosis Patients].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Oct;29(5):1637-1644

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China; Department of Hematology, The Third Affiliated Hospital of Xuzhou Medical University, Xuzhou 221003, Jiangsu Province, China E-mail:

Objective: To analyze the clinical characteristics, diagnosis and prognostic factors of bone marrow necrosis (BMN) patients, aim to avoid misdiagnosis, missed diagnosis or delayed treatment.

Methods: The clinical data of 51 BMN patients treated in the Affiliated Hospital of Xuzhou Medical University from January 2010 to December 2017 were retrospectively analyzed. The types of primary disease, etiology, clinical manifestations, laboratory tests, radiological findings, treatment outcomes and prognostic factors were summrized, and the reasons for misdiagnosis were analyzed. Read More

View Article and Full-Text PDF
October 2021

[Clinical Characteristics of Patients with JAK2 Gene Mutation Myeloproliferative Neoplasms].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Oct;29(5):1533-1539

Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China,E-mail:

Objective: To investigate the relationship between JAK2 gene mutation and clinical indicators in patients with myeloproliferative neoplasms (MPN).

Methods: 122 MPN patients in the Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences from September 2017 to January 2020 were retrospectively analyzed. The relationship between JAK2 gene mutation and sex, age, peripheral blood cell count, splenomegaly, and thrombosis and bleeding events were analyzed. Read More

View Article and Full-Text PDF
October 2021

Recurrence of postpartum hemorrhage in relatives: A population-based cohort study.

Acta Obstet Gynecol Scand 2021 Oct 8. Epub 2021 Oct 8.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Introduction: Studies on the family aggregation of postpartum hemorrhage (PPH) are scarce and with inconsistent results, and to what extent current birthweight influences recurrence between relatives remains to be studied. Further, family aggregation of PPH has been studied from an individual, but not from a public heath perspective. We aimed to investigate family aggregation of PPH in Norway, how birthweight influences these effects, and to estimate the proportion of PPH cases attributable to a family history of PPH and current birthweight. Read More

View Article and Full-Text PDF
October 2021

Incidence of liver and non-liver-related outcomes in patients with HCV-cirrhosis after SVR.

J Hepatol 2021 Sep 27. Epub 2021 Sep 27.

Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, Milan, Italy; CRC "A. M. and A. Migliavacca" Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background And Aim: As the long-term benefits of a sustained virological response (SVR) in hepatitis C virus (HCV) cirrhosis following direct-acting antivirals (DAA) remain undefined, we assessed the incidence and predictors of liver-related events (LRE), non-liver related events (NLRE) and mortality in DAA-treated cirrhotics.

Methods: Consecutive SVR cirrhotics were enrolled in a longitudinal, single-center study, and divided into 3 cohorts: Cohort A (CPT-A without previous LRE), Cohort B (CPT-B or CPT-A with prior non-HCC LRE), Cohort C (previous HCC).

Results: 636 cirrhotics (65 years-old, 58% males, 89% CPT-A) were followed for 51 (8-68) months [Cohort A n=480, Cohort B n=89, Cohort C n=67]. Read More

View Article and Full-Text PDF
September 2021

Microcatheter-Assisted Trabeculotomy Combined With Deep Sclerectomy and Trabeculectomy in Young to Middle-Aged Adults With Advanced Primary Open-Angle Glaucoma: 1-Year Result.

Front Med (Lausanne) 2021 3;8:712332. Epub 2021 Sep 3.

Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang, China.

We aimed to evaluate the safety and clinical efficacy of microcatheter-assisted trabeculotomy combined with deep sclerectomy and trabeculectomy (MATT-DS-Trab) in the surgical management of advanced primary open-angle glaucoma (POAG). According to the inclusion criteria, we retrospectively collected and analyzed 37 POAG cases in advanced stage who received MATT-DS-Trab. The intraocular pressure (IOP), best corrected visual acuity (BCVA), use of anti-glaucoma drugs, shape of the filtering bleb, size of the scleral lake, complications, and the surgical success rate were recorded. Read More

View Article and Full-Text PDF
September 2021

Clinical results and 30-day outcomes of self-expanding transcatheter aortic valves: comparative case-matched analysis of CoreValve versus ACURATE neo™.

Perfusion 2021 Sep 2:2676591211042562. Epub 2021 Sep 2.

Department of Cardiothoracic Surgery, Heart Centre Cologne, University Hospital Cologne, Cologne, Germany.

Background: Transcatheter aortic valve replacement (TAVR) is associated with excellent results in patients with severe aortic stenosis. In highly calcified aortic anuli with increased risk of annulus rupture and in favor of the supra-annular design, self-expandable prostheses are frequently used. In this regard, we aimed to perform a comparative analysis of clinical and 30-day outcomes after TAVR using the self-expanding CoreValve Evolut R or ACURATE neo™ prosthesis. Read More

View Article and Full-Text PDF
September 2021

[Analysis of gene mutation spectrum and pharmacokinetics of fibrinogen infusion in 146 cases of congenital fibrinogen disorders].

Zhonghua Xue Ye Xue Za Zhi 2021 Jul;42(7):555-562

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Laboratory of Blood Disease Gene Therapy, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To investigate the clinical type and gene mutations, clinical manifestations, laboratory tests, diagnosis, and fibrinogen replacement therapy of congenital fibrinogen disorders. Clinical data of 146 patients with congenital fibrinogen disorders diagnosed from April 2000 to November 2020 were retrospectively analyzed. Among the 146 patients, 61 (41. Read More

View Article and Full-Text PDF

Impact of interproximal composite restorations on periodontal tissue health: Clinical and cytokine profiles from a pre-post quasi-experimental study.

J Periodontol 2021 Aug 28. Epub 2021 Aug 28.

Unit of Endodontics and Restorative Dentistry, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Background: The aim of this study is to clinically and molecularly evaluate the effect of an interproximal iuxta/subgingival direct composite restoration on periodontal tissue healing.

Methods: Individuals in need of a posterior iuxta/subgingival interproximal restoration were consecutively enrolled. After enrollment, a test (site with tooth decay) and a control site (intact contralateral tooth) were identified. Read More

View Article and Full-Text PDF

Prehospital Intervention Analysis of Helicopter Crashes in Afghanistan.

Med J (Ft Sam Houst Tex) 2021 Jul-Sep(PB 8-21-07/08/09):69-73

Brooke Army Medical Center, JBSA Fort Sam Houston, TX.

Background: Based on isolated case reports, military helicopter mishaps often result in multiple critical casualties leading to complicated stabilization and evacuation by healthcare providers. The aim of this retrospective descriptive analysis is to describe the incidence of common prehospital injuries associated with rotary wing crashes in order to improve mission planning and casualty survivability.

Methods: This is a secondary analysis of data from the Prehospital Trauma Registry and the Department of Defense Trauma Registry (DoDTR) from April 2003 through May 2019. Read More

View Article and Full-Text PDF

[Exploration of the small intestine through single-balloon enteroscopy, experience in the Mohammed V Training Military Hospital in Rabat: about 51 cases].

Pan Afr Med J 2021 21;39:61. Epub 2021 May 21.

Service Gastroentérologie, Hôpital Militaire Instruction Mohamed V, Rabat, Maroc.

Enteroscopy has become an indispensable technique for the exploration and, in particular, the treatment of small intestine lesions. It is usually performed following video capsule endoscopy of the small intestine. Three equivalent techniques exist: double balloon enteroscopy, single balloon enteroscopy and spiral enteroscopy. Read More

View Article and Full-Text PDF
September 2021

A Bulk Retrospective Study of Robot-Assisted Stereotactic Biopsies of Intracranial Lesions Guided by Videometric Tracker.

Front Neurol 2021 4;12:682733. Epub 2021 Aug 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Biopsies play an important role in the diagnosis of intracranial lesions, and robot-assisted procedures are increasingly common in neurosurgery centers. This research investigates the diagnoses, complications, and technology yield of 700 robotic frameless intracranial stereotactic biopsies conducted with the Remebot system. This research considered 700 robotic biopsies performed between 2016 and 2020 by surgeons from the Department of Functional Neurosurgery in Beijing's Tiantan Hospital. Read More

View Article and Full-Text PDF

Analysis of Bleeding Site to Identify Associated Risk Factors of Intractable Epistaxis.

Ther Clin Risk Manag 2021 12;17:817-822. Epub 2021 Aug 12.

Allergy Center, Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China.

Introduction: Intractable epistaxis refers to deep occult bleeding and uncontrolled persistent bleeding. Effective treatment can only be implemented if the bleeding site is quickly identified and the underlying disease controlled.

Objective: The relationship between the bleeding site and the pathogenic factors of intractable epistaxis was analyzed to further strengthen the prevention and treatment of intractable epistaxis by outpatient doctors, family doctors and otolaryngologists. Read More

View Article and Full-Text PDF

Perioperative Management of Antithrombotic Medications: An Investigation into Current U. S. Ophthalmologic Recommendations.

J Curr Ophthalmol 2021 Apr-Jun;33(2):182-188. Epub 2021 Jul 5.

Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.

Purpose: To investigate the availability and content of educational statements or recommendations disseminated by U. S. ophthalmologic organizations regarding perioperative management of antithrombotic agents for ophthalmic and orbital surgery, given the highly variable management of these agents by U. Read More

View Article and Full-Text PDF

Clinical burden, risk factor impact and outcomes following myocardial infarction and stroke: A 25-year individual patient level linkage study.

Lancet Reg Health Eur 2021 Aug;7:100141

Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.

Background: Understanding trends in the incidence and outcomes of myocardial infarction and stroke, and how these are influenced by changes in cardiovascular risk factors can inform health policy and healthcare provision.

Methods: We identified all patients 30 years or older with myocardial infarction or stroke in Scotland. Risk factor levels were determined from national health surveys. Read More

View Article and Full-Text PDF

Acute kidney injury during pregnancy and puerperium: an Egyptian hospital-based study.

J Nephrol 2021 10 14;34(5):1611-1619. Epub 2021 Aug 14.

Faculty of Medicine, Mansoura University, Mansoura, Dakahliya, Egypt.

Introduction: While acute kidney injury (AKI) in pregnancy is currently a rare entity in developed countries, it is still a common occurrence in developing countries, representing a major cause of maternal and fetal morbidity and mortality. Scarce data are published regarding pregnancy-related acute kidney injury (PRAKI) in Middle Eastern and African countries. The aim of this work is to report on the frequency, the underlying causes, and the outcomes of patients with PRAKI in an Egyptian tertiary care hospital. Read More

View Article and Full-Text PDF
October 2021

Racial and Ethnic Disparities in Maternal Mortality in the United States Using Enhanced Vital Records, 2016‒2017.

Am J Public Health 2021 09 12;111(9):1673-1681. Epub 2021 Aug 12.

Marian F. MacDorman is with the Maryland Population Research Center, University of Maryland, College Park. Marie Thoma is with the School of Public Health, University of Maryland. Eugene Declercq is with the Boston University School of Public Health, Boston, MA. Elizabeth A. Howell is with the Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia.

To better understand racial and ethnic disparities in US maternal mortality. We analyzed 2016-2017 vital statistics mortality data with cause-of-death literals (actual words written on the death certificate) added. We created a subset of confirmed maternal deaths that had pregnancy mentions in the cause-of-death literals. Read More

View Article and Full-Text PDF
September 2021

Current practice and registration patterns among United Kingdom Haemophilia Centre Doctors' Organisation centers for patients with unclassified bleeding disorders.

J Thromb Haemost 2021 Nov 25;19(11):2738-2743. Epub 2021 Aug 25.

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Background: Bleeding of unknown cause (BUC) and unclassified bleeding disorders (UBD) are increasingly recognized. There is no guidance on diagnosis and management.

Objectives: To examine UK haemophilia centre registration patterns and current practice for UBD patients. Read More

View Article and Full-Text PDF
November 2021

[Myoma, fortuitous discovery or metrorrhagia: Which is more revealing?]

Pan Afr Med J 2021 20;38:388. Epub 2021 Apr 20.

Unité de Formation et de Recherche en Sciences de la Santé, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.

Introduction: myoma is commonly diagnosed in our hospital. It can be accidentally discovered or discovered due to metrorrhagia. The purpose of this study is to evaluate the association between the size of myomas and the circumstances under which they are detected and between the location of myomas and the occurrence of bleeding. Read More

View Article and Full-Text PDF

Gestational diabetes is associated with postpartum hemorrhage in Indigenous Australian women in the PANDORA study: A prospective cohort.

Int J Gynaecol Obstet 2021 Nov 19;155(2):296-304. Epub 2021 Aug 19.

Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Objective: To assess associations of hyperglycemia in pregnancy with the risk of postpartum hemorrhage (PPH) in a prospective cohort of Indigenous and non-Indigenous women, compared with normoglycemia.

Methods: Data were from 1102 (48% Indigenous) women of the Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study. Age-adjusted associations of gestational diabetes mellitus (GDM) or pre-existing type 2 diabetes mellitus (T2DM), obstetric and demographic covariables with PPH (blood loss ≥500 ml) were assessed using logistic regression. Read More

View Article and Full-Text PDF
November 2021

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance.

Am J Hum Genet 2021 09 26;108(9):1735-1751. Epub 2021 Jul 26.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed to over 15 million people annually and polymorphisms in CYP2C9 can affect individual drug response and lead to an increased risk of hemorrhage. We developed click-seq, a pooled yeast-based activity assay, to test thousands of variants. Read More

View Article and Full-Text PDF
September 2021

[The role of supraorbital ethmoid cell and the significance of a proposed classification of the anterior ethmoid artery in endoscopic sinus surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;35(6):495-500

Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing,100029,China.

To investigate the role of the supraorbital ethmoidal cell(SOEC) in identifying the frontal sinus ostium(FO) and the anterior ethmoidal artery(AEA) in endoscopic sinus surgery, and to evaluate the clinical significance of a proposed endoscopic classification of AEA. The clinical data of 116 patients with chronic rhinosinusitis were collected. Thirty-six patients(47 sides) with SOEC and DraftⅡA frontal sinusotomy were included. Read More

View Article and Full-Text PDF

Minor Traumatic Intracranial Hemorrhage: Identifying Prognostic Factors and Comparing Patients with Favorable and Unfavorable Outcomes.

World Neurosurg 2021 Sep 3;153:e428-e434. Epub 2021 Jul 3.

Emergency Department, Chi-Mei Medical Center, Tainan, Taiwan; Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Whether patients with minor traumatic intracranial hemorrhage (MTICH) require intensive care remains uncertain. This study aimed to identify the factors affecting the postinjury neurologic outcomes of patients with MTICH to determine optimal care.

Methods: We retrospectively reviewed the data of all patients with trauma discharged from a tertiary trauma center during a 2-year period and included adult patients with isolated MTICH. Read More

View Article and Full-Text PDF
September 2021

Fetoscopic compared with open repair of myelomeningocele: a 2-delivery cost-effectiveness analysis.

Am J Obstet Gynecol MFM 2021 Jul 1;3(6):100434. Epub 2021 Jul 1.

Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR (Ms Packer and Drs Hersh and Caughey).

Background: Recent studies have compared maternal and neonatal outcomes associated with fetoscopic surgical approach for repair of myelomeningocele compared with an open approach.

Objective: In this study, we compared the cost-effectiveness of these techniques in the setting of a woman seeking future pregnancies.

Study Design: A decision-analytical model using TreeAge software was designed to compare the costs and outcomes of fetoscopic vs open repair in patients with prenatally diagnosed myelomeningocele. Read More

View Article and Full-Text PDF

Cesarean Delivery Management of Stillbirth: In-Depth Analysis of 75 Cases in a Rural State.

South Med J 2021 Jul;114(7):384-387

From the Departments of Obstetrics and Gynecology and Biostatistics, and the Department of Epidemiology in the Fay W. Boozman College of Public Health, University of Arkansas for the Medical Sciences, Little Rock.

Objective: To analyze the characteristics surrounding women who underwent cesarean delivery for stillbirth management in the rural, southern US state of Arkansas.

Methods: This was a planned secondary analysis of a retrospective descriptive study evaluating mode of delivery following the stillbirth of singleton pregnancies without anomalies or aneuploidy delivered in our state between July 2015 and June 2019. Data were extracted from a statewide reproductive health monitoring system and reviewed by the first three authors. Read More

View Article and Full-Text PDF

Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19.

Clin Exp Nephrol 2021 Nov 1;25(11):1203-1214. Epub 2021 Jul 1.

Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.

Background: Acute kidney injury (AKI) is a severe complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate incidence, risk factors and case-fatality rate of AKI in patients with COVID-19.

Methods: We reviewed the health medical records of 307 consecutive patients with COVID-19 hospitalized at the University Hospital of Modena, Italy. Read More

View Article and Full-Text PDF
November 2021