547,193 results match your criteria bleeding


Angiographic characteristics of ruptured versus unruptured vertebral artery dissecting aneurysm.

J Cerebrovasc Endovasc Neurosurg 2021 Oct 26. Epub 2021 Oct 26.

Department of Neurosurgery, Daegu Catholic University Hospital, Daegu, Korea.

Objective: Vertebral artery dissecting aneurysm (VADA) is a rare and critical disease. VADA rupture can cause subarachnoid hemorrhage which is a major complication of VADA due to their high rebleeding rate and poor outcome. In the present study, ruptured and unruptured VADAs were compared by analyzing angiographic findings to determine useful predisposing factors for VADA rupture for appropriate treatment selection. Read More

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October 2021

A study on the proper catheter position in minimally invasive surgery using stereotactic aspiration plus urokinase for intracerebral hemorrhage.

J Cerebrovasc Endovasc Neurosurg 2021 Oct 26. Epub 2021 Oct 26.

Department of Neurosurgery, Presbyterian Medical Center, Jeonju, Korea.

Objective: The surgical method for treating spontaneous intracranial hemorrhage (ICH) is not well established despite ICH's high prevalence and poor prognosis. Minimally invasive surgery has recently received attention; however, literature on this method is scarce. In particular, the appropriate location of the catheter in the hematoma has not been described. Read More

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October 2021

Factors associated with rebleeding after coil embolization in patients with aneurysmal subarachnoid hemorrhage.

J Cerebrovasc Endovasc Neurosurg 2021 Oct 26. Epub 2021 Oct 26.

Department of Neurosurgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Objective: Aneurysmal subarachnoid hemorrhage (aSAH) has a high mortality rate, and hemorrhage amounts and perioperative rebleeding importantly determines prognosis. However, despite adequate treatment, prognosis is poor in many ruptured aneurysm cases. In this study, we identified and evaluated factors related to perioperative rebleeding in patients with aSAH. Read More

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October 2021

Clinical Outcomes of Different Warfarin Self-care Strategies: A Systematic Reviews and Network Meta-Analysis.

Thromb Haemost 2021 Oct 25. Epub 2021 Oct 25.

University of Washington, Seattle, United States.

Aim: To compare the effects of different strategies for warfarin self-care.

Methods: PubMed, EMBASE, CENTRAL, CINAHL, ProQuest Dissertations &Theses, and OpenGrey were searched from inception to May 2020. Randomized controlled trials (RCTs) were included if they explored the effect of warfarin self-care, either patient self-testing (PST) or patient self-management (PSM). Read More

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October 2021

CERVICAL RIPENING FOR A SINGLETON FETUS IN BREECH PRENSENTATION AT TERM: COMPARISON BETWEEN MECHANICAL AND PHARMACEUTICAL METHODS.

J Gynecol Obstet Hum Reprod 2021 Oct 22:102258. Epub 2021 Oct 22.

Department of Obstetrics and Gynecology, Robert Debré Hospital, APHP, Paris, France.

Although various international professional societies currently recommend trial of vaginal delivery of term fetuses in breech presentation, the question of the method of cervical ripening, when necessary, remains open.

Objective: To compare the effectiveness of two methods of cervical ripening for delivery of a singleton fetus in breech presentation at term: a mechanical method (balloon catheter) and a pharmaceutical method (prostaglandins).

Study Design: This two-center retrospective study reviewed records from 2014 through 2019 in two French maternity units with two different cervical ripening methods for fetuses in breech presentation. Read More

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October 2021

Prevalence and clinical implications of eligibility criteria for prolonged dual antithrombotic therapy in patients with PEGASUS and COMPASS phenotypes: Insights from the START-ANTIPLATELET registry.

Int J Cardiol 2021 Oct 22. Epub 2021 Oct 22.

Department of Experimental and Clinical Medicine, Center for Atherothrombotic diseases, University of Florence, Florence, Italy.

Aim: To analyze the prevalence and clinical implications of the eligibility criteria for prolonged dual antithrombotic therapy with ticagrelor 60 mg twice daily and/or rivaroxaban 2.5 mg twice daily in a contemporary real-world ACS registry.

Methods: Patients from the START-ANTIPLATELET registry (NCT02219984) were stratified according to the eligibility criteria of the PEGASUS and COMPASS studies to investigate the proportion of patients eligible for prolonged dual antithrombotic therapy at discharge and after 1-year of DAPT. Read More

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October 2021

Use of Intravenous Soybean and Fish Oil Emulsions in Pediatric Intestinal Failure Associated Liver Disease: A Multicenter Integrated Analysis Report on Extrahepatic Adverse Events.

J Pediatr 2021 Oct 22. Epub 2021 Oct 22.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pharmacy (KG); Department of Surgery and the Vascular Biology Program (MPU); Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.

Objective: To compare extrahepatic adverse events (AEs) during fish oil lipid emulsion (FOLE) or soybean oil lipid emulsion (SOLE) treatment in children with intestinal failure-associated liver disease (IFALD).

Study Design: In this multicenter integrated analysis, bleeding, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), infections, and signs of lipid emulsion intolerance were compared between FOLE recipients (1 g/kg/d) (n = 189) and historical controls who received SOLE (up to 3 g/kg/d) (n = 73).

Results: When compared with SOLE recipients, FOLE recipients had a lower gestational age (30. Read More

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October 2021

The outcomes of Clostridioides difficile infection in inpatient liver transplant population.

Transpl Infect Dis 2021 Oct 25. Epub 2021 Oct 25.

Gastroenterology and Transplant Hepatology, Henry Ford Health System, Detroit, MI.

Background: Chronic immunosuppression is a known cause of Clostridioides difficile which presents with colon infection. It is associated with increased mortality and morbidity. Our aim is to determine the inpatient outcomes of liver transplant patients with Clostridioides difficile infection (CDI) and trends in the last few years. Read More

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October 2021

Association between prehospital field to emergency department delta shock index and in-hospital mortality in patients with torso and extremity trauma: A multinational, observational study.

PLoS One 2021 25;16(10):e0258811. Epub 2021 Oct 25.

Department of Emergency Medicine, Universiti Teknologi MARA Sungai Buloh, Selangor, Malaysia.

Hemorrhage, a main cause of mortality in patients with trauma, affects vital signs such as blood pressure and heart rate. Shock index (SI), calculated as heart rate divided by systolic blood pressure, is widely used to estimate the shock status of patients with hemorrhage. The difference in SI between the emergency department and prehospital field can indirectly reflect urgency after trauma. Read More

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October 2021

A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury.

J Trauma Acute Care Surg 2021 Nov;91(5):867-871

From the Department of Surgery (G.K.W., B.E.B., M.T.K., C.A.V.) and Department of Clinical Pharmacy (M.P.P., K.L.R.), University of Michigan, Ann Arbor, Michigan; and Department of Surgery (R.L.O., K.C., H.B.A.), Northwestern University, Chicago, Illinois.

Background: We lack specific treatments for traumatic brain injury (TBI), which remains the leading cause of trauma-related morbidity and mortality. Treatment with valproic acid (VPA) improves outcomes in models of severe TBI with concurrent hemorrhage. However, it is unknown if VPA will have similar benefits after isolated nonlethal TBI, which is the more common clinical scenario. Read More

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November 2021

Early cognitive impairment is common in pediatric patients following mild traumatic brain injury.

J Trauma Acute Care Surg 2021 Nov;91(5):861-866

From the Division of Trauma, Burns and Surgical Critical Care, Department of Surgery (M.E.K., P.D., K.I.B., K.R., M.L., J.N.), University of California, Irvine, Orange, CA; Center for Statistical Consulting (K.A.K.), University of California, Irvine; and Department of Surgery, Los Angeles, CA (K.I.).

Introduction: The incidence and factors related to early cognitive impairment (ECI) after mild traumatic brain injury (mTBI) in pediatric trauma patients (PTPs) are unknown. Prior data in the adult population demonstrated an ECI incidence of 51% after mTBI and strong correlation with initial Glasgow Coma Scale (GCS) and Brain Injury Guidelines (BIG) category. Therefore, we hypothesized that ECI is common after mTBI in PTPs and associated with initial GCS and BIG category. Read More

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November 2021

Thromboelastography with platelet mapping: Limited predictive ability in detecting preinjury antiplatelet agent use.

J Trauma Acute Care Surg 2021 Nov;91(5):803-808

From the Department of Pharmacy (C.A.B., H.J.O., G.J.R.), and Department of Surgery (E.N.D., A.G., M.S.), Oregon Health & Science University, Portland, Oregon.

Background: Preinjury antiplatelet agent (APA) use in trauma patients can increase traumatic hemorrhage and worsen outcomes. Thromboelastography with platelet mapping (TEGPM) has characterized platelet function via arachidonic acid (AA) and adenosine diphosphate (ADP) inhibition in nontrauma settings, but limited data exist in the acute trauma population.

Methods: A prospective observational study of adult trauma patients with suspected preinjury APA use who received TEGPM testing from 2017 to 2020 was performed. Read More

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November 2021

Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity.

A A Pract 2021 Oct 22;15(10):e01537. Epub 2021 Oct 22.

From the Yale University School of Medicine, New Haven, Connecticut.

We describe a case of unusually persistent vasoplegia in the postoperative course of a patient recovering after elective right robotic nephroureterectomy with intravesical salvage gemcitabine. In the treatment of patients with intravesical adjuvant therapy, gemcitabine may precipitate persistent vasoplegia requiring further fluid resuscitative efforts, vasopressor support, and other supportive management. This potential adverse event should be considered when all common causes of persistent vasoplegia are ruled out, such as shock related to bleeding, infection, allergic reaction, or pulmonary embolic phenomenon. Read More

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October 2021

Use of aromatase inhibitors in menopausal deep endometriosis: a case report and literature review.

Climacteric 2021 Oct 25:1-5. Epub 2021 Oct 25.

Department of Obstetrics & Gynecology, Zucker School of Medicine at Hofstra/Northwell and NorthwellHealth, Hempstead, NY, USA.

We report and review the clinical effectiveness of aromatase inhibitors in a patient with refractory, recurrent and infiltrating endometriosis. We demonstrate excellent clinical, radiological and endoscopic responses after failure of multiple other modalities. Our case and the literature show that single-agent letrozole is capable to treat deep infiltrative endometriosis involving the rectum and the urinary tract. Read More

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October 2021

Outcomes after extracorporeal membrane oxygenation support in COVID-19 and non-COVID-19 patients.

Artif Organs 2021 Oct 25. Epub 2021 Oct 25.

Department of Surgery, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair Street, Suite 650, Chicago, Illinois, 60611, USA.

Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) support is increasingly used in the management of COVID-19-related acute respiratory distress syndrome (ARDS). However, the clinical decision-making to initiate V-V ECMO for severe COVID-19 still remains unclear. In order to determine the optimal timing and patient selection, we investigated the outcomes of both COVID-19 and non-COVID-19 patients undergoing V-V ECMO support. Read More

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October 2021

Systemic bevacizumab to facilitate anticoagulation in antiphospholipid syndrome and bleeding gastrointestinal angiodysplasia.

J Thromb Thrombolysis 2021 Oct 25. Epub 2021 Oct 25.

Harvard Medical School, Boston, MA, USA.

Bleeding gastrointestinal angiodysplasia may occur in patients with vasculitis and can be challenging to treat. We describe the novel use of bevacizumab therapy to treat bleeding gastrointestinal angiodysplasia and severe anemia in a patient with eosinophilic granulomatosis with angiitis complicated by antiphospholipid antibody syndrome requiring indefinite warfarin therapy. Studies confirmed multiple bleeding jejunal angiodysplasias unamenable to endoscopic intervention, and the patient required ongoing support with iron infusions and blood transfusions to maintain a minimally acceptable hemoglobin. Read More

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October 2021

Construction of a nomogram to reveal the prognostic benefit of spontaneous intracranial hemorrhage among Chinese adults: a population-based study.

Neurol Sci 2021 Oct 25. Epub 2021 Oct 25.

Department of Neurosurgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Background And Purpose: We aimed to build a nomogram, based on patients with spontaneous intracerebral hemorrhage (SICH), to predict the probability of mortality and morbidity at 7 days and 90 days, respectively.

Methods: We performed a retrospective study, with patients at less than 6 h from ictus admitted to the department of neurosurgery in a single institute, from January 2011 to December 2018. A total of 1036 patients with SICH were included, 486 patients (46. Read More

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October 2021

Aneurismal subarachnoid hemorrhage during the COVID-19 outbreak in a Hub and Spoke system: observational multicenter cohort study in Lombardy, Italy.

Acta Neurochir (Wien) 2021 Oct 25. Epub 2021 Oct 25.

Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Background: Lombardy was the most affected Italian region by the first phase of the COVID-19 pandemic and underwent urgent reorganization for the management of emergencies, including subarachnoid hemorrhage from a ruptured cerebral aneurysm (aSAH). The aim of the study was to define demographics, clinical, and therapeutic features of aSAH during the COVID-19 outbreak and compare these with a historical cohort.

Methods: In this observational multicenter cohort study, patients aged 18 years or older, who were diagnosed with aSAH at the participating centers in Lombardy from March 9 to May 10, 2020, were included (COVID-19 group). Read More

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October 2021

Micropulse transscleral cyclophotocoagulation in a Taiwanese population: 2-year clinical outcomes and prognostic factors.

Graefes Arch Clin Exp Ophthalmol 2021 Oct 25. Epub 2021 Oct 25.

Department of Ophthalmology, Chang Gung Memorial Hospital at Linkou, No. 5, Fu-Shin Street , Guishan Dist, 33302, Taoyuan City, Taiwan.

Purpose: To evaluate the 2-year efficacy and safety of micropulse transscleral cyclophotocoagulation (MP-TSCPC) in Taiwanese patients with glaucoma.

Methods: We included the patients who received standardized MP-TSCPC with follow-up examinations on a regular basis for 24 months. Treatment success was defined as the attainment of a postoperative intraocular pressure (IOP) between 6 and 21 mmHg or a ≥ 20% reduction in IOP from baseline without an increase in glaucoma medications. Read More

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October 2021

Dabigatran plasma concentration indicated the risk of patients with non-valvular atrial fibrillation.

Heart Vessels 2021 Oct 25. Epub 2021 Oct 25.

Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China.

This study aimed to evaluate the variability of dabigatran plasma concentration and the association with clinical events in Chinese patients treated with dabigatran etexilate (DE) for non-valvular atrial fibrillation (NVAF). The steady-state concentration of dabigatran (the active metabolite of DE) was determined at trough and peak. The effect of dabigatran concentration variability and related factors on clinical outcomes were explored. Read More

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October 2021

Bleeding pattern after medical management of early pregnancy loss with mifepristone-misoprostol and its prognostic value: a prospective observational cohort study.

Arch Gynecol Obstet 2021 Oct 25. Epub 2021 Oct 25.

Department of Gynecology, Obstetrics and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Altenberger Strasse 69, 4040, Linz, Austria.

Purpose: To improve counseling of women by reporting bleeding characteristics at home after medical management of an early pregnancy loss (EPL) with mifepristone and misoprostol, and to evaluate occurring bleeding patterns as a prognostic tool.

Methods: This prospective two-center observational cohort study enrolled 197 women who presented with an EPL (embryonic or anembryonic miscarriage) from December 2017 to April 2019 and chose a home-based medical management with 200 mg mifepristone and 800 mcg misoprostol. From the day of mifepristone intake, the strength of vaginal bleeding was recorded daily for 2 weeks by the patient herself using a diary sheet. Read More

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October 2021

Stroke prevention with direct oral anticoagulants in high risk elderly atrial fibrillation patients at increased bleeding risk.

Eur Heart J Qual Care Clin Outcomes 2021 Oct 25. Epub 2021 Oct 25.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Elderly atrial fibrillation (AF) patients with risk factors of bleeding are often considered ineligible for standard oral anticoagulants (OACs). The ELDERCARE-AF trial recently showed that edoxaban 15mg/day was superior to placebo for preventing stroke or systemic embolism and did not result in a significantly higher incidence of major bleeding.  Our aim was to investigate a real-world cohort of AF patients similar to the ELDERCARE-AF cohort, with regard to the impact of direct oral anticoagulant (DOAC) use compared to non-OAC use, in relation to clinical outcomes. Read More

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October 2021

Promoting physical activity in people with haemophilia: the MEMO (Movement for persons with haEMOphilia) expert consensus project.

Blood Transfus 2021 Oct 15. Epub 2021 Oct 15.

Haemophilia and Transfusion Centre, "M. Bufalini" Hospital, Cesena, Italy.

Regular physical activity can increase joint stability and function, reduce the risk of injury, and improve quality of life of people with haemophilia (PwH). However, a recent review of the literature shows that appropriate physical activity and sport are not always promoted enough in the overall management of PwH. A group of Italian experts in haemophilia care undertook a consensus procedure to provide practical guidance on when and how to recommend physical exercise programmes to PwH in clinical practice. Read More

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October 2021

Continuous nursing effect of senile coronary heart disease complicated with digestive tract hemorrhage.

Minerva Gastroenterol (Torino) 2021 Oct 25. Epub 2021 Oct 25.

Department of Cardiology, Zaozhuang Municipal Hospital, Zaozhuang, China -

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October 2021

Treatment planning of teeth with compromised clinical crowns: endodontic, reconstructive, and surgical strategy.

Int J Esthet Dent 2021 Oct;16(4):514-532

The present article describes a treatment planning clinical strategy based on a flowchart developed to facilitate the treatment of teeth with severely compromised clinical crowns. The study comprised a group of 978 patients presenting with 2327 teeth needing clinical crown reconstruction. The patients were screened, diagnosed, and treated with a multidisciplinary approach according to a flowchart structure. Read More

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October 2021

Abnormal Pulmonary Function Testing as an Independent Risk Factor for Procedural Complications During Transthoracic Needle Biopsies.

J Bronchology Interv Pulmonol 2021 Oct 25. Epub 2021 Oct 25.

Division of Pulmonary and Critical Care Medicine, Mount Sinai West Department of Medicine Division of Pulmonary and Critical Care Medicine Division of Interventional Radiology, Mount Sinai Beth Israel, New York, NY.

Background: Computed tomography (CT)-guided transthoracic needle biopsy is an important diagnostic tool for pulmonary nodules, offering a less invasive alternative to surgical procedures. This study aims to better risk stratify patients undergoing this procedure by analyzing the pulmonary function testing (PFT), imaging characteristics, and patient demographics most associated with complications.

Patients And Methods: This retrospective study involved 254 patients undergoing transthoracic needle biopsies at 3 hospitals between October 2016 and December 2019. Read More

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October 2021

Age-Specific Rates and Time-Courses of Gastrointestinal and Nongastrointestinal Complications Associated With Screening/Surveillance Colonoscopy.

Am J Gastroenterol 2021 Oct 25. Epub 2021 Oct 25.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Introduction: The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.

Methods: We performed a multistate population-based study using changepoint analysis to determine the rates and timing of serious gastrointestinal and nongastrointestinal adverse events associated with screening/surveillance colonoscopy, including analyses by age (45 to <55, 55 to <65, 65 to <75, and ≥75 years). Among 4. Read More

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October 2021

Naive haemophilia mice displayed different pattern of cytokine profiles of cytokine profiles changes might be associated with subclinical bleeding.

Blood Coagul Fibrinolysis 2021 Oct 21. Epub 2021 Oct 21.

School of Biotechnology School of Pharmacy, East China University of Science and Technology, Shanghai, China Department of Statistics Gene Therapy Center Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Subclinical bleeding is a haemorrhage event not clinically detected in haemophilia, and no reliable method is available for predicting subclinical bleeding. We investigated whether haemophilia mice have subclinical haemorrhage and evaluated potential biomarkers including multiple cytokine changes to predict subclinical haemorrhage. Plasma from naïve FVIII-/- and FIX-/- mice and their wild-type counterparts (FVIII WT and FIX WT, respectively) were measured for prothrombin fragment 1 + 2 (F1 + 2) and multiple cytokines. Read More

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October 2021

The effect of aspirin in patients with nonvaricose upper gastrointestinal bleeding and risk factors analysis.

Authors:
Ding Peng Mei Zhang

Scand J Gastroenterol 2021 Oct 23:1-5. Epub 2021 Oct 23.

Department of Gastroenterology, Xuanwu Hospital Capital Medical University, Beijing, China.

Objective: This paper aims to explore the effect of aspirin on the in-hospital mortality of patients with NVUGIB.

Methods: An observational study retrospectively examined 1514 patients with NVUGIB based on a multi-center database.

Result: Our study reported a mortality rate of 4. Read More

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October 2021