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Transsulcal parafascicular brain path-assisted approach to subcortical lesions: 2-dimensional operative video.

Surg Neurol Int 2021 17;12:107. Epub 2021 Mar 17.

Department of Neurological Surgery, University of Arkansas, United States.

Background: Approaches to subcortical lesions have traditionally been limited by the morbidity of white matter dissection and fixed blade retraction required to reach these targets. Visualization of deep surgical fields with a traditional operating microscope is also poor. Coordinated use of intra-operative image guidance, a tubular retractor (BrainPath, Nico Corp, Indianapolis, Indiana), a high-definition exoscope (Vitom, Karl Storz Endoscopy America, Inc, El Segundo, California), and a low-profile resection device (Myriad, Nico Corp) facilitates atraumatic access to and resection of subcortical lesions including primary brain tumors, brain metastases, and intracerebral hemorrhages. Read More

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Standardized artificially created stable pertrochanteric femur fractures present more homogenous results compared to osteotomies for orthopaedic implant testing.

BMC Musculoskelet Disord 2021 Apr 20;22(1):371. Epub 2021 Apr 20.

University of Basel, Basel, Switzerland.

Background: With regard to biomechanical testing of orthopaedic implants, there is no consensus on whether artificial creation of standardized bone fractures or their simulation by means of osteotomies result in more realistic outcomes. Therefore, the aim of this study was to artificially create and analyze in an appropriate setting the biomechanical behavior of standardized stable pertrochanteric fractures versus their simulation via osteotomizing.

Methods: Eight pairs of fresh-frozen human cadaveric femora aged 72. Read More

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Visualizing the distribution of elements within barley leaves by energy dispersive X-ray image maps (EDX maps).

New Phytol 1993 Oct;125(2):367-372

AFRC Institute of Grassland and Environmental Research, Welsh Plant Breeding Station, Pica Gogerddan, Aberystwyth, Dyfed SY23 3EB, UK.

X-ray image maps of transverse sections of barley leaf blades were compared with individual X-ray emission spectra from vacuoles of barley leaf mesophyll, epidermis and parenchymatous bundle sheath cells. Both forms of X-ray analysis revealed distinct patterns in element distribution within the leaf blade. Calcium and Cl predominated within the epidermal cell vacuoles whilst P appeared mainly in the mesophyll cell layer. Read More

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October 1993

Variation in salinity tolerance and ion uptake in accessions of brown beetle grass [Diplachne fusca (L.) Beauv.].

New Phytol 1991 Sep;119(1):161-168

School of Agriculture & Forestry, The University of Melbourne, Parkville, Victoria 3052, Australia.

Significant variation in tolerance was found in natural populations of Diplachne fusca (L.) Beauv, grown under a range of NaCl concentrations, with greatest variation in accessions from different sites and a narrower range of tolerance from those within sites. Significant differences were found between accessions for Na, Cl and K uptake. Read More

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September 1991


New Phytol 1987 Mar;105(3):477-486

Ex Physics and Engineering Laboratory, Department of Scientific and Industrial Research, Private Bag, Lower Hutt, New Zealand.

Seasonal changes in the content of Ca and Mg in leaf blades collected from mature kiwifruit [Actinidia deliciosa (A. Chev.) C. Read More

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Leaves at low versus high rainfall: coordination of structure, lifespan and physiology.

New Phytol 2002 Sep;155(3):403-416

Department of Biological Sciences, Macquarie University, Sydney 2109, Australia.

•  Across species, leaf lifespan (LL) tends to be correlated with leaf mass per area (LMA). Previously we found that Australian perennial species from low-rainfall sites had c . 40% shorter LL at a given LMA than high-rainfall species. Read More

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September 2002

Grass blades as tree rings: environmentally induced changes in the oxygen isotope ratio of cellulose along the length of grass blades.

New Phytol 2002 Sep;155(3):417-424

SIRFER, University of Utah, Department of Biology, 235 S 1400 E. Salt Lake City, Utah, USA.

•  In this study, we tested the hypothesis that environmentally induced changes in the oxygen isotope ratio of leaf water are recorded in grass blade cellulose during leaf-blade expansion. •  Grasses were grown hydroponically in chambers that allowed for control of relative humidity while keeping isotopic inputs (namely source water) constant. •  In experiments where relative humidity was changed from 35% to 93% during grass blade expansion, a 10‰ shift in cellulose δ O was observed along single grass blades of Lolium multiflorum . Read More

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September 2002

How Safe and Time Consuming is the Surgical Training of Young Orthopaedic Surgeons? A Retrospective Analysis of Proximal Femur Fractures.

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Department of Trauma, Hand and Reconstructive Surgery, University of Ulm, Germany.

Background: Fractures of the proximal femur in the elderly population are rising. Teaching the appropriate surgical treatment of these fractures is of paramount importance. The aim of the study was to evaluate differences in outcome of surgical procedures between supervised trainees and senior surgeons. Read More

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Comparison of Large-Gauge Needle, Corneal Knife, and No. 11 Blade for Percutaneous Achillotomy.

J Am Podiatr Med Assoc 2021 Mar;111(2)

Background: In the Ponseti technique, the residual equinus deformity is corrected with percutaneous tenotomy. This experimental study aimed to compare the safety and effectiveness of a large-gauge needle, a corneal knife, and a No. 11 blade in percutaneous achillotomy performed in rats. Read More

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Tibial plateau levelling osteotomy using a dome-shaped saw blade for canine cranial cruciate ligament insufficiency.

Vet Rec 2021 Apr 19:e41. Epub 2021 Apr 19.

AniCura Small Animal Referral Clinic, Babenhausen, Germany.

Background: Tibial plateau levelling osteotomy (TPLO) is commonly used to manage cranial cruciate ligament (CrCL) disease. The use of a spherical osteotomy blade (S-TPLO) enables correction of some tibial deformities with three rotational degrees of freedom.

Methods: As a proof of concept, this retrospective study included 45 dogs with CrCL disease that were treated with an S-TPLO. Read More

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#15 Versus #15c Scalpel Blades for Skin Incisions: Accuracy With and Without Magnification.

Dermatol Surg 2021 Apr 13. Epub 2021 Apr 13.

Departments of Neurosurgery, Neurology, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, Louisiana; Division of Gross and Clinical Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Division of General Dentistry, Nippon Dental University Hospital, Tokyo, Japan; Department of Anatomical Sciences, St. George's University, St. George's, Grenada; Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, Louisiana.

Background: Use of a #15 blade is the most popular way for making skin incisions in dermatology. For finer and more accurate incisions, a #15c blade can be used. However, there is no evidence that demonstrates the superiority of the #15c blade over the #15 blade. Read More

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Effects of substrate temperature on patterns produced by dried droplets of proteins.

Colloids Surf B Biointerfaces 2021 Apr 14;203:111763. Epub 2021 Apr 14.

Facultad de Ciencias en Física y Matemáticas, Universidad Autónoma de Chiapas, Tuxtla Gutiérrez, Chiapas, Mexico. Electronic address:

Rapid diagnosis provides better clinical management of patients, helps control possible outbreaks, and increases survival. The study of deposits produced by the evaporation of droplets is a useful tool in the diagnosis of some health problems. With the aim to improve diagnostic time in clinical practice where we use the evaporation of droplets, we explored the effects of substrate temperature on pattern formation of dried droplets in globular protein solutions. Read More

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Ab interno 180-degree trabeculectomy with a dual blade in a patient with refractory primary congenital glaucoma.

Eur J Ophthalmol 2021 Apr 16:11206721211010402. Epub 2021 Apr 16.

Department of Ophthalmology, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey.

A 13-year-old female patient with refractory primary congenital glaucoma (PCG) in the right eye who had a history of multiple glaucoma operations underwent ab interno 180-degree trabeculectomy with the Kahook Dual Blade (KDB) targeting the nasal and inferior angles. On postoperative day 1, the intraocular pressure (IOP) of the right eye reduced from 43 to 15 mmHg while on medical therapy. The patient maintained this IOP level throughout the 6-month follow-up. Read More

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Ink Engineering for Blade Coating FA-Dominated Perovskites in Ambient Air for Efficient Solar Cells and Modules.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Foshan 528216, Guangdong, P. R. China.

To accelerate the commercial application of organic-inorganic hybrid perovskite solar cells (PSCs), it is necessary to develop simple and low-cost methods to prepare pinhole-free large-area perovskite films with high quality. A one-step blade coating method is regarded as a scalable technique. It is demonstrated that with the addition of ,'-dimethylpropyleneurea (DMPU) in an FA-dominated perovskite precursor, a large-area high-quality perovskite film can be obtained by blade coating, achieving improved photovoltaic performance, thermal stability, and storage stability. Read More

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MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis.

Eur Respir J 2021 Apr 15;57(4). Epub 2021 Apr 15.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Dept of Medicine, University of California, San Francisco, CA, USA

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Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week.

J Am Coll Cardiol 2021 Apr;77(15):1922-1933

WCG Clinical and WCG-ACI Clinical, Bala Cynwood, Pennsylvania, USA.

The momentum of cardiovascular drug development has slowed dramatically. Use of validated cardiac biomarkers in clinical trials could accelerate development of much-needed therapies, but biomarkers have been used less for cardiovascular drug development than in therapeutic areas such as oncology. Moreover, there are inconsistences in biomarker use in clinical trials, such as sample type, collection times, analytical methods, and storage for future research. Read More

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Utilisation of Laparoscopic Choledochoscopy During Bile Duct Exploration and Evaluation of the Wiper Blade Manoeuvre for Transcystic Intrahepatic Access.

Ann Surg 2021 Apr 14. Epub 2021 Apr 14.

University Hospital Monklands, Lanarkshire, Scotland, UK NHS Greater Glasgow and Clyde, Glasgow, UK.

Objective: This study aims to examine the indications, techniques and outcomes of choledochoscopy during laparoscopic bile duct exploration and evaluate the results of the Wiper Blade Manoeuvre (WBM) for transcystic intrahepatic choledochoscopy.

Summary Background Data: Choledochoscopy has traditionally been integral to bile duct explorations. However, laparoscopic era studies have reported wide variations in choledochoscopy availability and use, particulary with the increasing role of transcystic exploration. Read More

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NAFLD-Associated HCC: Progress and Opportunities.

J Hepatocell Carcinoma 2021 8;8:223-239. Epub 2021 Apr 8.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Due to an increase in the obesity-associated metabolic syndrome of epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular carcinoma (HCC) in western countries. This presents added challenges, as NAFLD-associated HCC tends to present at an advanced stage in older patients with co-morbidities. Their prognosis is generally poor with the benefits of standard therapies less certain. Read More

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Comparative study of the digastric and the stylohyoid muscles between wild boars (Sus scrofa scrofa) and domestic swine (Sus scrofa domesticus): revisiting the gross anatomy.

Anat Cell Biol 2021 Apr 14. Epub 2021 Apr 14.

Animal Anatomy Laboratory, School of Veterinary Medicine and Animal Sciences, Federal University of Uberlândia, Uberlândia, Brazil.

Considering Suidae Familie as a perfect and viable experimental biomedical model for research applied to human medicine, it has been sought to describe the comparative anatomy of the digastric and the stylohyoid muscles between boars and domestic swine. Heads of Sus scrofa scrofa and Sus scrofa domesticus were dissected. The digastric muscle presented only one muscle belly as anatomical component of a tendinous origin in the jugular process of the occipital bone, and muscle insertion in the midventral edge of the caudal two thirds of the body of the mandible. Read More

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A comparative study of glottis visualization according to the method of lifting the epiglottis in video laryngoscopy: indirect and direct lifting methods.

Anesth Pain Med (Seoul) 2021 Apr 8. Epub 2021 Apr 8.

Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju, Korea.

Background: The direct entry of the camera under the epiglottis may provide a better view of the glottis than the indirect lifting of the epiglottis by placing the Macintosh blade tip on the vallecula when using the video laryngoscope. This study aimed to compare the efficiency of two different methods of lifting the epiglottis during the visualization of glottis using video laryngoscopy in the same patient.

Methods: This prospective study enrolled 60 patients who underwent general anesthesia with tracheal intubation. Read More

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Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues.

J Vis Exp 2021 03 29(169). Epub 2021 Mar 29.

Departments of Research Pathology, Genentech;

Tumor enrichment in low tumor content tissues, those below 20% tumor content depending on the method, is required to generate quality data reproducibly with many downstream assays such as next generation sequencing. Automated tissue dissection is a new methodology that automates and improves tumor enrichment in these common, low tumor content tissues by decreasing the user-dependent imprecision of traditional macro-dissection and time, cost, and expertise limitations of laser capture microdissection by using digital image annotation overlay onto unstained slides. Here, digital hematoxylin and eosin (H&E) annotations are used to target small tumor areas using a blade that is 250 µm in diameter in unstained formalin fixed paraffin embedded (FFPE) or fresh frozen sections up to 20 µm in thickness for automated tumor enrichment prior to nucleic acid extraction and whole exome sequencing (WES). Read More

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Analysis of COVID-19 Patients with Acute Respiratory Distress Syndrome Managed with Extracorporeal Membrane Oxygenation at us Academic Centers.

Ann Surg 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Surgery, University of California, Irvine Medical Center, Orange, California From Vizient, Centers for Advanced Analytics and Informatics, Chicago, Illinois From the Department of Medicine, University of California, Irvine Medical Center, Orange, California.

Objective: This study analyzed the outcomes of COVID-19 patients with ARDS who were managed with extracorporeal membrane oxygenation (ECMO) across 155 US academic centers.

Summary Background Data: ECMO has been utilized in COVID-19 patients with acute respiratory distress syndrome (ARDS) and refractory hypoxemia. Early case series with the use of ECMO in these patients reported high mortality exceeding 90%. Read More

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Relationship between intraocular pressure responses to selective laser trabeculoplasty and excisional goniotomy with Kahook Dual Blade combined with phacoemulsification in glaucomatous eyes.

Can J Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

University of Missouri, Columbia School of Medicine, Columbia, Mo; University of Missouri, University Eye Institute East, Columbia, Mo. Electronic address:

Objective: To evaluate the relationship between intraocular pressure (IOP)-lowering success with selective laser trabeculoplasty (SLT) and Kahook Dual Blade (KDB) goniotomy in eyes with glaucoma.

Design: Retrospective chart review.

Participants: 30 eyes of 24 patients undergoing phacoemulsification combined with a KDB with 6 months follow-up and who had previously undergone SLT in the same eye. Read More

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N-methylene phosphonic acid chitosan/graphene sheets decorated with silver nanoparticles as green antimicrobial agents.

Int J Biol Macromol 2021 Apr 7;182:680-688. Epub 2021 Apr 7.

Organic Nanomaterials Lab, Department of Chemistry, Hannam University, Daejeon 34054, Republic of Korea. Electronic address:

A green and scalable approach for the preparation of few-layered graphene utilizing the biowaste of potato peels has been developed. The potato peels have been dried and carbonized to obtain a new graphite structure that has been exfoliated in N-methylene phosphonic acid chitosan (MPC). The exfoliation process assisted the formation of graphene sheets with a high size diameter and quality of 50% based on the weight of graphite structure. Read More

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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.

Cell 2021 Mar 30. Epub 2021 Mar 30.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory factors are associated with both increased disease severity and mortality. Here, using multidimensional epigenetic, transcriptional, in vitro, and in vivo analyses, we report that topoisomerase 1 (TOP1) inhibition suppresses lethal inflammation induced by SARS-CoV-2. Read More

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Molecular characterization and phylogenetic analyses of Tripartiella macrosoma Basson and Van As, 1987 and Tripartiella obtusa Ergens and Lom, 1970 based on 18S rRNA gene sequence data.

Parasitol Res 2021 Apr 8. Epub 2021 Apr 8.

Chongqing Key Laboratory of Animal Biology, College of Life Sciences, Chongqing Normal University, Chongqing, 401331, People's Republic of China.

In the present study, we provided the first 18S rRNA gene sequence data of two Tripartiella species, Tripartiella macrosoma Basson and Van As, 1987 and Tripartiella obtusa Ergens and Lom, 1970, which were isolated from Tachysurus fulvidraco (Richardson, 1846) and Hemibarbus maculatus Bleeker, 1871 in Chongqing, China, respectively. Morphologically, both species fall within the morphometry range of the original descriptions and are very similar to the original populations in the overall appearance of the adhesive disc. Tripartiella macrosoma can be easily distinguished from the other Tripartiella species by possessing the denticle with a long strip and conspicuously inclined backward blade and a robust and short ray. Read More

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Indications for cement augmentation in fixation of geriatric intertrochanteric femur fractures: a systematic review of evidence.

Arch Orthop Trauma Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford, 450 Broadway St., Pavilion C, 4th Floor, Redwood, CA, 94063, USA.

Introduction: Achieving durable mechanical stability in geriatric intertrochanteric proximal femur fractures remains a challenge. Concomitant poor bone quality, unstable fracture patterns, and suboptimal reduction are additional risk factors for early mechanical failure. Cement augmentation of the proximal locking screw or blade is one proposed method to augment implant anchorage. Read More

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Lateral decubitus position to facilitate pelvic examination of the patient with severe obesity.

BMC Womens Health 2021 Apr 7;21(1):143. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN, 55902, USA.

Background: Patients with elevated BMI pose a number of challenges for the gynecologist. Pelvic examination may be more difficult due to adiposity in the perineum and labia, increasing the distance between the vulva and cervix. The objective of the current work was to describe use of the lateral decubitus position to improve visualization of the cervix in women with severe obesity. Read More

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The characteristics, disabilities, and spinal alignment of women with double crush syndrome: a case-control study.

Somatosens Mot Res 2021 Apr 5:1-7. Epub 2021 Apr 5.

Rheumatology Department, Erciyes University, Kayseri, Turkey.

Aims: Double crush syndrome is a clinical condition composed of neurological dysfunction due to compressive pathology at multiple sites along a single peripheral nerve. The aims were to investigate the characteristics and disabilities of women with double crush syndrome, to compare the spinal alignment to healthy women, and to determine the cut-offs for the spinal alignment characteristics.

Methods: Twenty women with double crush syndrome (age: 49. Read More

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Incidence and OR team awareness of "near-miss" and retained surgical sharps: a national survey on United States operating rooms.

Patient Saf Surg 2021 Apr 3;15(1):14. Epub 2021 Apr 3.

Division of Urology Denver Health Medical Center and University of Colorado Anschutz Medical Campus, Denver, USA.

Introduction: A retained surgical sharp (RSS) is a never event and defined as a lost sharp (needle, blade, instrument, guidewire, metal fragment) that is not recovered prior to the patient leaving the operating room. A "near-miss" sharp (NMS) is an intraoperative event where there is a lost surgical sharp that is recovered prior to the patient leaving the operating room. With underreporting of such incidents, it is unrealistic to expect aggressive development of new prevention and detection strategies. Read More

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