Search Our Scientific Publications & Authors

J Control Release 2022 May 23. Epub 2022 May 23.

The State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. Electronic address:

Currently, clinical intravesical instillation chemotherapy has been greatly compromised by the toxicological and physiological factors. New formulations that can specifically and efficiently kill bladder cancer cells are in urgent need to overcome the low residence efficiency and dose limiting toxicity of current ones. The combination of mucoadhesive nanocarriers and cancer cell selective prodrugs can to great extent address these limitations. Read More

Radiother Oncol 2022 May 23. Epub 2022 May 23.

CRUK & UCL Cancer Trials Centre, London, United Kingdom.

Background: Metastatic spinal cord compression (MSCC) carries a poor prognosis and management is based on the likelihood of maintaining mobility and predicted survival.

Patients And Method: SCORAD is a randomised trial of 686 patients comparing a single dose of 8Gy radiotherapy with 20Gy in 5 fractions. Data was split into a training set (412, 60%) and a validation set (274, 40%). Read More

ACS Appl Bio Mater 2022 May 26. Epub 2022 May 26.

Department of Applied Chemistry, National Pingtung University, Pingtung 90003, Taiwan.

The facile and straightforward fabrication of NIR-responsive theranostic materials with high biocompatibility is still an unmet need for nanomedicine applications. Here, we used a natural photosensitizer, iron chlorophyll (Chl/Fe), for the J-aggregate template-assisted synthesis of [email protected]/Fe nanorods with high stability. The assembly of a high amount of Chl/Fe J-aggregate onto the Au surface enabled red-NIR fluorescence for monitoring and tracking residential tumor lesions. Read More

Se Pu 2022 Jun;40(6):584-589

Jiangyin Customs Comprehensive Technical Service Center, Jiangyin 214440, China.

Ship ballast water can control the roll, trim, and draft of the ship, and thus ensuring the balance and stability of the ship in the course of sailing, and playing a vital role in the safe navigation of ships. The annual discharge of ship ballast water is very large in China. About three to five billion cubic meters of ship ballast water is discharged into offshore or inland waters every year. Read More

Int J Mol Med 2022 Jul 26;50(1). Epub 2022 May 26.

Department of Urology, Baoan Central Hospital of Shenzhen, The Fifth Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518102, P.R. China.

Following the publication of the above paper, the authors drew the Editor's attention to the fact that their article contained two textual errors located in the same sentence: In the '' subsection of the Materials and methods section on p. 1086 (the first sentence), the text here should have read as follows (changes highlighted in bold): 'In the present study, 85 bladder cancer tissues and 27 adjacent normal tissues were collected from patients with BC who attended the for treatment.' (i. Read More

Front Genet 2022 9;13:872441. Epub 2022 May 9.

Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.

Immune microenvironment is implicated in cancer progression. However, the role of immune microenvironment in bladder cancer has not been fully explored. Open-accessed datasets GSE120736, GSE128959, GSE13507, GSE31684, GSE32548, GSE48075, GSE83586, and The Cancer Genome Atlas (TCGA) database were enrolled in our study. Read More

Cell Death Dis 2022 May 25;13(5):499. Epub 2022 May 25.

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, China.

A major reason for the high mortality of patients with bladder cancer (BC) is that chemotherapy and surgery are only effective for very limited patients. Thus, developing novel treatment options becomes an urgent need for improving clinical outcomes and the quality of life for BC patients. Here, we demonstrated that proguanil significantly inhibited the growth of BC in vitro and in vivo. Read More

Clin Genitourin Cancer 2022 Apr 29. Epub 2022 Apr 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline 23 Ave., DANA 1230, Boston, MA 02215, United States. Electronic address:

Background: Renin-angiotensin system inhibitors (RASi) have been shown to improve outcomes in studies of multiple malignancies by effects on the tumor microenvironment to enhance the immune repertoire and improve drug delivery. Repurposing RASi to treat metastatic renal cell carcinoma (mRCC) in combination with immune-checkpoint inhibitors (ICI) may improve survival coupled with tolerability and cost efficacy. We evaluated the impact of RASi on outcomes in mRCC patients receiving ICI. Read More

Int J Urol 2022 May 25. Epub 2022 May 25.

Department of Urology, Sengkang General Hospital, Singapore.

Objectives: To report the perioperative outcomes of robot-assisted radical cystectomy and elucidate their risk factors.

Methods: A review of the Asian Robot-Assisted Radical Cystectomy Consortium database from 2007 to 2020 was performed. The perioperative outcomes studied included complication rates, time to solid food intake, estimated blood loss, length of hospital stay, and 30-day readmission rates. Read More

Hinyokika Kiyo 2022 Apr;68(4):117-121

The Department of Urology, Osaka City University, Graduate School of Medicine.

A 75-year-old woman with a complaint of gross hematuria was referred to our hospital. The patient was diagnosed as having bladder cancer (cT3bN1M0) and received two cycles of chemotherapy with gemcitabine and cisplatin. Radical cystectomy with pelvic lymph node dissection and bilateral ureterostomy was performed after achieving partial response in a lymph node metastasis following chemotherapy. Read More

ACS Sens 2022 May 25. Epub 2022 May 25.

School of Advanced Materials and Nanotechnology, Interdisciplinary Research Center of Smart Sensors, Xidian University, Xi'an 710126, China.

Globally, bladder cancer (BLC) is one of the most common cancers and has a high recurrence and mortality rate. Current clinical diagnostic approaches are either invasive or inaccurate. Here, we report on a cost-efficient, artificially intelligent chemiresistive sensor array made of polyaniline (PANI) derivatives that can noninvasively diagnose BLC at an early stage and maintain postoperative surveillance through ″smelling″ clinical urine samples at room temperature. Read More

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, University of British Columbia, Vancouver, BC, Canada.

Bladder cancer is a heterogeneous disease classified into two broad molecular subtype categories, basal and luminal, with critical treatment and prognostic implications. Recent studies have shown the utility of immunohistochemistry in predicting bladder cancer molecular subtypes, with a two-marker approach using GATA3 and CK5/6 showing over 80% reliability. In the current study, we calculated the accuracy of uroplakin II (UPII), a marker of urothelial differentiation, with different scores (0: <1%, 1+: 1-10%, 2+: 10-50%, 3+: >50%) to predict RNA-based luminal versus basal subtypes in a cohort of muscle-invasive bladder cancer-received neoadjuvant chemotherapy followed by radical cystectomy. Read More

Stud Health Technol Inform 2022 May;294:829-833

Janssen BeNeLux, Belgium.

The complexity and heterogeneity of cancers leads to variable responses of patients to treatments and interventions. Developing models that accurately predict patient's care pathways using prognostic and predictive biomarkers is increasingly important in both clinical practice and scientific research. The main objective of the ATHENA project is to: (1) accelerate data driven precision medicine for two use cases - bladder cancer and multiple myeloma, (2) apply distributed and privacy-preserving analytical methods/ algorithms to stratify patients (decision support), (3) help healthcare professionals deliver earlier and better targeted treatments, and (4) explore care pathway automations and improve outcomes for each patient. Read More

Cancer Sci 2022 May 24. Epub 2022 May 24.

Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, Japan.

Early detection and long-term monitoring are important for urothelial carcinoma of the bladder (UCB). Urine cytology and existing markers have insufficient diagnostic performance. Here, we examined medium-sized extracellular vesicles (EVs) in urine to identify specific markers for UCB and evaluated their usefulness as diagnostic material. Read More

BMC Urol 2022 May 24;22(1):79. Epub 2022 May 24.

Department of Urology, Xuzhou Central Hospital, No. 199 Jiefang Street, Quanshan District, Xuzhou, 221009, Jiangsu, China.

Background: To observe and explore the effect of metformin on the migration and proliferation of bladder cancer T24 and 5637 cells in vitro.

Methods: Bladder cancer T24 and 5637 cell lines were cultured in vitro, and were divided into group A (blank control group) and group B (metformin group: 5, 10, 15, and 20 mmol/L); both groups were plated on 6-well plates at the same time. Culture in 24-well plates was used for wound healing assays and in 96-well plates for Transwell migration and invasion, and Cell Counting Kit-8 proliferation experiments. Read More

Int Urol Nephrol 2022 May 24. Epub 2022 May 24.

Department of Urology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.

Upper-tract urothelial carcinoma is a relatively rare malignancy. Current guidelines strongly recommend radical nephroureterectomy with bladder cuff excision and template-based lymph node dissection for all high-risk upper-tract urothelial carcinomas. Although the open approach is still considered the standard of care, evolution of minimally invasive approaches especially the robotic-assisted approach, has been found to be oncologically equivalent. Read More

Cell Death Dis 2022 May 24;13(5):492. Epub 2022 May 24.

Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, PR China.

Multidrug resistance gene 1 (MDR1), a key factor contributing to drug insensitivity, has been associated with treatment failure and poor prognoses in various cancers, including bladder urothelial carcinoma (UC). Here we show that positive Nkx2.8 expression was associated with better prognosis of UC patients received chemotherapy. Read More

Phys Med Biol 2022 May 24. Epub 2022 May 24.

University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2C4, CANADA.

Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of magnetic resonance (MR) based treatment planning workflows, we sought to determine if an ML based treatment planning model, trained on computed tomography (CT) imaging, could be applied to MR through domain adaptation.

Methods: In this study, MR and CT imaging was collected from 55 prostate cancer patients treated on an MR linear accelerator. Read More

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-16

Division of Oncology 1, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD.

The role of adjuvant therapy in renal cell carcinoma and urothelial carcinoma is rapidly evolving. To date, the U.S. Read More

Int Urol Nephrol 2022 May 24. Epub 2022 May 24.

Department of Urology, Sir Run Run Shaw Hospital, Medicine School of Zhejiang University, 3 Qingchun East Road, Shangcheng District, Hangzhou, 310016, Zhejiang, China.

Purpose: To explore the gender differences in survival under different treatments in localized muscle-invasive bladder cancer (MIBC), and to find clinical strategies to improve the poor prognosis of female with bladder cancer (BC).

Methods: Patients with localized MIBC were collected in the SEER database from 2010 to 2016 to analyze the gender differences in clinical characteristics. Propensity score matching was used to balance the effects of confounding factors. Read More

Am J Clin Pathol 2022 May 24. Epub 2022 May 24.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objectives: Neoadjuvant chemotherapy (NAC) confers a survival advantage for muscle-invasive bladder cancer and is now recommended for chemotherapy-eligible patients. NAC may result in absent gross tumor, and current cystectomy gross examination protocols do not specify approach for these cases.

Methods: We included cystectomies performed from 2010 to 2018, capturing a period pre- and post-NAC recommendations. Read More

Medicine (Baltimore) 2022 May 20;101(20):e29229. Epub 2022 May 20.

Division of Pathology, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan.

Rationale: Chondromas are benign tumors comprising cartilaginous tissue that commonly occur in the small bones of the hands and feet. Chondromas are extremely rare in extraskeletal soft tissues, and only six cases of bladder chondromas have been reported thus far.

Patient Concerns: A 75-year-old woman presented with abdominal pain and urinary symptoms, including increased frequency and a weak stream. Read More

Future Oncol 2022 May 24. Epub 2022 May 24.

Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.

PROOF 302 is an ongoing randomized, double-blind, placebo-controlled, adjuvant phase III trial (NCT04197986) in approximately 218 patients from 120 centers worldwide. Eligibility criteria include post-surgical high-risk muscle-invasive upper tract urothelial cancer (85% of patients) or urothelial bladder cancer (15%), susceptible alterations (activating mutations, gene fusions or rearrangements), ≤120 days following radical surgery and ineligible for/or refusing cisplatin-based (neo)adjuvant chemotherapy. Patients receive either oral infigratinib 125 mg or placebo daily on days 1-21 of a 28-day cycle for up to 52 weeks or until recurrence, unacceptable toxicity or death. Read More

Minerva Urol Nephrol 2022 Jun;74(3):376-378

Unit of Urology, Division of Oncology (URI), IRCCS San Raffaele Hospital, Milan, Italy.

Minerva Urol Nephrol 2022 Jun;74(3):363-364

Keck School of Medicine, Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Los Angeles, CA, USA.

Cureus 2022 Apr 21;14(4):e24345. Epub 2022 Apr 21.

Department of Radiology, Brooke Army Medical Center, San Antonio, USA.

Paraphimosis is a urologic emergency that requires prompt diagnosis to avoid potential morbidity. Diagnosis is made clinically and imaging findings have not been described. We will present the case of an 84-year-old man with a history of metastatic prostate cancer and prior pelvic external beam radiation therapy who presented to the emergency department with urinary retention. Read More

J Oncol 2022 14;2022:7306198. Epub 2022 May 14.

Department of Epidemiology, School of Public Health, Soochow University, Suzhou 215123, China.

Background: Although radical cystectomy (RC) is the clinical practice guideline-recommended treatment of muscle-invasive bladder cancer (MIBC), bladder-sparing trimodality therapy (TMT) has emerged as a valid treatment option. Findings comparing the survival outcomes for MIBC patients who underwent RC and TMT are inconclusive.

Objective: We designed a large hospital-based multicohort study to compare the effectiveness of TMT with RC. Read More

J Oncol 2022 14;2022:3465459. Epub 2022 May 14.

Department of Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.

Purpose: M2-like tumor-associated macrophages (TAMs) are crucial component of immune infiltration in tumor microenvironment (TME), and exosomes derived from TAMs contributed to the regulation of tumor progression through cellular communication. However, in bladder cancer, the role of exosomal components still remains largely unknown. In the current study, we investigated the role of exosomes derived from M2-like TAMs in the regulation of autophagy in bladder cancer (BC) cells. Read More

Biomed Res Int 2022 19;2022:5739574. Epub 2022 May 19.

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Aim: Through investigation and analysis of the course management of 314 patients with benign prostatic hyperplasia (BPH) during the COVID-19 pandemic, we expected to offer effective recommendations for the management of patients with BPH against the background of the COVID-19 pandemic.

Methods: We implemented telephone follow-ups of 314 patients with BPH who were diagnosed at the Urology Clinic of Xiangya Hospital of Central South University before January 24, 2020, and who were admitted to the hospital for reexamination after the epidemic was controlled in China, and we conducted research and analysis of their disease management during the COVID-19 pandemic.

Results: In the follow-up, we found 245 patients (79. Read More

Biomed Res Int 2022 14;2022:5032172. Epub 2022 May 14.

Department of Zoology, College of Science, King Saud University, P.O. Box: 2455, 11451 Riyadh, Saudi Arabia.

Cigarette SMOKE (CS) considerably contributes to causing some diseases such as cancer, and it has a role in the alternation of gene expression through several mechanisms including epigenetics modification, particularly DNA methylation. is one of the genes, that whose expression has been dysregulated in lung, colon, bladder, and breast cancer, leading to tumor progression. The alternation of DNA methylation levels has been implicated in regulating the expression of the gene. Read More