3 results match your criteria bis2-butoxyethyl 3-hydroxyl-2-butoxyethyl

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Characterized in Vitro Metabolism Kinetics of Alkyl Organophosphate Esters in Fish Liver and Intestinal Microsomes.

Environ Sci Technol 2018 03 22;52(5):3202-3210. Epub 2018 Feb 22.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences , Chinese Academy of Sciences , Beijing 100085 , China.

Tris(2-butoxyethyl) phosphate (TBOEP) and tris( n-butyl) phosphate (TNBP) are the most commonly used alkyl organophosphate esters (alkyl-OPEs), and they increasingly accumulate in organisms and create potential health hazards. This study examined the metabolism of TNBP and TBOEP in Carassius carassius liver and intestinal microsomes and the production of their corresponding monohydroxylated and dealkylated metabolites. After 140 min of incubation with fish liver microsomes, the rapid depletion of TNBP and TBOEP were both best fitted to the Michaelis-Menten model (at administrated concentrations ranging from 0. Read More

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Urinary metabolites of organophosphate esters: Concentrations and age trends in Australian children.

Environ Int 2018 02 28;111:124-130. Epub 2017 Nov 28.

QAEHS, Queensland Alliance for Environmental Health Science, The University of Queensland, 4108 Brisbane, Australia.

There is growing concern around the use of organophosphate esters (OPEs) due to their suspected reproductive toxicity, carcinogenicity, and neurotoxicity. OPEs are used as flame retardants and plasticizers, and due to their extensive application in consumer products, are found globally in the indoor environment. Early life exposure to OPEs is an important risk factor for children's health, but poorly understood. Read More

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February 2018

In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum.

Toxicol Appl Pharmacol 2015 Apr 11;284(2):246-53. Epub 2015 Feb 11.

Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. Electronic address:

Tris(2-butoxyethyl) phosphate (TBOEP) is a plasticizer present in indoor dust, reaching levels of several micrograms per gram. Such levels could lead to significant daily exposure of adults and children. Currently, no toxicokinetic data are available to estimate TBOEP clearance in humans after uptake and therefore, one objective of this study was to investigate intrinsic clearance of TBOEP by human liver microsome (HLM) and serum enzymes. Read More

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