Epidemiology 2021 Jul 9. Epub 2021 Jul 9.
Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, Canada Division of Biostatistics, School of Public Health, University of California at Berkeley, Berkeley CA Division of Epidemiology, School of Public Health, University of California at Berkeley, Berkeley CA Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. . Magee-Womens Research Institute, Pittsburgh, Pennsylvania.
Background: Fetal growth restriction is commonly defined using small-for-gestational-age (SGA) birth (birthweight <10th percentile) as a proxy, but this approach is problematic because most SGA infants are small but healthy. In this proof-of-concept study, we sought to develop a new approach for identifying fetal growth restriction at birth that combines information on multiple, imperfect measures of fetal growth restriction in a probabilistic manner.
Methods: We combined information on birthweight, placental weight, placental malperfusion lesions, maternal disease, and fetal acidemia using latent profile analysis to classify fetal growth in births at the Royal Victoria Hospital in Montreal, Canada, 2001-2009. Read More