55,564 results match your criteria bipolar disorder


Low-Dose Lurasidone-Induced Polydipsia Complicated by Hyponatremia in a Patient With Bipolar Disorder.

Clin Neuropharmacol 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Objective: Atypical antipsychotic-induced hyponatremia has been reported in patients with psychiatric disorders. To date, hyponatremia due to lurasidone, an atypical antipsychotic approved for the treatment of schizophrenia and bipolar depression, has never been reported.

Case Report: A female patient with bipolar depression and a history of subdural hematoma experienced a rapid onset of hyponatremia after the initiation of low-dose lurasidone. Read More

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September 2021

Midazolam-Induced Parasomnia as Online-Shopping Behaviors.

Clin Neuropharmacol 2021 Sep 20. Epub 2021 Sep 20.

School of Medicine Teaching Office, Tri-Service General Hospital, National Defense Medical Center Institute of Brain Sciences, National Yang Ming Chiao Tung University Department of Psychiatry, Tri-Service General Hospital, School of Medicine Student Counseling Center, National Defense Medical Center, Taipei, Taiwan, ROC.

Objectives: The objective of this study was to report a case of sleep online shopping.

Methods: A single case study of midazolam-induced sleep online shopping behavior in a 35-year-old woman with posttraumatic stress disorder and bipolar II disorder was performed.

Results: The Naranjo score was 7, which supported the probability of midazolam-induced sleep online shopping behaviors. Read More

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September 2021

Comparison of the Neurocognitive Profile of the Children of Parents with Bipolar Disorder and Controls: a Transnational Cross-Sectional Study.

Rev Colomb Psiquiatr 2021 Sep 21. Epub 2021 Sep 21.

Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address:

Introduction: Studies that have compared the cognitive alterations of the children of parents with bipolar disorder (CPBD) versus the children of control parents (CCP), present heterogeneous results due to the studies' methodological differences, the age of the population studied, and the lack of standardisation of the measures used for the different neurocognitive domains. The objective was to compare the neurocognitive profile of CPBD versus CCP to observe if there are differences that could be proposed as possible endophenotypes of BD.

Results: A total of 107 individuals (51 CPBD, and 56 CCP) with ages between 6 and 16 (mean, 12. Read More

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September 2021

Shared decision making in a semi-secluded chronic psychiatric ward: The reflective lifeworld experiences of patients with schizophrenia or schizoaffective disorders and nursing staff.

Arch Psychiatr Nurs 2021 Oct 12;35(5):519-525. Epub 2021 Jul 12.

Dimence Group, Center for Mental Health Care, SCBS Bipolar Disorders, Deventer, the Netherlands; Saxion University of Applied Sciences, Deventer, the Netherlands. Electronic address:

Background: Shared decision making (SDM) enhances recovery-oriented mental healthcare, but literature predominately focuses on doctor-patient collaboration leaving the role of mental health nurses (MHN's) underexposed.

Aim: This study describes the experiences of patients with schizophrenia or schizoaffective disorder with SDM in a semi-secluded psychiatric facility, and the attitudes toward SDM by MHN's.

Method: A hermeneutic phenomenological design. Read More

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October 2021

Strong evidence for genotype-phenotype correlations in Phelan-McDermid syndrome: Results from the developmental Synaptopathies consortium.

Hum Mol Genet 2021 Sep 24. Epub 2021 Sep 24.

Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Individuals with Phelan-McDermid syndrome (PMS) present with a wide range of developmental, medical, cognitive, and behavioral abnormalities. Previous literature has begun to elucidate genotype-phenotype associations that may contribute to the wide spectrum of features. Here, we report results of genotype-phenotype associations in a cohort of 170 individuals with PMS. Read More

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September 2021

Prevalence and 5-year trend of incidence for medical illnesses after the diagnosis of bipolar disorder: A nationwide cohort study.

Aust N Z J Psychiatry 2021 Sep 24:48674211046891. Epub 2021 Sep 24.

Psychiatric Research Center, Taipei Medical University Hospital, Taipei.

Objective: Medical comorbidities are prevalent in patients with bipolar disorder. Evaluating longitudinal trends of the incidence of medical illnesses enables implementation of early prevention strategies to reduce the high mortality rate in this at-risk population. However, the incidence risks of medical illnesses in the early stages of bipolar disorder remain unclear. Read More

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September 2021

Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.

Schizophr Res Cogn 2022 Mar 14;27:100214. Epub 2021 Sep 14.

Institute of Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Despite fast progress in neuroscientific approaches, the neurobiological continuum links psychotic spectrum, and affective disorder is obscure. White matter WM abnormalities found utilizing Diffusion Tensor Imaging (DTI) showing impaired communication in both disorders have been consistently demonstrated; however, direct comparisons of findings between them are scarce. This study aims to study WM abnormalities in single episode bipolar I disorder, and single episode brief psychotic disorder related to healthy control with the association of executive function. Read More

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Psychiatric comorbidity and treatment outcomes in patients with opioid use disorder: Results from a multisite trial of buprenorphine-naloxone and methadone.

Drug Alcohol Depend 2021 Aug 28;228:108996. Epub 2021 Aug 28.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA. Electronic address:

Background: Individuals treated for opioid use disorder (OUD) have high rates of psychiatric disorders potentially diminishing treatment outcomes. We examined long-term treatment experiences and outcomes by type of psychiatric disorder among participants who participated in the Starting Treatment with Agonist Replacement Therapies (START) study and its follow-up study.

Methods: We categorized the 593 participants who completed the Mini-International Neuropsychiatric Interview (MINI) during the START follow-up study into four mutually exclusive groups to indicate current psychiatric diagnosis: 1) bipolar disorder (BPD; n = 51), 2) major depressive disorder (MDD; n = 85), 3) anxiety disorder (AXD; n = 121), and 4) no comorbid mental disorder (NMD; n = 336). Read More

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Investigating racing thoughts in insomnia: A neglected piece of the mood-sleep puzzle?

Compr Psychiatry 2021 Sep 17;111:152271. Epub 2021 Sep 17.

Department of Neurology, Sleep disorder Center, University Hospital of Strasbourg, Strasbourg, France; CNRS UPR312, Strasbourg, France.

Background: Cognitive arousal is thought to play a key role in insomnia disorder. However, although patients frequently complain about racing thoughts appearing at bedtime, studies have considered 'cognitive arousal' as a synonym of rumination and worry, but not as racing thoughts per se. The latter have been mainly linked to hypomanic/manic episodes of bipolar disorder (BD). Read More

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September 2021

Effects of the COVID-19 pandemic in a preexisting longitudinal study of patients with recently diagnosed bipolar disorder: Indications for increases in manic symptoms.

Brain Behav 2021 Sep 23:e2326. Epub 2021 Sep 23.

Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.

Background: The coronavirus disease 2019 (COVID-19) pandemic interfered in the daily lives of people and is assumed to adversely affect mental health. However, the effects on mood (in)stability of bipolar disorder (BD) patients and the comparison to pre-COVID-19 symptom severity levels are unknown.

Method: Between April and September, 2020, symptoms and well-being were assessed in the Bipolar Netherlands Cohort (BINCO) study of recently diagnosed patients with BD I and II. Read More

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September 2021

Transition Between Sensitive Delusion of Reference and Mood Disorder: A Case Report.

Front Psychiatry 2021 6;12:712552. Epub 2021 Sep 6.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

The Sensitive Delusion of Reference is a clinical entity described by Ernst Kretschmer and never integrated into mainstream nosographic systems. It represents the possibility of developing psychosis starting from a personality characterized by sensitivity, scrupulousness, and fear of judgment of others. The presentation of the following clinical case highlights how the overlap between this clinical entity and mood disorders leads to characteristic psychopathology, which has not been sufficiently detailed. Read More

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September 2021

Efficacy and safety of clozapine in psychotic disorders-a systematic quantitative meta-review.

Transl Psychiatry 2021 Sep 22;11(1):487. Epub 2021 Sep 22.

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

A recent increase in the literature regarding the evidence base for clozapine has made it increasingly difficult for clinicians to judge "best evidence" for clozapine use. As such, we aimed at elucidating the state-of-the-art for clozapine with regard to efficacy, effectiveness, tolerability, and management of clozapine and clozapine-related adverse events in neuropsychiatric disorders. We conducted a systematic PRISMA-conforming quantitative meta-review of available meta-analytic evidence regarding clozapine use. Read More

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September 2021

Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders.

Curr Med Chem 2021 Sep 22. Epub 2021 Sep 22.

Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa. Italy.

Major depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs, while reporting increasing data on the relationships between these processes and classical neurotransmitters, hypothalamus-pituitary-adrenal axis (HPA), and neurotrophic factors. The assessment of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) in peripheral blood represents a simple method to evaluate the inflammatory status. Read More

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September 2021

Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial.

Am J Psychiatry 2021 Sep 23:appiajp202120091339. Epub 2021 Sep 23.

Department of Psychiatry, Case Western Reserve School of Medicine, Cleveland, and University Hospitals Cleveland Medical Center, Cleveland (Calabrese); Intra-Cellular Therapies, Inc., New York (Durgam, Satlin [formerly], Vanover [formerly], Davis, Chen, Kozauer, Mates); Massachusetts General Hospital, Boston, and Signant Health, Plymouth Meeting, Pa. (Sachs).

Objective: In a phase 3 randomized double-blind placebo-controlled study, the authors investigated the efficacy and safety of 42 mg/day of lumateperone in patients with bipolar I or bipolar II disorder experiencing a major depressive episode.

Methods: Patients 18-75 years old with a clinical diagnosis of bipolar I or bipolar II disorder and experiencing a major depressive episode were eligible for the study. Patients were randomized in a 1:1 ratio to receive 42 mg/day of lumateperone (N=188) or placebo (N=189), administered orally once daily in the evening for 6 weeks. Read More

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September 2021

Association between visceral adipose tissue and major depressive disorder across the lifespan: a Scoping Review.

Bipolar Disord 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objectives: Increasing evidence supports a bidirectional relationship between major depressive disorder (MDD) and obesity, but the role of visceral adipose tissue (VAT) as a measure of obesity in relation to MDD is not well understood. Here we review literature investigating the link between MDD and VAT in terms of biomarkers, sex differences, and aging.

Methods: PubMed, EMBASE, PsycINFO, and CINAHL searches were conducted on December 11, 2020. Read More

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September 2021

New-Onset Psychosis Following COVID-19 Infection.

Cureus 2021 Sep 12;13(9):e17904. Epub 2021 Sep 12.

Department of Psychiatry, Brookdale University Hospital Medical Center, Brooklyn, USA.

Previous studies have suggested that some individuals experience neuropsychiatric symptoms following coronavirus disease 2019 (COVID-19) infection. We describe a case of new-onset psychosis following COVID-19 infection in a 55-year-old female with no prior psychiatric history. The patient started exhibiting symptoms of COVID-19 infection three weeks prior and was treated in the hospital with 4 L oxygen, dexamethasone 6 mg, and remdesivir therapy for seven days. Read More

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September 2021

Treatment of bipolar disorders in older adults: a review.

Ann Gen Psychiatry 2021 Sep 21;20(1):45. Epub 2021 Sep 21.

Bereich Forschung & Wissenschaft, LWL-Klinik, Marsbruchstr. 179, 44287, Dortmund, Germany.

Background: Old age bipolar disorder has been an orphan of psychiatric research for a long time despite the fact that bipolar disorder (BD)-I and II together may affect 0.5-1.0% of the elderly. Read More

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September 2021

Facial emotion recognition and its association with quality of life and socio-occupational functioning in patients with bipolar disorder and their first-degree relatives.

Asian J Psychiatr 2021 Sep 11;65:102843. Epub 2021 Sep 11.

Wellcome Trust / DBT Alliance Intermediate Fellow, Associate Consultant Psychiatry, KEM Hospital Research Centre, 489, Rastapeth, Sardar Moodliar Road, Pune, Maharashtra 411011, India. Electronic address:

Introduction: Facial emotion recognition deficits (FERD) are common even in the remitted phase of bipolar disorder (BD). Research regarding FERD in first-degree relatives is inconclusive. This study aimed to assess the facial emotion recognition in remitted patients of bipolar disorder and first-degree relatives(FDR) in comparison with healthy controls. Read More

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September 2021

Gray matter volume covariance networks are associated with altered emotional processing in bipolar disorder: a source-based morphometry study.

Brain Imaging Behav 2021 Sep 21. Epub 2021 Sep 21.

Department of Neuroscience (DNS), University of Padova, Via Giustiniani 5, Padova, Italy.

Widespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of the brain, and their clinical and psychological function have not been investigated yet in BD. 24 patients with BD type-I (BD-I), and 30 with BD type-II (BD-II), and 45 controls underwent MRI scan. Read More

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September 2021

Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.

Transl Psychiatry 2021 Sep 20;11(1):485. Epub 2021 Sep 20.

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Read More

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September 2021

A distinct neurocognitive profile: unipolar mania.

Nord J Psychiatry 2021 Sep 20:1-7. Epub 2021 Sep 20.

Psychiatry Department, Eskişehir Osmangazi University, Odunpazarı, Turkey.

Objective: Despite a growing number of studies reporting patients with a history of mania without depression have several socio-demographic and clinical differences than bipolar disorder patients, unipolar mania is recognized as bipolar I disorder in the most commonly used classification systems. Studies showing that unipolar mania is a separate clinical entity are insufficient in number, and to the best of our knowledge, there has been no study investigating the neuropsychological differences in this area. The aim of this study is to evaluate the neurocognitive differences between unipolar mania, bipolar I disorder and healthy controls, and to reveal the underlying neurocognitive differences. Read More

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September 2021

Lamotrigine for Treating Anger in Veterans With Posttraumatic Stress Disorder.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):184-185

Phoenix VA Health Care System, Phoenix, AZ.

Abstract: Lamotrigine is an antiepileptic drug that was Food and Drug Administration approved in 2003 for use in the maintenance treatment of bipolar I disorder to delay the time to recurrence of new mood episodes. The mechanism by which lamotrigine achieves its therapeutic effect in the treatment of bipolar disorder is unknown. Here, we report on 2 Veterans with combat-related posttraumatic stress disorder (PTSD) endorsing significant anger, aggression, and agitation, who were treated with selective serotonin reuptake inhibitors, but whose residual symptoms of anger and aggression were ultimately successfully managed with lamotrigine augmentation. Read More

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September 2021

Predictors of cancer screening among Black and White Maryland Medicaid enrollees with serious mental illness.

Psychooncology 2021 Sep 19. Epub 2021 Sep 19.

Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: Cancer is the second leading cause of death for people with serious mental illness (SMI), such as schizophrenia and bipolar disorder. People with SMI receive cancer screenings at lower rates than the general population.

Aims: We sought to identify factors associated with cancer screening in a publicly insured population with SMI and stratified by race, a factor itself linked with differential rates of cancer screening. Read More

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September 2021

A cross-diagnostic study of Adherence to Ecological Momentary Assessment: Comparisons across study length and daily survey frequency find that early adherence is a potent predictor of study-long adherence.

Pers Med Psychiatry 2021 Nov-Dec;29-30. Epub 2021 Jul 16.

University of Miami Miller School of Medicine, Miami, FL.

Background: Ecological momentary assessment (EMA) offers a highly valid strategy to assess everyday functioning in people with severe mental illness. Adherence is generally good, but several questions regarding the impact of study length, daily density of sampling, and symptom severity on adherence remain.

Methods: EMA adherence in two separate studies was examined. Read More

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Asenapine: an atypical antipsychotic with atypical formulations.

Ther Adv Psychopharmacol 2021 11;11:20451253211035269. Epub 2021 Sep 11.

New York Medical College, Valhalla, NY, USA.

Asenapine is a second-generation (atypical) antipsychotic medication not available in a pill that can be swallowed; rather, it is commercialized in sublingual and transdermal formulations. This is a consequence of extensive first-pass metabolism if ingested. The sublingual formulation is approved in many jurisdictions for the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder and is available generically. Read More

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September 2021

Exploring Signatures of Neurodegeneration in Early-Onset Older-Age Bipolar Disorder and Behavioral Variant Frontotemporal Dementia.

Front Neurol 2021 3;12:713388. Epub 2021 Sep 3.

Ph.D. Program in Neuroscience, Department of Psychiatry, Pontificia Universidad Javeriana, Bogotá, Colombia.

Older-age bipolar disorder (OABD) may involve neurocognitive decline and behavioral disturbances that could share features with the behavioral variant of frontotemporal dementia (bvFTD), making the differential diagnosis difficult in cases of suspected dementia. To compare the neuropsychological profile, brain morphometry, and structural connectivity patterns between patients diagnosed with bvFTD, patients classified as OABD with an early onset of the disease (EO-OABD), and healthy controls (HC). bvFTD patients ( = 25, age: 66 ± 7, female: 64%, disease duration: 6 ± 4 years), EO-OABD patients ( = 17, age: 65 ± 9, female: 71%, disease duration: 38 ± 8 years), and HC ( = 28, age: 62 ± 7, female: 64%) were evaluated through neuropsychological tests concerning attention, memory, executive function, praxis, and language. Read More

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September 2021