83,041 results match your criteria bipolar

Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells.

Neuroimmunomodulation 2021 May 5:1-9. Epub 2021 May 5.

Institute of Education and Research, Santa Casa BH, Belo Horizonte, Brazil.

Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with increased plasma levels of pro-inflammatory mediators targeting all tissues including the brain. Importantly, pro-inflammatory cytokines (ex., tumor-necrosis factor alpha [TNF-α], interleukin [IL]-6) regulate mood behavior and cognition by influencing neurotransmitter levels, activating stress-responsive endocrine axes, among other effects. Read More

View Article and Full-Text PDF

Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder.

J Affect Disord 2021 Apr 20;289:81-87. Epub 2021 Apr 20.

Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, TX 77054, USA.

In proton magnetic resonance spectroscopy (¹H MRS) studies, aberrant levels of choline-containing compounds that include glycerophosphocholine plus phosphocholine (GPC+PC), can signify alterations in the metabolism of cellular membrane phospholipids (MPLs) from a healthy baseline. In a recent ¹H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I). Post-traumatic stress disorder (PTSD) can worsen the severity of BP-I, but it is unclear whether the effect of a PTSD comorbidity in BP-I is associated with altered MPL metabolism. Read More

View Article and Full-Text PDF

Is unipolar mania a distinct entity: findings from the bipolar disorder course and outcome study from India (BiD-CoIN study).

Nord J Psychiatry 2021 May 5:1-6. Epub 2021 May 5.

Murshidabad Medical College and Hospital, Murshidabad, India.

Aim: This study aimed to evaluate the prevalence of unipolar mania (UM) in a group of patients of bipolar disorder (BD). Additionally, effort was made to evaluate the demographic, clinical and treatment related factors, which distinguish subjects of UM from BD.

Methodology: Seven hundred and seventy-three patients with BD, of at least 10 years duration, recruited from 14 General Hospital Units of tertiary care centers from India were evaluated for UM. Read More

View Article and Full-Text PDF

Moderators of Treatment for Pediatric Bipolar Spectrum Disorders.

J Clin Child Adolesc Psychol 2020 Jun 17:1-14. Epub 2020 Jun 17.

Department of Psychiatry, The Ohio State University Wexner Medical Center.

Objective: We review the current limited research on pediatric bipolar spectrum disorder (BPSD) treatment moderators..

Method: Four pharmacotherapy and nine psychotherapy moderator studies in youth with pediatric BPSD is summarized. Read More

View Article and Full-Text PDF

The relationship between emotional intelligence and quality of life in schizophrenia and bipolar I disorder.

Qual Life Res 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.

Purpose: Social cognitive skills, both psychosocial functioning and well-being of patients with schizophrenia (SZ) or bipolar disorder (BD), have consistently been shown to be interrelated. While previous research mainly focused on emotion perception, the present study investigates the impact of the other subdomains of emotion processing on a subjective Quality of Life (QoL) estimate and objective QoL indicators. We hypothesized that patients with better performance in the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) report better QoL; and assumed that SZ and BD patients report comparable subjective QoL, whereas BD patients show higher levels of objective QoL. Read More

View Article and Full-Text PDF

Bipolar disorder: an association of body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation.

Trends Psychiatry Psychother 2021 May 4. Epub 2021 May 4.

Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre (HCPA). Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria e Medicina Legal da Universidade Federal do Rio Grande do Sul, Brazil.

Objective: To investigate body mass index (BMI) associations with white matter fractional anisotropy (FA) and C-reactive protein (CRP) in individuals with bipolar disorder (BD) during euthymia in comparison with a control group of healthy subjects (CTR).

Methods: The sample consisted of 101 individuals (BD n=35 and CTR n=66). Regions of interest (ROI) were defined through machine learning approach. Read More

View Article and Full-Text PDF

Depression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients.

Brain Behav 2021 May 5:e02164. Epub 2021 May 5.

Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Objective: In community dwelling older adults, depression and anxiety symptoms can be associated with early cognitive decline. Symptoms of depression and anxiety are common in older adults prior to surgery. However, their significance is unknown. Read More

View Article and Full-Text PDF

Nonvolatile resistive switching and synaptic characteristics of lead-free all-inorganic perovskite-based flexible memristive devices for neuromorphic systems.

Nanoscale 2021 May 4. Epub 2021 May 4.

Department of Applied Science and Humanities, Assam University, Silchar 788011, India.

Recently, several types of lead halide perovskites have been actively researched for resistive switching (RS) memory or artificial synaptic devices due to their current-voltage hysteresis along with the feasibility of fabrication, low-temperature processability and superior charge mobility. However, the toxicity and environmental pollution potential of lead halide perovskites severely restrict their large-scale commercial prospects. In the present work, the environmentally friendly and uniform CsSnCl3 perovskite films are introduced to act as an active layer in the flexible memristors. Read More

View Article and Full-Text PDF

Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder.

World J Biol Psychiatry 2021 May 5:1-35. Epub 2021 May 5.

Londrina State University, Health Sciences Graduate Program, Londrina, Brazil.

Objectives: This study examined cognition-immune interactions, specifically executive function, working memory, peripheral levels of tumour necrosis factor-alpha (TNF-α), and soluble tumour necrosis factor receptors-1 and -2 (sTNFR1 and 2) levels in patients in comparison with controls.

Methods: Thirty-one BD participants and twenty-seven controls participated in the study. The neurocognitive assessment was performed through three of CogState Research Battery tasks for executive function and working memory. Read More

View Article and Full-Text PDF

Repetitive transcranial magnetic stimulation (rTMS) in Bipolar Disorder: A Systematic Review.

Bipolar Disord 2021 May 4. Epub 2021 May 4.

Department of Psychiatry, University of Toronto.

Objectives: Repetitive transcranial magnetic stimulation (rTMS) is commonly used in unipolar depression; yet there its evidence in bipolar disorder (BD) is limited. We sought to review the evidence on the use of rTMS across the different stages of BD.

Methods: MEDLINE database was systematically searched using the PubMed interface following the PRISMA guidelines. Read More

View Article and Full-Text PDF

Higher order theory of mind in patients with bipolar disorder and schizophrenia/schizoaffective disorder.

Eur Arch Psychiatry Clin Neurosci 2021 May 4. Epub 2021 May 4.

Department of Mental Health, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Catalonia, Spain.

Some evidence suggests that patients with bipolar disorder (BD) have better Theory of Mind (ToM) skills than patients with schizophrenia/schizoaffective disorder (SCH). However, this difference is not consistently reported across studies, so rather than being global, it may be restricted to specific aspects of ToM. Our primary objective was to compare higher order ToM performance between BD and SCH patients using the Hinting Task (HT). Read More

View Article and Full-Text PDF

Comparatıve assessment of thermal ınjury ınduced by bıpolar electrocautery systems ın a porcıne model.

Surg Neurol Int 2021 8;12:146. Epub 2021 Apr 8.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, United States.

Background: Bipolar electrocautery systems used during neurosurgical procedures have been shown to induce thermal injury to surrounding tissue. The goal of this study was to compare the thermal injury induced by two different systems commonly used in neurosurgical procedures (Silverglide by Stryker Corporation and SpetzlerMalis by Codman Neuro), with that of a newly introduced device (TRIOwand by NICO Corporation).

Methods: A farm swine underwent craniectomy and durotomy with subsequent exposure of cortical brain tissue. Read More

View Article and Full-Text PDF

Differential Co-Occurring Patterns Between Depressive Symptomatology and Sleep-Wake-Related Disturbances in Mood Disorders.

Nat Sci Sleep 2021 27;13:503-514. Epub 2021 Apr 27.

Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: This study aimed to elucidate the various co-occurring patterns of depressive symptomatology and sleep-wake-related disturbances (SWRDs) in patients with mood disorders.

Patients And Methods: Individuals in non-acute states of major depressive disorder or bipolar disorder were recruited. The Beck Depression Inventory II (BDI-II) was utilized to evaluate depressive symptoms. Read More

View Article and Full-Text PDF

Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?

Biol Philos 2021 30;36(3):27. Epub 2021 Apr 30.

Wellcome Centre for Human Neuroimaging, London, UK.

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. Read More

View Article and Full-Text PDF

Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study.

Sci Rep 2021 May 4;11(1):9452. Epub 2021 May 4.

Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei, 23142, Taiwan.

The diagnostic peripheral biomarkers are still lacking for the bipolar II disorder (BD-II). We used isobaric tags for relative and absolute quantification technology to identify five upregulated candidate proteins [matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)] for the diagnosis of BD-II. We analysed the differences in the plasma levels of these candidate proteins between BD-II patients and controls (BD-II, n = 185; Controls, n = 186) using ELISA. Read More

View Article and Full-Text PDF

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers.

J Clin Med 2021 Apr 29;10(9). Epub 2021 Apr 29.

Department of Psychiatry, 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry, 041914 Bucharest, Romania.

(1) Background: Recent research suggests inflammation as a factor involved in the pathophysiology of mood disorders. Neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory (SII) index ratios have been studied as peripheral markers of inflammation in bipolar and major depressive disorders. The purpose of this study is to comparatively analyze these inflammatory ratios among manic episodes of bipolar disorder, bipolar depression and unipolar depression. Read More

View Article and Full-Text PDF

Non-Doped Deep-Blue OLEDs Based on Carbazole-π-Imidazole Derivatives.

Pengfei Yu Yin Xiao

Materials (Basel) 2021 Apr 30;14(9). Epub 2021 Apr 30.

School of Chemical Engineering and Technology, Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin University, Tianjin 300072, China.

In this work, we designed and synthesized four bipolar blue-emitting materials with carbazole, imidazole, and biphenyl as donor, acceptor, and p bridge, respectively. The twisted phenylimidazole acceptor leads to a wider band-gap and hence deeper blue emission than the conjugated phenanthrimidazole acceptor. For the substituents on the carbazole donor, the t-butyl group could prevent the intramolecular charge transfer (ICT) process more effectively than the methoxy group. Read More

View Article and Full-Text PDF

The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Laboratory of Molecular and Chemical Cell Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8530, Japan.

Cells form a bipolar spindle during mitosis to ensure accurate chromosome segregation. Proper spindle architecture is established by a set of kinesin motors and microtubule-associated proteins. In most eukaryotes, kinesin-5 motors are essential for this process, and genetic or chemical inhibition of their activity leads to the emergence of monopolar spindles and cell death. Read More

View Article and Full-Text PDF

Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder.

Medicina (Kaunas) 2021 Apr 30;57(5). Epub 2021 Apr 30.

Psychiatrie Schwäbisch Hall, 74523 Schwäbisch Hall, Germany.

This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper will discuss the evidence of their efficacy relative to the polarity of relapse from controlled acute and maintenance/relapse prevention studies in bipolar patients. A Medline search was conducted for controlled acute and maintenance studies with carbamazepine, oxcarbazepine, and eslicarbazepine in bipolar disorder. Read More

View Article and Full-Text PDF

The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects.

J Affect Disord 2021 Apr 16;289:66-73. Epub 2021 Apr 16.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 28, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122 Milano, Italy.

Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), lifetime stressful events (SLEs) and psychopathological symptoms in BD patients during euthymia and controls (HC).

Methods: A total of 261 participants (93 euthymic patients with BD, 168 HC) were enrolled. Read More

View Article and Full-Text PDF

Parental death by external causes during childhood and risk of psychiatric disorders in bereaved offspring.

Child Adolesc Ment Health 2021 May 4. Epub 2021 May 4.

National Centre for Suicide Research and Prevention, University of Oslo, Oslo, Norway.

Background: Previous studies have reported increased risks of psychiatric disorders in offspring who have lost a parent, but knowledge is lacking on the risks of several specific disorders and comorbidity. The present study investigated the influence of parental death by external causes during childhood and adolescence on risk of a range of psychiatric disorders and comorbidity.

Method: The study cohort comprised 655,477 individuals born 1970-2012 with a link to both parents. Read More

View Article and Full-Text PDF

methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes.

Epigenomics 2021 May 4. Epub 2021 May 4.

Hospital Universitari Institut Pere Mata, Ctra. de l'Institut Pere Mata, s/n. 43206, Reus, Catalonia, Spain.

To investigate  methylation in the brains of bipolar disorder (BD) patients and its association with mRNA levels and comethylation with myelin genes. Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. 5-methylcytosine levels were increased and directly associated with b mRNA expression in the brains of BD patients. Read More

View Article and Full-Text PDF

Bipolar Fractional Radiofrequency Treatment of Suprapatellar Skin Assessment Using Non-Invasive Devices and Microbiopsy.

Aesthet Surg J 2021 May 4. Epub 2021 May 4.

Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX.

Background: Non-invasive treatments for skin tightening are gaining popularity. However, there are no studies assessing bipolar fractional radiofrequency on suprapatellar skin.

Objectives: The purpose of this study is to evaluate the efficacy of bipolar fractional radiofrequency on suprapatellar skin. Read More

View Article and Full-Text PDF

Bipolar (Bio)electroanalysis.

Annu Rev Anal Chem (Palo Alto Calif) 2021 May 3. Epub 2021 May 3.

Bordeaux INP, Institute of Molecular Science, and CNRS UMR 5255, University of Bordeaux, 33607 Pessac, France; email:

This contribution reviews a selection of the most recent studies on the use of bipolar electrochemistry in the framework of analytical chemistry. Despite the fact that the concept is not new, with several important studies dating back to the middle of the last century, completely novel and very original approaches have emerged over the last decade. This current revival illustrates that scientists still (re)discover some exciting virtues of this approach, which are useful in many different areas, especially for tackling analytical challenges in an unconventional way. Read More

View Article and Full-Text PDF

Perceived helpfulness of treatment for specific phobia: Findings from the World Mental Health Surveys.

J Affect Disord 2021 Apr 20;288:199-209. Epub 2021 Apr 20.

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Although randomized trials show that specific phobia treatments can be effective, it is unclear whether patients experience treatment as helpful in clinical practice. We investigated this issue by assessing perceived treatment helpfulness for specific phobia in a cross-national epidemiological survey.

Methods: Cross-sectional population-based WHO World Mental Health (WMH) surveys in 24 countries (n=112,507) assessed lifetime specific phobia. Read More

View Article and Full-Text PDF

Memristive Behavior of Mixed Oxide Nanocrystal Assemblies.

ACS Appl Mater Interfaces 2021 May 3. Epub 2021 May 3.

Department of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.

Recent advances in memristive nanocrystal assemblies leverage controllable colloidal chemistry to induce a broad range of defect-mediated electrochemical reactions, switching phenomena, and modulate active parameters. The sample geometry of virtually all resistive switching studies involves thin film layers comprising monomodal diameter nanocrystals. Here we explore the evolution of bipolar and threshold resistive switching across highly ordered, solution-processed nanoribbon assemblies and mixtures comprising BaZrO (BZO) and SrZrO (SZO) nanocrystals. Read More

View Article and Full-Text PDF

A prospective study to determine the clinical utility of pharmacogenetic testing of veterans with treatment-resistant depression.

J Psychopharmacol 2021 May 3:2698811211015224. Epub 2021 May 3.

Mental Health Service, VA San Diego Healthcare System, San Diego, CA, USA.

Background: Pharmacotherapies for depression are often ineffective and treatment-resistant depression (TRD) is common across bipolar disorder (BD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD). Patient genetic information can be used to predict treatment outcomes. Prospective studies indicate that pharmacogenetic (PGX) tests have utility in the treatment of depression. Read More

View Article and Full-Text PDF

Effect of medication on risk of traumatic brain injury in patients with bipolar disorder: A nationwide population-based cohort study.

J Psychopharmacol 2021 May 3:2698811211013582. Epub 2021 May 3.

Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Increased traumatic brain injury (TBI) risk was found in patients with bipolar disorder (BPD). Whether the medications for BPD and dosage moderate the risk of TBI is not clear.

Aim: This study aimed to determine whether an association exists between BPD and TBI and whether the prescription of psychotropics moderates TBI risk. Read More

View Article and Full-Text PDF