5,256 results match your criteria biphasic calcium

Restoring Facial Contour and Harmony Using Biphasic Calcium Phosphate Bioceramics.

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3516. Epub 2021 Apr 8.

EINCO Biomaterial Ltda., Belo Horizonte, Minas Gerais, Brazil.

Background: The restoration of facial contour is one of the pillars for the treatment of facial disharmonies and deformities. Fat transplantation and fillers have been widely used to improve the positioning of soft tissues, which are, however, directly related to the conditions and positioning of the underlying bone tissue. Recontouring of the latter has been performed using osteotomies and several types of bone grafts or biomaterials, as inlay or onlay grafts/implants. Read More

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Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.

Université Côte d'Azur, CNRS (UMR 7277), Inserm (U1091), iBV, Nice, France. Electronic address:

Immediately upon implantation, scaffolds for bone repair are exposed to the patient's blood. Blood proteins adhere to the biomaterial surface and the protein layer affects both blood cell functions and biomaterial bioactivity. Previously, we reported that 80-200 µm biphasic calcium phosphate (BCP) microparticles embedded in a blood clot, induce ectopic woven bone formation in mice, when 200-500 µm BCP particles induce mainly fibrous tissue. Read More

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Programmed BMP-2 release from biphasic calcium phosphates for optimal bone regeneration.

Biomaterials 2021 Mar 29;272:120785. Epub 2021 Mar 29.

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:

This study aimed to fabricate a multi-layered biphasic calcium phosphate (BCP) platform for programmed bone morphogenetic protein-2 (BMP-2) release, which means to block the initial burst release and promote releasing during the differentiation phase of osteogenic cells. And it is to confirm in vivo whether this platform has osteogenic inductivity even when extremely low doses of BMP-2 are loaded compared to the conventional soaking method. Our strategy consisted of preparing a multilayer coating on BCP to minimize the contact between BMP-2 and BCP and allow the loading of BMP-2. Read More

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Enhancing osteoregenerative potential of biphasic calcium phosphates by using bioinspired ZIF8 coating.

Mater Sci Eng C Mater Biol Appl 2021 Apr 17;123:111972. Epub 2021 Feb 17.

School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia; Institute of Molecular Medicine, Sechenov First Moscow State University, Moscow 119991, Russia. Electronic address:

Biphasic calcium phosphate ceramics (BCPs) have been extensively used as a bone graft in dental clinics to reconstruct lost bone in the jaw and peri-implant hard tissue due to their good bone conduction and similar chemical structure to the teeth and bone. However, BCPs are not inherently osteoinductive and need additional modification and treatment to enhance their osteoinductivity. The present study aims to develop an innovative strategy to improve the osteoinductivity of BCPs using unique features of zeolitic imidazolate framework-8 (ZIF8). Read More

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Scanning Electron Microscopic Evaluation of the Internal Fit Accuracy of 3D-Printed Biphasic Calcium Phosphate Block: An Ex Vivo Pilot Study.

Materials (Basel) 2021 Mar 22;14(6). Epub 2021 Mar 22.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea.

The aim of this study was to assess the internal fit accuracy of a three-dimensional (3D)-printed biphasic calcium phosphate (BCP) block compared with a 3D-milled poly methyl methacrylate (PMMA) block by scanning electron microscope (SEM) analysis. In a total of 20 porcine rib bones, two different types of defects having two adjacent walls and a floor were produced: a defect with a flat floor (flat defect; = 10) and a defect with a concave floor (curved defect; = 10). Each defect was grafted with either the 3D-printed BCP block or the 3D-milled PMMA block fabricated following the computer aided design. Read More

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Ex Vivo and In Vivo Analyses of Novel 3D-Printed Bone Substitute Scaffolds Incorporating Biphasic Calcium Phosphate Granules for Bone Regeneration.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Department of Ceramic Materials, Chair of Advanced Ceramic Materials, Institute for Materials Science and Technologies, Technical University Berlin, 10623 Berlin, Germany.

(1) Background: The aim of this study was examining the ex vivo and in vivo properties of a composite made from polycaprolactone (PCL) and biphasic calcium phosphate (BCP) (synprint, ScientiFY GmbH) fabricated via fused deposition modelling (FDM); (2) Methods: Scaffolds were tested ex vivo for their mechanical properties using porous and solid designs. Subcutaneous implantation model analyzed the biocompatibility of PCL + BCP and PCL scaffolds. Calvaria implantation model analyzed the osteoconductive properties of PCL and PCL + BCP scaffolds compared to BCP as control group. Read More

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Tissue Level Changes after Maxillary Sinus Floor Elevation with Three Types of Calcium Phosphate Ceramics: A Radiological Study with a 5-Year Follow-Up.

Materials (Basel) 2021 Mar 17;14(6). Epub 2021 Mar 17.

Department of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam Movement Sciences, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

This study evaluates the radiological changes in tissue height after maxillary sinus floor elevation (MSFE) using three types of calcium phosphate ceramics over a period of up to 5 years after dental implant placement. In 163 patients, MSFE was performed. Three groups of patients were distinguished and treated based on the type of calcium phosphate ceramic used and radiologically evaluated: 40 patients with β-tricalcium phosphate (β-TCP), 76 patients with biphasic calcium phosphate (BCP) 20% hydroxyapatite (HA)-80% β-TCP, and 47 patients with BCP 60% HA-40% β-TCP. Read More

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Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering.

Nanomaterials (Basel) 2021 Mar 2;11(3). Epub 2021 Mar 2.

Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si 54896, Jeollabuk-do, Korea.

In the field of bone tissue, maintaining adequate mechanical strength and tissue volume is an important part. Recently, biphasic calcium phosphate (BCP) was fabricated to solve the shortcomings of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP), and it is widely studied in the field of bone-tissue engineering. In this study, a composite hydrogel was fabricated by applying BCP to gelatin methacrylate (GelMA). Read More

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Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics.

Sci Rep 2021 Mar 24;11(1):6751. Epub 2021 Mar 24.

Inserm, UMR 1238, PHY-OS Laboratory, Bone Sarcomas and Remodelling of Calcified Tissues, Faculty of Medicine, University of Nantes, Nantes, France.

Bone marrow mesenchymal stem/stromal cells (BMSCs) show great promise for bone repair, however they are isolated by an invasive bone marrow harvest and their regenerative potential decreases with age. Conversely, cord blood can be collected non-invasively after birth and contains MSCs (CBMSCs) that can be stored for future use. However, whether CBMSCs can replace BMSCs targeting bone repair is unknown. Read More

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Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair.

Regen Biomater 2021 Mar 13;8(2):rbab007. Epub 2021 Mar 13.

Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China.

It is still a challenge to optimize the component distribution and microporous structures in scaffolds for tailoring biodegradation (ion releasing) and enhancing bone defect repair within an expected time stage. Herein, the core-shell-typed nonstoichiometric wollastonite (4% and 10% Mg-doping calcium silicate; CSiMg4, CSiMg10) macroporous scaffolds with microporous shells (adding ∼10 μm PS microspheres into shell-layer slurry) were fabricated via 3D printing. The initial mechanical properties and bio-dissolution (ion releasing) , and osteogenic capacity of the bioceramic scaffolds were evaluated systematically. Read More

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A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model.

Regen Biomater 2021 Feb 30;8(1):rbaa040. Epub 2020 Sep 30.

National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, Sichuan, China.

Repair and reconstruction of large bone defect were often difficult, and bone substitute materials, including autogenous bone, allogenic bone and artificial bone, were common treatment strategies. The key to elucidate the clinical effect of these bone repair materials was to study their osteogenic capacity and immunotoxicological compatibility. In this paper, the mechanical properties, micro-CT imaging analysis, digital image analysis and histological slice analysis of the three bone grafts were investigated and compared after different time points of implantation in rat femur defect model. Read More

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February 2021

Permissive Modulation of Sphingosine-1-Phosphate-Enhanced Intracellular Calcium on BK Channel of Chromaffin Cells.

Int J Mol Sci 2021 Feb 22;22(4). Epub 2021 Feb 22.

Department of Physiology, National Cheng-Kung University Medical College, Tainan 701401, Taiwan.

Sphingosine-1-phosphate (S1P), is a signaling sphingolipid which acts as a bioactive lipid mediator. We assessed whether S1P had multiplex effects in regulating the large-conductance Ca-activated K channel (BK) in catecholamine-secreting chromaffin cells. Using multiple patch-clamp modes, Ca imaging, and computational modeling, we evaluated the effects of S1P on the Ca-activated K currents () in bovine adrenal chromaffin cells and in a pheochromocytoma cell line (PC12). Read More

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February 2021

Effects of extracellular potassium on calcium handling and force generation in a model of excitation-contraction coupling in skeletal muscle.

J Theor Biol 2021 Jun 2;519:110656. Epub 2021 Mar 2.

School of Electrical and Electronic Engineering, University College Dublin, Belfield, Dublin 4, Ireland.

It is well-established that extracellular potassium (K) accumulation reduces muscle fiber excitability, however the effects of K on the excitation-contraction coupling (ECC) pathway are less understood. In vivo and in vitro studies following fatiguing stimulation protocols are limited in their ability to capture the effects of K on force production in combination with other simultaneously changing factors. To address this, a computational model of ECC for slow and fast twitch muscle is presented to explore the relative contributions of excitability-induced and metabolic-induced changes in force generation in response to increasing [Formula: see text] . Read More

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The conduction velocity-potassium relationship in the heart is modulated by sodium and calcium.

Pflugers Arch 2021 Mar 4;473(3):557-571. Epub 2021 Mar 4.

Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

The relationship between cardiac conduction velocity (CV) and extracellular potassium (K) is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV. Recent studies from our group suggest that elevating extracellular sodium (Na) and calcium (Ca) can enhance CV by an extracellular pathway parallel to gap junctional coupling (GJC) called ephaptic coupling that can occur in the gap junction adjacent perinexus. However, it remains unknown whether these same interventions modulate CV as a function of K. Read More

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Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits.

PLoS Comput Biol 2021 Mar 3;17(3):e1008706. Epub 2021 Mar 3.

Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, United Kingdom.

In this paper we apply a novel JAVA version of a model on the homeostasis of human red blood cells (RBCs) to investigate the changes RBCs experience during single capillary transits. In the companion paper we apply a model extension to investigate the changes in RBC homeostasis over the approximately 200000 capillary transits during the ~120 days lifespan of the cells. These are topics inaccessible to direct experimentation but rendered mature for a computational modelling approach by the large body of recent and early experimental results which robustly constrain the range of parameter values and model outcomes, offering a unique opportunity for an in depth study of the mechanisms involved. Read More

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Alloplastic Bone Substitutes for Periodontal and Bone Regeneration in Dentistry: Current Status and Prospects.

Materials (Basel) 2021 Feb 26;14(5). Epub 2021 Feb 26.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.

Various bone graft products are commercially available worldwide. However, there is no clear consensus regarding the appropriate bone graft products in different clinical situations. This review is intended to summarize bone graft products, especially alloplastic bone substitutes that are available in multiple countries. Read More

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February 2021

Diverse patterns of bone regeneration in rabbit calvarial defects depending on the type of collagen membrane.

J Periodontal Implant Sci 2021 Feb;51(1):40-52

Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.

Purpose: Various crosslinking methods have been introduced to increase the longevity of collagen membranes. The aim of this study was to compare and evaluate the degradation and bone regeneration patterns of 3 collagen membranes.

Methods: Four 8-mm-diameter circular bone defects were created in the calvaria of 10 rabbits. Read More

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February 2021

Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri-implant dehiscence defects: An experimental in vivo study.

Clin Oral Implants Res 2021 Feb 25. Epub 2021 Feb 25.

Department of Periodontology, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.

Aim: To investigate the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross-linked collagen membrane for guided bone regeneration.

Methods: Three experimental groups were randomly allocated at chronic peri-implant dehiscence defect in 8 beagle dogs: (i) biphasic calcium phosphate covered by a cross-linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control) and (iii) no treatment (negative control). After 8 and 16 weeks of submerged healing, dissected tissue blocks were processed for immunohistochemical analysis. Read More

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February 2021

Physical characterization of biphasic bioceramic materials with different granulation sizes and their influence on bone repair and inflammation in rat calvaria.

Sci Rep 2021 Feb 24;11(1):4484. Epub 2021 Feb 24.

Division of Cell Biology and Oral Pathology, São Leopoldo Mandic Research Institute, Campinas, SP, 13045-755, Brazil.

Biphasic calcium phosphate bioceramics (BCP) consist of a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) within the same particle. Due to their osteoconductive properties, biocompatibility and resemblance to natural bone, these materials have become a promising and suitable alternative to autologous bone grafting. First, the topography characteristics, specific surface area, and total pore volume of BCP were evaluated using scanning electron microscopy and the BET and BJH methods. Read More

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February 2021

Biphasic Calcium Phosphate Microparticles Mixed With Autologous Blood: Application for the Reconstruction of a Large Mandibular Bone Defect in a Dog.

J Vet Dent 2020 Dec 19;37(4):201-209. Epub 2021 Feb 19.

560854Azurvet Veterinary Referal Center, Saint Laurent du Var, France.

Large mandibular bone defects can be difficult to treat in dogs, with a high risk of mal or nonunion due to instability and risk of infection. This case report describes the use of autologous clotted blood mixed with biphasic calcium phosphate microparticles to fill a defect in a nonunion fracture and promote bone regeneration in a dog using a 2-stage surgical approach. This new method was designed and tried in a dog with a chronic, unstable mandibular fracture associated with a large sequestrum. Read More

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December 2020

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field.

Regen Ther 2021 Mar 5;16:63-72. Epub 2021 Feb 5.

Department of Plastic Surgery, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, Liaoning, People's Republic of China.

Due to traffic accidents, injuries, burns, congenital malformations and other reasons, a large number of patients with tissue or organ defects need urgent treatment every year. The shortage of donors, graft rejection and other problems cause a deficient supply for organ and tissue replacement, repair and regeneration of patients, so regenerative medicine came into being. Stem cell therapy plays an important role in the field of regenerative medicine, but it is difficult to fill large tissue defects by injection alone. Read More

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Photobiomodulation Therapy on the Guided Bone Regeneration Process in Defects Filled by Biphasic Calcium Phosphate Associated with Fibrin Biopolymer.

Molecules 2021 Feb 5;26(4). Epub 2021 Feb 5.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru 17012-901, São Paulo, Brazil.

The aim is to evaluate the effects of photobiomodulation therapy (PBMT) on the guided bone regeneration process (GBR) in defects in the calvaria of rats filled with biphasic calcium phosphate associated with fibrin biopolymer. Thirty male Wistar rats were randomly separated: BMG ( 10), defects filled with biomaterial and covered by membrane; BFMG ( 10), biomaterial and fibrin biopolymer covered by membrane; and BFMLG ( 10), biomaterial and fibrin biopolymer covered by membrane and biostimulated with PBMT. The animals were euthanized at 14 and 42 days postoperatively. Read More

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February 2021

The Use of Biphasic Calcium Phosphate Substitute (BCP) in Mandibular Defects in Dogs: Use of CBCT to Evaluate Bone Healing.

J Vet Dent 2020 Dec 8;37(4):210-219. Epub 2021 Feb 8.

Azurvet Veterinary Referal Center, Saint Laurent du Var, France.

This study aimed to assess the use of cone beam computed tomography (CBCT) to follow-up bone healing of mandibular bone defects in dogs, filled with a combination of autologous blood and millimetric BCP granules. CBCT was performed ≥4 weeks postoperatively. CBCT gray-scale values were measured from multiplanar reconstructions of the defects and compared to that of normal contralateral mandibular bone and to pure BCP/blood composite time 0 (T0) value. Read More

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December 2020

Osteoblasts mineralization and collagen matrix are conserved upon specific silencing.

Matrix Biol Plus 2020 May 31;6-7:100028. Epub 2020 Jan 31.

Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.

Classical osteogenesis imperfecta (OI) is an inherited rare brittle bone disease caused by dominant mutations in the or genes, encoding for the α chains of collagen type I. The definitive cure for the disease will require a gene therapy approach, aimed to correct or suppress the mutant allele. Interestingly, individuals lacking α2(I) chain and synthetizing collagen α1(I) homotrimers do not show bone phenotype, making appealing a bone specific silencing approach for OI therapy. Read More

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The impact of the size of bone substitute granules on macrophage and osteoblast behaviors in vitro.

Clin Oral Investig 2021 Feb 4. Epub 2021 Feb 4.

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objective: Bone substitute (BS) size might influence the clinical outcomes of guided bone regeneration (GBR) procedures. The aim of the present study was to investigate the influence of BS size on macrophage (Mφ) and osteoblast behaviors in vitro.

Materials And Methods: Two different granule sizes (S and M/L) were assessed for four different commercial BSs: deproteinized bovine bone mineral (DBBM), biphasic calcium phosphate type 1 (BCP1), BCP type 2 (BCP2), and carbonate apatite (COAp). Read More

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February 2021

Toward Biofabrication of Resorbable Implants Consisting of a Calcium Phosphate Cement and Fibrin-A Characterization In Vitro and In Vivo.

Int J Mol Sci 2021 Jan 26;22(3). Epub 2021 Jan 26.

Department of Oral and Maxillofacial Surgery Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany.

Cleft alveolar bone defects can be treated potentially with tissue engineered bone grafts. Herein, we developed novel biphasic bone constructs consisting of two clinically certified materials, a calcium phosphate cement (CPC) and a fibrin gel that were biofabricated using 3D plotting. The fibrin gel was loaded with mesenchymal stromal cells (MSC) derived from bone marrow. Read More

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January 2021

Influence of strain rate on the mechanical behavior of dry and hydrated chitosan-based dense materials for bioabsorbable implant applications.

J Mech Behav Biomed Mater 2021 04 21;116:104337. Epub 2021 Jan 21.

IDMEC, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal.

Chitosan has generated enormous interest in the scientific community because of its distinctive biological and physicochemical properties, which allow new advanced structures and applications. Porous chitosan scaffolds have been extensively studied and explored in bone generation, however it is still a challenge to obtain bioabsorbable orthopedic implants that involves pure 3D dense chitosan geometries due to the inherent difficulties in producing and shaping such structures. In this work, chitosan was blended with 10% glycerol and 10% glycerol + 10% biphasic mixture of calcium phosphate (70% hydroxyapatite with 30% β-tricalcium phosphate) to produce dense chitosan-based blocks, which were then shaped into rods. Read More

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Phycogenic bone substitutes for sinus floor augmentation: Histomorphometric comparison of hydroxyapatite and biphasic calcium phosphate in a randomised clinical pilot study.

Int J Oral Implantol (Berl) 2020 ;13(4):387-399

Aims: While numerous materials are available for sinus floor elevation, plant-based alternatives still hold promise of overcoming concerns about allogeneic or xenogeneic materials. Thus, the present authors designed a randomised clinical trial to histologically compare an almost pure hydroxyapatite (HA) to a biphasic calcium phosphate comprising 80% β-tricalcium phosphate (β-TCP) and 20% hydroxyapatite (β-TCP/HA), all of phycogenic origin.
Materials and methods: Twenty patients scheduled for lateral window sinus floor elevation were randomised to either an HA or a β-TCP/HA group. Read More

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January 2021

Assessment of biphasic calcium phosphate 70/30 alginate scaffold on the tibia in pigs.

Vet World 2020 Dec 11;13(12):2635-2642. Epub 2020 Dec 11.

Department of Veterinary Clinic Reproduction and Pathology, Division of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.

Background And Aim: Calcium phosphate bioceramics have been used for at least a decade, and many investigations have focused on the use of hydroxyapatite (HA) derivative in the regeneration of bone defects. Biphasic calcium phosphate (BCP) is a biomaterial composed of HA and beta-tricalcium phosphate (BCP), with a structure similar to bone. The aim of the study was to determine the influence of the BCP/alginate scaffold on tissue growth, blood, the lungs, and the electrical activity of the heart during bone healing in the tibia of pig. Read More

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December 2020

Physical and biological characterizations of TiNbSn/(Mg) system produced by powder metallurgy for use as prostheses material.

J Mech Behav Biomed Mater 2021 03 17;115:104260. Epub 2020 Dec 17.

São Paulo State University, Regenerative Medicine Lab, Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, SP, Brazil. Electronic address:

Titanium scaffolds with non-toxic β stabilizing elements (Nb and Sn), Ti-34Nb-6Sn (TNS), and with magnesium as spacer (TNS/M), were processed by powder metallurgy, and sintered at 800 °C. The X-ray diffraction (XRD) pattern showed that materials are biphasic alloys, presenting 45 to 42% (wt %) in hcp (α-phase) and the rest is bcc (β-phase), and the presence of a slight peak relating to TiO in both materials. Pores of approximately 50 μm for TNS and 300 μm to TNS/M were observed in the micrographic analysis by scanning electron microscopy (SEM). Read More

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