Search Our Scientific Publications & Authors

Adv Healthc Mater 2021 Apr 21:e2100070. Epub 2021 Apr 21.

Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, 02115, USA.

Regeneration of large bones remains a challenge in surgery. Recent developmental engineering efforts aim to recapitulate endochondral ossification (EO), a critical step in bone formation. However, this process entails the condensation of mesenchymal stem cells (MSCs) into cartilaginous templates, which requires long-term cultures and is challenging to scale up. Read More

J Neurophysiol 2021 Apr 21. Epub 2021 Apr 21.

Université de Montréal.

Galvanic vestibular stimulation (GVS) is used to assess vestibular function, but vestibular responses can exhibit variability depending on protocols or intensities used. We measured head acceleration in healthy subjects to identify an objective motor threshold on which to base GVS intensity when assessing postural responses. Thirteen healthy right-handed subjects stood on a force platform, eyes closed, head facing forward. Read More

Respir Res 2021 Apr 20;22(1):112. Epub 2021 Apr 20.

Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, RP1, 800 N. Research Pkwy., Oklahoma City, OK, 73104, USA.

Background: Influenza is a highly contagious, acute, febrile respiratory infection caused by a negative-sense, single-stranded RNA virus, which belongs in the Orthomyxoviridae family. Cigarette smoke (CS) exposure worsens influenza infection in terms of frequency and severity in both human and animal models.

Methods: C57BL/6 mice with or without CS exposure for 6 weeks were inoculated intranasally with a single, non-lethal dose of the influenza A virus (IAV) A/Puerto Rico/8/1934 (PR8) strain. Read More

Plant Signal Behav 2021 Apr 21:1917169. Epub 2021 Apr 21.

Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Tartu, Estonia.

Exogenous application of methyl jasmonate (MeJA) has been extensively used to study jasmonate-dependent signaling events triggered by biotic stresses. MeJA application leads to complex jasmonate-dependent physiological responses, including changes in stomatal openness and induction of emissions of a multitude of volatile compounds. Whether the alterations in stomatal conductance and emissions of MeJA-induced volatiles are quantitatively associated with MeJA dose, and whether the induced volatile emissions are regulated by modifications in stomatal conductance had been poorly known until recently. Read More

Biomaterials 2021 Apr 12;273:120797. Epub 2021 Apr 12.

Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA. Electronic address:

T cell activation is sensitive to the mechanical properties of an activating substrate. However, there are also contrasting results on how substrate stiffness affects T cell activation, including differences between T cells of mouse and human origin. Towards reconciling these differences, this report examines the response of primary human T cells to polyacrylamide gels with stiffness between 5 and 110 kPa presenting activating antibodies to CD3 and CD28. Read More

Elife 2021 Apr 20;10. Epub 2021 Apr 20.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, United States.

Aging is accompanied by disrupted information flow, resulting from accumulation of molecular mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal muscle wasting, or sarcopenia. To derive a global metric of growing 'disorderliness' of aging muscle, we employed a statistical physics approach to estimate the state parameter, entropy, as a function of genes associated with hallmarks of aging. Read More

J Biomol Struct Dyn 2021 Apr 20:1-8. Epub 2021 Apr 20.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.

Modulation of proteasome function by pharmacological interventions and molecular biology tools is an active area of research in cancer biology and neurodegenerative diseases. Curcumin (diferuloylmethane) is a naturally occurring polyphenol that affects multiple signaling pathways. Curcumin shows anti-inflammatory, antioxidant, anti-angiogenic, or anti-apoptotic properties. Read More

Clin Pharmacol Drug Dev 2021 Apr 19. Epub 2021 Apr 19.

BeiGene USA, Inc., San Mateo, California, USA.

Pamiparib, a selective poly (ADP-ribose) polymerase 1/2 inhibitor, demonstrated tolerability and antitumor activity in patients with solid tumors at 60 mg orally twice daily. This phase 1 open-label study (NCT03991494; BGB-290-106) investigated the absorption, metabolism, and excretion (AME) of 60 mg [ C]-pamiparib in 4 patients with solid tumors. The mass balance in excreta, blood, and plasma radioactivity and plasma pamiparib concentration were determined along with metabolite profiles in plasma, urine, and feces. Read More

Phys Chem Chem Phys 2021 Apr 26;23(14):8598-8606. Epub 2021 Mar 26.

Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, 832 32 Bratislava, Slovakia.

The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-CnOH, n = 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 CnOH : DMPC molar ratio range. Up to n≤ 10 a significant biphasic effect depending on the main transition temperature t on the CnOH concentration was observed. Read More

New Phytol 1991 Mar;117(3):423-429

Institute of Plant Biology, University of Zürich, Zollikerstr. 107 CH-8008 Zürich, Switzerland.

The sugar alcohol mannitol is, together with glucose and fructose, the main soluble carbohydrate of celery petioles. It is accumulated in the storage parenchyma of mature petioles and remobilized during senescence. The mechanisms of mannitol uptake into discs isolated from petiole parenchyma was studied. Read More

New Phytol 1991 Mar;117(3):413-422

Institute of Plant Biology, University of Zürich, Zollikerstr. 107 CH-8008 Zürich, Switzerland.

Petioles of celery leaves function successively as net importing (sink) and net exporting (source) organs during ontogeny. The parenchyma of these petioles is the main store for large amounts of D-glucose, D-fructose and mannitol. The mechanism of uptake of glucose and fructose into discs isolated from storage parenchyma of celery petioles was investigated. Read More

New Phytol 1993 Mar;123(3):485-489

Department of Range Science and The Ecology Center, Utah State University, Logan, Utah 84322-5230, USA.

Plant NO - acquisition is largely determined by root uptake capacity. Although root uptake capacity has been shown to be sensitive to both root temperature and previous nitrogen (N) supply in hydroponic systems, the uptake capacity response to similar environmental factors under field conditions has not been investigated. Using NO , root uptake capacities were determined in excised roots of Agropyron desertorum (Fisch. Read More

New Phytol 1989 Mar;111(3):381-390

The Biology Department, Building 44, The University, Southampton, SO9 5NH, UK.

The accumulation of exogenous D-fructose, D-glucose and sucrose into root tips of Ricinus communis was studied. Accumulation of sucrose is biphasic with respect to substrate concentration, both saturable and non-saturable Phases being discerned. Accumulation is sensitive to pH, the exogenous solute potential, PCMBS, and other sugars. Read More

New Phytol 2002 Dec;156(3):427-436

School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.

•   Bicarbonate acquisition mechanisms and the kinetics of dissolved inorganic carbon (DIC) use in photosynthesis and calcification were investigated in Emiliania huxleyi. •   Photosynthesis was measured using O evolution and C incorporation and calcification was measured with C. Noncalcifying (coccolith-free) cells were produced from calcifying (coccolith-bearing) cells of the same strain of E. Read More

New Phytol 2002 Dec;156(3):517-525

Department of Botany, Stockholm University, SE-10691 Stockholm, Sweden.

•   The lack of nitrogen in agriculture, and negative environmental effects of fertilizers, have stimulated interest in creating artificial associations between N -fixing cyanobacteria and rice (Oryza sativa). •   For the first time, numerous (57) Nostoc isolates from natural symbioses were screened for their ability to associate with rice. Successful colonizers were tested for N -fixation by acetylene reduction and for their ability to adsorb to roots by chlorophyll a measurements. Read More

Cell Signal 2021 Apr 16:110010. Epub 2021 Apr 16.

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, United States of America. Electronic address:

Activation of the protein kinase mechanistic target of rapamycin (mTOR) in both complexes 1 and 2 (mTORC1/2) in the liver is repressed during fasting and rapidly stimulated in response to a meal. The effect of feeding on hepatic mTORC1/2 is attributed to an increase in plasma levels of nutrients, such as amino acids, and insulin. By contrast, fasting is associated with elevated plasma levels of glucagon, which is conventionally viewed as having a counter-regulatory role to insulin. Read More

Pediatr Dev Pathol 2021 Apr 19:10935266211008443. Epub 2021 Apr 19.

Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

DICER1 tumor predisposition syndrome is a rare genetic disorder that predisposes individuals to multiple benign and malignant neoplasms. The phenotype is vast and includes pleuropulmonary blastoma (PPB), thyroid nodules, cystic nephroma, Wilms tumor, ovarian Sertoli-Leydig cell tumor, and medulloepithelioma, among others. Herein, we describe a patient with a germline pathogenic variant presenting with two neoplasms that are not commonly encountered in the context of DICER1 syndrome. Read More

ACS Omega 2021 Apr 1;6(14):9852-9856. Epub 2021 Apr 1.

Department of Chemistry University of Swabi, Swabi, Anbar 23430, KPK, Pakistan.

Anti-inflammatory, analgesic, and sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, and other complications. In this regard, discovery research is undergoing a process to discover effective, safe, and economical drugs with no side effects. The aim of this study was to assess chloroform extracts and isolated compounds for anti-inflammatory, analgesic, and sedative activities in animal models. Read More

J Biol Chem 2021 Apr 15:100632. Epub 2021 Apr 15.

Department of Medicine, Division of Nephrology, University of California at San Francisco, San Francisco, CA, USA,; Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA, USA,. Electronic address:

Non-shivering thermogenesis is essential for mammals to maintain body temperature. According to the canonical view, temperature is sensed by cutaneous thermoreceptors and nerve impulses transmitted to the hypothalamus, which generates sympathetic signals to ß-adrenergic receptors in brown adipocytes. The energy for heat generation is primarily provided by the oxidation of fatty acids derived from triglyceride hydrolysis and cellular uptake. Read More

Alcohol Clin Exp Res 2021 Apr 17. Epub 2021 Apr 17.

Department of Psychiatry & Behavioral Neuroscience, The University of Chicago, Chicago, Illinois, USA, 60637.

Background: For decades, laboratory alcohol challenges have been the "gold standard" for measuring individual differences in alcohol's subjective effects. However, these approaches are expensive and labor-intensive, making them impractical for large-scale use. This study examined the reliability and validity of a new high-resolution EMA (HR-EMA) ambulatory approach to assessing alcohol use and subjective responses in drinkers' natural environments. Read More

J Intensive Care 2021 Apr 16;9(1):35. Epub 2021 Apr 16.

Department of Emergency, Critical Care and Disaster Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Background: Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the impact of RH. Therefore, we aimed to establish and validate an animal model of heatstroke considering RH. Read More

Auton Neurosci 2021 Apr 7;233:102809. Epub 2021 Apr 7.

Department of Physical Therapy, School of Health & Human Sciences; and (2)Departments of Dermatology and Anatomy, Cell Biology, & Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA. Electronic address:

Local neuronal circuits in non-glabrous skin drive the initial increase of the biphasic cutaneous vasodilation response to fast non-noxious heating. Voltage-sensitive Na (NaV) channel inhibition blocks the afferent limb of the non-glabrous forearm cutaneous axon reflex. Slow local heating does not engage this response. Read More

IEEE Trans Biomed Circuits Syst 2021 Apr 16;PP. Epub 2021 Apr 16.

Plantar cutaneous feedback plays an important role in stable and efficient gait, by modulating the activity of ankle dorsi-and plantar-flexor muscles. However, central and peripheral nervous trauma often decrease plantar cutaneous feedback and/or interneuronal excitability in processing the plantar cutaneous feedback. In this study, we tested if a fully implantable neural recording and stimulation system could augment plantar cutaneous feedback. Read More

J Chromatogr Sci 2021 Apr 15. Epub 2021 Apr 15.

School of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330000, P.R. China.

Four caffeoylquinic acid derivatives from the Gunura procumbens flowers (GPF) were successfully isolated and purified by high-speed counter-current chromatography (HSCCC). Ethyl acetate-methanol-water (3:1:3, v/v/v) was the optimum biphasic solvent system, which was selected by high-performance liquid chromatography (HPLC) and run on a preparative scale where the lower aqueous phase was used as the mobile phase with a head-to-tail elution mode. Chlorogenic acid (3. Read More

J Chromatogr A 2021 Mar 26;1645:462108. Epub 2021 Mar 26.

Department of Chemistry, Wayne State University, Detroit, MI, 48202, USA. Electronic address:

The solvation parameter model affords a useful tool to model distribution properties of neutral compounds in biphasic separation systems. Common applications include column characterization and method development in gas chromatography; reversed-phase, micellar and hydrophilic interaction liquid chromatography; supercritical fluid chromatography; and micellar electrokinetic chromatography. The characterization of the distribution properties of liquid-liquid partition systems is another major application of this model. Read More

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3516. Epub 2021 Apr 8.

EINCO Biomaterial Ltda., Belo Horizonte, Minas Gerais, Brazil.

Background: The restoration of facial contour is one of the pillars for the treatment of facial disharmonies and deformities. Fat transplantation and fillers have been widely used to improve the positioning of soft tissues, which are, however, directly related to the conditions and positioning of the underlying bone tissue. Recontouring of the latter has been performed using osteotomies and several types of bone grafts or biomaterials, as inlay or onlay grafts/implants. Read More

J Dent Res 2021 Apr 14:220345211007429. Epub 2021 Apr 14.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA.

Cementum, a specialized bony layer covering an entire molar root surface, anchors teeth into alveolar bone. Gli1, a key transcriptional activator in Hedgehog signaling, has been identified as a mesenchymal progenitor cell marker in various tissues, including the periodontal ligament (PDL). To address the mechanisms by which Gli1 progenitor cells contribute to cementogenesis, we used the knock-in line to mark Gli1 progenitors and the ; line (named ) to trace Gli1 progeny cells during cementogenesis. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):310-315

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad; Department of Pathology and Lab Medicine, Basavatharakam Indoamerican Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Background And Aims: Molecular analysis is gold standard for diagnosis of synovial sarcoma (SS) but use of these ancillary techniques is limited by many practical issues like cost and limited resources. Several studies analyzed TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma and few studies disagreed. The objective of the study was to evaluate immunohistochemical expression of TLE1 in synovial sarcoma and its histological mimics. Read More

Aesthetic Plast Surg 2021 Apr 13. Epub 2021 Apr 13.

Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, School of Medicine, Eulji University, 68, Hangeulbiseok-ro, Nowon-gu, Seoul, South Korea.

Background: Hyaluronic acid (HA) fillers have been widely used in humans since 1958 because of their biomedical safety. Restylane was introduced in the1990s as a favorable temporary filler option for facial augmentation. Subsequently, many new HA filler products, including the Sardenyashape, have been introduced, but comparative studies of these products are limited. Read More

Int J Pharm X 2021 Dec 17;3:100076. Epub 2021 Mar 17.

Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, 53121 Bonn, Germany.

Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the matrix and the supersaturated solution. Therefore, we investigated the influence of low-viscosity hydroxypropyl cellulose (HPC) polymers as an additive in HPMC based ternary ASD formulations made by hot-melt extrusion (HME) on the bioavailability of itraconazole (ITZ). The partitioning potential of the different HPC grades was screened in biphasic supersaturation assays. Read More