1,388 results match your criteria biomedical researches

The rise of deep learning and transformations in bioactivity prediction power of molecular modeling tools.

Chem Biol Drug Des 2021 Sep 16. Epub 2021 Sep 16.

Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

The search and design for the better use of bioactive compounds are used in many experiments to best mimic compounds' functions in the human body. However, finding a cost-effective and timesaving approach is a top priority in different disciplines. Nowadays, artificial intelligence (AI) and particularly deep learning (DL) methods are widely applied to improve the precision and accuracy of models used in the drug discovery process. Read More

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September 2021

RoDiCE: robust differential protein co-expression analysis for cancer complexome.

Bioinformatics 2021 Sep 16. Epub 2021 Sep 16.

Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.

Motivation: The full spectrum of abnormalities in cancer-associated protein complexes remains largely unknown. Comparing the co-expression structure of each protein complex between tumor and healthy cells may provide insights regarding cancer-specific protein dysfunction. However, the technical limitations of mass spectrometry-based proteomics, including contamination with biological protein variants, causes noise that leads to non-negligible over- (or under-) estimating co-expression. Read More

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September 2021

Group-guided individual functional parcellation of the hippocampus and application to normal aging.

Hum Brain Mapp 2021 Sep 16. Epub 2021 Sep 16.

State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.

Aging is closely associated with cognitive decline affecting attention, memory and executive functions. The hippocampus is the core brain area for human memory, learning, and cognition processing. To delineate the individual functional patterns of hippocampus is pivotal to reveal the neural basis of aging. Read More

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September 2021

Construction of a damage site-specific fluorescent biosensor for single-molecule detection of DNA damage.

Talanta 2021 Dec 14;235:122809. Epub 2021 Aug 14.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, China. Electronic address:

The 8-oxoguanine (8-oxoG) represents the most common DNA damage type, and it has been regarded as the oxidative stress biomarker, but the reported 8-oxoguanine assays are limited by poor specificity and low sensitivity. Herein, we demonstrate the construction of damage site-specific fluorescent biosensor for 8-oxoG assay by integrating single-molecule detection with hyperbranched signal amplification. In this assay, the 8-oxoG damages in DNA can generate free 3' OH with the assistance of formamidopyrimidine DNA glycosylase (Fpg) and polynucleotide kinase (PNK), which subsequently triggers the incorporation of abundant Cy5-labeled dUTPs via terminal deoxynucleotidyl transferase (TDT)-mediated site-specific hyperbranched nucleic acid amplification. Read More

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December 2021

Computational framework for generating large panoramic super-resolution images from localization microscopy.

Biomed Opt Express 2021 Aug 12;12(8):4759-4778. Epub 2021 Jul 12.

School of Biomedical Engineering, Hainan University, Haikou 570228, China.

Combining super-resolution localization microscopy with pathology creates new opportunities for biomedical researches. This combination requires a suitable image mosaic method for generating a panoramic image from many overlapping super-resolution images. However, current image mosaic methods are not suitable for this purpose. Read More

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Toward new multi-wavelets: associated filters and algorithms. Part I: theoretical framework and investigation of biomedical signals, ECG, and coronavirus cases.

Soft comput 2021 Sep 6:1-21. Epub 2021 Sep 6.

LATIS, Laboratory of Advanced Technology, and Intelligent Systems, Université de Sousse, Ecole Nationale d'Ingénieurs de Sousse, 4023 Sousse, Tunisie.

Biosignals are nowadays important subjects for scientific researches from both theory, and applications, especially, with the appearance of new pandemics threatening the humanity such as the new coronavirus. One aim in the present work is to prove that wavelets may be a successful machinery to understand such phenomena by applying a step forward extension of wavelets to multi-wavelets. We proposed in a first step to improve multi-wavelet notion by constructing more general families using independent components for multi-scaling and multi-wavelet mother functions. Read More

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September 2021

Bioaccessibility-based monitoring and risk assessment of indoor dust-bound PAHs collected from housing and public buildings: Effect of influencing factors.

Environ Res 2021 Sep 9;204(Pt B):112039. Epub 2021 Sep 9.

Department of Environmental Health, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran; Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) bounded in indoor dust have significant effects in residents' health. Although various researches has evaluated exposure to PAHs in some indoor areas around the world, no work has been conducted on bioaccessibility of indoor PAHs in the buildings of Bushehr city. Therefore, dust samples were collected from various indoor microenvironments including residential buildings (RB), office buildings (OB), commercial buildings (CB), industrial buildings (IB), school classroom (SC), laboratory (LR), drugstores (DS), beauty salons (BS), smoking cafés (SC) and restaurants (Res) - 10 from each microenvironment. Read More

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September 2021

Research and Medical Students: Some Notable Contributions Made in History.

JNMA J Nepal Med Assoc 2021 Jan 31;59(233):94-97. Epub 2021 Jan 31.

Nepalese Army Institute of Health Sciences, Sanobharyang, Kathmandu, Nepal.

The practice of medicine has started since the existence of humankind on the earth. But the commencement of scientific and evidence-based medicine cannot be traced back so far. The insight we are getting from the current medical science is the output of the laborious effort and contributions made by people before us. Read More

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January 2021

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals-An Updated Review.

Int J Mol Sci 2021 Sep 4;22(17). Epub 2021 Sep 4.

Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.

In this paper, we review the effects of large-scale neonicotinoid contaminations in the aquatic environment on non-target aquatic invertebrate and vertebrate species. These aquatic species are the fauna widely exposed to environmental changes and chemical accumulation in bodies of water. Neonicotinoids are insecticides that target the nicotinic type acetylcholine receptors (nAChRs) in the central nervous systems (CNS) and are considered selective neurotoxins for insects. Read More

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September 2021

Black Phosphorus Nanosheet Encapsulated by Zeolitic Imidazole Framework-8 for Tumor Multimodal Treatments.

ACS Appl Mater Interfaces 2021 Sep 8. Epub 2021 Sep 8.

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin University of Science and Technology, Tianjin 300457, China.

Black phosphorus (BP) nanosheet is easily oxidized by oxygen and water under ambient environment, thus, reliable BP passivation techniques for biomedical applications is urgently needed. A simple and applicable passivation strategy for biomedical applications was established by encapsulating BP nanosheet into zeolitic imidazole framework-8 (ZIF-8). The resulted BP nanosheet in ZIF-8 ([email protected]) shows not only satisfied chemical stability in both water and phosphate buffered saline (PBS), but also excellent biocompatibility. Read More

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September 2021

Study Design and Rationale for Espera Trial: A Multicentre, Randomized, Phase II Clinical Trial Evaluating the Potential Efficacy of Adding SBRT to Pembrolizumab-Pemetrexed Maintenance in Responsive or Stable Advanced Non-Squamous NSCLC After Chemo-Immunotherapy Induction.

Clin Lung Cancer 2021 Jul 20. Epub 2021 Jul 20.

Section of Oncology, Department of Medicine, University of Verona School of Medicine and Verona University Hospital Trust, Verona, Italy. Electronic address:

Background: Improvement in radiotherapy techniques and expected outcomes, as well as in understanding the underlying biological mechanisms contributing to its action (immunomodulation in primis), led to the integration of this therapeutical approach in the current management of advanced non-small cell lung cancer (NSCLC), not only in oncogene-driven tumors, but also in non-oncogene addicted NSCLC where the combination of platinum-based chemotherapy plus pembrolizumab represents nowadays the pivotal strategy. In this light, we have designed a randomized phase II (ESPERa) trial to evaluate the efficacy and safety of adding Stereotactic Body Radiotherapy (SBRT) to pembrolizumab-pemetrexed maintenance in advanced NSCLC patients experiencing disease response or stability after chemo-immunotherapy induction.

Patients And Methods: Advanced non-oncogene addicted NSCLC patients with ECOG performance status of 0 or 1, who obtained disease response or stability after 4 cycles of platinum-based chemotherapy plus pembrolizumab will be randomized 2:1 to receive pembrolizumab-pemetrexed maintenance plus SBRT vs pembrolizumab-pemetrexed alone. Read More

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The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy .

Bioact Mater 2022 Jan 11;7:263-274. Epub 2021 Jun 11.

School of Materials Science and Engineering, Southeast University, Nanjing, 211189, Jiangsu, China.

The real physiological environment of human body is complicated with different degrees and forms of dynamic loads applied to implanted medical devices due to the daily activities of the patients, which would have impacts on the degradation behaviors of magnesium alloy implants. In this work, the bio-corrosion behaviors of AZ31B magnesium alloy under alternating cyclic dynamic loads with different low frequencies (0.1-2. Read More

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January 2022

[The research progress of bionic scaffolds in ligament tissue engineering].

Fei Xu Lei Zhang

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2021 Aug;38(4):812-818

Biomedical Research Center, Affiliated Calmette Hospital of Kunming Medical University, Kunming 650011, P.R.China.

Ligaments are dense fibrous connective tissue that maintains joint stability through bone-to-bone connections. Ligament tears that due to sports injury or tissue aging usually require surgical intervention, and transplanting autologous, allogeneic, or artificial ligaments for reconstruction is the gold standard for treating such diseases in spite of many drawbacks. With the development of materialogy and manufacturing technology, engineered ligament tissue based on bioscaffold is expected to become a new substitute, which can lead to tissue regeneration by simulating the structure, composition, and biomechanical properties of natural tissue. Read More

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[Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2021 Aug;38(4):797-804

School of Physical Education, China University of Geosciences, Wuhan 430074, P.R.China.

Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. However, many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes. Read More

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[Study on the temperature characteristics of fast capacitance in patch clamp experiments].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2021 Aug;38(4):695-702

Biomedical Optics Laboratory, School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, Liaoning 116000, P.R.China.

Patch clamp is a technique that can measure weak current in the level of picoampere (pA). It has been widely used for cellular electrophysiological recording in fundamental medical researches, such as membrane potential and ion channel currents recording, etc. In order to obtain accurate measurement results, both the resistance and capacitance of the pipette are required to be compensated. Read More

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Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing.

Biologics 2021 21;15:353-361. Epub 2021 Aug 21.

Division of Biochemistry, Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in all living cells and utilized in many applied disciplines. Guide RNA (gRNA) and CRISPR-associated (Cas-9) proteins are the two essential components in CRISPR/Cas-9 system. The mechanism of CRISPR/Cas-9 genome editing contains three steps, recognition, cleavage, and repair. Read More

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Comprehensive evaluation of protein-coding sORFs prediction based on a random sequence strategy.

Front Biosci (Landmark Ed) 2021 Aug;26(8):272-278

Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, 253023 Dezhou, Shandong, China.

: Small open reading frames (sORFs) with protein-coding ability present unprecedented challenge for genome annotation because of their short sequence and low expression level. In the past decade, only several prediction methods have been proposed for discovery of protein-coding sORFs and lack of objective and uniform negative datasets has become an important obstacle to sORFs prediction. The prediction efficiency of current sORFs prediction methods needs to be further evaluated to provide better research strategies for protein-coding sORFs discovery. Read More

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Neural Alterations in Interpersonal Distance (IPD) Cognition and Its Correlation with IPD Behavior: A Systematic Review.

Brain Sci 2021 Jul 30;11(8). Epub 2021 Jul 30.

Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.

Background: Interpersonal distance (IPD) plays a critical role in a human being's social life, especially during interpersonal interaction, and IPD is non-verbal social information and not only provides silent cues but also provides a secure space for personal relationships. IPD has been a research field of neural studies from the recent decade, researches had provided behavior and neural correlates of IPD.

Objectives: This review aims to summarize the experimental paradigms of IPD-neural research, to reveal the neural activity processes associated with it, and to explore the correlation between IPD-neural activity and IPD-behavior. Read More

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Effectiveness and Safety of Acupuncture for Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis.

Front Aging Neurosci 2021 6;13:692508. Epub 2021 Aug 6.

International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.

Acupuncture may be a promising complementary therapy for vascular cognitive impairment (VCI) and has been extensively applied in China. However, its potential effects remain uncertain, and the clinical findings are inconsistent. This review aimed to systematically appraise the overall effectiveness and safety of acupuncture in treating VCI. Read More

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In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications.

J Biomed Mater Res A 2021 Aug 21. Epub 2021 Aug 21.

Bioceramics & Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata, India.

Magnesium (Mg) and its alloys have been widely explored as a potential biodegradable implant material. However, the fast degradation of Mg-based alloys under physiological environment has hindered their widespread use for implant applications till date. The present review focuses on in vitro and in vivo degradation of biodegradable Mg alloys, and preventive measures for biomedical applications. Read More

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Physical Inactivity as a Pandemic: Daily Activities and Dietary Practices.

Tariku Sisay

Risk Manag Healthc Policy 2021 10;14:3287-3293. Epub 2021 Aug 10.

Department of Biomedical Sciences, College of Health Sciences, Mizan Tepi University, Mizan, Ethiopia.

Background: Numerous studies have linked a decline in physical activity (PA) around the world to an increase in chronic diseases. There were two key goals for this study. The first was to observe how daily activities affected physical health in terms of VOmax. Read More

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Harvesting light to produce heat: photothermal nanoparticles for technological applications and biomedical devices.

Chemistry 2021 Aug 18. Epub 2021 Aug 18.

Universita degli Studi di Pavia, Chimica, ITALY.

The photothermal properties of nanoparticles (NP), i.e. their ability to convert absorbed light into heat, have been studied since the end of the past century mainly on gold NP. Read More

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Immunomodulation effect of mesenchymal stem cells in islet transplantation.

Biomed Pharmacother 2021 Aug 14;142:112042. Epub 2021 Aug 14.

College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address:

Mesenchymal stem cells (MSCs) therapy has brought a great enthusiasm to the treatment of various immune disorders, tissue regeneration and transplantation therapy. MSCs are being extensively investigated for their immunomodulatory actions. MSCs can deliver immunomodulatory signals to inhibit allogeneic T cell immune responses by downregulating pro-inflammatory cytokines and increasing regulatory cytokines and growth factors. Read More

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The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome: A meta-analysis and systematic review.

Medicine (Baltimore) 2021 Aug;100(31):e26622

Department of Gynecology, Litongde Hospital of Zhejiang Province, China.

Background: Several previous randomized controlled trials (RCTs) evaluated the efficacy of metformin combined with simvastatin in the treatment of polycystic ovary syndrome (PCOS), yet the results of the researches are not consistent. It is necessary to conduct a meta-analysis to explore the efficacy and safety of metformin combined with simvastatin in the treatment of PCOS, to provide evidence supports for the treatment of PCOS.

Methods: We searched PubMed, EMbase, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and Chinese biomedical literature databases online to identify the RCTs evaluating the efficacy of metformin combined with simvastatin in the treatment of PCOS. Read More

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Dental Implant for Maxillary Cancellous Alveolar Bone with Expandable Transformation in Apical Part.

S Sozkes

Niger J Clin Pract 2021 Aug;24(8):1126-1132

Department of Biomedical Engineering Biomaterials, Corlu Engineering Faculty, Namık Kemal University, Tekirdag, Turkey.

Aim: The focus of this study is to propose a new implant design that will resemble the tooth anatomy as with three roots thus increase the primary stability in bone and open new indications to dental implant applications.

Methods: Developed implant design and control implants were fabricated from Grade 4 type medical titanium. Three different media are selected as similar structural mechanical properties of alveolar cancellous bone quality; bovine iliac bone, bovine spinal bone, and polymer block. Read More

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Effective isolation of Sertoli cells from New Zealand rabbit testis.

J Adv Vet Anim Res 2021 Jun 18;8(2):218-223. Epub 2021 Jun 18.

Animal Histology and Embryology, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China.

Objective: Sertoli cells (SCs) are important sustentacular cells in the seminiferous tubules of the testis. Isolation and identification of SCs are the premise for studying their functions. Since New Zealand rabbit is a stable strain which is widely used for biomedical research and animal farming, this study aimed to develop a simple and effective protocol for SC isolation in New Zealand rabbits. Read More

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The Ratón Pérez collection: Modern deciduous human teeth at the Centro Nacional de Investigación sobre la Evolución Humana (Burgos, Spain).

Am J Phys Anthropol 2021 Aug 12. Epub 2021 Aug 12.

CENIEH (National Research Center on Human Evolution), Paseo de la Sierra de Atapuerca 3, Burgos, Spain.

Objectives: The aim of this report is to present the large deciduous tooth collection of identified children that is housed at the National Research Center on Human Evolution (CENIEH) in Burgos, Spain.

Methods: Yearly, members of the Dental Anthropology Group of the CENIEH are in charge of collecting the teeth and registering all the relevant information from the donors at the time of collection. In compliance with Spanish Law 14/2007 of July 3, 2007, on Biomedical Research (BOE-A-2007-12945), all individuals are guaranteed anonymity and confidentiality. Read More

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Automatic cell counting for phase-contrast microscopic images based on a combination of Otsu and watershed segmentation method.

Microsc Res Tech 2021 Aug 9. Epub 2021 Aug 9.

School of Medicine, Huaqiao University, Quanzhou, China.

Cell counting plays a vital role in biomedical researches. However, manual cell counting is time-consuming, laborious, and low efficiency and has a high counting error rate problem. An automatic counting approach for Hela cells of phase-contrast microscopic images is proposed based on the combination of Otsu and watershed segmentation methods to solve the mentioned issues. Read More

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Tailoring Materials with Specific Wettability in Biomedical Engineering.

Adv Sci (Weinh) 2021 Aug 8:e2100126. Epub 2021 Aug 8.

Institute of Translational Medicine, Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210002, China.

As a fundamental feature of solid surfaces, wettability is playing an increasingly important role in our daily life. Benefitting from the inspiration of biological paradigms and the development in manufacturing technology, numerous wettability materials with elaborately designed surface topology and chemical compositions have been fabricated. Based on these advances, wettability materials have found broad technological implications in various fields ranging from academy, industry, agriculture to biomedical engineering. Read More

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Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine.

Br J Clin Pharmacol 2021 Aug 4. Epub 2021 Aug 4.

Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Aims: Carbamazepine (CBZ) is one of the most common causative drugs of severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reactions with eosinophilia and systemic symptoms. Although genetic polymorphisms of the human leucocyte antigens (HLA) are well recognized key elements for the susceptibility to CBZ-induced SCARs, some evidence suggest that polymorphisms of microsomal epoxide hydrolase 1 (EPHX1) may also contribute to the risk of these SCARs. This study investigated the association between the HLA and EPHX1 polymorphisms on CBZ-induced SCARs in large sample sizes and well-defined SCARs patients. Read More

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