100,811 results match your criteria biomarkers measured


Small RNA-sequencing for Analysis of Circulating miRNAs: Benchmark Study.

J Mol Diagn 2022 Jan 23. Epub 2022 Jan 23.

Laboratory of Gene Expression, Institute of Biotechnology CAS, BIOCEV, 252 50 Vestec, Czech Republic. Electronic address:

Small RNA-sequencing (RNA-Seq) is being increasingly used for profiling of circulating microRNAs (miRNAs), a new group of promising biomarkers. Unfortunately, small RNA-Seq protocols are prone to biases limiting quantification accuracy, which motivated development of several novel methods. Here, we present comparison of all small RNA-Seq library preparation approaches that are commercially available for quantification of miRNAs in biofluids. Read More

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January 2022

RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections.

PLoS One 2022 26;17(1):e0261679. Epub 2022 Jan 26.

Department of Medicine, Division of Genomic Medicine, The George Washington University Medical Center, Washington, DC, United States of America.

Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate disease, up to critically severe. Severe disease, termed COVID-19, involves acute respiratory deterioration that is frequently fatal. To understand the highly variable presentation, and identify biomarkers for disease severity, blood RNA from COVID-19 patient in an intensive care unit was analyzed by whole transcriptome RNA sequencing. Read More

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January 2022

A decrease in serum 1,25(OH)D after elective hip replacement and during bone healing is associated with changes in serum iron and plasma FGF23.

J Endocrinol Invest 2022 Jan 26. Epub 2022 Jan 26.

Institute of Rheumatology, Prague, Czech Republic.

Objective: Although calcitriol is essential for bone healing, its serum concentrations are low after hip surgery, and they continue to decline during bone healing. This study aimed to test the hypothesis of an association of changes in calcitriol production with the status of fibroblast growth factor 23 (FGF23) and iron deficiency after elective hip replacement for coxarthrosis.

Methods: In this prospective study, we measured the biomarkers of 17 patients undergoing elective hip replacement on admission, on the first day after surgery, and at the regular check-up after 48 ± 8 days. Read More

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January 2022

Impact of Social Defeat Stress on DNA Methylation in Drd2, Nr3c1, and Stmn1 in Wild-type and Stmn1 Knock-out Mice.

Clin Psychopharmacol Neurosci 2022 Feb;20(1):51-60

Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Korea.

Objective: Epigenetic profiles can be modified by stress. Dopamine receptor D2 (Drd2), glucocorticoid receptor gene (Nr3c1) and Stathmin 1 (Stmn1) genes are all implicated in adaptation to stress. The aim of study is to investigate impact of social defeat on DNA methylation in Drd2, Nr3c1, and Stmn1 in wild-type (WT) and Stmn1 knock-out (KO) mice. Read More

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February 2022

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy.

J Neurol Neurosurg Psychiatry 2022 Jan 25. Epub 2022 Jan 25.

Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Objectives: This longitudinal study compared emerging plasma biomarkers for neurodegenerative disease between controls, patients with Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP).

Methods: Plasma phosphorylated tau at threonine-181 (p-tau181), amyloid beta (Αβ)42, Aβ40, neurofilament light (NfL) and glial fibrillar acidic protein (GFAP) were measured using highly sensitive single molecule immunoassays (Simoa) in a multicentre cohort of 300 participants (controls=73, amyloid positive mild cognitive impairment (MCI+) and AD dementia=63, LBD=117, FTD=28, PSP=19). LBD participants had known positron emission tomography (PET)-Aβ status. Read More

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January 2022

Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis.

Heart 2022 Jan 25. Epub 2022 Jan 25.

Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Objective: Sudden cardiac death (SCD) is the major cause of death in cardiac sarcoidosis (CS). We aimed to identify the prognostic markers for sustained ventricular tachycardia (sVT) and SCD in patients with CS.

Methods: We performed a prospective observational cohort study for patients with CS diagnosed according to the Japanese or Heart Rhythm Society guidelines between June 2008 and March 2020 in our hospital. Read More

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January 2022

Effects of cinnamaldehyde on glucose-6-phosphate dehydrogenase activity, some biochemical and hematological parameters in diabetic rats.

Biomarkers 2022 Jan 26:1-15. Epub 2022 Jan 26.

Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Biochemistry, 65080 Van, Turkey.

Context: Diabetes is a metabolic disorder related to blood insulin deficiency and high glucose level. Cinnamaldehyde is an important component of cinnamon and has an effect on blood glucose.

Objective: It was aimed to investigate the the effect of cinnamaldehyde on the liver glutathione (GSH), glucose-6-phosphate dehidrogenase (G6PD) activity, blood glucose, protein, lipid and erythrocyte parameters, live weight in diabetic rats. Read More

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January 2022

Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events.

Biomarkers 2022 Jan 26:1-17. Epub 2022 Jan 26.

Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, the Netherlands.

Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS or cardiac death. We used the BIOMArCS case-cohort, consisting of 187 patients who underwent serial blood sampling during one year follow-up post-ACS. Read More

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January 2022

Over a decade of field physiology reveals life-history specific strategies to drought in garter snakes ().

Proc Biol Sci 2022 Jan 26;289(1967):20212187. Epub 2022 Jan 26.

Department of Ecology, Evolution, and Organismal Biology, Iowa State University, 2200 Osborn Drive, 251 Bessey Hall, Ames, IA 50011, USA.

Changing climates and severe weather events can affect population viability. Individuals need to buffer such negative fitness consequences through physiological plasticity. Whether certain life-history strategies are more conducive to surviving changing climates is unknown, but theory predicts that strategies prioritizing maintenance and survival over current reproduction should be better able to withstand such change. Read More

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January 2022

Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia.

Theriogenology 2022 Jan 19;181:113-118. Epub 2022 Jan 19.

Selcuk University, Faculty of Veterinary Medicine, Department of Internal Medicine, Konya, 42003, Turkey.

The objective of the present study was to evaluate the biomarkers specific to lung endothelial and epithelial damage in the determination of lung injury and its severity in calves with perinatal asphyxia and to evaluate their prognostic importance among survivors and non-survivor calves. Ten healthy calves and 20 calves with perinatal asphyxia were enrolled in the study. Clinical examination and laboratory analysis were performed at admission. Read More

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January 2022

Soluble CD40 receptor is a biomarker of the burden of carotid artery atherosclerosis in subjects at high cardiovascular risk.

Atherosclerosis 2022 Jan 19;343:1-9. Epub 2022 Jan 19.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address:

Background And Aims: The severity of the atherosclerotic burden is hardly quantifiable in subjects at high cardiovascular (CV) risk under intensive pharmacological therapy. Several molecules have been proposed as circulating biomarkers of atherosclerosis, but none has emerged as clinically meaningful.

Methods: Circulating proteins involved in inflammation, plaque remodeling, smooth muscle cell migration, apoptosis and endothelial activity were measured by Proximity Extension Assay in the SUMMIT study cohort (n = 1500), including patients with type 2 diabetes (66%) and established CV disease (50%), who underwent ultrasound assessment of carotid atherosclerosis with total plaque area quantification. Read More

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January 2022

Screening and validation of biomarkers for cadmium-induced liver injury based on targeted bile acid metabolomics1.

Environ Pollut 2022 Jan 22:118837. Epub 2022 Jan 22.

The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, China; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Medical College Cancer Center of Lanzhou University, Lanzhou, 730000, Gansu, China; Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou, 730000, Gansu, China. Electronic address:

Although cadmium (Cd) is a toxic heavy metal that reportedly causes liver injury, few studies have investigated biomarkers of Cd-induced liver injury. The purpose of this study is to investigate the role of bile acid (BA) in Cd-induced liver injury and determine reliable and sensitive biochemical parameters for the diagnosis of Cd-induced liver injury. In this study, 48 Sprague-Dawley rats were randomly divided into six groups and administered either normal saline or 2. Read More

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January 2022

Analysis of rheumatoid factor and acute phase proteins using microarrays in patients with rheumatoid arthritis.

Klin Lab Diagn 2022 Jan;67(1):43-47

FSBIS Engelhardt Institute of Molecular Biology, Russian Academy of Sciences.

One of the biomarkers of biggest clinical importance in rheumatoid arthritis (RA) is rheumatoid factor (IgM RF). The rheumatoid factor has insufficient sensitivity and specificity, therefore, to increase the diagnostic information of the test, acute phase proteins were used as concomitant biomarkers. Using biological microchips, we measured IgM RF, C-reactive protein (CRP) and Serum amyloid protein A (SAA) in patients with RA (n = 60), ankylosing spondylitis (AS) (n=55), systemic lupus erythematosus (SLE) (n=20) and healthy donors (HD) (n=9). Read More

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January 2022

Increased Gal-3BP plasma levels in hospitalized patients infected with SARS-CoV-2.

Clin Exp Med 2022 Jan 25. Epub 2022 Jan 25.

Biostructures and Biosystems National Institute (INBB), Rome, Italy.

Coronavirus disease 2019 (COVID-19) has quickly turned into a health, financial and societal problem globally. The complex pathogenesis of severe acute respiratory syndrome coronavirus centers on the unpredictable clinical progression of the disease, which may evolve abruptly and results in critical and life-threatening clinical complications. Effective laboratory biomarkers that can classify patients according to risk of progression to severe disease are essential for ensuring timely treatment. Read More

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January 2022

Prognostic Value of Serum/Plasma Neurofilament Light Chain for COVID-19 Associated Mortality.

medRxiv 2022 Jan 14. Epub 2022 Jan 14.

Given the continued spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), early predictors of coronavirus disease 19 (COVID-19) mortality might improve patients’ outcomes. Increased levels of circulating neurofilament light chain (NfL), a biomarker of neuro-axonal injury, have been observed in patients with severe COVID-19. We investigated whether NfL provides non-redundant clinical value to previously identified predictors of COVID-19 mortality. Read More

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January 2022

Diagnostic Value of Serum Golgi Protein 73 for Liver Inflammation in Patients with Autoimmune Hepatitis and Primary Biliary Cholangitis.

Dis Markers 2022 15;2022:4253566. Epub 2022 Jan 15.

Department of Microbiology & Infectious Disease Center, School of Basic Medicine, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

Background: There is lack of reliable serum biomarkers to reflect the severity of liver necroinflammation for those who suffer autoimmune liver diseases (AILDs). In this study, a previously established patient cohort was used to explore the potential of serum Golgi protein 73 (GP73) as a noninvasive marker of AILD-related liver necroinflammation.

Methods: Serum GP73 concentration was measured in a retrospective cohort of 168 AILD patients, which included 74 patients with autoimmune hepatitis (AIH) and 94 with primary biliary cholangitis (PBC) who had undergone liver biopsy. Read More

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January 2022

Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico.

J Expo Sci Environ Epidemiol 2022 Jan 24. Epub 2022 Jan 24.

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Background: Phthalates have been reported to alter circulating lipid concentrations in animals, and investigation of these associations in humans will provide greater understanding of potential mechanisms for health outcomes.

Objective: To explore associations between phthalate metabolite biomarkers and lipidomic profiles among pregnant women (n = 99) in the Puerto Rico PROTECT cohort.

Methods: We measured 19 urinary phthalate metabolites during 24-28 weeks of pregnancy. Read More

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January 2022

Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects.

Sci Rep 2022 Jan 24;12(1):1192. Epub 2022 Jan 24.

MagQu Co., Ltd., New Taipei City, 231, Taiwan.

Subjects with comorbidities are at risk for neurodegeneration. There is a lack of a direct relationship between comorbidities and neurodegeneration. In this study, immunomagnetic reduction (IMR) assays were utilized to assay plasma Aβ and total tau protein (T-Tau) levels in poststroke (PS, n = 27), family history of Alzheimer's disease (ADFH, n = 35), diabetes (n = 21), end-stage renal disease (ESRD, n = 41), obstructive sleep apnea (OSA, n = 20), Alzheimer's disease (AD, n = 65). Read More

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January 2022

Diagnostic value of different interleukins and procalcitonin in critically ill patients admitted with suspected sepsis.

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):111-116

Department of Critical care and Anesthesia, Institute of Critical Care and Anaesthesiology, Medanta - The Medicity, Gurgaon, Haryana, India.

Background: : Many biomarkers have now been studied such as C-reactive Protein (CRP), procalcitonin (PCT), etc., and are widely used for the diagnosis of sepsis in clinical practice which may determine the appropriate antibiotic treatment. A flowcytometric cytokine bead array (CBA) assay has now been used to determine multiple interleukins (IL), simultaneously. Read More

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January 2022

Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans.

Respir Res 2022 Jan 24;23(1):15. Epub 2022 Jan 24.

Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Background: There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put forward as promising biomarker for COPD in general and emphysema in particular. Here, we measured plasma sRAGE levels using quantitative LC-MS and assessed whether the plasma sRAGE levels associate with (changes in) lung function, radiological emphysema parameters, and radiological subtypes of emphysema. Read More

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January 2022

No association of BMI and body adiposity with cardiometabolic biomarkers among a small sample of reindeer herders of sub-Arctic Finland.

Int J Circumpolar Health 2022 Dec;81(1):2024960

Arctic Centre, University of Lapland, Rovaniemi, Finland.

The rising global obesity rate is alarming due to its real health and socioeconomic consequences. Finland, like other circumpolar regions, is also experiencing a rise in obesity . Here we assess BMI, body adiposity, and measures of cardiometabolic health among a small population of reindeer herders in sub-Arctic Finland. Read More

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December 2022

Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome.

J Bone Miner Metab 2022 Jan 24. Epub 2022 Jan 24.

Department of Statistics and Operations, AMU, Aligarh, Uttar Pradesh, India.

Introduction: Studies suggest an association between poly-cystic ovarian syndrome (PCOS) and chronic periodontitis (CP), both being inflammatory conditions. However, insufficient evidence assesses the impact of this inflammation on bone metabolism and bone turnover markers (BTMs). The present study aimed to determine the association between BTMs, bone mineral density (BMD), and clinical periodontal parameters in PCOS women with CP. Read More

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January 2022

Leaky gut biomarkers in casein- and gluten-rich diet fed rat model of autism.

Transl Neurosci 2021 Jan 31;12(1):601-610. Epub 2021 Dec 31.

Central Research Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, P.O. Box 22452, Riyadh, Saudi Arabia.

It is proposed that gluten- and casein-rich diets (GRD and CRD) can synergistically exacerbate dysbiosis as comorbidity in autism by worsening leaky gut that affects the brain through the gut-brain axis. In this study, 35 young male rats were divided into 7 groups, Group 1 serves as control; Group 2, clindamycin (CL)-treated; and Group 3, propionic acid (PPA)-induced rodent model of autism. These three groups were fed standard diet until the end of the experiment. Read More

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January 2021

Specific genomic alterations and prognostic analysis of perihilar cholangiocarcinoma and distal cholangiocarcinoma.

J Gastrointest Oncol 2021 Dec;12(6):2631-2642

Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Background: Cholangiocarcinoma (CCA), which consists of intrahepatic CCA (iCCA), perihilar CCA (pCCA), and distal CCA (dCCA), is an aggressive malignancy worldwide. PCCA and dCCA are often classified as extrahepatic CCA (exCCA). However, the differences in mutational characteristics between pCCA and dCCA remain unclear. Read More

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December 2021

Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.

Eur J Psychotraumatol 2021 21;12(1):1987655. Epub 2021 Dec 21.

Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Background: About 30% of major depressive disorder (MDD) patients are classified as resistant to treatment (treatment-resistant depression, TRD). Among the factors associated with unfavourable treatment outcomes, stressful life events play a relevant role, and trauma-focused psychotherapy has been successfully proposed for the treatment of patients with a history of such events. Stressful experiences are related to enhanced inflammation and, recently, microRNAs (miRNAs) have emerged as potential mediators of the association between these experiences and psychiatric disorders. Read More

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December 2021

Ultrasonic Elastography of the Rectus Femoris, a Potential Tool to Predict Sarcopenia in Patients With Chronic Obstructive Pulmonary Disease.

Front Physiol 2021 5;12:783421. Epub 2022 Jan 5.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD) and is associated with a poor prognosis. Abnormal muscle quantity of the lower limbs is a manifestation of skeletal muscle dysfunction in patients with COPD. Shear wave ultrasound elastography (SWE) is a novel and possible tool to evaluate qualitative muscle parameters. Read More

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January 2022

Potential Value of Cerebrospinal Fluid Progranulin in the Identification of Postoperative Delirium in Geriatrics Patients Undergoing Knee Replacement: The Perioperative Neurocognitive Disorder and Biomarker LifestylE Study.

Front Aging Neurosci 2021 6;13:772795. Epub 2022 Jan 6.

Department of Anesthesiology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.

The aim of this study was to investigate whether progranulin (PGRN) levels in cerebrospinal fluid (CSF) were associated with postoperative delirium (POD) in geriatric patients undergoing knee replacement. A total of 600 Han Chinese patients aged 65-90 years and who underwent unilateral total knee arthroplasty were included in the Perioperative Neurocognitive Disorder And Biomarker LifestylE (PNDABLE) study from June 2020 to November 2020. All participants were assessed using the Confusion Assessment Method and the Memorial Delirium Assessment Scale on postoperative days 1-7 (or before discharge) by an anesthesiologist. Read More

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January 2022

Multivariate Assessment of Lipoxidative Metabolites, Trace Biometals, and Antioxidant and Detoxifying Activities in the Cerebrospinal Fluid Define a Fingerprint of Preclinical Stages of Alzheimer's Disease.

J Alzheimers Dis 2022 Jan 19. Epub 2022 Jan 19.

Department of Physics, Faculty of Sciences, Universidad de La Laguna, Spain.

Background: There exists considerable interest in the identification of molecular traits during early stages of Alzheimer's disease (AD). Mild cognitive impairment (MCI) is considered the closest prodromal stage of AD, and to develop gradually from earlier stages although not always progresses to AD. Classical cerebrospinal fluid (CSF) AD biomarkers, amyloid-β peptides and tau/p-tau proteins, have been measured in prodromal stages yet results are heterogeneous and far from conclusive. Read More

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January 2022

Prognostic significance of a complement factor H autoantibody in early stage NSCLC.

Cancer Biomark 2022 Jan 14. Epub 2022 Jan 14.

Department of Radiology, Duke University Medical Center, Durham, NC, USA.

Background: Biomarkers that predict which patients with early stage NSCLC will develop recurrent disease would be of clinical value. We previously discovered that an autoantibody to a complement regulatory protein, complement factor H (CFH), is associated with early stage, non-recurrent NSCLC, and hypothesized that the anti-CFH antibody inhibits metastasis.

Objectives: The primary objective of this study was to evaluate the anti-CFH antibody as a prognostic marker for recurrence in stage I NSCLC. Read More

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January 2022

Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection.

Epidemiol Infect 2022 01 7;150:e20. Epub 2022 Jan 7.

Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, UT, USA.

Serosurveillance is an important epidemiologic tool for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), used to estimate infection rates and the degree of population immunity. There is no general agreement on which antibody biomarker(s) should be used, especially with the rollout of vaccines globally. Here, we used random forest models to demonstrate that a single spike or receptor-binding domain (RBD) antibody was adequate for classifying prior infection, while a combination of two antibody biomarkers performed better than any single marker for estimating time-since-infection. Read More

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January 2022