91,733 results match your criteria biomarkers evaluated


Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde.

Environ Int 2021 Sep 21;158:106871. Epub 2021 Sep 21.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA.

Epigenetic aging biomarkers are associated with increased morbidity and mortality. We evaluated if occupational exposure to three established chemical carcinogens is associated with acceleration of epigenetic aging. We studied workers in China occupationally exposed to benzene, trichloroethylene (TCE) or formaldehyde by measuring personal air exposures prior to blood collection. Read More

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September 2021

Bismuth-based nanoparticles impair adipogenic differentiation of human adipose-derived mesenchymal stem cells.

Toxicol In Vitro 2021 Sep 21:105248. Epub 2021 Sep 21.

Rede de Plataformas Tecnológicas FIOCRUZ - Bioensaios com Métodos Alternativos em Citotoxicidade, Instituto Carlos Chagas, FIOCRUZ Paraná, Curitiba, Paraná, Brazil. Electronic address:

Bismuth-based nanoparticles (BiNPs) have attracted attention for their potential biomedical applications. However, there is a lack of information concerning their interaction with biological systems. In this study, it was investigated the effect of physically synthesized BiNPs to human adipose-derived stem cells (ADSCs). Read More

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September 2021

The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation.

Life Sci 2021 Sep 21:119974. Epub 2021 Sep 21.

Pharmacology and Toxicology Dep., Faculty of Pharmacy, Mansoura University, Egypt.

Aims: Chemical renal toxicity is common and has limited therapeutic interventions. The NLRP3 inhibitor dapansutrile (DAPA) undergoes clinical phase II trials and it shows promising beneficial effects in various inflammatory diseases. The current study aims at evaluating the effect of DAPA on folic acid (FA) induced acute kidney injury (AKI) and its possible transition to chronic injury. Read More

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September 2021

Longitudinal Neurocognitive and Pulmonological Profile of Long Covid: the COVIMMUNE-Clin Study Protocol.

JMIR Res Protoc 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Bonn, DE.

Background: There is a dearth of information about "brain fog", concentration, word-finding or memory problems associated with the new World Health Organization provisional classification "U09.9 Post-COVID-19 Condition." Beyond this, the extent to which these symptoms may be associated with neurological, pulmonary or psychiatric difficulties is unclear. Read More

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September 2021

Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.

J Magn Reson Imaging 2021 Sep 24. Epub 2021 Sep 24.

Neurovascular Surgery Program, Department of Neurosurgery, University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.

Background: Cerebral cavernous angioma (CA) is a capillary vasculopathy affecting more than a million Americans with a small fraction of cases demonstrating lesional bleed or growth with major clinical sequelae. Perfusion and permeability are fundamental features of CA pathophysiology, but their role as prognostic biomarkers is unclear.

Purpose: To investigate whether perfusion or permeability lesional descriptors derived from dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging (MRI) can predict subsequent lesional bleed/growth in the year following imaging. Read More

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September 2021

Doppler Ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds.

Br J Clin Pharmacol 2021 Sep 23. Epub 2021 Sep 23.

Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium.

Aim: In search of non-invasive biomarkers to assess the pharmacodynamic effects of portal pressure-lowering drugs, the reproducibility of flow measurements in the superior mesenteric artery (SMA) was evaluated using Doppler ultrasound.

Methods: A reproducibility study was conducted in 15 healthy male volunteers (18-50 years). Per subject, eight ultrasound measurements were performed: two observers each conducted two measurements during two separate visits. Read More

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September 2021

Radiomic Features Associated With HPV Status on Pretreatment Computed Tomography in Oropharyngeal Squamous Cell Carcinoma Inform Clinical Prognosis.

Front Oncol 2021 7;11:744250. Epub 2021 Sep 7.

Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, United States.

Purpose: There is a lack of biomarkers for accurately prognosticating outcome in both human papillomavirus-related (HPV+) and tobacco- and alcohol-related (HPV-) oropharyngeal squamous cell carcinoma (OPSCC). The aims of this study were to i) develop and evaluate radiomic features within (intratumoral) and around tumor (peritumoral) on CT scans to predict HPV status; ii) investigate the prognostic value of the radiomic features for both HPV- and HPV+ patients, including within individual AJCC eighth edition-defined stage groups; and iii) develop and evaluate a clinicopathologic imaging nomogram involving radiomic, clinical, and pathologic factors for disease-free survival (DFS) prediction for HPV+ patients.

Experimental Design: This retrospective study included 582 OPSCC patients, of which 462 were obtained from The Cancer Imaging Archive (TCIA) with available tumor segmentation and 120 were from Cleveland Clinic Foundation (CCF, denoted as S) with HPV+ OPSCC. Read More

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September 2021

Preoperative Prediction of Microvascular Invasion in Patients With Hepatocellular Carcinoma Based on Radiomics Nomogram Using Contrast-Enhanced Ultrasound.

Front Oncol 2021 7;11:709339. Epub 2021 Sep 7.

Department of Internal Medicine, Hirslanden Clinic, Bern, Switzerland.

Purpose: This study aimed to develop a radiomics nomogram based on contrast-enhanced ultrasound (CEUS) for preoperatively assessing microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.

Methods: A retrospective dataset of 313 HCC patients who underwent CEUS between September 20, 2016 and March 20, 2020 was enrolled in our study. The study population was randomly grouped as a primary dataset of 192 patients and a validation dataset of 121 patients. Read More

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September 2021

A Cornflower Extract Containing -Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX.

Mediators Inflamm 2021 13;2021:6652791. Epub 2021 Sep 13.

Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.

Thymus and Activation-Regulated Chemokine (TARC/CCL17) and Macrophage-Derived Chemokine (MDC/CCL22) are two key chemokines exerting their biological effect binding and activating a common receptor CCR4, expressed at the surface of type 2 helper T (Th2) cells. By recruiting Th2 cells in the dermis, CCL17 and CCL22 promote the development of inflammation in atopic skin. The aim of this research was to develop a plant extract whose biological properties, when applied topically, could be beneficial for people with atopic-prone skin. Read More

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September 2021

Clinical Utility of Urinary Biomarkers for Prediction of Acute Kidney Injury and Chronic Renal Dysfunction After Open Abdominal Aortic Aneurysm Repair.

Int J Nephrol Renovasc Dis 2021 17;14:371-384. Epub 2021 Sep 17.

Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Purpose: We examined the clinical utility of perioperative monitoring of urinary liver-type fatty acid binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), and albumin, for prediction of acute kidney injury (AKI) and prediction of chronic renal dysfunction in patients undergoing open surgical repair (OSR) of an abdominal aortic aneurysm.

Patients And Methods: Urine and serum samples were obtained perioperatively from 64 such patients (=64). Patients in whom OSR-related AKI (defined by the Kidney Disease Improving Global Outcomes criteria) occurred were identified. Read More

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September 2021

Adrenal steroids reference ranges in infancy determined by LC-MS/MS.

Pediatr Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Pediatric Endocrinology and Diabetes, School of Medicine, Marmara University, Istanbul, Turkey.

Background: Interpretation of the results of steroid hormone measurements is challenging at early infancy. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) method provides a powerful tool for diagnosing steroidogenesis disorders. We aimed to develop normative data for a 14-steroid panel and four adrenal enzyme activity indices, determined by LC-MS/MS from 3 days to 6 months of age. Read More

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September 2021

Histology to 3D in vivo MR registration for volumetric evaluation of MRgFUS treatment assessment biomarkers.

Sci Rep 2021 Sep 23;11(1):18923. Epub 2021 Sep 23.

Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, USA.

Advances in imaging and early cancer detection have increased interest in magnetic resonance (MR) guided focused ultrasound (MRgFUS) technologies for cancer treatment. MRgFUS ablation treatments could reduce surgical risks, preserve organ tissue and function, and improve patient quality of life. However, surgical resection and histological analysis remain the gold standard to assess cancer treatment response. Read More

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September 2021

Extracellular vesicles in seminal fluid and effects on male reproduction. An overview in farm animals and pets.

Anim Reprod Sci 2021 Sep 16:106853. Epub 2021 Sep 16.

Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, IT-40064 Bologna, Italy.

Extracellular vesicles (EVs) are lipid bilayer nanovesicles released by most functional cells to body fluids, containing bioactive molecules, mainly proteins, lipids, and nucleic acids having actions at target cells. The EVs have essential functions in cell-to-cell communication by regulating different biological processes in target cells. Fluids from the male reproductive tract, including seminal plasma, contain many extracellular vesicles (sEVs), which have been evaluated to a lesser extent than those of other body fluids, particularly in farm animals and pets. Read More

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September 2021

Development of a 3-transcript host expression assay to differentiate between viral and bacterial infections in pigs.

PLoS One 2021 23;16(9):e0256106. Epub 2021 Sep 23.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, SLU, Uppsala, Sweden.

Indiscriminate use of antibiotics to treat infections that are of viral origin contributes to unnecessary use which potentially may induce resistance in commensal bacteria. To counteract this a number of host gene transcriptional studies have been conducted to identify genes that are differently expressed during bacterial and viral infections in humans, and thus could be used as a tool to base decisions on the use of antibiotics. In this paper, we aimed to evaluate the potential of a selection of genes that have been considered biomarkers in humans, to differentially diagnose bacterial from viral infections in the pig. Read More

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September 2021

Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.

Magn Reson Med 2021 Sep 23. Epub 2021 Sep 23.

Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Purpose: To evaluate the precision profile (repeatability and reproducibility) of quantitative STEAM-MRS and to determine the relationships between multiple MR biomarkers of chronic liver disease in subjects with iron overload at both 1.5 Tesla (T) and 3T.

Methods: MRS data were acquired in patients with known or suspected liver iron overload. Read More

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September 2021

Temporal variations in glucose level, oxidative stress and antioxidant profile of Koi carps (Cyprinus carpio var koi) in response to hypoxic tolerance.

Authors:
Proteek Dasgupta

Biol Futur 2021 Feb 2. Epub 2021 Feb 2.

Department of Zoology, Bangalore University, Jnana Bharathi Campus, Bengaluru, 560056, India.

Biochemical analyses were conducted temporally to understand the impact of prolonged hypoxic environment on gill and white muscle of juvenile Koi carps (Cyprinus carpio var koi). The 16-day study involved quantification of Glucose (GLU), oxidative stress (Lipid Peroxidation-LPO) and antioxidant profile (Catalase-CAT, Glutathione-GSH, Glutathione-S-Transferase-GST) every 96th hour to understand the physiological consequences of hypoxic environment compared to normoxia (Control). There was no mortality throughout the study period, however, fishes were physically exhausted and exhibited Aquatic Surface Respiration (ASR) after day 8. Read More

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February 2021

Plasma calprotectin in the emergency department: a potential clinical biomarker for patients with infectious diseases.

Scand J Clin Lab Invest 2021 Sep 23:1-5. Epub 2021 Sep 23.

Department of Emergency and Internal Medicine, Skånes University Hospital, Malmö, Sweden.

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Read More

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September 2021

The Immune Landscape of Chinese Head and Neck Adenoid Cystic Carcinoma and Clinical Implication.

Front Immunol 2021 6;12:618367. Epub 2021 Sep 6.

Radiotherapy Division, Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Novel systemic agents and effective treatment strategies for recurrence adenoid cystic carcinoma (ACC) of the head and neck are still worthy of further exploration. Here, we analyzed the mutations and expression profiles of 75 Chinese ACC patients, characterized the prognostic value of the immune signature for recurrence or distant metastasis, and explored the potential of immunotherapeutic biomarkers in ACC. In general, MYB fusion and somatic mutations accounted for a high proportion, which was 46. Read More

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September 2021

The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review.

Front Endocrinol (Lausanne) 2021 6;12:668417. Epub 2021 Sep 6.

Division of Obstetrics and Prenatal Diagnosis, Erasmus University Medical Centre, Rotterdam, Netherlands.

Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Read More

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September 2021

(L.) Schott Flower Extract Alleviates Oxidative Stress and Inflammatory Factors in the Adjuvant-Induced Arthritis Rat Model.

J Pain Res 2021 14;14:2907-2919. Epub 2021 Sep 14.

Department of Research, Characteristic Medical Center of PAP, Tianjin, 300162, People's Republic of China.

Introduction: This research was to evaluate the beneficial effects of (L.) Schott flower extract (SJF) on the adjuvant-induced arthritis rat model.

Methods: Arthritis was evoked by injection of complete Freund's adjuvant (CFA) in the hind paw. Read More

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September 2021

FDG PET biomarkers for prediction of survival in metastatic melanoma prior to anti-PD1 immunotherapy.

Sci Rep 2021 Sep 22;11(1):18795. Epub 2021 Sep 22.

Nuclear Medicine Department, Jean Perrin Cancer Center of Clermont-Ferrand, Clermont-Ferrand, France.

Our aim was to analyse whether biomarkers extracted from baseline F-FDG PET before anti-PD1 treatment contribute to prognostic survival information for early risk stratification in metastatic melanoma. Fifty-six patients, without prior systemic treatment, BRAF wild type, explored using F-FDG PET were included retrospectively. Our primary endpoint was overall survival (OS). Read More

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September 2021

Comparison of individual and combination treatments with naproxen, prednisolone and hydroxychloroquine to treat Complete Freund's Adjuvant induced arthritis.

Inflammopharmacology 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah, 21442, Saudi Arabia.

Aim of this study was to evaluate and compare the efficacy of anti-arthritic drugs (naproxen, prednisolone, and hydroxychloroquine) alone and in combination. The in vitro anti-arthritic activity was evaluated by stabilization of human erythrocytes (HRBCs) membrane assays. In vivo activity was carried out using Complete Freund's Adjuvant (CFA) induced arthritic model in Wistar rat. Read More

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September 2021

Efficacy of subsp. , BB-12 on infant colic - a randomised, double-blinded, placebo-controlled study.

Benef Microbes 2021 Sep 22:1-10. Epub 2021 Sep 22.

Department of Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Riyue Avenue, Qingyang District, Chengdu, 6100131, China P.R.

To evaluate the administration of subsp. , BB-12 (BB-12) on infant colic in breastfed infants, a double-blind, placebo-controlled randomised study was conducted in Chengdu, China from April 2016 to October 2017 with 192 full-term infants less than 3 months of age and meeting the ROME III criteria for infant colic. After a 1-week run-in the infants were randomly assigned to receive daily BB-12 (1×10 cfu/day) or placebo for 3 weeks. Read More

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September 2021

The Gastric Conduction System in Health and Disease: A Translational Review.

Am J Physiol Gastrointest Liver Physiol 2021 Sep 22. Epub 2021 Sep 22.

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Canada.

Gastric peristalsis is critically dependent on an underlying electrical conduction system. Recent years have witnessed substantial progress in clarifying the operations of this system, including its pacemaking units, its cellular architecture, and slow wave propagation patterns. Advanced techniques have been developed for assessing its functions at high spatiotemporal resolutions. Read More

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September 2021

Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures.

NPJ Genom Med 2021 Sep 21;6(1):76. Epub 2021 Sep 21.

Department of Human Oncology, University of Wisconsin, Madison, WI, USA.

We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGETS). Read More

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September 2021

Association between diffusion tensor imaging findings and domain-specific cognitive impairment in cerebral small vessel disease: a protocol for systematic review and meta-analysis.

BMJ Open 2021 Sep 21;11(9):e049203. Epub 2021 Sep 21.

Department of Neurology, Hunan University of Chinese Medicine Integrated Chinese Medicine Affiliated Hospital, Changsha, Hunan, China

Introduction: Cognitive impairment is the main clinical manifestation of cerebral small vessel disease (CSVD). However, the mechanism and structural damage in different domains of cognitive disorders are poorly understood. There is an urgent need to quantify the relation between diffusion tensor imaging (DTI) data and impaired cognitive testing in CSVD, which may help to find biomarkers for early diagnosis or treatment evaluation. Read More

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September 2021

Mode of Delivery, Birth Characteristics and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study.

Cancer Epidemiol Biomarkers Prev 2021 Sep 20. Epub 2021 Sep 20.

Chronic Disease Epidemiology, Yale School of Public Health

Background: The etiology of non-Hodgkin lymphoma (NHL) in children, adolescents, and young adults (AYA) is not well-understood.

Methods: We evaluated potential associations between mode of delivery, birth characteristics and NHL risk in a population-based case-control study, which included 3,064 cases of NHL (490 with Burkitt lymphoma, 981 with diffuse large B-cell lymphoma [DLBCL], and 978 with T-cell NHL) diagnosed at the age of 0-37 years in California during 1988-2015 and 153,200 controls frequency-matched on year of birth. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from an unconditional multivariable logistic regression model that included year of birth and birth characteristics. Read More

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September 2021

Whole-body PET imaging of T cell response to Glioblastoma.

Clin Cancer Res 2021 Sep 21. Epub 2021 Sep 21.

Radiology, Stanford University.

Purpose: Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in glioblastoma patients treated with immunotherapy. Here, the utility of OX40, a co-stimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a positron emission tomography (PET) imaging biomarker to quantify and track response to immunotherapy.

Experimental Design: A subcutaneous vaccination approach of CpG oligodeoxynucleotide, OX40 mAb, and tumor lysate at a remote site in a murine orthotopic glioma model was developed to induce activation of T cells distantly while monitoring their distribution in stimulated lymphoid organs with respect to observed therapeutic effects. Read More

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September 2021

Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia.

J Pediatr 2021 Sep 18. Epub 2021 Sep 18.

Section of Neonatology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR.

Objective: To evaluate the predictive performance of urine biomarkers for acute kidney injury (AKI) in neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia.

Study Design: We performed a multicenter prospective observational study of 64 neonates. Urine was obtained at 12, 24, 48, and 72 hours of life and evaluated for neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C, interleukin 18 (IL-18), tissue inhibitor of metalloproteinases 2 (TIMP2), insulin like growth factor binding protein 7 (IGFBP7). Read More

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September 2021

Microfluidic Platform to Transduce Cell Viability to Distinct Flow Pathways for High-Accuracy Sensing.

ACS Sens 2021 Sep 21. Epub 2021 Sep 21.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

Mechanical properties of cells such as stiffness can act as biomarkers to sort or detect cell functional properties such as viability. In this study, we report the use of a microfluidic device as a high-sensitivity sensor that transduces cell biomechanics to cell separation to accurately detect viability. Cell populations are flowed and deflected at a number of skew ridges such that deflection per ridge, cell-ridge interaction time, and cell size can all be used as sensor inputs to accurately determine the cell state. Read More

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September 2021