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DNA Repair (Amst) 2021 Apr 1;102:103112. Epub 2021 Apr 1.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin, 300052, China; Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin, 300052, China. Electronic address:

Ovarian cancer has a poor prognosis due to drug resistance, relapse and metastasis. In recent years, immunotherapy has been applied in numerous cancers clinically. However, the effect of immunotherapy monotherapy in ovarian cancer is limited. Read More

J Hazard Mater 2021 Mar 30;416:125770. Epub 2021 Mar 30.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Beijing 100193, China. Electronic address:

The wide application of mesosulfuron-methyl (MS) in soil may affect soil microbial community, yet the information is limited. In this work, two distinct soil types from Anyang (AY) and Nanjing (NJ) were spiked with MS (0, 0.006, 0. Read More

Biomed Pharmacother 2021 Apr 7;139:111572. Epub 2021 Apr 7.

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address:

Long non-coding RNAs (lncRNAs) represent a group of ncRNAs with more than 200 nucleotides. These RNAs can specifically regulate gene expression at both the transcriptional and the post-transcriptional levels, and increasing evidence indicates that they play vital roles in a variety of disease-related cellular processes. The lncRNA GAS8 antisense RNA 1 (GAS8-AS1, also known as C16orf3) is located in the second intron of GAS8 and has been reported to be both abnormally expressed in several diseases and closely correlated with many clinical characteristics. Read More

Aquat Toxicol 2021 Mar 12;235:105807. Epub 2021 Mar 12.

US Environmental Protection Agency, Office of Research and Development, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, United States. Electronic address:

The number of chemicals requiring risk evaluation exceeds our capacity to provide the underlying data using traditional methodology. This has led to an increased focus on the development of novel approach methodologies. This work aimed to expand the panel of gene expression-based biomarkers to include responses to estrogens, to identify training strategies that maximize the range of applicable concentrations, and to evaluate the potential for two classes of small non-coding RNAs (sncRNAs), microRNA (miRNA) and piwi-interacting RNA (piRNA), as biomarkers. Read More

Lung Cancer 2021 Mar 26;155:170-174. Epub 2021 Mar 26.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China; Jiangxi Key Laboratory of Clinical Translational Cancer Research, Nanchang, Jiangxi Province, China. Electronic address:

Pulmonary pleomorphic carcinoma (PPC) is a rare and highly malignant subtype of non-small-cell lung cancer (NSCLC), and chemotherapy and radiotherapy are insensitive. Some clinical trials have shown that targetable driver gene mutations, such as EGFR, ALK or BRAF, have rarely been detected in PPC patients, but the incidence of MET exon 14 mutations is more frequent. For these patients with driver gene mutations, corresponding molecular targeted therapy may be valid. Read More

Ecotoxicol Environ Saf 2021 Apr 7;216:112202. Epub 2021 Apr 7.

Nature Research Centre, Laboratory of Geoenvironmental Research, Akademijos St. 2, LT-08412 Vilnius, Lithuania; Vilnius University, Faculty of Chemistry and Geosciences, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.

The present study tested the biological consequences of exposure to a multimetal mixture as a multiple chemical stressor on Oncorhynchus mykiss at molecular, cellular, physiological and whole-organism levels and on biomarker responses of this fish during the depuration period. To represent environmentally relevant multiple chemical stressors, in our study, we used the mixture of Zn, Cu, Ni, Cr, Pb and Cd at the concentrations corresponding to Maximum-Permissible-Concentrations (MPCs) acceptable for the EU inland waters. This study was undertaken with a view to elucidate if changes in the MPC of the test mixture components (Ni, Pb, Cd) could cause significantly different biomarker responses in O. Read More

Environ Pollut 2021 Mar 31;282:117036. Epub 2021 Mar 31.

Department of Biology, University of Nevada, Reno, Reno, NV, USA.

Artificial light is transforming the nighttime environment and quickly becoming one of the most pervasive pollutants on earth. Across taxa, light entrains endogenous circadian clocks that function to synchronize behavioral and physiological rhythms with natural photoperiod. Artificial light at night (ALAN) disrupts these photoperiodic cues and has consequences for humans and wildlife including sleep disruption, physiological stress and increased risk of cardiovascular disease. Read More

Food Chem 2021 Feb 23;353:129366. Epub 2021 Feb 23.

Istituto Zooprofilattico Sperimentale delle Venezie, Department of Chemistry, Legnaro (PD), Italy.

Surveillance of illegal use of growth promoters such as β-agonists in food producing animals rely on the detection of drug residues by LC-MS/MS. Screening strategies focusing on indirect physiological responses following administration of active compounds are promising approaches to strengthen existing targeted methods and ensure food safety. A metabolomics analysis based on LC-HRMS was carried out on liver extracts from bulls experimentally treated with clenbuterol combined with dexamethasone (n = 8) to mimic a potential anabolic practice, and control animals (n = 8). Read More

Eur J Cancer 2021 Apr 7;149:94-101. Epub 2021 Apr 7.

Digital Biomarkers for Oncology Group, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany. Electronic address:

Background: Clinicians and pathologists traditionally use patient data in addition to clinical examination to support their diagnoses.

Objectives: We investigated whether a combination of histologic whole slides image (WSI) analysis based on convolutional neural networks (CNNs) and commonly available patient data (age, sex and anatomical site of the lesion) in a binary melanoma/nevus classification task could increase the performance compared with CNNs alone.

Methods: We used 431 WSIs from two different laboratories and analysed the performance of classifiers that used the image or patient data individually or three common fusion techniques. Read More

Eur J Cancer 2021 Apr 7;149:82-90. Epub 2021 Apr 7.

ANSM Agence Nationale de Sécurité des Médicaments Direction Onco-hématologie et Thérapie Cellulaire, 147 Boulevard Anatole France, Saint-Denis, France; Avec Groupe Hospitalier Mutualiste de Grenoble - Institut Daniel Hollard, 8, Rue Docteur Calmette, 38028 Grenoble cedex 1, France. Electronic address:

Introduction: The cancer incidence continues to rise worldwide. Medical innovation has a major impact on patient survival, but within drug development, it can take more than 10 years to obtain marketing authorisation (MA). The time required for access to therapeutic innovation remains critical, so France has developed a specific expanded access program named ATU, which allows the administration of drugs before the European Medicines Agency (EMA) approval. Read More

Int J Biochem Cell Biol 2021 Apr 7:105975. Epub 2021 Apr 7.

Tianjin International Joint Research and Development Center of Ophthalmology and Vision Science, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin, 300384, China. Electronic address:

Early diagnosis and precise monitoring of the development of proliferative diabetic retinopathy (PDR) can significantly improve therapeutic strategies and help decrease blindness caused by it. Extracellular vesicles (EVs) were recently found to be involved in intercellular communications and are a potential source for the discovery of novel biomarkers. The current study aims to investigate the effectiveness of microRNAs (miRNAs) encapsulated in small EVs (sEVs) as minimally invasive biomarkers for PDR. Read More

Int J Antimicrob Agents 2021 Apr 7:106334. Epub 2021 Apr 7.

Research & Innovation Centre, King Saud Medical City, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

Objective: To assess the efficacy of therapeutic plasma exchange (TPE) following life-threatening COVID-19.

Design, Setting, And Participants: Open-label, randomized clinical trial of intensive care unit (ICU) patients with life-threatening COVID-19 [positive real-time-polymerase-chain-reaction test, plus acute respiratory distress syndrome (ARDS), sepsis, organ failure, hyperinflammation]. The study was terminated after 87/120 patients were enrolled. Read More

Int J Radiat Oncol Biol Phys 2021 Apr 7. Epub 2021 Apr 7.

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Purpose: Recent pre-clinical studies suggest combining the HSP90 inhibitor AT13387 (Onalespib) with radiation (IR) against colon cancer and HNSCC. These studies emphasized that AT13387 down-regulates HSP90 client proteins involved in oncogenic signaling and DNA repair mechanisms as major drivers of enhanced radiosensitivity. Given the large array of client proteins HSP90 directs, we hypothesized that other key proteins or signaling pathways may be inhibited by AT13387 and contribute to enhanced radiosensitivity. Read More

Int J Biol Macromol 2021 Apr 7. Epub 2021 Apr 7.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Algal polysaccharide activates macrophages to alter physiologic biomarkers to drive the immunomodulatory phenotype, but it lacks specific biomarkers involved in the biochemical underpinning process. Here, we undertook an extensive analysis of the RAW 264.7 macrophages induced by an immunostimulating sulfated polysaccharide from Caulerpa racemosa var. Read More

Food Chem Toxicol 2021 Apr 7:112175. Epub 2021 Apr 7.

Environmental Toxicology Program, Clemson University, Clemson, SC, 29634. Electronic address:

PFOS is a persistent, fluorosurfactant used in multiple products. Murine Cyp2b's are induced by PFOS and high-fat diets (HFD) and therefore we hypothesized that human CYP2B6 may alleviate PFOS-induced steatosis. Cyp2b-null and hCYP2B6-Tg mice were treated with 0, 1, or 10mg/kg/day PFOS by oral gavage for 21-days while provided a chow diet (ND) or HFD. Read More

Resuscitation 2021 Apr 7. Epub 2021 Apr 7.

Emergency Medicine, Geisinger Commonwealth School of Medicine Residency Research Director, Guthrie Robert Packer Emergency Medicine Residency, United States. Electronic address:

Clin Chim Acta 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao266000, China. Electronic address:

Background: In recent years, LRG1 was found to be closely related to atrial fibrillation, heart failure, and myocardial remodeling after myocardial infarction. While its role in cerebral infarction was still controversial. We aimed to explore the value of LRG1 to identify the cardioembolic stroke. Read More

Cancer Med 2021 Apr 10. Epub 2021 Apr 10.

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Recent studies have identified microRNAs (miRNAs) as a compelling novel class of biomarker in colorectal cancer (CRC) development and metastasis. Here, we demonstrated that the level of plasma exosomal miR-140-3p in CRC patients was lower than that in healthy controls. The decreased miR-140-3p level was also observed in CRC patients with liver metastasis. Read More

Mol Biol Rep 2021 Apr 10. Epub 2021 Apr 10.

Biochemistry Division of Chemistry Department, Faculty of Science, Menoufia University, Menoufia, Egypt.

One of the most recent of tumor molecular characterization approaches is the microRNA (miR) expression profile. No single marker is sufficiently accurate for clinical use. Numerous biomarkers panels were created for three main purposes: tumor subtype, classification and, early detection, and prediction of tumor responses to treatment and prognosis of patients. Read More

Clin Exp Med 2021 Apr 10. Epub 2021 Apr 10.

Department of 3rd General Surgery, The Fourth Affiliated Hospital of China Medical University, Chongshan East Road in Huanggu District, Shenyang, Liaoning, 11032, China.

MiR-1253 has been reported to play vital roles in a variety of cancers. However, its function in the progression and prognosis of colon cancer remains unclear. Here, the clinical significance and biological function of miR-1253 in the development of colon cancer was investigated. Read More

Biogerontology 2021 Apr 10. Epub 2021 Apr 10.

Department of Medical Sciences, iBiMED - Institute of Biomedicine, University of Aveiro, 3810-193, Aveiro, Portugal.

Life expectancy, and longevity have been increasing in recent years. However, this is, in most cases, accompanied by age-related diseases. Thus, it became essential to better understand the mechanisms inherent to aging, and to establish biomarkers that characterize this physiological process. Read More

J Cancer Res Clin Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

Purpose: Immune checkpoint inhibitors (ICI) are highly effective in several cancer entities, but also invoke a variety of immune-related adverse events (irAE). These are mostly reversible, but can be life-threatening or even fatal. Currently, the pathogenesis is not fully understood, but crucial for effective treatment. Read More

J Clin Endocrinol Metab 2021 Apr 10. Epub 2021 Apr 10.

Department of Medicine, Division of Endocrinology and Center for Endocrine Tumors Leiden (CETL), Leiden University Medical Center, Leiden, The Netherlands.

Context: Serum inflammation-based scores reflect systemic inflammatory response and/or patients' nutritional status, and may predict clinical outcomes in cancer. While these are well-described and increasingly used in different cancers, their clinical usefulness in the management of patients with endocrine tumors is less known.

Evidence Acquisition: A comprehensive PubMed search was performed using the terms "endocrine tumor", "inflammation", "serum inflammation-based score", "inflammatory-based score", "inflammatory response-related scoring", "systemic inflammatory response markers", "Neutrophil-to-lymphocyte ratio", "Neutrophil-to-platelet ratio", "Lymphocyte-to-monocyte ratio", "Glasgow Prognostic Score", "Neutrophil-Platelet Score", "Systemic Immune-Inflammation Index", and "Prognostic Nutrition Index" in clinical studies. Read More

J Crohns Colitis 2021 Apr 10. Epub 2021 Apr 10.

Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Background: Real-life-data regarding pharmacokinetics of vedolizumab in patients needing dose-optimization are scarce. We set to examine whether pre-optimization vedolizumab-levels associate with therapy-outcomes and which mechanisms explain the associations.

Methods: A multi-center observational study assessed the outcome of dose-increase in association with pre-escalation levels in vedolizumab-treated patients. Read More

Int J Lab Hematol 2021 Apr 9. Epub 2021 Apr 9.

Section of Hematology, Department of Pathology, Shifa International Hospital, Islamabad, Pakistan.

Introduction: Outbreak of corona virus disease in 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Our aim is to document hematological parameters of patients with COVID-19 during initial stage of diagnosis and to identify early hematological indicators of severe infection.

Materials And Methods: This retrospective study was conducted at Shifa International Hospital, Pakistan from April to November 2020. Read More

Oral Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, No.1677 Wutaishan Road, Qingdao, 266003, China.

Objective: Medication-related osteonecrosis of the jaw (MRONJ) is the main adverse side effect of bisphosphonates (BPs), mainly owing to the inhibitory effect of BPs on osteoclastogenesis. CircRNAs were identified to be an important factor in regulating cellular processes. The aim of this study was to explore the effect of mmu_circ_0001066 on BP-inhibited osteoclastogenesis. Read More

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.

Increasing evidences have showed that autophagy played a significant role in oral squamous cell carcinoma (OSCC). Purpose of our study was to explore the prognostic value of autophagy-related genes (ATGs) and screen autophagy-related biomarkers for OSCC. RNA-seq and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database following extracting ATG expression profiles. Read More

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.

Plexin D1 (PLXND1), which was previously thought to mediate semaphorin signalling, belongs to the Plexin family of transmembrane proteins. PLXND1 cooperates mostly with the coreceptor neuropilin and participates in many aspects of axonal guidance. PLXND1 can also act as both a tumour promoter and a tumour suppressor. Read More

Glob Chang Biol 2021 Apr 10. Epub 2021 Apr 10.

Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada.

Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high-resolution mass spectrometry based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species-Arctic char (Salvelinus alpinus), with a detailed multi-tissue analysis of the lipidome in response to chronic shifts in temperature by use of a validated lipidomics workflow. Read More

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Low-grade gliomas (LGGs) are grade III gliomas based on the WHO classification with significant genetic heterogeneity and clinical properties. Traditional histological classification of gliomas has been challenged by the improvement of molecular stratification; however, the reproducibility and diagnostic accuracy of LGGs classification still remain poor. Herein, we identified fatty acid binding protein 5 (FABP5) as one of the most enriched genes in malignant LGGs and elevated FABP5 revealed severe outcomes in LGGs. Read More