298,418 results match your criteria biological properties


Biphenylene monolayer as a two-dimensional nonbenzenoid carbon allotrope: A first-principles study.

J Phys Condens Matter 2021 Sep 27. Epub 2021 Sep 27.

Semiconductors, Linkoping University Department of Physics Chemistry and Biology, Linkoping, Linkoping, 581 83, SWEDEN.

In a very recent accomplishment, the two-dimensional form of Biphenylene network (BPN) has been fabricated. Motivated by this exciting experimental result on 2D layered BPN structure, herein we perform detailed density functional theory-based first-principles calculations, in order to gain insight into the structural, mechanical, electronic and optical properties of this promising nanomaterial. Our theoretical results reveal the BPN structure is constructed from three rings of tetragon, hexagon and octagon, meanwhile the electron localization function shows very strong bonds between the C atoms in the structure. Read More

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September 2021

Modified lignite and black coal reduce ammonia volatilization from cattle manure.

J Environ Manage 2021 Sep 24;301:113807. Epub 2021 Sep 24.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Victoria, 3010, Australia. Electronic address:

Modified lignite and black coal (BC) are potential amendments for animal bedding to abate ammonia (NH) emissions due to their large adsorption capacities for ammoniacal nitrogen (N). However, the ability of modified lignite and BC in reducing NH volatilization from livestock manure and the underlying mechanisms remain unknown. The present study has investigated the effect of lignite, modified lignite, BC and modified BC on NH volatilization from cattle manure, biological immobilization of manure ammoniacal N and manure properties. Read More

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September 2021

Salinity-dependent impacts on the effects of antiepileptic and antihistaminic drugs in Ruditapes philippinarum.

Sci Total Environ 2021 Sep 16;806(Pt 1):150369. Epub 2021 Sep 16.

Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In coastal systems, pollutants as pharmaceutical drugs exert changes from the molecular to the organism level in marine bivalves. Besides pollutants, coastal systems are prone to changes in environmental parameters, as the alteration of salinity values because of Climate Change. Together, these stressors (pharmaceutical drugs and salinity changes) can exert different threats than each stressor acting individually; for example, salinity can change the physical-chemical properties of the drugs and/or the sensitivity of the organisms to them. Read More

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September 2021

Mesoporous silica incorporated PCL/Curcumin nanofiber for wound healing application.

Eur J Pharm Sci 2021 Sep 24:106021. Epub 2021 Sep 24.

Department of Mechanical Engineering, Anna University, Chennai, Tamil Nadu, India, Tel: +9144- 2235 7763, Fax: +91- 44- 2235 7744. Electronic address:

Electrospinning, a recent fast-emerging technique highly applicable in the production of nanofibers has gained vast recognition owing to its explicit applications in various domains. Amongst which, the production of nanoscaffolds for wound healing applications has been focused recently due to advantages over conventional wound healing methods. In the present research, a composite nanoscaffold comprising SBA-15 (Santa Barbara Amorphous), amine functionalized SBA-15 polycaprolactone (PCL) and curcumin was investigated for its potentiality in wound healing therapeutics. Read More

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September 2021

4mC-RF: Improving the prediction of 4mC sites using composition and position relative features and statistical moment.

Anal Biochem 2021 Sep 24:114385. Epub 2021 Sep 24.

Department of Computer Science, University of Management and Technology, Lahore 54770, Pakistan. Electronic address:

N4-methylcytosine (4 mC) is an important epigenetic modification that occurs enzymatically by the action of DNA methyltransferases. 4 mC sites exist in prokaryotes and eukaryotes while playing a vital role in regulating gene expression, DNA replication, and cell cycle. The efficient and accurate prediction of 4 mC sites has a significant role in the insight of 4 mC biological properties and functions. Read More

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September 2021

Catalytic Enantioselective Construction of Chiroptical Boron-Stereogenic Compounds.

J Am Chem Soc 2021 Sep 27. Epub 2021 Sep 27.

Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, Guangdong518055, China.

The construction of main group heteroatom-stereogenic compounds is of great importance due to their intriguing chemical, physical, biological, and stereoelectronic properties. Despite that organoboron compounds are widely used in organic chemistry, the creation of a tetrahedral boron-stereogenic center in one enantiomeric form remains highly challenging. Given the labile nature of ligands attached to the tetracoordinate boron atom, only a handful of enantioenriched boron-stereogenic compounds have been reported via resolution or a chiral substrate-induced diastereoselective approach. Read More

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September 2021

Pd-Catalyzed Enantioselective Dearomative Allylic Annulation to Access PPAPs Analogues.

Org Lett 2021 Sep 27. Epub 2021 Sep 27.

Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.

Polycyclic polyprenylated acylphloroglucinols (PPAPs) share a common bicyclo[3.3.1]alkenone core structure and attract numerous attention from synthetic organic chemists due to their fascinating biological properties and associated synthetic challenges. Read More

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September 2021

Pickering Emulsion Stabilized by Metal-Phenolic Architectures: A Straightforward In Situ Assembly Strategy.

J Agric Food Chem 2021 Sep 27. Epub 2021 Sep 27.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Interfacial self-assembly has been a powerful driving force for fabricating functional and therapeutic carriers in emulsion systems. Herein, we reported a straightforward metal-phenolic supramolecular architecture, directly absorbed and cross-linked at the surfaces of oil drops and acted as the regulator between the oil and water interface to stabilize the emulsion systems. The results showed that the diverse interfacial properties and emulsion stability were tuned by the kinds and concentrations of polyphenols as well as the ratios of polyphenols to metal ions. Read More

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September 2021

Formation of β-Lactoglobulin Self-Assemblies via Liquid-Liquid Phase Separation for Applications beyond the Biological Functions.

ACS Appl Mater Interfaces 2021 Sep 27. Epub 2021 Sep 27.

School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, Shaanxi, People's Republic of China.

Proteins are like miracle machines, playing important roles in living organisms. They perform vital biofunctions by further combining together and/or with other biomacromolecules to form assemblies or condensates such as membraneless organelles. Therefore, studying the self-assembly of biomacromolecules is of fundamental importance. Read More

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September 2021

Waste to resource: use of water treatment residual for increased maize productivity and micronutrient content.

Environ Geochem Health 2021 Sep 27. Epub 2021 Sep 27.

Department of Engineering, Durham University, Durham, DH1 3LE, UK.

Soil degradation, which is linked to poor nutrient management, remains a major constraint to sustained crop production in smallholder urban agriculture (UA) in sub-Saharan Africa (SSA). While organic nutrient resources are often used in UA to complement mineral fertilizers in soil fertility management, they are usually scarce and of poor quality to provide optimum nutrients for crop uptake. Alternative soil nutrient management options are required. Read More

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September 2021

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

Nucleic Acids Res 2021 Sep 27. Epub 2021 Sep 27.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18RaOp) responsible for both the classical mouse mutant Ragged Opossum and the human genetic disorder Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Read More

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September 2021

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents.

Nucleic Acids Res 2021 Sep 27. Epub 2021 Sep 27.

School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

Metallodrugs provide important first-line treatment against various forms of human cancer. To overcome chemotherapeutic resistance and widen treatment possibilities, new agents with improved or alternative modes of action are highly sought after. Here, we present a click chemistry strategy for developing DNA damaging metallodrugs. Read More

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September 2021

Multifunctional superparamagnetic nanoparticles with a fluorescent silica shell for the study of bio-nano interactions at the subcellular scale.

Nanoscale 2021 Sep 27. Epub 2021 Sep 27.

Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.

Despite the high level of interest in bio-nano interactions, detailed intracellular mechanisms that govern nanoscale recognition and signalling still need to be unravelled. Magnetic nanoparticles (NPs) are valuable tools for elucidating complex intracellular bio-nano interactions. Using magnetic NPs, it is possible to isolate cell compartments that the particles interact with during intracellular trafficking. Read More

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September 2021

Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy.

Drug Deliv 2021 Dec;28(1):2033-2043

Department of Liver Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.

Triptolide (TPL) is a diterpenoid triepoxide with broad antitumor efficacy, while lack of mechanism of action, severe systemic toxicity, and poor water solubility of TPL limited its usage. To unveil the mechanism of action and improve the pharmaceutical properties of TPL, here we explored the molecular mechanism of TPL and then fabricated TPL-loaded membrane protein-chimeric liposomes ([email protected]) and tested its anticancer efficacy against hepatocellular carcinoma (HCC). CCK8 assay, colony formation assay, EdU assay, and flow cytometry were used to examine the activity of TPL. Read More

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December 2021

MoS Nanosheets-Cyanobacteria Interaction: Reprogrammed Carbon and Nitrogen Metabolism.

ACS Nano 2021 Sep 27. Epub 2021 Sep 27.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.

Fully understanding the environmental implications of engineered nanomaterials is crucial for their safe and sustainable use. Cyanobacteria, as the pioneers of the planet earth, play important roles in global carbon and nitrogen cycling. Here, we evaluated the biological effects of molybdenum disulfide (MoS) nanosheets on a N-fixation cyanobacteria () by monitoring growth and metabolome changes. Read More

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September 2021

Osteogenic potential and properties of injectable silk fibroin/tetracalcium phosphate/monetite composite powder biocement systems.

J Biomed Mater Res B Appl Biomater 2021 Sep 27. Epub 2021 Sep 27.

Department of Functional and Hybrid Materials, Institute of Materials Research of SAS, Kosice, Slovakia.

The powdered cement tetracalcium phosphate/monetite/silk fibroin composite (CFIB) was prepared by simple mechanical milling of tetracalcium phosphate/monetite powder mixture with fibrous soluble silk fibroin (SF). The powder composite cement mixtures contained 5 and 10 wt % of SF and 2% NaH PO solution with 0.1% genipin was used as a liquid component. Read More

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September 2021

Fabricating Robust Constructs with Internal Phase Nanostructures via Liquid-in-Liquid 3D Printing.

Macromol Rapid Commun 2021 Sep 27:e2100445. Epub 2021 Sep 27.

Department of Civil & Mechanical Engineering, University of Missouri-Kansas City, Kansas City, Missouri, 64110, USA.

The ability to print soft materials into predefined architectures with programmable nanostructures and mechanical properties is a necessary requirement for creating synthetic biomaterials that mimic living tissues. However, the low viscosity of common materials and lack of required mechanical properties in the final product present an obstacle to the use of traditional additive manufacturing approaches. Here, a new liquid-in-liquid 3D printing approach is used to successfully fabricate constructs with internal nanostructures using in situ self-assembly during the extrusion of an aqueous solution containing surfactant and photocurable polymer into a stabilizing polar oil bath. Read More

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September 2021

The metabolite GLP-1 (9-36) is neuroprotective and anti-inflammatory in cellular models of neurodegeneration.

J Neurochem 2021 Sep 27. Epub 2021 Sep 27.

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.

Glucagon-like peptide-1 (GLP-1) is best known for its insulinotropic action following food intake. Its metabolite, GLP-1 (9-36), was assumed biologically inactive due to low GLP-1 receptor (GLP-1R) affinity and non-insulinotropic properties; however, recent studies contradict this assumption. Increased use of FDA approved GLP-1 analogues for treating metabolic disorders and neurodegenerative diseases raises interest in GLP-1 (9-36)'s biological role. Read More

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September 2021

Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration.

ASN Neuro 2021 Jan-Dec;13:17590914211044882

Department of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences-National Institute of thе Republic of Serbia, 89101University of Belgrade, Belgrade, Serbia.

The present study examined the involvement of purinergic signaling components in the rat model of hippocampal degeneration induced by trimethyltin (TMT) intoxication (8 mg/kg, single intraperitoneal injection), which results in behavioral and neurological dysfunction similar to neurodegenerative disorders. We investigated spatial and temporal patterns of ecto-nucleoside triphosphate diphosphohydrolase 1 (NTPDase1/CD39) and ecto-5' nucleotidase (eN/CD73) activity, their cell-specific localization, and analyzed gene expression pattern and/or cellular localization of purinoreceptors and proinflammatory mediators associated with reactive glial cells. Our study demonstrated that all Iba1+ cells at the injured area, irrespective of their morphology, upregulated NTPDase1/CD39, while induction of eN/CD73 has been observed at amoeboid Iba1+ cells localized within the hippocampal neuronal layers with pronounced cell death. Read More

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September 2021

Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota.

ACS Appl Mater Interfaces 2021 Sep 27. Epub 2021 Sep 27.

College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.

Alzheimer's disease (AD) is a neurodegenerative disease associated with amyloid-β (Aβ) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) and gut microbiota imbalance. Resveratrol (Res) has neuroprotective properties, but its bioavailability is very low. Herein, we developed a small Res-selenium-peptide nanocomposite to enable the application of Res for eliminating Aβ aggregate-induced neurotoxicity and mitigating gut microbiota disorder in aluminum chloride (AlCl) and d-galactose(d-gal)-induced AD model mice. Read More

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September 2021

Dual-Light-Triggered In Situ Structure and Function Regulation of Injectable Hydrogels for High-Efficient Anti-Infective Wound Therapy.

Adv Healthc Mater 2021 Sep 26:e2101722. Epub 2021 Sep 26.

College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, 235 University West Street, Hohhot, 010021, China.

Most injectable hydrogels used in biomedical engineering have unsatisfactory and untunable mechanical properties, making it difficult to match them with the mechanical strengths of different tissues and organs, which can cause a series of adverse consequences such as immune rejection and soft tissue contusion. In this contribution, dopamine-modified hyaluronic acid (HA-DA) is developed as the backbone for an injectable hydrogel using a catechol-Fe coordination crosslinking strategy. Due to dynamic physical crosslinking, the hydrogel can be easily injected through a single syringe. Read More

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September 2021

Municipal wastewater sludge rheology: impact of temperature, solid content and settling solids.

Water Environ Res 2021 Sep 26. Epub 2021 Sep 26.

National Research Council, Institute for Agriculture and Forest Systems in the Mediterranean, Rende, (CS), Italy.

The analysis of the rheological properties of the sludge produced in biological purification plants is paramount for the design of equipment (pumping, mixing, conditioning, aeration, filtration, etc.) and the management of these plants. In particular, solid content in the sludge plays a significant role in the rheological quantities. Read More

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September 2021

Post-activation potentiation induced by concentric contractions at three speeds in humans.

Exp Physiol 2021 Sep 26. Epub 2021 Sep 26.

School of Kinesiology, Faculty of Health Sciences, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond St, London, London, ON, N6A 3K7, Canada.

New Findings: What is the central question of this study? To understand the effect of concentric contractions in inducing post-activation potentiation (PAP) in humans. Is the degree of PAP affected by different muscle shortening velocities? Studies have explored PAP following isometric contractions, but there is limited understanding of PAP responses following active changes in shortening speed. What are the main findings and their importance? The PAP response following maximal concentric contractions was independent of velocity. Read More

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September 2021

Biotechnological production of diterpenoid lactones from cell and organ cultures of Andrographis paniculata.

Appl Microbiol Biotechnol 2021 Sep 27. Epub 2021 Sep 27.

Department of Botany, Karnatak University, Dharwad, 580003, India.

Andrographis paniculata (AP) is a medicinal plant that is traditionally used in Indian, Chinese, Malay, Thai, and Oriental system of medicines to treat various disorders. AP consists of andrographolide (AD), 14-deoxy-11,12-didehydroandrographolide (DDAD), and neoandrographolide (NAD) as major diterpene lactones which has extremely bitter properties; therefore, AP is commonly called "King of bitters." AD, DDAD, and NAD are reported to possess therapeutic values such as antioxidant, immunostimulatory, hepatoprotective, anti-cancer, anti-inflammatory, anti-rheumatoidal, anti-malarial, anti-leishmanial, anti-fertility, anti-obesity, antipyretic, and antimicrobial attributes. Read More

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September 2021

A self-assembled amphiphilic polysaccharide-based co-delivery system for egg white derived peptides and curcumin with oral bioavailability enhancement.

Food Funct 2021 Sep 27. Epub 2021 Sep 27.

Jilin Provincial Key Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.

Egg white derived peptides (EWDP) and curcumin are well known for diverse biological activities, but the combinational usage of the two natural nutraceuticals is extremely limited by their low oral bioavailability and distinctly different polarities. Therefore, this study aimed to exploit a facile self-assembled amphiphilic system for oral co-delivery of hydrophilic egg white derived peptides (EWDP) and hydrophobic curcumin. The hydrophobic curcumin was first loaded into the hydrophobic cavity of β-cyclodextrin (β-CD) as a core. Read More

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September 2021

Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method.

Biophys Rep 2021 Sep 8;1(1):None. Epub 2021 Sep 8.

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Voltage-dependent anion-selective channel (VDAC) is one of the main proteins of the outer mitochondrial membrane of all eukaryotes, where it forms aqueous, voltage-sensitive, and ion-selective channels. Its electrophysiological properties have been thoroughly analyzed with the planar lipid bilayer technique. To date, however, available results are based on isolations of VDACs from tissue or from recombinant VDACs produced in bacterial systems. Read More

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September 2021

Marginal Contribution Feature Importance - an Axiomatic Approach for Explaining Data.

Proc Mach Learn Res 2021 Jul;139:1324-1335

Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel.

In recent years, methods were proposed for assigning feature importance scores to measure the contribution of individual features. While in some cases the goal is to understand a specific model, in many cases the goal is to understand the contribution of certain properties (features) to a real-world phenomenon. Thus, a distinction has been made between feature importance scores that explain a and scores that explain the . Read More

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Exploration of the HO Oxidation Process and Characteristic Evaluation of Humic Acids from Two Typical Lignites.

ACS Omega 2021 Sep 9;6(37):24051-24061. Epub 2021 Sep 9.

Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.

To study the effect of HO on the content and properties of humic acids (HAs) in lignites, the experimental conditions including oxidation time, HO concentration, and the solid-liquid ratio were investigated. Under the optimum oxidation conditions, the contents of HAs of YL and HB lignite were 45.4 and 40. Read More

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September 2021

Comprehensive Analysis of the Influence of Fulvic Acid from Paper Mill Effluent on Soil Properties, Soil Microbiome, and Growth of Rehd. Seedlings under Replant Conditions.

ACS Omega 2021 Sep 10;6(37):24027-24038. Epub 2021 Sep 10.

College of Horticulture Science and Engineering, State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an 271018, China.

In this study, the potential regulatory effects of fulvic acid extracted from paper mill effluent (PFA) in apple replant disease (ARD) were investigated through a comprehensive experimental evaluation of the effects of PFA on soil properties, growth inhibition of apple replant pathogens, and growth of replanted Rehd. seedlings. PFA with a relatively lower molecular weight was mainly composed of carbohydrates, lignin derivatives, and polysaccharides and was rich in functional groups such as carboxyl and phenolic hydroxyl groups. Read More

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September 2021

Effect of Sonochemical Treatment on Thermal Stability, Elemental Mercury (Hg) Removal, and Regenerable Performance of Magnetic Tea Biochar.

ACS Omega 2021 Sep 8;6(37):23913-23923. Epub 2021 Sep 8.

School of Chemical Engineering, Northwest University, Xi'an 710069, China.

Elemental mercury (Hg) removal from a hot gas is still challenging since high temperature influences the Hg removal and regenerable performance of the sorbent. In this work, a facile yet innovative sonochemical method was developed to synthesize a thermally stable magnetic tea biochar to capture the Hg from syngas. A sonochemically synthesized magnetic sorbent (TUF) exhibited a more prodigious surface area with developed pore structures, ultra-paramagnetic properties, and high dispersion of FeO/γ-FeO particles than a simply synthesized magnetic sorbent (TF). Read More

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September 2021