40 results match your criteria biofabricated nanomaterials


Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine.

iScience 2021 Mar 12;24(3):102183. Epub 2021 Feb 12.

Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, De-Jur Bldg. Office 607, Technion City, 3200003 Haifa, Israel.

Nanoneuromedicine investigates nanotechnology to target the brain and treat neurological diseases. In this work, we biofabricated heterocellular spheroids comprising human brain microvascular endothelial cells, brain vascular pericytes and astrocytes combined with primary cortical neurons and microglia isolated from neonate rats. The structure and function are characterized by confocal laser scanning and light sheet fluorescence microscopy, electron microscopy, western blotting, and RNA sequencing. Read More

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Remediation of emerging environmental pollutants: A review based on advances in the uses of eco-friendly biofabricated nanomaterials.

Chemosphere 2021 Jul 15;275:129975. Epub 2021 Feb 15.

Laboratory of Plant Healthcare and Diagnostics, PG Department of Biotechnology and Microbiology, Karnataka University, Dharwad, 580 003, Karnataka, India. Electronic address:

The increased environmental pollutants due to anthropogenic activities are posing an adverse effects and threat on various biotic forms on the planet. Heavy metals and certain organic pollutants by their toxic persistence in the environment are regarded as significant pollutants worldwide. In recent years, pollutants exist in various forms in the environment are difficult to eliminate by traditional technologies due to various drawbacks. Read More

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Cytotoxic, Antimitotic, DNA Binding, Photocatalytic, HO Sensing, and Antioxidant Properties of Biofabricated Silver Nanoparticles Using Leaf Extract of (Lam.) Oken.

Front Mol Biosci 2020 28;7:593040. Epub 2021 Jan 28.

Laboratory of Bio-Resource Technology, Department of Botany, Indira Gandhi National Tribal University, Amarkantak, India.

is a perennial herb traditionally used in ethnomedicine. In the present report, silver nanoparticles (AgNPs) were synthesized using leaf extract. BP-AgNPs were confirmed following UV-Vis spectroscopy with SPR peak at 412 nm and further characterized by FTIR, XRD, SEM-EDX, and TEM. Read More

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January 2021

Nanoparticle-based amelioration of drought stress and cadmium toxicity in rice via triggering the stress responsive genetic mechanisms and nutrient acquisition.

Ecotoxicol Environ Saf 2021 Feb 28;209:111829. Epub 2020 Dec 28.

State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, 310058 Hangzhou, China. Electronic address:

Cadmium and drought are the most destructive of the abiotic stresses with negative consequences in terms of impaired metabolism, restricted nutrient use efficiency and disruptive photosynthesis of plants. The present study investigated the mitigation strategy of both aforementioned stresses by the application of iron oxide (IONPs) and hydrogel nanoparticles (HGNPs) simultaneously probably for the first time. IONPs were biofabricated by using a locally identified Bacillus strain RNT1, while HGNPs were produced chemically followed by the confirmation and characterization of both NPs through nanomaterials characterization techniques. Read More

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February 2021

Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice.

Environ Toxicol 2021 Apr 28;36(4):572-585. Epub 2020 Nov 28.

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Prayagraj, India.

Current work was designed to explore the effect of ZnO nanoparticles (ZnONP) biofabricated by using Trianthema portulacastrum (TP) leaves extract on mice brain hippocampus. ZnO nanoparticles of TP leaves (ZnOTP) were synthesized by co-precipitation method and further characterized by using various techniques such as UV-Vis spectrophotometer, Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR), and Energy Dispersive X-ray (EDX). ZnOTP were evaluated for in vitro antioxidant activity, in vivo behavior models (for assessment of cognitive ability), acetylcholinesterase (AChE) activity along with other neurotransmitters content determination, estimation of various oxidative stress parameters and analysis of zinc content in the brain as well as plasma. Read More

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Study of adsorption of anionic dyes over biofabricated crystalline α-MnO nanoparticles.

Environ Sci Pollut Res Int 2021 Mar 25;28(12):15504-15518. Epub 2020 Nov 25.

Department of Basic Sciences & Humanities, Rajiv Gandhi Institute of Petroleum Technology, Bahadurpur, Jais, Amethi, Uttar Pradesh, 229305, India.

The leaf extract of Ficus retusa plant was used for fabrication of α-MnO nanoparticles (NPs). The extract was utilized as a reducing agent for green synthesis of nanomaterial. The synthesis of nanocrystals was confirmed using different analytical techniques such as field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) spectroscopy and thermogravimetric analysis (TGA). Read More

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Novel Approach for Efficient Recovery for Spinal Cord Injury Repair via Biofabricated Nano-Cerium Oxide Loaded PCL With Resveratrol to Improve in Vitro Biocompatibility and Autorecovery Abilities.

Dose Response 2020 Jul-Sep;18(3):1559325820933518. Epub 2020 Sep 2.

Department of Orthopedic, Hong-Hui Hospital, Xi' an Jiaotong University College of Medicine, Xi'an, Shaanxi Province, People's Republic of China.

It is more difficult to develop the low-cost spinal cord injury repair materials with high stability and biocompatibility for the biomedical applications. Herein, for the first time, we demonstrated the functional restoration of an injured spinal cord by the nano CeO particles assembled onto poly (∊-caprolactone) (PCL)/resveratrol (RVL) were synthesized using the biocompatible ionic liquid. The as-prepared biocompatible nanomaterials were characterized and confirmed by using different instruments such as Fourier transform infra-red spectroscopy for functional groups identification, X-ray diffraction for crystalline nature, Scanning electron microscopy, transmission electron microscopy for morphological structure, Dynamic light scattering for size distribution of the nanoparticles and thermogravimetric analysis for thermal properties. Read More

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September 2020

Phytosynthesis of colloidal nanosilver from Mentha longifolia and Mentha arvensis: Comparative morphological and optical characterization.

Microsc Res Tech 2020 Nov 3;83(11):1299-1307. Epub 2020 Sep 3.

Department of Botany, PMAS-Arid Agriculture University, Rawalpindi, Punjab, Pakistan.

The present study involves an ecofriendly strategy for the reduction of bulk silver into its nanoforms by using the aqueous extracts of Mentha longifolia leaves (MLL), M. longifolia branches (MLB), and Mentha arvensis (MA). Synthesis of silver nanoparticles (AgNPs) was confirmed initially by observing a change in the color of the reaction mixture followed by measuring the absorbance, and a characteristic surface plasmon resonance band was observed between 400 and 500 nm of the λ of light. Read More

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November 2020

Development and evaluation of a novel beneficent antimicrobial bioscaffold based on animal waste-fish swim bladder (FSB) doped with silver nanoparticles.

Environ Res 2020 09 20;188:109823. Epub 2020 Jun 20.

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran. Electronic address:

Treated fish wastes have found many applications in industry and medicine. Besides, nowadays low-cost scaffold with antimicrobial activity which can accelerates the process of wound healing is very demanding. In this study fish swim bladder (FSB), taken from Rutilus frisii, which is a disposable waste was doped with silver nanoparticles (AgNPs) and evaluated as antimicrobial wound dressing. Read More

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September 2020

Antibacterial and biofilm inhibition activity of biofabricated silver nanoparticles against Xanthomonas oryzae pv. oryzae causing blight disease of rice instigates disease suppression.

World J Microbiol Biotechnol 2020 Mar 16;36(4):55. Epub 2020 Mar 16.

Department of Mycology and Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, 221005, India.

Antimicrobial activity of silver nanoparticles (AgNPs) has been well documented in earlier studies. As their efficient role in combating phytopathogens has begun recently, there is a huge scope to explore their effectiveness in agriculture. Considering the strong antifungal activity of biosynthesized AgNPs (as reported in our previous study), our main aim is to elucidate their antibacterial activity against bacterial plant pathogens to authenticate their wide range of agricultural applications. Read More

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Hierarchically-structured metalloprotein composite coatings biofabricated from co-existing condensed liquid phases.

Nat Commun 2020 02 13;11(1):862. Epub 2020 Feb 13.

Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany.

Complex hierarchical structure governs emergent properties in biopolymeric materials; yet, the material processing involved remains poorly understood. Here, we investigated the multi-scale structure and composition of the mussel byssus cuticle before, during and after formation to gain insight into the processing of this hard, yet extensible metal cross-linked protein composite. Our findings reveal that the granular substructure crucial to the cuticle's function as a wear-resistant coating of an extensible polymer fiber is pre-organized in condensed liquid phase secretory vesicles. Read More

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February 2020

Nannochloropsis Extract-Mediated Synthesis of Biogenic Silver Nanoparticles, Characterization and In Vitro Assessment of Antimicrobial, Antioxidant and Cytotoxic Activities.

Asian Pac J Cancer Prev 2019 08 1;20(8):2353-2364. Epub 2019 Aug 1.

Department of Pharmaceutical Sciences, Research Director, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India. Email:

Objective: To investigate the biogenic synthesis of silver nanoparticles (AgNPs) using partially purified ethyl acetate extract of Nannochloropsis sp. hexane (EAENH) fraction of microalga. Methods: The green synthesis of AgNPs was confirmed with UV-Vis spectrum which shows the surface plasmon resonance (SPR) at 421 nm. Read More

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Biofabrication of bacterial nanocellulose scaffolds with complex vascular structure.

Biofabrication 2019 07 25;11(4):045010. Epub 2019 Jul 25.

Department of Chemistry and Chemical Engineering, Analytical Chemistry, Chalmers University of Technology, Gothenburg, Sweden.

Bacterial nanocellulose (BNC) has proven to be an effective hydrogel-like material for different tissue engineering applications due to its biocompatibility and good mechanical properties. However, as for all biomaterials, in vitro biosynthesis of large tissue constructs remains challenging due to insufficient oxygen and nutrient transport in engineered scaffold-cell matrices. In this study we designed, biofabricated and evaluated bacterial nanocellulose scaffolds with a complex vascular mimetic lumen structure. Read More

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Phloretin loaded chitosan nanoparticles enhance the antioxidants and apoptotic mechanisms in DMBA induced experimental carcinogenesis.

Chem Biol Interact 2019 Aug 7;308:11-19. Epub 2019 May 7.

Department of Biotechnology, Thiruvalluvar University, Serkadu, Vellore, 632 115, Tamilnadu, India. Electronic address:

The main aim of this study was to investigate the effects of phloretin loaded chitosan nanoparticles (PhCsNPs) on 7,12-dimethylbenz[a]anthracene (DMBA) induced experimental cancer in hamsters. Oral squamous cell carcinoma (OSCC) was induced in male golden Syrian hamsters by painting with 0.5% DMBA three times a week for 14 weeks. Read More

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Silver-gold alloy nanoparticles biofabricated by fungal xylanases exhibited potent biomedical and catalytic activities.

Biotechnol Prog 2019 09 20;35(5):e2829. Epub 2019 May 20.

Department of Microbiology, School of Life Sciences, University of KwaZulu-Natal, PieterMaritzburg, South Africa.

The search for biocompatible nanoparticles with vast applicability has impacted on exploration of various biomaterials for the synthesis of mono and bimetallic nanoparticles. Xylanase is widely regarded as an industrially important enzyme but its potentials in nanotechnological applications are yet to be fully explored. The current study investigates the exploit of xylanases of Aspergillus niger L3 (NE) and Trichoderma longibrachiatum L2 (TE) produced through valorization of corn-cob, to synthesize silver-gold alloy nanoparticles (Ag-AuNPs). Read More

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September 2019

A novel cadmium-containing wastewater treatment method: Bio-immobilization by microalgae cell and their mechanism.

J Hazard Mater 2019 07 22;374:420-427. Epub 2019 Apr 22.

School of Science, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Heavy metal cadmium (Cd) has drawn tremendous comcern due to its rigorous environmental and health hazards. Herein, we have presented an efficient and economical strategy for the removal and recycling of hazardous Cd ions using microalgae cells as the bioreactors. Remarkably, the green bio-platform for the bioproduction of CdSe nanoparticles (NPs) was developed depending on their orderly regulated and sustainable cellular environment. Read More

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Molecular targets of biofabricated silver nanoparticles in Candida albicans.

J Antibiot (Tokyo) 2019 08 24;72(8):640-644. Epub 2019 Apr 24.

School of Life Sciences, SRTM University, Nanded, Maharashtra, 431606, India.

We have analyzed the expressions of genes which regulate Ras-cAMP-EFG1 and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in Candida albicans. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene, ECE1, was downregulated by 5. Read More

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Effects of gallic acid biofabricated rGO nanosheets combined with radiofrequency radiation for the treatment of renal cell carcinoma.

Mater Sci Eng C Mater Biol Appl 2018 Dec 18;93:846-852. Epub 2018 Aug 18.

Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Electronic address:

The combination of biologically active compounds and nanomaterials in biomedicine field is growing rapidly and provided excellent forecasts for the progress of facile non-invasive approaches for the diagnosis of cancer therapy. In this present study, we demonstrated that as-prepared gallic acid (GA) coated reduced graphene oxide (rGO) combined with radiofrequency (RF) ablation has facilitated for the treatment of human renal epithelial cancer (A-489) cells without disturbing the renal proximal epithelial (HK-2) cells. The successful biofabrication of GA onto the rGO nanostructure has been elaborated with the support of peak intensities of diffracted X-ray patterns and Raman spectral visualizations. Read More

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December 2018

Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation.

Inflammopharmacology 2019 Oct 15;27(5):1037-1054. Epub 2018 Sep 15.

Bio-organic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, 211007, India.

Oxidative stress and inflammation play a pivotal role in the expansion and progression of hepatic cancer. Nanoparticle-based drug delivery can quickly enhance the restorative capability of hepatic cancer. Silver nanoparticles synthesized from plant source are of great importance due to their small size, economic, non-hazardous and different biomedical applications. Read More

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October 2019

Biogenic synthesis of silver nanoparticles using extracts of Leptolyngbya JSC-1 that induce apoptosis in HeLa cell line and exterminate pathogenic bacteria.

Artif Cells Nanomed Biotechnol 2018 8;46(sup3):S471-S480. Epub 2018 Sep 8.

a College of Life Science and Technology , Beijing University of Chemical Technology , Beijing , China.

Utilizing novel approaches for the green synthesis of metal nanoparticles are of great importance. Therefore, we reported biogenic synthesis of silver nanoparticles (AgNPs) using extracts of Leptolyngbya strain JSC-1, and their significant applications against pathogenic bacteria and cancerous HeLa cell line. The biofabricated AgNPs were characterized by UV-visible spectroscopy, FTIR, SEM, TEM, DLS and zeta-potential. Read More

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Enhanced wound healing activity of PEG/PCL copolymer combined with bioactive nanoparticles in wound care after anorectal surgery: Via bio-inspired methodology.

J Photochem Photobiol B 2018 Oct 22;187:54-60. Epub 2018 Jul 22.

Rehabilitation Department, Dongying City People's Hospital, PR China.

Over the past decade, the implementation of the novel nanomaterials in the field of nanotechnology for the biomedical applications is essential for the comfort factors such as non-toxicity and biocompatibility in the human biological systems. In this context, a novel synthesis was worked out through bacterial species (citrobacter braakii) in the biofabrication of bioactive gold nanoparticles (Au NPs) for the wound healing management. The biosynthesized Au NPs were further modified and improved its compatibility with polyethylene glycol (PEG) and polycaprolactone (PCL) for formed as Au-PEG/PCL nanocomposites to extent the activity in wound healing application. Read More

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October 2018

Biofabrication of silver nanoparticles using bacteria from mangrove swamp.

IET Nanobiotechnol 2018 08;12(5):626-632

Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.

The last decade has observed a rapid advancement in utilising biological system towards bioremediation of metal ions in the form of respective metal nanostructures or microstructures. The process may also be adopted for respective metal nanoparticle biofabrication. Among different biological methods, bacteria-mediated method is gaining great attention for nanoparticle fabrication due to their eco-friendly and cost-effective process. Read More

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Antibacterial and Growth Inhibition Study of Struvite Urinary Stones Using Linn. Leaf Extract and its Biofabricated Silver Nanoparticles.

Recent Pat Drug Deliv Formul 2018 ;12(3):170-178

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, India.

Background: Herbal drugs are gaining exponential scientific recognition due to their distinct advantages. In the last 2-3 decades, a gradual increase in worldwide patents on herbal nanoformulations has been noted to address the solubility and bioavailability issues of phytoceuticals. Struvite or ammonium magnesium phosphate hexahydrate (NH4MgPO4. Read More

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Toxicity studies of nanofabricated palladium against filariasis and malaria vectors.

Environ Sci Pollut Res Int 2018 Jan 15;25(1):324-332. Epub 2017 Oct 15.

Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Vellore, Tamil Nadu, 632006, India.

The present study was carried out to establish the biofabrication of palladium nanoparticles (PdNPs) using the plant leaf extract of Tinospora cordifolia Miers and its toxicity studies on the larvae of filariasis vector, Culex quinquefasciatus Say and malaria vector, Anopheles subpictus Grassi. The biofabricated PdNPs were characterized by using UV-visible spectrum, FTIR, XRD, FESEM, EDX and HRTEM. HRTEM confirmed the PdNPs were slightly agglomerated and spherical in shape and the average size was 16 nm. Read More

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January 2018

Larvicidal and pupicidal evaluation of silver nanoparticles synthesized using Aquilaria sinensis and Pogostemon cablin essential oils against dengue and zika viruses vector Aedes albopictus mosquito and its histopathological analysis.

Artif Cells Nanomed Biotechnol 2018 Sep 31;46(6):1171-1179. Epub 2017 Aug 31.

a Ministry of Agriculture Key Laboratory of Agricultural Entomology , Institute of Insect Sciences, Zhejiang University , Hangzhou , Zhejiang , PR China.

Mosquitoes pose a threat to humans and animals, causing millions of deaths every year. Vector control by effective eco-friendly pesticides of natural origin is a serious issue that requires urgent attention. The employment of green-reducing extracts for nanoparticles biosynthesis in a rapid and single-step process represents a promising strategy. Read More

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September 2018

Bioremediation potential of arsenic by non-enzymatically biofabricated silver nanoparticles adhered to the mesoporous carbonized fungal cell surface of Aspergillus foetidus MTCC8876.

J Environ Manage 2017 Oct 12;201:435-446. Epub 2017 Jul 12.

Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, India. Electronic address:

Our study aiming for the diminution of arsenic concentration in arsenic contaminated aqua environment by using novel adsorbents based on bio-fabricated silver nanoparticles on a fungal cell surface. Bioreduction of silver ion was done in a non-enzymatic manner in presence of the biomass of fungus Aspergillus foetidus MTCC8876. Aspergillus spp. Read More

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October 2017

Potential therapeutic activity of Phlogacanthus thyrsiformis Hardow (Mabb) flower extract and its biofabricated silver nanoparticles against chemically induced urolithiasis in male Wistar rats.

Int J Biol Macromol 2017 Oct 18;103:621-629. Epub 2017 May 18.

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India. Electronic address:

Urolithiasis is a painful disorder in which stones are formed in the kidney, bladder or urethra. There are no proper therapeutic treatments available for kidney stones and people suffering from larger stones have to undergo surgery which has many side effects. A natural remedy with therapeutic effects that can dissipate and remove even the larger stones would eliminate the need of a surgery and the risks associated with it. Read More

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October 2017

Bacteriogenic synthesis of selenium nanoparticles by ATCC 35218 and its structural characterisation.

IET Nanobiotechnol 2017 Mar;11(2):179-184

National Centre for Compositional Characterisation of Materials (NCCCM), Bhabha Atomic Research Centre (BARC), ECIL PO, Hyderabad 500 062, India.

A biosynthetic method for the production of selenium nanoparticles under ambient temperature and pressure from sodium selenite was developed using Gram-negative bacterial strain ATCC 35218. Bacteriogenic nanoparticles were methodologically characterized employing UV-vis, XRD, Raman spectroscopy, SEM, TEM, DLS and FTIR techniques. Generation of nanoparticles was visualized from the appearance of red colour in the selenite supplemented culture medium and broad absorption bands in the UV-vis. Read More

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Green engineered biomolecule-capped silver and copper nanohybrids using Prosopis cineraria leaf extract: Enhanced antibacterial activity against microbial pathogens of public health relevance and cytotoxicity on human breast cancer cells (MCF-7).

Microb Pathog 2017 Apr 16;105:86-95. Epub 2017 Feb 16.

Plant Genetic Engineering and Molecular Biology Lab, Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem-11, TN, India. Electronic address:

This research focused on green engineering and characterization of silver (PcAgNPs) and copper nanoparticles (PcCuNPs) using Prosopis cineraria (Pc) leaf extract prepared by using microwave irradiation. We studied their enhanced antimicrobial activity on human pathogens as well as cytotoxicity on breast cancer cells (MCF-7). Biofabricated silver and copper nanoparticles exhibited UV-Visible absorbance peaks at 420 nm and 575 nm, confirming the bioreduction and stabilization of nanoparticles. Read More

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One-pot fabrication of silver nanocrystals using Nicandra physalodes: A novel route for mosquito vector control with moderate toxicity on non-target water bugs.

Res Vet Sci 2016 Aug 31;107:95-101. Epub 2016 May 31.

Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy. Electronic address:

Mosquitoes (Diptera: Culicidae) as vectors for important diseases and parasites causing millions of deaths every year. The use of synthetic pesticides against Culicidae leads to resistance and environmental concerns. Therefore, eco-friendly control tools are a priority. Read More

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