9,142 results match your criteria bioactive surface

Polymer-Based Honeycomb Films on Bioactive Glass: Toward a Biphasic Material for Bone Tissue Engineering Applications.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Biomaterials and Tissue Engineering, Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 3, 33720 Tampere, Finland.

The development of innovative materials for bone tissue engineering to promote bone regeneration while avoiding fibrous tissue infiltration is of paramount importance. Here, we combined the known osteopromotive properties of bioactive glasses (BaGs) with the biodegradability, biocompatibility, and ease to shape/handle of poly-l--d,l-lactic acid (PLDLA) into a single biphasic material. The aim of this work was to unravel the role of the surface chemistry and topography of BaG surfaces on the stability of a PLDLA honeycomb membrane, in dry and wet conditions. Read More

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New insights of phenolic compounds from optimized fruit extract of Ficus auriculata.

Sci Rep 2021 Jun 14;11(1):12503. Epub 2021 Jun 14.

Solar Energy Research Institute, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.

In this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS as well as reducing power assays on total phenolic content (TPC). For the extraction purpose, the ultrasonic assisted extraction technique was employed. Read More

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Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters.

Nanoscale Adv 2021 Apr 28;3(11):2995-3027. Epub 2021 Apr 28.

BCBB, National Institute of Allergy and Infectious Diseases, NIH Bethesda MD 20892 USA

The use of nanoparticles (NPs) in biomedicine has made a gradual transition from proof-of-concept to clinical applications, with several NP types meeting regulatory approval or undergoing clinical trials. A new type of metallic nanostructures called ultrasmall nanoparticles (usNPs) and nanoclusters (NCs), while retaining essential properties of the larger (classical) NPs, have features common to bioactive proteins. This combination expands the potential use of usNPs and NCs to areas of diagnosis and therapy traditionally reserved for small-molecule medicine. Read More

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Optimization of enzymatic hydrolysis of immature citrus ( Marcov.) for flavonoid content and antioxidant activity using a response surface methodology.

Food Sci Biotechnol 2021 May 7;30(5):663-673. Epub 2021 May 7.

Department of Food and Nutrition, Daegu University, Gyeonsan-si, 38453 Gyeongsangbukdo Korea.

Immature citrus with peel was enzymatically treated for production of a hydrolysate with enriched bioactive components and higher antioxidant activity. The effects of reaction factors, including enzyme concentration, reaction time, and temperature on hesperetin and naringenin contents, total phenolic content (TPC), and antioxidant activity were investigated using response surface methodology. The models were adequate, and the enzyme concentration, temperature, and time positively affected hesperetin and naringenin contents and TPC, but negatively affected DPPH radical scavenging capacity. Read More

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Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li O·11.10ZrO ·69.32SiO glass-ceramic.

J Biomed Mater Res B Appl Biomater 2021 Jun 14. Epub 2021 Jun 14.

Engenharia Química, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.

Glass and bioactive glass-ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass-ceramics of the LZS (Li O-ZrO -SiO ) system are very interesting because of their mechanical, electrical, and thermal properties. Read More

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Development of bioactive sodium alginate/sulfonated polyether ether ketone/hydroxyapatite nanocomposites: Synthesis and in-vitro studies.

Esmaeil Salimi

Carbohydr Polym 2021 Sep 23;267:118236. Epub 2021 May 23.

Faculty of Chemical and Materials Engineering, Shahrood University of Technology, P. O. Box: 3619995161, Shahrood, Iran. Electronic address:

Developing bioactive composites to fill bone cavities caused by disease, injury or surgery still remains a challenge. The aim of this research was to develop a new nanostructured sodium alginate/sulfonated polyether ether ketone/nano-hydroxyapatite (Alg/SPEEK/HA) biocomposite via a simple chemical precipitation strategy. Structural analysis was carried out using X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FTIR). Read More

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September 2021

A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.

Magnesium (Mg) is well-tolerated by the body, displaying exceedingly low toxicity, rapid excretion, and numerous bioactive effects, including improved bone formation and protection against oxidative stresses; further, Mg alloys can be degraded in vivo to allow complete removal of an implant without surgical intervention, avoiding revision surgery and thrombosis concerns seen with permanent implants. Rare earth elements (REEs) have been of particular interest in alloying Mg alloys for nearly a century due to their unique chemical and physical properties but have attracted increasing attention in recent decades. The REEs contribute greatly to the mechanical and biological properties of metal alloys, and so are common in Mg alloys in a wide variety of applications; in particular, they represent the dominant alloying additions in current, clinically applied Mg alloys. Read More

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Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of -Methylated Catechin.

J Nat Prod 2021 Jun 9. Epub 2021 Jun 9.

Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

(-)-Epigallocatechin-3--(3--methyl) gallate (, EGCG3″Me), an antiallergic -methylated catechin, is present in high quantities in the green tea cultivar "Benifuuki" ( L.). Previous studies have shown that EGCG3″Me inhibited basophil degranulation mediated through the cell-surface 67-kDa laminin receptor (67LR), but the mechanisms are not fully elucidated. Read More

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KAT Ligation for Rapid and Facile Covalent Attachment of Biomolecules to Surfaces.

ACS Appl Mater Interfaces 2021 Jun 9. Epub 2021 Jun 9.

Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland.

The efficient and bioorthogonal chemical ligation reaction between potassium acyltrifluoroborates (KATs) and hydroxylamines (HAs) was used for the surface functionalization of a self-assembled monolayer (SAM) with biomolecules. An alkane thioether molecule with one terminal KAT group () was synthesized and adsorbed onto a gold surface, placing a KAT group on the top of the monolayer (). As an initial test case, an aqueous solution of a hydroxylamine (HA) derivative of poly(ethylene glycol) (PEG) () was added to this at room temperature to perform the surface KAT ligation. Read More

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Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by -cinnamaldehyde in C2C12 Myoblasts.

Int J Med Sci 2021 23;18(12):2480-2492. Epub 2021 Apr 23.

Anti-Aging Research Center, Dong-eui University, Busan 47340, Republic of Korea.

-cinnamaldehyde (tCA), a bioactive component found in , has been reported to exhibit anti-inflammatory and antioxidant effects, but its efficacy in muscle cells has yet to be found. In this study, we investigated the inhibitory effect of tCA on inflammatory and oxidative stress induced by lipopolysaccharide (LPS) in C2C12 mouse skeletal myoblasts. To investigate the anti-inflammatory and antioxidant effects of tCA in LPS-treated C2C12 cells, we measured the levels of pro-inflammatory mediator, cytokines, and reactive oxygen species (ROS). Read More

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Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration and .

Bioact Mater 2021 Dec 15;6(12):4568-4579. Epub 2021 May 15.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.

Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. Read More

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December 2021

Food packaging wastes amid the COVID-19 pandemic: Trends and challenges.

Trends Food Sci Technol 2021 Jun 1. Epub 2021 Jun 1.

Laboratory of Bioflavours and Bioactive Compounds, Department of Food Science, Faculty of Food Engineering, University of Campinas, 13083-862, Campinas, SP, Brazil.

Background: The COVID-19 crisis generated changes in consumer behavior related to food purchase and the management of food packaging. Due to the intensification of online purchases for home delivery, there has been an increase in the use of food packaging (mostly non-biodegradable or non-renewable). Moreover, the fear of contamination with SARS-CoV-2 through contact with materials and surfaces has led to an intensified disposal of food packaging, promoting a setback in waste management. Read More

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Potential strategies to prevent encrustations on urinary stents and catheters - thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative.

Expert Rev Med Devices 2021 Jun 11:1-9. Epub 2021 Jun 11.

ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

Urinary stents have been around for the last 4 decades, urinary catheters even longer. They are associated with infections, encrustation, migration, and patient discomfort. Research efforts to improve them have shifted onto molecular and cellular levels. Read More

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Antibody-Functionalized Halloysite Nanotubes for Targeting Bacterial Cells.

ACS Appl Bio Mater 2021 May 11;4(5):4094-4104. Epub 2021 Apr 11.

Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.

Halloysite nanotubes (HNTs) are naturally occurring tubular clay particles which have emerged in recent years as a promising nanomaterial for numerous applications. Specifically, HNTs' large pore volume and high specific surface area in combination with their biocompatibility make them ideal nanocarriers for bioactive compounds. This research aims to design and synthesize functionalized HNTs, which could selectively bind to target bacterial cells in suspension. Read More

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Glycosaminoglycans: From Vascular Physiology to Tissue Engineering Applications.

Front Chem 2021 18;9:680836. Epub 2021 May 18.

Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, Maastricht, Netherlands.

Cardiovascular diseases represent the number one cause of death globally, with atherosclerosis a major contributor. Despite the clinical need for functional arterial substitutes, success has been limited to arterial replacements of large-caliber vessels (diameter > 6 mm), leaving the bulk of demand unmet. In this respect, one of the most challenging goals in tissue engineering is to design a "bioactive" resorbable scaffold, analogous to the natural extracellular matrix (ECM), able to guide the process of vascular tissue regeneration. Read More

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Effect of bioactive glasses and neodymium:yttrium-aluminum-garnet laser on dentin permeability.

J Conserv Dent 2020 Nov-Dec;23(6):583-588. Epub 2021 Feb 11.

Department of Dentistry I, Federal University of Maranhão, São Luis, Maranhão, Brazil.

Context: Dental hypersensitivity and loss of dental tissues are commonly observed in patients, and most of the problems are caused due to total or partial exposure of dentinal tubules.

Aims: The purpose of this study is to evaluate the performance of 45S5 bioactive glass and niobophosphate (NbG) associated with neodymium: yttrium-aluminum-garnet (Nd:YAG) laser for the reduction of dentin permeability.

Materials And Methods: Fifty bovine dentin discs were made and distributed randomly into five groups ( = 10). Read More

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February 2021

Anti-demineralizing protective effects on enamel identified in experimental and commercial restorative materials with functional fillers.

Sci Rep 2021 Jun 3;11(1):11806. Epub 2021 Jun 3.

Department of Conservative and Preventive Dentistry, Center for Dental Medicine, University of Zurich, Plattenstrasse 11, Zurich, Switzerland.

The aim of this study was to investigate whether experimental and commercial dental restorative materials with functional fillers can exert a protective anti-demineralizing effect on enamel that is not immediately adjacent to the restoration. Four experimental resin composites with bioactive glass and three commercial restorative materials were investigated. Enamel blocks were incubated in a lactic acid solution (pH = 4. Read More

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Bio-inspired multifunctional collagen/electrospun bioactive glass membranes for bone tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2021 Jul 6;126:111856. Epub 2021 Jan 6.

National Centre for Nanoscience and Nanotechnology, University of Madras, 600 025, Tamil Nadu, India.

Treatment of bone disease and disorders is often challenging due to its complex structure. Each year millions of people needs bone substitution materials with quick recovery from diseases conditions. Synthetic bone substitutes mimicking structural, chemical and biological properties of bone matrix structure will be very obliging and of copious need. Read More

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Microscopy-based infrared spectroscopy as a tool to evaluate the influence of essential oil on the surface of loaded bilayered-nanoparticles.

Nanotechnology 2021 Jun 3;32(34). Epub 2021 Jun 3.

Programa de Pós-graduação em Ciência e Engenharia de Materiais (PPGCEM), Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brasil.

Increasing interest in nanoparticles of technological application has been improving their fabrication processes. The encapsulation of essential oils as bioactive compounds has proved to be an excellent alternative to the use of less environment friendly compounds. However, the difficulty of identifying their constitution and interaction with carrier agents have aroused scientific interest and a problem to overcome. Read More

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Nanodiamond-chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity.

J Biomed Mater Res A 2021 Jun 3. Epub 2021 Jun 3.

Center for Materials Innovation and Future Fashion (CMIFF), School of Fashion and Textiles, RMIT University, Australia.

Polypropylene (PP) mesh is most commonly used for the treatment of hernia and pelvic floor construction. However, some of the patients have a few complications after surgery due to the rejection or infection of the implanted meshes. The poor biocompatibility of PP mesh, low wettability results in poor cell attachment/proliferation and restricts the loading of antibacterial agent, leading to a slow healing process and high risk of infection after surgery. Read More

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Outer Membrane Vesicles of Vibrio cholerae Protect and Deliver Active Cholera Toxin to Host Cells via Porin-Dependent Uptake.

mBio 2021 May 26:e0053421. Epub 2021 May 26.

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Outer membrane vesicles (OMVs) are an emerging research field due to their multifactorial composition and involvement in interspecies and intraspecies communication. Recent studies indicate that vesicle release by Gram-negative bacterial pathogens is increased during colonization, as exemplified by the facultative human pathogen Vibrio cholerae upon oral ingestion by the host. In this study, we investigate the fate of OMVs produced by the Gram-negative facultative pathogen V. Read More

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Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast .

Antibiotics (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Centro de Química Estrutural (CQE), Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

Currently there is a gap between the rate of new antifungal development and the emergence of resistance among clinical strains, particularly threatened by the extreme adhesiveness of to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OCHN(CH)NCHO}] (compound P) and [{Ag(OCHNCHCH-p)}(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of and clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by and colonize the surface of indwelling medical devices, resulting in persistent infections. Read More

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Biosynthesized Poly(3-Hydroxybutyrate) on Coated Pineapple Leaf Fiber Papers for Biodegradable Packaging Application.

Polymers (Basel) 2021 May 26;13(11). Epub 2021 May 26.

Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, Bangkok 10900, Thailand.

This paper is aimed at investigating the usage of biosynthesized poly(3-hydroxybutyrate) (P(3-HB)) for a coating on pineapple leaf fiber paper (PLFP). For this purpose, (P(3-HB)) was produced by BSRT1-1, a highly potential P(3-HB) producing bacterium, with a weight-average molecular weight () of 6.07 × 10 g/mol. Read More

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Extracellular-Vesicle-Based Coatings Enhance Bioactivity of Titanium Implants-SurfEV.

Nanomaterials (Basel) 2021 05 29;11(6). Epub 2021 May 29.

Faculty of Medicine and Health, Sydney School of Pharmacy, Sydney Nano Institute, The University of Sydney, Camperdown, NSW 2006, Australia.

Extracellular vesicles (EVs) are nanoparticles released by cells that contain a multitude of biomolecules, which act synergistically to signal multiple cell types. EVs are ideal candidates for promoting tissue growth and regeneration. The tissue regenerative potential of EVs raises the tantalizing possibility that immobilizing EVs on implant surfaces could potentially generate highly bioactive and cell-instructive surfaces that would enhance implant integration into the body. Read More

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Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products.

Foods 2021 May 18;10(5). Epub 2021 May 18.

Department of Nutrition and Food Science, Campus of Cartuja, University of Granada, 18011 Granada, Spain.

Orange peel is the main by-product from orange juice industry. It is a known source of bioactive compounds, mostly phenolic compounds, and it has been widely studied for its healthy activities. Thus, this research focuses on the establishment of ultrasound-assisted extraction of phenolic compounds in orange peel using a sonotrode. Read More

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Comparative Studies of Selected Criteria Enabling Optimization of the Extraction of Polar Biologically Active Compounds from Alfalfa with Supercritical Carbon Dioxide.

Molecules 2021 May 18;26(10). Epub 2021 May 18.

Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.

The aim of this research was to provide crucial and useful data about the selection of the optimization criteria of supercritical carbon dioxide extraction of alfalfa at a quarter-technical plant. The correlation between more general output, including total phenolics and flavonoids content, and a more specified composition of polar constituents was extensively studied. In all alfalfa extracts, polar bioactive constituents were analyzed by both spectrometric (general output) and chromatographic (detailed output) analyses. Read More

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Antibacterial, Antifungal and Antibiofilm Activities of Silver Nanoparticles Supported by Crude Bioactive Metabolites of Bionanofactories Isolated from Lake Mariout.

Molecules 2021 May 19;26(10). Epub 2021 May 19.

Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Lake Mariout is one of the polluted coastal marine ecosystems in Egypt which is considered to be a reservoir of serious effluents from different anthropogenic activities. Such selective pressure enforces indigenous microbial populations to acquire new advantageous themes. Thus, in this study, two strains were screened, from Lake Mariout's sediment for bioreduction of 5 mM AgNO. Read More

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PCL/Andiroba Oil ( Aubl.) Hybrid Film for Wound Healing Applications.

Polymers (Basel) 2021 May 14;13(10). Epub 2021 May 14.

Laboratory of Oils of the Amazon, Federal University of Pará, Belém 66075-750, PA, Brazil.

Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing's requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (). Read More

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Valorization of Bilberry ( L.) Pomace by Enzyme-Assisted Extraction: Process Optimization and Comparison with Conventional Solid-Liquid Extraction.

Antioxidants (Basel) 2021 May 13;10(5). Epub 2021 May 13.

Bioprocess Research Centre, Faculty of Chemical Technology, Kaunas University of Technology, Radvilėnų Pl. 19, LT-50254 Kaunas, Lithuania.

Bilberry ( L.) pomace contains a significant amount of polyphenols and can serve as a basis for food additives, nutraceuticals, and functional foods. Although various techniques can be employed to recover bioactive fractions from berry pomaces, data on enzyme-assisted extraction (EAE) of bilberry pomace are rather scarce. Read More

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DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped NaO-CaO-PO Glasses.

Materials (Basel) 2021 May 17;14(10). Epub 2021 May 17.

Advanced Materials Center, Gdańsk University of Technology, ul. Narutowicza 11/12, 80-233 Gdańsk, Poland.

Bioactive glasses have recently been extensively used to replace, regenerate, and repair hard tissues in the human body because of their ability to bond with living tissue. In this work, the effects of replacing NaO with MgO on the electrical, biosolubility, and thermal properties of the target glass 10NaO-60PO-30CaO (in mol%) were investigated. The electrical properties of the glasses were studied with the impedance spectroscopy technique. Read More

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