375 results match your criteria bio-medical natural

Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment.

Theranostics 2021 27;11(19):9687-9704. Epub 2021 Sep 27.

Center for Scientific Instrumentation, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.

Glioblastoma (GBM) is one of the most aggressive types of brain cancer. GBM progression is closely associated with microglia activation; therefore, understanding the regulation of the crosstalk between human GBM and microglia may help develop effective therapeutic strategies. Elucidation of efficient delivery of microRNA (miRNA) via extracellular vesicles (EVs) and their intracellular communications is required for therapeutic applications in GBM treatment. Read More

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September 2021

LitCovid-AGAC: cellular and molecular level annotation data set based on COVID-19.

Genomics Inform 2021 Sep 30;19(3):e23. Epub 2021 Sep 30.

Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, 430070 Wuhan, China.

Currently, coronavirus disease 2019 (COVID-19) literature has been increasing dramatically, and the increased text amount make it possible to perform large scale text mining and knowledge discovery. Therefore, curation of these texts becomes a crucial issue for Bio-medical Natural Language Processing (BioNLP) community, so as to retrieve the important information about the mechanism of COVID-19. PubAnnotation is an aligned annotation system which provides an efficient platform for biological curators to upload their annotations or merge other external annotations. Read More

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September 2021

Interference-free, lightweight wireless neural probe system for investigating brain activity during natural competition.

Biosens Bioelectron 2021 Sep 23;195:113665. Epub 2021 Sep 23.

Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea; School of Electrical and Electronics Engineering, Yonsei University, Seoul, Republic of Korea; Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, Republic of Korea. Electronic address:

Competition is one of the most fundamental, yet complex, conflicts between social animals, and previous studies have indicated that the medial prefrontal cortex (mPFC) region of a brain is involved in social interactions. However, because we do not have a lightweight, wireless recording system that is free of interference, it is still unclear how the neural activity of the mPFC region is involved in the diverse, interacting behaviors that comprise competition. Herein, we present an interference-free, lightweight, wireless neural probe system that we applied to two mice to measure mPFC neural activities during a food competition test. Read More

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September 2021

A decade of machine learning-based predictive models for human pharmacokinetics: Advances and challenges.

Drug Discov Today 2021 Sep 27. Epub 2021 Sep 27.

Department of Bio & Medical Big Data (BK4), Division of Life Sciences, Research Institute of Natural Sciences (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 52828, Republic of Korea. Electronic address:

Traditionally, in vitro and in vivo methods are useful for estimating human pharmacokinetics (PK) parameters; however, it is impractical to perform these complex and expensive experiments on a large number of compounds. The integration of publicly available chemical, or medical Big Data and artificial intelligence (AI)-based approaches led to qualitative and quantitative prediction of human PK of a candidate drug. However, predicting drug response with these approaches is challenging, partially because of the adaptation of algorithmic and limitations related to experimental data. Read More

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September 2021

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment.

Int J Mol Sci 2021 Sep 16;22(18). Epub 2021 Sep 16.

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. Read More

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September 2021

Identification of CDK7 Inhibitors from Natural Sources Using Pharmacoinformatics and Molecular Dynamics Simulations.

Biomedicines 2021 Sep 10;9(9). Epub 2021 Sep 10.

Department of Bio & Medical Big Data (BK4 Program), Division of Life Sciences, Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 52828, Korea.

The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and RNA polymerase-based transcription. Overexpression of this kinase is linked with various cancers in humans due to its dual involvement in cell development. Furthermore, emerging evidence has revealed that inhibiting CDK7 has anti-cancer effects, driving the development of novel and more cost-effective inhibitors with enhanced selectivity for CDK7 over other CDKs. Read More

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September 2021

Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity.

Biomedicines 2021 Sep 1;9(9). Epub 2021 Sep 1.

Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Although the sea ecosystem offers a broad range of bioactivities including anticancer, none of the FDA-approved antiproliferative protein kinase inhibitors are derived from a marine source. In a step to develop new marine-inspired potent kinase inhibitors with antiproliferative activities, a new series of hybrid small molecules () was designed and synthesized based on chemical moieties derived from two marine natural products (Meridianin E and Leucettamine B). Over a panel of 14 cancer-related kinases, a single dose of 10 µM of the parent hybrid possessing the benzo[][1,3]dioxole moiety of Leucettamine B was able to inhibit the activity of FMS, LCK, LYN, and DAPK1 kinases with 82. Read More

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September 2021

All around suboptimal health - a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine.

EPMA J 2021 Sep 13:1-31. Epub 2021 Sep 13.

Suboptimal Health Study Consortium, Kumasi, Ghana.

First two decades of the twenty-first century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. Read More

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September 2021

Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy.

Cancers (Basel) 2021 Sep 2;13(17). Epub 2021 Sep 2.

Center for Theragnosis, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes. Read More

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September 2021

A Novel Cardenolide Glycoside Isolated from Reduces Levels of the Alzheimer's Disease-Associated β-Amyloid Peptides Aβ42 In Vitro.

Pharmaceuticals (Basel) 2021 Jul 29;14(8). Epub 2021 Jul 29.

Department of Chemistry, University of Pretoria, Pretoria 0028, South Africa.

Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer's disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). To identify natural products that block the formation of Aβ-proteins from APPs, we previously screened a library of plant extracts and identified (Apocynaceae) as a potential plant for further research. Read More

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Genomic Characterization of Fluoroquinolone-Resistant Thermophilic Strains Isolated from Layer Chicken Feces in Gangneung, South Korea by Whole-Genome Sequencing.

Genes (Basel) 2021 Jul 25;12(8). Epub 2021 Jul 25.

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606, USA.

Thermophilic species of poultry origin have been associated with up to 80% of human campylobacteriosis cases. Layer chickens have received less attention as possible reservoirs of species. Initially, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of two archived isolates ( strain 200605 and strain 200606) from layer chickens to five antimicrobials (ciprofloxacin, nalidixic acid, erythromycin, tetracycline, and gentamicin) were determined using broth microdilution while the presence of selected antimicrobial resistance genes was performed by polymerase chain reaction (PCR) using specific primers. Read More

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Multi-layered proteogenomic analysis unravels cancer metastasis directed by MMP-2 and focal adhesion kinase signaling.

Sci Rep 2021 08 24;11(1):17130. Epub 2021 Aug 24.

Center for Theragnosis, Korea Institute of Science and Technology, 5 Hwarangro-14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.

The role of matrix metalloproteinase-2 (MMP-2) in tumor cell migration has been widely studied, however, the characteristics and effects of MMP-2 in clinical sample of metastatic colorectal cancer (CRC) remain poorly understood. Here, in order to unveil the perturbed proteomic signal during MMP-2 induced cancer progression, we analyzed plasma proteome of CRC patients according to disease progression, HCT116 cancer secretome upon MMP-2 knockdown, and publicly available CRC tissue proteome data. Collectively, the integrative analysis of multi-layered proteomes revealed that a protein cluster containing EMT (Epithelial-to-Mesenchymal Transition)-associated proteins such as CD9-integrin as well as MMP-2. Read More

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The multi-functional roles of forkhead box protein O in skin aging and diseases.

Redox Biol 2021 Oct 13;46:102101. Epub 2021 Aug 13.

Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea. Electronic address:

Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. Read More

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October 2021

Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth.

Small 2021 Sep 19;17(38):e2102062. Epub 2021 Aug 19.

Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, 210008, China.

Spiral ganglion neuron (SGN) degeneration can lead to severe hearing loss, and the directional regeneration of SGNs has shown great potential for improving the efficacy of auditory therapy. Here, a novel 3D conductive microstructure with surface topologies is presented by integrating superaligned carbon-nanotube sheets (SA-CNTs) onto Morpho Menelaus butterfly wings for SGN culture. The parallel groove-like topological structures of M. Read More

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September 2021

Light-fueled transient supramolecular assemblies in water as fluorescence modulators.

Nat Commun 2021 08 17;12(1):4993. Epub 2021 Aug 17.

Institute of Advanced Materials, School of Chemistry and Chemical Engineering, and Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing, China.

Dissipative self-assembly, which requires a continuous supply of fuel to maintain the assembled states far from equilibrium, is the foundation of biological systems. Among a variety of fuels, light, the original fuel of natural dissipative self-assembly, is fundamentally important but remains a challenge to introduce into artificial dissipative self-assemblies. Here, we report an artificial dissipative self-assembly system that is constructed from light-induced amphiphiles. Read More

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Distinct Persistence Fate of Mycobacterium tuberculosis in Various Types of Cells.

mSystems 2021 Aug 17;6(4):e0078321. Epub 2021 Aug 17.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural Universitygrid.35155.37, Wuhan, China.

Mycobacterium tuberculosis can invade different cells with distinct persistence fates because cells are equipped with different host restriction factors. However, the underlying mechanisms remain elusive. Here, we infected THP1 and Raw264. Read More

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Cation-Exchange-Induced Metal and Alloy Dual-Exsolution in Perovskite Ferrite Oxides Boosting the Performance of Li-O Battery.

Angew Chem Int Ed Engl 2021 Oct 13;60(43):23380-23387. Epub 2021 Sep 13.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.

A temperature-controlled cation-exchange approach is introduced to achieve a unique dual-exsolution in perovskite La Fe Co O where both CoFe alloy and Co metal are simultaneously exsolved from the parent perovskite, forming an alloy and metal co-decorated perovskite oxide. Mossbauer spectra show that cation exchange of Fe atoms in CoFe alloy and Co cations in the perovskite is the key to the co-existence of Co metal and CoFe alloy. The obtained composite exhibits an enhanced catalytic activity as Li-O battery cathode catalysts with a specific discharge capacity of 6549. Read More

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October 2021

Deep associative learning approach for bio-medical sentiment analysis utilizing unsupervised representation from large-scale patients' narratives.

Pers Ubiquitous Comput 2021 Aug 11:1-15. Epub 2021 Aug 11.

LISAC Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Owing to the quick spread of minute health-related experiences, the distillation of knowledge from such unstructured narratives is an extremely challenging task. In spite of the success of neural networks methods in improving learning structural reliability, they result in inadequate accuracy of the bio-medical sentiment classification when employing less useful features sets. Therefore, they lack discriminatory potential. Read More

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Neuroprotective effects of 2-heptyl-3-hydroxy-4-quinolone in HT22 mouse hippocampal neuronal cells.

Bioorg Med Chem Lett 2021 Oct 8;49:128312. Epub 2021 Aug 8.

Natural Product Research Center, Institute of Natural Product, Korea Institute of Science and Technology, Gangnueng 25451, Republic of Korea; Convergence Research Center of Dementia, Brain Science Institute, Korea Institute of Science and Technology, 02792, Republic of Korea; Division of Bio-medical Science & Technology, University of Science and Technology, Daejun 34113, Republic of Korea. Electronic address:

The neuroprotective activity of 2-heptyl-3-hydroxy-4(1H)-quinolone (compound 1) was evaluated using the neurotoxicity of glutamate in the HT22 cell line. Compound 1, known as a signal molecule of the bacterial quorum-sensing system, protects neuronal cells from glutamate-induced neurotoxicity by inhibiting cellular Ca uptake and glutamate-triggered ROS accumulation. MAPK signaling pathway inhibition by compound 1 was evaluated by immunoblotting the phosphorylation status of the proteins. Read More

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October 2021

Yttrium-mediated red fluorescent carbon dots for sensitive and selective detection of calcium ions.

Luminescence 2021 Aug 9. Epub 2021 Aug 9.

Key Laboratory of Applied Chemistry and Nanotechnology at University of Jilin Province, Changchun University of Science and Technology, Changchun, China.

As the second messenger in cells, calcium ions are indispensable in various physiological activities of the body. In this work, a special red fluorescent carbon dot was designed and synthesized using the secondary hydrothermal method with yttrium, p-phenylenediamine, and ethylene glycol tetraacetic acid as precursors for the detection of calcium ions. The designed carbon dot exhibited bright red fluorescence, and the fluorescence emission wavelength showed good photostability. Read More

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Daratumumab Immunopolymersome-Enabled Safe and CD38-Targeted Chemotherapy and Depletion of Multiple Myeloma.

Adv Mater 2021 Oct 8;33(39):e2007787. Epub 2021 Aug 8.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and, Materials Science, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, P. R. China.

Multiple myeloma (MM) is a second ranking hematological malignancy. Despite the fast advancement of new treatments such as bortezormib and daratumumab, MM patients remain incurable and tend to eventually become relapsed and drug-resistant. Development of novel therapies capable of depleting MM cells is strongly needed. Read More

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October 2021

Fabrication of substituted hydroxyapatite-starch-clay bio-composite coated titanium implant for new bone formation.

Carbohydr Polym 2021 Nov 14;271:118432. Epub 2021 Jul 14.

Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, China; Shenzhen Research Institute of Shandong University, Shenzhen, Guangdong 518057, China. Electronic address:

The clay/polymeric matrices have much attention from researchers in bio-medical applications due to their numerous uses. This study introduces new orthopedic titanium (Ti) implant with increasing bio-activity by treating the surface of the Ti implant with bio-compatible composite coating. Wollastonite (WST) clay combined minerals (Mgand Gd) substituted hydroxyapatite (HAP)/Starch composite was prepared using in-situ co-precipitation method. Read More

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November 2021

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of .

Molecules 2021 Jul 25;26(15). Epub 2021 Jul 25.

Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea.

extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of The drying process mainly involves heat (36 h at 60 °C) and freeze-drying (36 h at -80 °C). We investigated the effects of different postharvest drying protocols on the metabolites profiling of using GC-MS, followed by an investigation of the anti-neuroinflammatory potential in LPS-treated BV2 microglial cells. Read More

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Development of Machine Learning Models for Accurately Predicting and Ranking the Activity of Lead Molecules to Inhibit PRC2 Dependent Cancer.

Pharmaceuticals (Basel) 2021 Jul 20;14(7). Epub 2021 Jul 20.

Department of Bio & Medical Big Data (BK21 Program), Division of Life Sciences, Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 5282, Korea.

Disruption of epigenetic processes to eradicate tumor cells is among the most promising interventions for cancer control. EZH2 (Enhancer of zeste homolog 2), a catalytic component of polycomb repressive complex 2 (PRC2), methylates lysine 27 of histone H3 to promote transcriptional silencing and is an important drug target for controlling cancer via epigenetic processes. In the present study, we have developed various predictive models for modeling the inhibitory activity of EZH2. Read More

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The efficient synthesis and biological evaluation of justicidin B.

Nat Prod Res 2021 Jul 6:1-7. Epub 2021 Jul 6.

Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.

A facile new synthetic method for the preparation of a Type-A 1-arylnaphthalene lactone skeleton was developed and used to synthesise justicidin B and several derivatives. Key synthesis steps included Hauser-Kraus annulation of a phthalide intermediate and Suzuki-Miyaura cross coupling between a triflated naphthalene lactone intermediate and various potassium organotrifluoroborates. With two exceptions, the derivatives showed significant inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophages. Read More

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Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells.

Bioorg Chem 2021 Sep 23;114:105112. Epub 2021 Jun 23.

KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea. Electronic address:

The consumption of sprouts has been steadily increasing due to their being an excellent source of nutrition. It is known that the bioactive constituents of legumes can be increased after germination. In this study, the extract from Senna tora sprouts is shown to exhibit improved radical scavenging activities and better neuroprotective effects in HT22 hippocampal neuronal (HT22) and R28 retina precursor (R28) cells than those from seeds due to an increased content of phenolic constituents, especially compounds 1 and 3-6. Read More

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September 2021

Neuroprotective Effect of Astersaponin I against Parkinson's Disease through Autophagy Induction.

Biomol Ther (Seoul) 2021 Jul 2. Epub 2021 Jul 2.

Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea.

An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on and Parkinson's disease (PD) models. The autophagy-regulating effect of AKNS-2 was monitored by analyzing the expression of autophagy-related protein markers in SHSY5Y cells using Western blot and fluorescent protein quenching assays. The neuroprotection of AKNS-2 was tested by using a 1-methyl-4-phenyl-2,3-dihydropyridium ion (MPP)-induced PD model in SH-SY5Y cells and an MPTP-induced PD model in mice. Read More

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KJ623766: A Natural Producer of Two Anthracycline Cytotoxic Metabolites β- and γ-Rhodomycinone.

Molecules 2021 Jun 30;26(13). Epub 2021 Jun 30.

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Organization of African Unity St, Abbassia, Cairo P.O. Box 11566, Egypt.

Background: This study aimed to produce, purify, structurally elucidate, and explore the biological activities of metabolites produced by isolate KJ623766, a recovered soil bacterium previously screened in our lab that showed promising cytotoxic activities against various cancer cell lines.

Methods: Production of cytotoxic metabolites from isolate KJ623766 was carried out in a 14L laboratory fermenter under specified optimum conditions. Using a 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl tetrazolium-bromide assay, the cytotoxic activity of the ethyl acetate extract against 2 and cancer cell lines was determined. Read More

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Multi-Functional Core-Shell Nanofibers for Wound Healing.

Nanomaterials (Basel) 2021 Jun 11;11(6). Epub 2021 Jun 11.

Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia.

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Read More

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Comparative Analysis for Genetic Characterization in Korean Native Jeju Horse.

Animals (Basel) 2021 Jun 28;11(7). Epub 2021 Jun 28.

Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan 31116, Korea.

The Jeju horse is a native Korean species that has been breeding on Jeju Island since the 13th century. Their shape has a distinct appearance from the representative species, Thoroughbred. Here, we performed a comparison of the Jeju horse and Thoroughbred horse for the identification of genome-wide structure variation by using the next-generation sequencing (NGS) technique. Read More

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