6,520 results match your criteria binary outcomes


Same Day Surgical Intervention Dramatically Minimizes Complication Occurrence and Optimizes Perioperative Outcomes for Central Cord Syndrome.

Clin Spine Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY Department of Pediatric Neurosurgery, UT Southwestern Medical Center, Dallas, TX Department of Neurologic Surgery, University of Michigan, Ann Arbor, MI Department of Orthopaedic Surgery, University of Calgary, Calgary, AB, Canada Department of Neurological Surgery Montefiore Medical Center/Albert Einstein College of Medicine Bronx, NY Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD Deparment of Orthopedic Surgery, SUNY Downstate, New York, NY.

Study Design: This was a retrospective cohort study.

Objective: The aim of this study was to investigate associations between time to surgical intervention and outcomes for central cord syndrome (CCS) patients.

Background: As surgery is increasingly recommended for patients with neurological deterioration CCS, it is important to investigate the relationship between time to surgery and outcomes. Read More

View Article and Full-Text PDF

Low bone mineral density is associated with severe periodontitis at the end of the second decade of life: a population-based study.

J Clin Periodontol 2021 Jul 20. Epub 2021 Jul 20.

Department of Dentistry II, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Aim: To evaluate the association between low bone mineral density (BMD) and severe periodontitis at the end of the second decade of life.

Methods: This population-based study analyzed 2032 youngers (18-19 y-old) of the RPS cohort. Lumbar spine (BMD-LS) and whole-body (BMD-WB) BMD were assessed by dual X-ray emission densitometry. Read More

View Article and Full-Text PDF

Clinical and epidemiological characteristics and outcomes of Coronavirus disease-19 patients in a large longitudinal study.

Int J Health Sci (Qassim) 2021 Jul-Aug;15(4):29-41

Director General of Health, Duhok Directorate General of Health, Iraqi Kurdistan, Iraq.

Objective: This study aimed to determine the clinical and epidemiological characteristics and outcomes of Coronavirus disease (COVID)-19 patients.

Methods: In this large cohort study, 15,409 confirmed patients with the COVID-19 of different severities were followed-up from three specialized COVID-19 hospitals between March 18 and October 11, 2020 in Iraqi Kurdistan. The predictors of mortality and severity were examined in binary logistic regression analysis. Read More

View Article and Full-Text PDF

Application of machine learning to predict the outcome of pediatric traumatic brain injury.

Chin J Traumatol 2021 Jun 8. Epub 2021 Jun 8.

Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Purpose: Traumatic brain injury (TBI) generally causes mortality and disability, particularly in children. Machine learning (ML) is a computer algorithm, applied as a clinical prediction tool. The present study aims to assess the predictability of ML for the functional outcomes of pediatric TBI. Read More

View Article and Full-Text PDF

Adolescents' Relationships With Important Adults: Exploring This Novel Protective Factor Against Interpersonal Violence Victimization and Perpetration.

J Interpers Violence 2021 Jul 20:8862605211031252. Epub 2021 Jul 20.

Rutgers University, New Brunswick, NJ, USA.

Despite the increasing influence of peers during adolescence, adults continue to play a significant role in impacting the lives of adolescents. Adolescents' relationships with caring adults are associated with a host of positive outcomes, including improved psychosocial, educational, and behavioral outcomes, and reduced problem behaviors. However, research has not explored the influence of relationships with caring adults on adolescent interpersonal violence (AIV) risk. Read More

View Article and Full-Text PDF

Examining the effect of an education intervention on nurses' medicines management knowledge.

Nurs Manag (Harrow) 2021 Jul 20. Epub 2021 Jul 20.

University of Oslo, Norway.

Background: Suboptimal medicines management due to inadequate knowledge can cause risks to patient safety and affect the quality of care and patient outcomes.

Aim: To examine the effect of an educational programme on nurses' knowledge of medicines management.

Method: A pre and post-design was used to evaluate the effectiveness of an educational medicines management programme. Read More

View Article and Full-Text PDF

The Role of Frailty in Predicting 3 and 6 Months Functional Decline in Hospitalized Older Adults: Findings from a Secondary Analysis.

Int J Environ Res Public Health 2021 Jul 3;18(13). Epub 2021 Jul 3.

School of Nursing, Hunter College of the City University of New York, New York, NY 10010, USA.

Frailty represents one of the most relevant geriatric syndromes in the 21st century and is a predictor of adverse outcomes in hospitalized older adult, such as, functional decline (FD). This study aimed to examine if frailty, evaluated with the Frailty Index (FI), can predict FD during and after hospitalization (3 and 6 months). Secondary data analysis of a prospective cohort study of 101 hospitalized older adults was performed. Read More

View Article and Full-Text PDF

Influence of Education and Income on Receipt of Dementia Care in Sweden.

J Am Med Dir Assoc 2021 Jul 17. Epub 2021 Jul 17.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Aging Theme, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Objective: To explore the dementia diagnostic process and drug prescription for persons with dementia (PWD) with different socioeconomic status (SES).

Design: Register-based cohort study.

Setting And Participants: This study included 74,414 PWD aged ≥65 years from the Swedish Dementia Register (2007-2018). Read More

View Article and Full-Text PDF

An Examination of Substance Use Disorder Type, Legal Status of Drug, and Treatment Outcomes.

Subst Use Misuse 2021 Jul 19:1-7. Epub 2021 Jul 19.

Department of Sociology, Anthropology and Criminal Justice, Clemson University, Clemson, South Carolina, USA.

Background: From the anti-tobacco and anti-marijuana campaigns of the twentieth century to the current controversies surrounding vaporizer use and the opioid epidemic, substances and substance use have been at the forefront of cultural, public health, and legal debates for decades. This work explores treatment outcomes among those with substance use disorders (SUD) by 1) comparing legal, semi-legal, and illegal drug types and their impact on treatment outcomes and 2) evaluating the extent that there exist discrepancies between those who need and those who receive treatment. Binary logistic regression models were employed with data from the 2018 National Survey on Drug Use and Health (NSDUH) to examine the relationship between type of SUD and treatment outcomes. Read More

View Article and Full-Text PDF

Traits of patients seen via telemedicine versus in person for new-patient visits in a fertility practice.

F S Rep 2021 Jun 15;2(2):224-229. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Washington University, St. Louis, Missouri.

Objective: To assess the differences in demographics, the likelihood of receiving treatment, and the clinical outcomes between new patients seen via telemedicine and those seen in person in an academic fertility practice.

Design: Retrospective cohort study.

Setting: University-based fertility clinic. Read More

View Article and Full-Text PDF

A review on the theory of stable dendritic growth.

Philos Trans A Math Phys Eng Sci 2021 Sep 19;379(2205):20200325. Epub 2021 Jul 19.

Department of Theoretical and Mathematical Physics, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, Ekaterinburg, 620000, Russian Federation.

This review article summarizes the main outcomes following from recently developed theories of stable dendritic growth in undercooled one-component and binary melts. The nonlinear heat and mass transfer mechanisms that control the crystal growth process are connected with hydrodynamic flows (forced and natural convection), as well as with the non-local diffusion transport of dissolved impurities in the undercooled liquid phase. The main conclusions following from stability analysis, solvability and selection theories are presented. Read More

View Article and Full-Text PDF
September 2021

Rejoinder for discussions on correct and logical causal inference for binary and time-to-event outcomes in randomized controlled trials.

Biom J 2021 Jul 16. Epub 2021 Jul 16.

Department of Statistics, The Ohio State University, Columbus, OH, USA.

Our paper differs from previous literature in two ways: 1.We think in terms of clinical consequences, what benefits patients, what harms patients. Our main message is: using a not logic-respecting efficacy measure can potentially harm patients in a randomized controlled trial (RCT), as we prove analytically, and demonstrate with the OAK blood-based tumor mutational burden (bTMB) study. Read More

View Article and Full-Text PDF

Osseous Tumor Reporting and Data System-Multireader Validation Study.

J Comput Assist Tomogr 2021 Jul 13. Epub 2021 Jul 13.

From the Department of Radiology, UT Southwestern Medical Center, Dallas, TX Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX Department of Population and Data Sciences UT Southwestern Medical Center, Dallas, TX.

Objective: To develop and validate an Osseous Tumor Reporting and Data System (OT-RADS) with the hypothesis that the proposed guideline is reliable and assists in separating benign from malignant osseous tumors with a good area under the curve, and that could assist further patient management.

Methods: In this multireader cross-sectional validation study, an agreement was reached for OT-RADS categories based on previously described magnetic resonance imaging features and consensus of expert musculoskeletal radiologists. World Health Organization classification was used, and a wide spectrum of benign and malignant osseous tumors was evaluated. Read More

View Article and Full-Text PDF

The effect of ventilator-associated pneumonia on the prognosis of intensive care unit patients within 90 days and 180 days.

BMC Infect Dis 2021 Jul 15;21(1):684. Epub 2021 Jul 15.

Department of Critical Care Medicine, Guangdong Second Provincial General Hospital, No.466 Xingang Middle Road, Guangzhou, 510000, Guangdong, China.

Background: Mechanical ventilation (MV) is often applied in critically ill patients in intensive care unit (ICU) to protect the airway from aspiration, and supplement more oxygen. MV may result in ventilator-associated pneumonia (VAP) in ICU patients. This study was to estimate the 90-day and 180-day mortalities of ICU patients with VAP, and to explore the influence of VAP on the outcomes of ICU patients. Read More

View Article and Full-Text PDF

The relationship between antiepileptic drug load and challenging behaviors in older adults with intellectual disability and epilepsy.

Epilepsy Behav 2021 Jul 12;122:108191. Epub 2021 Jul 12.

School of Pharmacy and Pharmaceutical Sciences, Trinity College, College Green, Dublin 2, Ireland.

Antiepileptic drugs (AEDs) may affect mood and behavior in people with epilepsy and intellectual disability. A high AED load, derived from AED polytherapy and/or high doses of AEDs, has been suggested to be a risk factor for behavioral side effects. Data were drawn from Wave 3 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). Read More

View Article and Full-Text PDF

Margin Positivity and Survival in Papillary Thyroid Microcarcinoma: A National Cancer Database Analysis.

J Am Coll Surg 2021 Jun 25. Epub 2021 Jun 25.

Division of Endocrine Surgery; DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, US.

Background: The rising incidence of thyroid cancer has been attributed to increased detection of papillary thyroid microcarcinoma (PTMC). Although some PTMCs are thought to harbor aggressive pathologic features, the clinical significance of these features remains unclear. This study examines factors associated with survival in this patient population. Read More

View Article and Full-Text PDF

Indications, Outcome and Risk Factors of Cesarean Delivery Among Pregnant Women Utilizing Delivery Services at Selected Public Health Institutions, Oromia Region, South West Ethiopia.

Patient Relat Outcome Meas 2021 7;12:227-236. Epub 2021 Jul 7.

Zonal Health Office, Oromia, Ethiopia.

Background: Approximately 10% of deliveries are considered as high risk, which may require cesarean section. Besides, a rise in cesarean section delivery is a real public health concern; cesareans are costly and carry 8-12 and 8 times higher feto-maternal morbidity and mortality, respectively, as compared to vaginal delivery. Like in other countries where unnecessary cesarean delivery is performed, it is also rising in our country, posing potential risk to the mothers and their newborns. Read More

View Article and Full-Text PDF

Direct versus Bridging Mechanical Thrombectomy in Elderly Patients with Acute Large Vessel Occlusion: A Multicenter Cohort Study.

Clin Interv Aging 2021 5;16:1265-1274. Epub 2021 Jul 5.

Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.

Purpose: Elderly people represent a growing stroke population with different pathophysiological states than younger. Whether intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is beneficial for elderly patients remains unclear. This study compared the efficacy and safety between elderly patients treated with MT alone and those treated with both IVT and MT. Read More

View Article and Full-Text PDF

Community norms of the Muscle Dysmorphic Disorder Inventory (MDDI) among gender minority populations.

J Eat Disord 2021 Jul 14;9(1):87. Epub 2021 Jul 14.

The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: Representing the pathological extreme pursuit of muscularity, muscle dysmorphia (MD) is characterized by a pervasive belief or fear around insufficient muscularity and an elevated drive for muscularity. Despite evidence of heightened body image-related concerns among gender minority populations, little is known about the degree of MD symptoms among gender minorities, particularly based on Muscle Dysmorphic Disorder Inventory (MDDI) scores. The objective of this study was to assess community norms of the MDDI in gender-expansive people, transgender men, and transgender women. Read More

View Article and Full-Text PDF

Laboratory Approaches to Test the Function of Antiphospholipid Antibodies.

Semin Thromb Hemost 2021 Jul 14. Epub 2021 Jul 14.

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder caused by the presence of aPLs (antiphospholipid antibodies, i.e., anti-β-glycoprotein I and anti-cardiolipin). Read More

View Article and Full-Text PDF

The Women's Study for the Alleviation of Vasomotor Symptoms (WAVS): a randomized, controlled trial of a plant-based diet and whole soybeans for postmenopausal women.

Menopause 2021 Jul 12. Epub 2021 Jul 12.

Physicians Committee for Responsible Medicine, Washington, DC Adjunct Faculty, George Washington University School of Medicine, Washington, DC School of Medicine, University of Utah, Salt Lake City, UT.

Objective: This study aimed to assess the effects of the combination of a low-fat plant-based diet and soybeans on the frequency and severity of menopausal hot flashes.

Methods: Postmenopausal women (n = 38) reporting two or more hot flashes/day were randomly assigned to a low-fat, vegan diet, including ½ cup (86 g) of cooked soybeans daily, or to no diet changes for 12 weeks. Frequency and severity of hot flashes were recorded using a mobile application, and vasomotor, psychosocial, physical, and sexual symptoms were assessed using the Menopause-Specific Quality of Life Questionnaire. Read More

View Article and Full-Text PDF

Acceptability of an mHealth App That Provides Harm Reduction Services Among People Who Inject Drugs: Survey Study.

J Med Internet Res 2021 Jul 14;23(7):e25428. Epub 2021 Jul 14.

Department of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT, United States.

Background: Harm reduction services reduce the negative consequences of drug injection and are often embedded within syringe service programs (SSPs). However, people who inject drugs (PWID) suboptimally engage with such services because of stigma, fear, transportation restrictions, and limited hours of operation. Mobile health (mHealth) apps may provide an opportunity to overcome these barriers and extend the reach of SSPs beyond that of the traditional brick-and-mortar models. Read More

View Article and Full-Text PDF

Prognostic implications of atrial fibrillation in patients with stable coronary artery disease: a systematic review and meta-analysis of adjusted observational studies.

Rev Cardiovasc Med 2021 Jun;22(2):439-444

Division of Cardiology, "Città della Salute e della Scienza di Torino" Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. Despite the frequent coexistence with coronary artery disease (CAD), the prognostic independent implication of AF in patients with stable CAD remains controversial. Our aim was to perform a pairwise meta-analysis of adjusted observational studies comparing cardiovascular outcomes in patients with stable CAD with and without concomitant AF, in search of AF-specific prognostic implications. Read More

View Article and Full-Text PDF

Modeling of pre-transplantation liver viability with spatial-temporal smooth variable selection.

Comput Methods Programs Biomed 2021 Jul 3;208:106264. Epub 2021 Jul 3.

Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA.

Background And Objective: Liver viability assessment plays a critical role in liver transplantation, and the accuracy of the assessment directly determines the success of the transplantation surgery and patient's outcomes. With various factors that affect liver viability, including pre-existing medical conditions of donors, the procurement process, and preservation conditions, liver viability assessment is typically subjective, invasive or inconsistent in results among different surgeons and pathologists. Motivated by these challenges, we aimed to create a non-invasive statistical model utilizing spatial-temporal infrared image (IR) data to predict the binary liver viability (acceptable/unacceptable) during the preservation. Read More

View Article and Full-Text PDF

Changes in Initial Opioid Prescribing Practices After the 2016 Release of the CDC Guideline for Prescribing Opioids for Chronic Pain.

JAMA Netw Open 2021 Jul 1;4(7):e2116860. Epub 2021 Jul 1.

Injury Prevention Center, University of Michigan, Ann Arbor.

Importance: The Centers for Disease Control and Prevention (CDC) released the "Guideline For Prescribing Opioids For Chronic Pain" (hereafter, CDC guideline) in 2016, but its association with prescribing practices for patients who are opioid naive is unknown.

Objective: To estimate changes in initial prescribing rates, duration, and dosage practices to patients who are opioid naive after the release of the CDC guideline.

Design, Setting, And Participants: This cohort study used 6 sequential cohorts to estimate preguideline trends in prescribing among patients who were opioid naive, project that trend forward, and compare it with postguideline prescribing practices. Read More

View Article and Full-Text PDF

Associations between symptom severity and well-being among Thai patients with schizophrenia: a cross-sectional analytical study.

BMC Psychiatry 2021 Jul 12;21(1):348. Epub 2021 Jul 12.

Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Background: Severity of symptoms in patients with schizophrenia is a determinant of patient's well-being, but evidence in low- and middle-income countries is limited. We aimed to measure the symptom severity using objective measurements, the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression-Severity scale (CGI-S), and their associations with well-being in patients with schizophrenia.

Methods: Patients with schizophrenia aged ≥18 years, without active psychosis including no history of hospitalization within the last 6 months, were included. Read More

View Article and Full-Text PDF

Access to fertility preservation for trans and non-binary people in Aotearoa New Zealand.

Cult Health Sex 2021 Jul 12:1-16. Epub 2021 Jul 12.

Trans Health Research Lab and School of Psychology, University of Waikato, Hamilton, New Zealand.

There is a growing need for healthcare professionals to discuss fertility preservation options with trans and non-binary people before commencing medical transition as part of informed consent-based models of care. In this article, we adapt the Five-A framework of healthcare access to examine fertility preservation information and services. To do so, we present an analysis of data from , the first comprehensive national survey in Aotearoa New Zealand of trans and non-binary people's health and the first study exploring their access to cryopreservation information and services. Read More

View Article and Full-Text PDF

The association between internet usage and sleep problems among Japanese adolescents: three repeated cross-sectional studies.

Sleep 2021 Jul 12. Epub 2021 Jul 12.

Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Yonago-city, Tottori 683-8503, Japan.

Study Objectives: Sleep problems and problematic internet use have important implications for adolescent health; however, there have been no large-scale surveys using comprehensive measures. We examined the association between internet use duration and sleep problems among Japanese adolescents.

Methods: We used data from the Lifestyle Survey of Adolescents collected in 2012, 2014, and 2017. Read More

View Article and Full-Text PDF

Comparison of Long-term Radiographic Outcomes and Rate and Time for Conversion to Total Knee Arthroplasty Between Repair and Meniscectomy for Medial Meniscus Posterior Root Tears: A Systematic Review and Meta-analysis.

Am J Sports Med 2021 Jul 12:3635465211017514. Epub 2021 Jul 12.

Midwest Orthopaedics at Rush University, Chicago, Illinois, USA.

Background: Previous meta-analyses have demonstrated superior outcomes in patients undergoing arthroscopic repair of medial meniscus posterior root tears (MMPRTs) compared with meniscectomy. However, these analyses have considered only short- or midterm outcomes and low-quality evidence.

Purpose: To compare the mid- to long-term rates of radiographic osteoarthritis (OA) between repair and meniscectomy for MMPRT. Read More

View Article and Full-Text PDF

Patient Choice and Willingness Toward Gatekeepers as First-Contact Medical Institutions in Chinese Tiered Healthcare Delivery System: A Cross-Sectional Study.

Front Public Health 2021 23;9:665282. Epub 2021 Jun 23.

School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.

Gatekeeping mechanism of primary care institutions (PCIs) is essential in promoting tiered healthcare delivery system in China. However, patients seeking for higher-level institutions instead of gatekeepers as their first contact has persisted in the past decade. This study aims to explain patients' choice and willingness and to provide potential solutions. Read More

View Article and Full-Text PDF