83,804 results match your criteria bile duct

Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis.

Viral Immunol 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology and Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a marked tropism for the biliary tract; it damages the bile ducts and hepatocytes and can lead to liver decompensation, cirrhosis, and sepsis. The pathogenesis of liver damage and its association with damage to the lung, heart, and brain and to the other protean manifestations of COVID-19 disease are not fully understood. In particular, tissue damage from thinning and leaky blood vessels appears to result from an inflammatory response to the virus rather than the virus itself. Read More

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"Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model".

J Appl Microbiol 2021 May 13. Epub 2021 May 13.

Instituto de Investigación en Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica. CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, 44340, México.

Aim: Intestinal dysfunction in cirrhosis patients is linked to death by bacterial infections. Currently, there is no effective therapy for this complication. This study aims to evaluate butyrate, a novel postbiotic, on the intestinal inflammatory response, tight junction proteins, and the microbiota in the cholestasis model. Read More

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Increasing use of intraoperative cholangiogram in Australia: is it evidence-based?

ANZ J Surg 2021 May 12. Epub 2021 May 12.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.

Background: The role of routine intraoperative cholangiograms (IOCs) for prevention of bile duct injury (BDI) is contentious. There are recent reports of limited utility of IOC in preventing BDI. In Australia, IOCs are used more frequently than internationally. Read More

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[Treatment and prevention of bile duct injury in hepatocellular carcinoma after transarterial chemoembolization].

J H He H Sun C X Wu

Zhonghua Gan Zang Bing Za Zhi 2021 Apr;29(4):377-380

Department of Hepatobiliary, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Transarterial chemoembolization is the first choice for patients with advanced stage liver cancer who are not apt for surgical resection. In clinical practice, rare and serious complications occur occasionally, and bile duct injury is one of the complications after transarterial chemoembolization. Therefore, understanding its mechanism and high-risk factors can reduce the occurrence of bile duct injury, and early detection and treatment can significantly improve the prognosis. Read More

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Antioxidants resveratrol and SkQ1 attenuate praziquantel adverse effects on the liver in Opisthorchis felineus infected hamsters.

Acta Trop 2021 May 9:105954. Epub 2021 May 9.

Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Lavrentiev Ave., Novosibirsk 630090, Russia; Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia; Institute of Molecular Biology and Biophysics, 2/12, Timakov Str., Novosibirsk, 630117, Russia. Electronic address:

Anthelmintic praziquantel (PZQ) is the drug of the choice for opisthorchiasis, schistosomiasis and other trematodiases therapy for several decades. Despite its good therapeutic performance and effective control of trematode infections, PZQ has some shortcomings; its inability to counteract disease sequelae necessitates novel therapeutic strategies. Testing of antioxidants that have proven themselves in clinical practice, in combination with this anthelmintic drug, offers new opportunities for developing alternatives to PZQ monotherapy. Read More

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[Efficiency of minilaparotomy in the treatment of choledochal malformation in children].

Khirurgiia (Mosk) 2021 (5):63-71

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: To evaluate an effectiveness of minilaparotomy in the treatment of choledochal malformation (CM) in children.

Material And Methods: The study included children with CM who underwent surgery from January 2010 to May 2020. All patients were divided into 3 groups depending on surgical approach: minilaparotomy (ML), laparoscopy (LS) and laparotomy (LT). Read More

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[A Case of Pancreaticoduodenectomy for Vater Papillary Cancer with Celiac Axis Stricture].

Gan To Kagaku Ryoho 2021 Apr;48(4):572-574

Dept. of Surgery, Ikeda City Hospital.

During the follow‒up of Vater papillary adenoma, a 74‒year‒old man was admitted to our hospital with a chief complaint of upper abdominal pain and diagnosed as cholangitis with obstructive jaundice. Cholestasis had been considered to be caused by papillary adenoma, however, EUS exam showed continuous bile duct wall irregularity from papilla of Vater. So we diagnosed as papillary carcinoma with extension to the distal bile duct. Read More

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[A Case of Stage Ⅳ Cholangiocarcinoma with an Improved Quality of Life after Resection of a Symptomatic Giant Ovarian Teratoma].

Gan To Kagaku Ryoho 2021 Apr;48(4):557-559

Dept. of Surgery, Takaoka City Hospital.

An 82‒year‒old female presented to our hospital with abdominal fullness and loss of appetite. Abdominal computed tomography revealed a cholangiocarcinoma(Stage Ⅳ)with liver metastases and multiple lymph node metastases. In addition, we found a left ovarian teratoma(approximately 33 cm in diameter)occupying most of the abdominal cavity. Read More

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[A Case of Intrahepatic Cholangiocarcinoma Confused with a Recurrent Hepatocellular Carcinoma Treated by RFA at Diagnosis].

Gan To Kagaku Ryoho 2021 Apr;48(4):543-545

Dept. of Surgery, Chiba Rosai Hospital.

Intrahepatic cholangiocarcinoma(ICC)is the second most common malignant liver tumor after hepatocellular carcinoma (HCC). ICC is usually ischemic; however, it has variable findings and may be difficult to differentiate from HCC. We report about a case of ICC that was difficult to distinguish from HCC treated by radiofrequency ablation(RFA). Read More

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The critical view of safety and bile duct injuries in laparoscopic cholecystectomy: a photo evaluation study on 1532 patients.

HPB (Oxford) 2021 Apr 27. Epub 2021 Apr 27.

Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Finland. Electronic address:

Background: Laparoscopic cholecystectomy (LCC) carries a 0.3-1.8% risk of bile duct injury (BDI). Read More

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Practical approach for the diagnosis of biliary atresia on imaging, part 2: magnetic resonance cholecystopancreatography, hepatobiliary scintigraphy, percutaneous cholecysto-cholangiography, endoscopic retrograde cholangiopancreatography, percutaneous liver biopsy, risk scores and decisional flowchart.

Pediatr Radiol 2021 May 11. Epub 2021 May 11.

APHM, Equipe d'Accueil 3279 - IFR 125, Service d'Imagerie Pédiatrique et Prénatale, Hôpital Timone Enfants, Aix Marseille Univ, Marseille, France.

We aim to present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses to biliary cirrhosis, end-stage liver failure and death within the first years of life. Differentiating biliary atresia from other nonsurgical causes of neonatal cholestasis is difficult as there is no single method for diagnosing biliary atresia and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis. Read More

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Systematic Review and Meta-analysis of Laparoscopic Common Bile Duct Exploration in Patients With Previous Failed Endoscopic Retrograde Cholangiopancreatography.

Surg Laparosc Endosc Percutan Tech 2021 May 11. Epub 2021 May 11.

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Background: The aim was to compare the outcomes of laparoscopic common bile duct exploration (LCBDE) after failed endoscopic retrograde cholangiopancreatography (group A) versus primary LCBDE (group B) for the management of gallbladder and common bile duct stones.

Materials And Methods: A comprehensive and systematic literature search was performed in several databases, including PubMed, Ovid, and Cochrane Library. Meta-analysis of operative outcomes, postoperative outcomes, and gallstone clearance rates was conducted using random-effect models. Read More

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Continuous suture is a risk factor for benign hepaticojejunostomy stenosis after pancreatoduodenectomy in patients with a non-dilated bile duct.

HPB (Oxford) 2021 Apr 27. Epub 2021 Apr 27.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Kanokoden 1-1, Chikusa-ku, Nagoya, Japan.

Background: It is unclear whether hepaticojejunostomy with a continuous suture is suitable for patients with a non-dilated bile duct.

Methods: Medical records of patients who underwent pancreatoduodenectomy between 2003 and 2013 were retrospectively reviewed, focusing on the incidence of benign anastomotic stenosis and its relationship with suture method (continuous vs interrupted) and common hepatic duct size.

Results: Among 336 patients, 172 had a non-dilated (<8 mm) duct, and the remaining 164 had a dilated duct. Read More

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Hepatogenous photosensitisation in cows grazing turnips (Brassica rapa) in South Africa.

J S Afr Vet Assoc 2021 May 6;92(0):e1-e6. Epub 2021 May 6.

Humansdorp Veterinary Clinic, Humansdorp.

Holstein cows on a farm in the Humansdorp district, Eastern Cape province, South Africa, developed reddened, painful teat skin 3 days after grazing a mixed forage crop dominated by bulb turnip (Brassica rapa, Barkant cultivar). The crop was grazed 45 days after planting and 10% of the herd developed symptoms. More characteristic non-pigmented skin lesions started manifesting 1-2 days after the appearance of the teat lesions. Read More

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Clinical characteristics of intrahepatic biliary papilloma: A case report.

World J Clin Cases 2021 May;9(13):3185-3193

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun 130012, Jilin Province, China.

Background: Intrahepatic bile duct papilloma (IPNB) is a rare benign tumour from the bile duct epithelium and has a high malignant transformation rate. Early radical resection can obviously improve the prognosis of patients, but it is difficult to be sure of the diagnosis of IPNB before operating.

Case Summary: This study included 28 patients with intraductal papilloma admitted to the First Hospital of Jilin University from January 2010 to November 2020 and recorded their clinical manifestations, imaging features, complications and prognosis. Read More

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Acute pancreatitis and small bowel obstruction caused by a migratory gastric bezoar after dissolution therapy: A case report.

World J Clin Cases 2021 May;9(13):3114-3119

Endoscopy Center, Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou 225009, Jiangsu Province, China.

Background: Bezoars are conglomerates of indigestible foreign material that can be found in the gastrointestinal tract. Gastric ulcer, gastrointestinal perforation, and intestinal obstruction are the main complications. Acute pancreatitis secondary to bezoar is rare. Read More

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Primary Duodenal Periampullary Adenocarcinoma: An Uncommon Presentation.

Cureus 2021 Apr 6;13(4):e14323. Epub 2021 Apr 6.

Internal Medicine, University of California, Riverside School of Medicine, Riverside, USA.

Periampullary carcinoma is a broad term used to define the group of carcinomas arising from the head of the pancreas, the distal common bile duct, and the duodenum. It is clinically important to differentiate ampullary from periampullary carcinoma as this can affect resectability and prognosis. Atypical left-sided chest pain is an atypical presentation of periampullary duodenal adenocarcinoma. Read More

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Cartilage-hair Hypoplasia Complicated with Liver Cirrhosis Due to Chronic Intrahepatic Cholestasis: A Case Report.

Intern Med 2021 May 7. Epub 2021 May 7.

Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan.

We herein report a rare case of cartilage-hair hypoplasia (CHH) complicated with liver cirrhosis. A 20-year-old Japanese man with CHH was found incidentally to have liver cirrhosis and an esophageal varix. This patient had been treated for infections due to immunodeficiency since early childhood. Read More

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Predictors of recurrent bile duct stone after clearance by endoscopic retrograde cholangiopancreatography: A case-control study.

Hepatobiliary Pancreat Dis Int 2021 Apr 28. Epub 2021 Apr 28.

Department of Gastroenterology, Galilee Medical Center, Nahariya, Israel; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel. Electronic address:

Background: Recurrent common bile duct (CBD) stone are a long-term sequalae among patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with CBD stone extraction. Data regarding risk factors for recurrent CBD stone are scarce. We aimed to identify predictors of recurrent CBD stone. Read More

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Spontaneous common bile duct perforation in full term pregnancy: a rare case report and review of literature.

BMC Surg 2021 May 8;21(1):239. Epub 2021 May 8.

Department of General Surgery, Amiri Medical Complex, Qargha Road, Afshar, Kabul, Afghanistan.

Background: Spontaneous biliary system perforation is a rare presentation in clinical practice especially in adults. It is rarely suspected and diagnosed preoperatively due to small number of cases, vague sign and symptoms, and ambiguous presentation.

Case Presentation: We describe an interesting case of spontaneous perforation of the common bile duct in a 16 year-old female who presented a week after her first birth to the emergency department with complaints of diffuse abdominal pain, abdominal distention, fever, vomiting, and constipation. Read More

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Diffuse large B-cell lymphoma in the liver accompanied by primary biliary cholangitis: A rare and difficult-to-diagnose tumor with portal venous thrombosis.

Int J Surg Case Rep 2021 Apr 30;82:105936. Epub 2021 Apr 30.

Department of Surgery, Shiga General Hospital, Moriyama, 5-4-30 Moriyama, Moriyama, Shiga 524-8524, Japan. Electronic address:

Introduction And Importance: The most common liver malignancies are hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic tumors. Hepatocellular carcinoma and intrahepatic cholangiocarcinoma may invade the portal vein (PV). An association between diffuse large B-cell lymphoma (DLBCL) and primary biliary cholangitis (PBC) remains unclear. Read More

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Biliary tree neuroendocrine tumor, an incidental finding.

Int J Surg Case Rep 2021 Apr 30;82:105940. Epub 2021 Apr 30.

General Surgery Department, School of Medicine, University of Jordan, Jordan. Electronic address:

Introduction And Importance: Biliary tree neuroendocrine tumors (NET) are rare, with 100 cases in the literature, and have an excellent prognosis. Although they are rarely diagnosed before surgery, complete surgical excision offers optimal treatment.

Case Presentation: We report a case of a 36-year-old female patient referred to the surgical team with obstructive jaundice for which she was investigated and found to have a common bile duct tumor showing proximal obstruction. Read More

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Degradable magnesium implants inhibit gallbladder cancer.

Acta Biomater 2021 May 5. Epub 2021 May 5.

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Suzhou Origin Medical Technology Co. Ltd., Suzhou, Jiangsu 215513, China. Electronic address:

Gallbladder cancer can be difficult to detect in its early stages and is prone to metastasize, causing bile duct obstruction, which is usually treated by stent implantation in clinic. However, the commonly used biliary stents are non-degradable, which not only prone to secondary blockage, but also need to be removed by secondary surgery. Biodegradable magnesium (Mg) is expected to one of the promising candidates for degradable biliary stents due to its excellent physicochemical property and biocompatibility. Read More

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Long-term outcomes in the repair of intrahepatic iatrogenic bile duct lesions using a combined intraglissonian and extraglissonian approach.

Langenbecks Arch Surg 2021 May 8. Epub 2021 May 8.

Department of Surgery. HBP Unit, Virgen de la Arrixaca University Hospital, IMIB-Arrixaca, Murcia, Spain.

Purspose: Iatrogenic bile duct injuries (IBDI) with intrahepatic involvement are a serious and challenging surgical complication that can have disastrous consequences in terms of morbidity and mortality.

Methods: We collected the patients with IBDI type (E4) between January 1991 and March 2020 in our hospital. The objective of the study was to present the long-term results of a extraglissonian approach and intraglissonian biliary reconstruction in a series of patients with intrahepatic bile duct injuries after cholecystectomy. Read More

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A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2.

World J Surg Oncol 2021 May 7;19(1):142. Epub 2021 May 7.

Department of Surgery, Tokushima University, Tokushima, 770-8503, Japan.

Background: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group.

Methods: Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Read More

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Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis.

BMC Cancer 2021 May 7;21(1):513. Epub 2021 May 7.

Department of Radiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.

Purpose: The mechanism of postoperative nausea and vomiting after TACE is not clear. This study retrospectively analyzed the patient data to explore the mechanism and risk factors of postoperative nausea and vomiting after TACE.

Materials And Methods: The data of 221 patients who underwent TACE in the interventional department from January 2019 to December 2020 were collected. Read More

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The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways.

Toxicol Lett 2021 May 4;347:23-35. Epub 2021 May 4.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Liver fibrosis is the conjoint consequence of almost all chronic liver diseases. Cholestatic liver injury is a significant stimulus for fibrotic liver. This study was conducted to investigate the hepatoprotective effect of niclosamide as a NOTCH inhibitor and on the Wnt pathway against cholestatic liver fibrosis (CLF) which was experimentally induced by bile duct ligation (BDL). Read More

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