1,933 results match your criteria bifidobacterium longum


Exercise training combined with treatment regulates insulin resistance and physical performance in / mice.

Food Funct 2021 Jul 23. Epub 2021 Jul 23.

Graduate Institute of Sports Science, Natioal Taiwan Sport University, Taoyuan City 33301, Taiwan.

Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease characterized by hyperglycemia and insulin resistance. Regular exercise is one of the effective lifestyle interventions for maintaining healthy weight and blood glucose levels in the normal range and lowering risk factors. Probiotics, live microorganisms that are beneficial to health, are involved in the regulation of host metabolism. Read More

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Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.

Biosci Microbiota Food Health 2021 20;40(3):150-155. Epub 2021 Feb 20.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Niigata 951-8510, Japan.

Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. Read More

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February 2021

The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial.

Indian J Nephrol 2021 Mar-Apr;31(2):149-156. Epub 2021 Jan 27.

Department of Radiation Oncology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The purpose of this double-blind clinical trial, was to examine the effect of supplementation with the synbiotic and probiotic on the mental health, quality of life, and anemia in HD patients.

Methods: Seventy-five HD patients were randomly assigned to receive the synbiotic ( = 23) as 15 g of prebiotics, 5 g of probiotic powder containing , and (2.7 × 107 CFU/g each); probiotics ( = 23) as 5 g probiotics similar to the synbiotic group with 15 g of maltodextrin as placebo; and placebo ( = 19) as 20 g of maltodextrin. Read More

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January 2021

Genome Features and Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic Strains.

Biomed Res Int 2021 18;2021:6662027. Epub 2021 Jun 18.

Vector State Research Centre of Virology and Biotechnology, Koltsovo, Novosibirsk Region 630559, Russia.

Purpose: The aim of this work was to analyze the complete genome of probiotic bacteria 8 RA 3, 90 TC-4, 39, 791, 1, and 379 and to test their activity against influenza A and SARS-CoV-2 viruses.

Methods: To confirm the taxonomic affiliation of the bacterial strains, MALDI TOF mass spectrometry and biochemical test systems were used. Whole genome sequencing was performed on the Illumina Inc. Read More

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Metabolic and enzymatic elucidation of cooperative degradation of red seaweed agarose by two human gut bacteria.

Sci Rep 2021 Jul 6;11(1):13955. Epub 2021 Jul 6.

Department of Biotechnology, Graduate School, Korea University, Seoul, 02841, Republic of Korea.

Various health beneficial outcomes associated with red seaweeds, especially their polysaccharides, have been claimed, but the molecular pathway of how red seaweed polysaccharides are degraded and utilized by cooperative actions of human gut bacteria has not been elucidated. Here, we investigated the enzymatic and metabolic cooperation between two human gut symbionts, Bacteroides plebeius and Bifidobacterium longum ssp. infantis, with regard to the degradation of agarose, the main carbohydrate of red seaweed. Read More

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Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study.

Nutrients 2021 Jun 30;13(7). Epub 2021 Jun 30.

Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.

The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic ( = 41) or no supplementation control ( = 19) groups. Read More

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Synergistic interactions prevail in multispecies biofilms formed by the human gut microbiota on mucin.

FEMS Microbiol Ecol 2021 07;97(8)

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Bacterial species in the human gut predominantly exist in the form of mixed-species biofilms on mucosal surfaces. In this study, the biofilm-forming ability of many human gut bacterial strains (133 strains recovered from human faeces) on mucin-coated and non-coated polystyrene surfaces was determined. A significant variation (P < 0. Read More

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Comparative genomics and in silico gene evaluation involved in the probiotic potential of Bifidobacterium longum 5.

Gene 2021 Aug 19;795:145781. Epub 2021 Jun 19.

Laboratory of Cellular and Molecular Genetics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The Bifidobacterium longum 5 strain of isolated from feces of a healthy child, has demonstrated probiotic properties by in vivo and in vitro studies, which may be assigned to its production of metabolites such as acetate. Thus, through the study of comparative genomics, the present work sought to identify unique genes that might be related to the production of acetate. To perform the study, the DNA strain was sequenced using Illumina HiSeq technology, followed by assembly and manual curation of coding sequences. Read More

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Effect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study.

Front Nutr 2021 31;8:661794. Epub 2021 May 31.

Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan.

The aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10 colony-forming units (CFU)/day (high-dose) and 10 CFU/day (low-dose) probiotics containing (TYCA06), subspecies (BLI-02), and (VDD088). Read More

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Comparison of the composition and function of the gut microbiome in herdsmen from two pasture regions, Hongyuan and Xilingol.

Food Sci Nutr 2021 Jun 4;9(6):3258-3268. Epub 2021 May 4.

Key Laboratory of Dairy Biotechnology and Engineering Key Laboratory of Dairy Products Processing Inner Mongolia Agricultural University Hohhot China.

There is a close relationship between the gut microbiome and health in humans including regulation of immunity and energy metabolism. This study investigated differences in the gut microbiome of herdsmen from two regions: Hongyuan pasture in Sichuan and Xilingol pasture in Inner Mongolia. We found significant differences in the gut microbiome between the two groups. Read More

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Microbial Glycoside Hydrolases in the First Year of Life: An Analysis Review on Their Presence and Importance in Infant Gut.

Front Microbiol 2021 28;12:631282. Epub 2021 May 28.

Laboratory of Microbiology, Wageningen University & Research, Wageningen, Netherlands.

The first year of life is a crucial period during which the composition and functionality of the gut microbiota develop to stabilize and resemble that of adults. Throughout this process, the gut microbiota has been found to contribute to the maturation of the immune system, in gastrointestinal physiology, in cognitive advancement and in metabolic regulation. Breastfeeding, the "golden standard of infant nutrition," is a cornerstone during this period, not only for its direct effect but also due to its indirect effect through the modulation of gut microbiota. Read More

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[N-Domain of ArdA Antirestriction Proteins Inhibits the Repression Activity of the Histone-Like H-NS Protein].

Mol Biol (Mosk) 2021 May-Jun;55(3):491-499

State Research Institute of Genetics and Selection of Industrial Microorganisms of the National Research Center "Kurchatov Institute", Moscow, 117545 Russia.

DNA mimicking ArdA anti-restriction proteins specifically inhibit restriction (endonuclease) activity of the type I restriction-modification (RM) system. An ArdA monomer is comprised of three α-β domains (the N-domain, Central domain, and C-domain), each with a different fold. Here we describe an alignment of the amino acid (a. Read More

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Dysbiosis of the gut microbiome is a risk factor for osteoarthritis in older female adults: a case control study.

BMC Bioinformatics 2021 Jun 3;22(1):299. Epub 2021 Jun 3.

Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, People's Republic of China.

Background: Osteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation. The gut microbiome has recently emerged as an pathogenic factor of OA, and prebiotics supplementation could alleviate OA symptoms in animal models. However, the relationship between the gut microbiome and OA in the older female adults is hitherto not clear. Read More

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Combination of and Galacto-Oligosaccharide Protects the Skin from Photoaging.

J Med Food 2021 Jun 2;24(6):606-616. Epub 2021 Jun 2.

Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Korea.

Overexposure to ultraviolet B (UVB) irradiation induces photoaging that is characterized by the formation of wrinkles and loss of skin elasticity. To understand the mechanism of action of probiotics and prebiotics in skin protection against photoaging, we investigated the effects of dietary supplementation with the probiotic, , and prebiotic, galacto-oligosaccharide, on UVB-induced photoaging in hairless mice. We measured short chain fatty acid (SCFA) levels, antioxidant enzyme activity, and inflammatory signaling protein levels to elucidate the possible mechanisms underlying the effects of the dietary supplements and galacto-oligosaccharide. Read More

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Quantitative Detection of Strains in Feces Using Strain-Specific Primers.

Microorganisms 2021 May 28;9(6). Epub 2021 May 28.

State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Road No.1800, Binhu District, Wuxi 214122, China.

We adopted a bioinformatics-based technique to identify strain-specific markers, which were then used to quantify the abundances of three distinct sup. strains in fecal samples of humans and mice. A pangenome analysis of 205 sup. Read More

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Modulation of the Gut Microbiota Structure with Probiotics and Isoflavone Alleviates Metabolic Disorder in Ovariectomized Mice.

Nutrients 2021 May 25;13(6). Epub 2021 May 25.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

The decrease in ovarian hormone secretion that occurs during menopause results in an increase in body weight and adipose tissue mass. Probiotics and soy isoflavones (SIFs) could affect the gut microbiota and exert anti-obesity effects. The objective of this study was to investigate the effects of probiotics and a diet containing SIF (SIF diet) on ovariectomized mice with menopausal obesity, including the gut microbiome. Read More

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A Machine Learning Approach to Study Glycosidase Activities from .

Microorganisms 2021 May 11;9(5). Epub 2021 May 11.

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA), Consejo Superior de Investigaciones Científicas (CSIC), Paseo Río Linares S/N, 33300 Villaviciosa, Asturias, Spain.

This study aimed to recover metagenome-assembled genomes (MAGs) from human fecal samples to characterize the glycosidase profiles of species exposed to different prebiotic oligosaccharides (galacto-oligosaccharides, fructo-oligosaccharides and human milk oligosaccharides, HMOs) as well as high-fiber diets. A total of 1806 MAGs were recovered from 487 infant and adult metagenomes. Unsupervised and supervised classification of glycosidases codified in MAGs using machine-learning algorithms allowed establishing characteristic hydrolytic profiles for , , , and , yielding classification rates above 90%. Read More

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Exploring the bone sparing effects of postbiotics in the post-menopausal rat model.

BMC Complement Med Ther 2021 May 28;21(1):155. Epub 2021 May 28.

Biotechnology Research Center, Shiraz University of Medical Sciences, P.O. Box: 71348-14336, Shiraz, Iran.

Background: Post-menopausal osteoporosis is a concern of health organizations, and current treatments do not seem enough. Postbiotics as bioactive compounds produced by probiotics may be an attractive alternative for bone health. In this study, we prepared, formulated, and compared the effects of cell lysate and supernatant of five native probiotic strains (Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium longum, and Bacillus coagulans) in ovariectomized (OVX) rats. Read More

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Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus.

Biomed Pharmacother 2021 Aug 23;140:111736. Epub 2021 May 23.

Research Department, Sidra Medicine, OPC, P.O. Box 26999, Doha, Qatar. Electronic address:

Children with Type 1 diabetes mellitus (T1DM) have an elevated risk of abnormal blood pressure (BP) measurements and patterns. Both hypertension and T1DM are well-known risk factors for cardiovascular disease and kidney failure. The human microbiome has been linked to both diabetes and hypertension, but the relationship between the gut microbiome and BP in children with T1DM is not well-understood. Read More

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[Prospects of probiotic strains of bifidobacteria and enterococcus in treatment and prevention of diseases in gastroenterology].

Vopr Pitan 2021;90(2):15-25. Epub 2021 Mar 11.

I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), 119991, Moscow, Russian Federation.

Variability of the intestinal microbiota has been under close scientific study in recent years; more and more studies confirm specific changes in microbiota under certain pathologies. Enterococcus faecium and Bifidobacterium longum strains are naturally occurring symbiotic bacteria that inhabit the gastrointestinal tract. The safety and efficacy profile of bifidobacteria, widely used as probiotics, has been thoroughly studied. Read More

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subsp. YB0411 Inhibits Adipogenesis in 3T3-L1 Pre-adipocytes and Reduces High-Fat-Diet-Induced Obesity in Mice.

J Agric Food Chem 2021 Jun 19;69(21):6032-6042. Epub 2021 May 19.

Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Chung-nam 31151, Republic of Korea.

Although the health benefits of probiotics have been widely known for decades, there has still been limited use of probiotic bacteria in anti-obesity therapy. Herein, we demonstrated the role of subsp. YB0411 (YB, which was selected by an adipogenesis assay) in adipogenic differentiation in 3T3-L1 pre-adipocytes. Read More

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Construction of a reporter system for bifidobacteria using chloramphenicol acetyltransferase and its application for evaluation of promoters and terminators.

Biosci Microbiota Food Health 2021 19;40(2):115-122. Epub 2021 Jan 19.

United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.

A reporter assay system is an essential tool for investigating gene expression mechanisms. In the case of bifidobacteria, several convenient and sensitive reporter systems have been developed. Here, we developed a new reporter system for bifidobacteria using the chloramphenicol acetyltransferase gene () from . Read More

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January 2021

Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.

PLoS One 2021 14;16(5):e0251803. Epub 2021 May 14.

Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.

Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. Read More

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Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter.

Commun Biol 2021 May 10;4(1):541. Epub 2021 May 10.

Next Generation Science Institute, RD Division, Morinaga Milk Industry Co., Ltd., Zama, Japan.

This study aims to understand the mechanistic basis underlying the response of Bifidobacterium to lactulose ingestion in guts of healthy Japanese subjects, with specific focus on a lactulose transporter. An in vitro assay using mutant strains of Bifidobacterium longum subsp. longum 105-A shows that a solute-binding protein with locus tag number BL105A_0502 (termed LT-SBP) is primarily involved in lactulose uptake. Read More

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Fecal and Duodenal Microbiota in Pediatric Celiac Disease.

Front Pediatr 2021 22;9:652208. Epub 2021 Apr 22.

Department of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan, Kazakhstan.

The gut microbiota plays a role in regulating the host immunity. Therefore, alterations in gut microbiota (or dysbiosis) have been investigated in several gastrointestinal diseases, including Celiac Disease (CD). The aim of this study is to summarize the main characteristics of the gut microbiota in pediatric CD. Read More

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Molecular analysis of the replication functions of the bifidobacterial conjugative megaplasmid pMP7017.

Microb Biotechnol 2021 Jul 3;14(4):1494-1511. Epub 2021 May 3.

APC Microbiome Ireland, University College Cork, Western Road, Cork, Ireland.

pMP7017 is a conjugative megaplasmid isolated from the gut commensal Bifidobacterium breve JCM7017 and was shown to encode two putative replicases, designated here as RepA and RepB. In the current work, RepB was identified as the pMP7017 replicative initiator, as the repB gene, and its surrounding region was shown to be sufficient to allow autonomous replication in two bifidobacterial species, B. breve and Bifidobacterium longum subsp. Read More

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Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice.

Gut Microbes 2021 Jan-Dec;13(1):1-20

Laboratorio de Bacterias Lácticas y Probióticos, Departamento de Biotecnología de Alimentos, IATA-CSIC, Paterna, Spain.

Human milk glycans present a unique diversity of structures that suggest different mechanisms by which they may affect the infant microbiome development. A humanized mouse model generated by infant fecal transplantation was utilized here to evaluate the impact of fucosyl-α1,3-GlcNAc (3FN), fucosyl-α1,6-GlcNAc, lacto--biose (LNB) and galacto--biose on the fecal microbiota and host-microbiota interactions. 16S rRNA amplicon sequencing showed that certain bacterial genera significantly increased ( and ) or decreased ( and ) in all disaccharide-supplemented groups. Read More

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Impact of a fermented soy beverage supplemented with acerola by-product on the gut microbiota from lean and obese subjects using an in vitro model of the human colon.

Appl Microbiol Biotechnol 2021 May 3;105(9):3771-3785. Epub 2021 May 3.

Centre for Healthy Eating & Food Innovation, Maastricht University - Campus Venlo, Villafloraweg 1, 5928 SZ, Venlo, The Netherlands.

The aim of this study was to evaluate the effects of soy-based beverages manufactured with water-soluble soy extract, containing probiotic strains (Lactobacillus acidophilus LA-5 and Bifidobacterium longum BB-46) and/or acerola by-product (ABP) on pooled faecal microbiota obtained from lean and obese donors. Four fermented soy beverages (FSs) ("placebo" (FS-Pla), probiotic (FS-Pro), prebiotic (FS-Pre), and synbiotic (FS-Syn)) were subjected to in vitro digestion, followed by inoculation in the TIM-2 system, a dynamic in vitro model that mimics the conditions of the human colon. Short- and branched-chain fatty acids (SCFA and BCFA) and microbiota composition were determined. Read More

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Effects of the Administration of subsp. CECT 7210 and HN001 and Their Synbiotic Combination With Galacto-Oligosaccharides Against Enterotoxigenic F4 in an Early Weaned Piglet Model.

Front Microbiol 2021 16;12:642549. Epub 2021 Apr 16.

Servicio de Nutrición y Bienestar Animal, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain.

We evaluated the potential of multi-strain probiotic ( subsp. CECT 7210 and HN001) with or without galacto-oligosaccharides against enterotoxigenic (ETEC) F4 infection in post-weaning pigs. Ninety-six piglets were distributed into 32 pens assigned to five treatments: one non-challenged (CTR+) and four challenged: control diet (CTR-), with probiotics (>3 × 10 CFU/kg body weight each, PRO), prebiotic (5%, PRE), or their combination (SYN). Read More

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Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study.

Nutrients 2021 Apr 16;13(4). Epub 2021 Apr 16.

Grupo de Investigación en Inmunofisiología, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), University of Extremadura, Av. Elvas s/n, 06006 Badajoz, Spain.

The main objective of this research was to carry out an experimental study, triple-blind, on the possible immunophysiological effects of a nutritional supplement (synbiotic, Gasteel Plus, Heel España S.A.U. Read More

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