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Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.

Cochrane Database Syst Rev 2021 Apr 14;4:CD012789. Epub 2021 Apr 14.

Cochrane Singapore, Singapore, Singapore.

Background: Trigger finger is a common hand condition that occurs when movement of a finger flexor tendon through the first annular (A1) pulley is impaired by degeneration, inflammation, and swelling. This causes pain and restricted movement of the affected finger. Non-surgical treatment options include activity modification, oral and topical non-steroidal anti-inflammatory drugs (NSAIDs), splinting, and local injections with anti-inflammatory drugs. Read More

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The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies.

Brain Behav Evol 2021 Apr 13:1-17. Epub 2021 Apr 13.

Department of Pharmacology and Experimental Therapeutics, College of Pharmacology and Pharmacological Science, University of Toledo, Toledo, Ohio, USA.

Drug dependence has long been thought to have a genetic component. Research seeking to identify the genetic basis of addiction has gone through important transitions over its history, in part based upon the emergence of new technologies, but also as the result of changing perspectives. Early research approaches were largely dictated by available technology, with technological advancements having highly transformative effects on genetic research, but the limitations of technology also affected modes of thinking about the genetic causes of disease. Read More

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Association of circulating C-reactive protein and high-sensitivity C-reactive protein with components of sarcopenia: A systematic review and meta-analysis of observational studies.

Exp Gerontol 2021 Apr 10:111330. Epub 2021 Apr 10.

Department of Computer Sciences, Faculty of Mathematics and Natural Sciences, Heinrich Heine Universität, Düsseldorf, Germany.

Background: Sarcopenia, a multi-faceted skeletal muscle disorder in the older population, has poor health outcomes. Some previous observational studies investigated the association between circulating inflammatory markers and sarcopenia components to evaluate chronic inflammation as a risk factor for sarcopenia in the elderly population. Nevertheless, the association between circulating C-reactive protein (CRP) and hs-CRP, as the recognized markers of systemic inflammation and components of sarcopenia, is unclear. Read More

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Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.

Cell Stem Cell 2021 Apr 7. Epub 2021 Apr 7.

The Jackson Laboratory, Bar Harbor, ME, USA. Electronic address:

Decline in hematopoietic stem cell (HSC) function with age underlies limited health span of our blood and immune systems. In order to preserve health into older age, it is necessary to understand the nature and timing of initiating events that cause HSC aging. By performing a cross-sectional study in mice, we discover that hallmarks of aging in HSCs and hematopoiesis begin to accumulate by middle age and that the bone marrow (BM) microenvironment at middle age induces and is indispensable for hematopoietic aging. Read More

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The effect of plaque control in the treatment of Oral Lichen Planus with gingival manifestations: a Systematic Review.

Community Dent Health 2021 Apr 9. Epub 2021 Apr 9.

Centre for Host Microbiome Interactions, Kings College, London.

Background: Oral lichen planus (OLP) is a chronic autoimmune disease that frequently affects the oral mucosa. Patients with OLP tend to present with plaque accumulation which may further exacerbate the lichenoid lesion, thus plaque control may improve the quality of life of patients. The aim of this review was to test the effect of plaque control on OLP with gingival manifestations. Read More

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Knowledge, attitudes, and perceptions of long-acting reversible contraceptive (LARC) methods among healthcare workers in sub-Saharan Africa.

Trop Med Int Health 2021 Apr 13. Epub 2021 Apr 13.

National Department of Health, Affordable Medicines Directorate, Essential Drugs Programme, South Africa.

Objective: To assess the knowledge, attitudes, and perceptions (KAP) of long-acting reversible contraceptive (LARC) methods among healthcare workers (HCWs) in sub-Saharan Africa (SSA).

Methods: A systematic review and meta-analysis were conducted following the PRISMA method. Two authors independently searched three electronic databases for studies published between 2000 and January 2020 reporting on the KAP of LARC methods among HCWs in SSA. Read More

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Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls.

PLoS Biol 2021 Apr 13;19(4):e3000751. Epub 2021 Apr 13.

Cognitive and Affective Neuroscience Unit, University of Zurich, Zurich, Switzerland.

Across many species, scream calls signal the affective significance of events to other agents. Scream calls were often thought to be of generic alarming and fearful nature, to signal potential threats, with instantaneous, involuntary, and accurate recognition by perceivers. However, scream calls are more diverse in their affective signaling nature than being limited to fearfully alarming a threat, and thus the broader sociobiological relevance of various scream types is unclear. Read More

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Male bias in ACE2 basic science research: Missed opportunity for discovery in the time of COVID-19.

Am J Physiol Regul Integr Comp Physiol 2021 Apr 13. Epub 2021 Apr 13.

Medicine, Georgetown University Medical Center, United States.

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting-enzyme-2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin-system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin-type-1-receptor. Read More

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Ecofriendly Solution-Combustion-Processed Thin-Film Transistors for Synaptic Emulation and Neuromorphic Computing.

ACS Appl Mater Interfaces 2021 Apr 13. Epub 2021 Apr 13.

Department of Electrical and Electronic Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.

The ecofriendly combustion synthesis (ECS) and self-combustion synthesis (ESCS) have been successfully utilized to deposit high- aluminum oxide (AlO) dielectrics at low temperatures and applied for aqueous InO thin-film transistors (TFTs) accordingly. The ECS and ESCS processes facilitate the formation of high-quality dielectrics at lower temperatures compared to conventional methods based on an ethanol precursor, as confirmed by thermal analysis and chemical composition characterization. The aqueous InO TFTs based on ECS and ESCS-AlO show enhanced electrical characteristics and counterclockwise transfer-curve hysteresis. Read More

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Examination of Caregiver Social Factors and Its Influence on Low-Acuity Pediatric Emergency Department Utilization.

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the *Division of Emergency Medicine, Children's Hospital of Philadelphia †Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania ‡Center for Violence Prevention, Children's Hospital of Philadelphia, Philadelphia, PA.

Objectives: Social factors, such as adverse childhood experiences (ACEs), often influence health care utilization. Our study explores the association between caregiver social factors and low-acuity pediatric emergency department (ED) utilization, with the hypothesis that caregivers with high ACE exposure may use ED services more frequently for low-acuity complaints.

Methods: In this case-control study, we performed surveys of caregivers with children aged 1 to 12 years registered for care in our pediatric ED. Read More

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Profiles of Ethnic-Racial Identity, Socialization, and Model Minority Experiences: Associations with Well-Being Among Asian American Adolescents.

J Youth Adolesc 2021 Apr 13. Epub 2021 Apr 13.

Department of Psychology, Fordham University, New York, NY, USA.

Ethnic-racial identity, ethnic-racial socialization, and racialized experiences are fundamental to the development of youth of color. However, most prior studies have examined their developmental impact in isolation. The present study fills this gap using a person-centered approach to elucidate patterns of ethnic-racial identity, socialization, and model minority experiences among 145 Asian American adolescents (M = 14. Read More

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The scalp cooling therapy for hair loss in breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis.

Support Care Cancer 2021 Apr 13. Epub 2021 Apr 13.

Nursing Department, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Purpose: To systematically assess the efficacy and side effects of scalp cooling in patients with breast cancer.

Methods: A systematic literature search was conducted in October 2020 across Cochrane Library, PubMed, Embase, CINAHL, Web of Science, Scopus, and four Chinese databases (CNKI, Wanfang, SinoMed, and VIP database). Our review included all randomized controlled trials, cohort studies, and cross-sectional studies. Read More

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Accuracy of quantitative diffusion-weighted imaging for differentiating benign and malignant pancreatic lesions: a systematic review and meta-analysis.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: A variety of imaging techniques can be used to evaluate diffusion characteristics to differentiate malignant and benign pancreatic lesions. The diagnostic performance of diffusion parameters has not been systematic assessed.

Purpose: We aimed to investigate the diagnostic efficacy of quantitative diffusion-weighted imaging (DWI) for pancreatic lesions. Read More

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Congenital Malformations and Perinatal Deaths among the Children of Atomic Bomb Survivors: A Reappraisal.

Am J Epidemiol 2021 Apr 13. Epub 2021 Apr 13.

Natural Radiation Regulation and Health Environmental Radiation Surveillance, STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland.

From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes of children of atomic bomb survivors who had received radiation doses from zero to near-lethal levels. Past reports (1956, 1981, and 1990) on the cohort did not identify significant associations of radiation exposure with untoward pregnancy outcomes such as major congenital malformations, stillbirths, or neonatal deaths, individually or in aggregate. We have re-examined the risk of major congenital malformations and perinatal deaths in the children of the atomic bomb survivors (N=71,603) using fully reconstructed data to minimize the potential for bias, with refined estimates of the gonadal dose from the Dosimetry System 2002 and refined analytical methods for characterizing dose-response relationships. Read More

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Lung Cancer Mortality and Styrene Exposure in the Reinforced Plastics Boatbuilding Industry: Evaluation of Healthy Worker Survivor Bias.

Am J Epidemiol 2021 Apr 13. Epub 2021 Apr 13.

National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.

The evidence of styrene as a human lung carcinogen has been inconclusive. Occupational cohorts within the reinforced plastics industry are an ideal population to study this association due to relatively high levels of exposure to styrene and lack of concomitant exposures to other known carcinogens. However, healthy worker survivor bias (HWSB), where healthier workers stay employed longer and thus have higher exposure potential, is a likely source of confounding bias for exposure-response associations, in part due to styrene's acute effects. Read More

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ATP2B1 gene polymorphisms rs2681472 and rs17249754 are associated with susceptibility to hypertension and blood pressure levels: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25530

Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha.

Objective: The present study aimed to conduct a systematic review and meta-analysis to evaluate the relationships between ATP2B1 gene polymorphisms with blood pressure (BP) level and susceptibility to hypertension.

Methods: PubMed, Web of Science, Embase and China National Knowledge Infrastructure (CNKI) Databases were systematically searched by 2 independent researchers to screen studies on ATP2B1 gene polymorphisms and BP related phenotypes. The records retrieval period was limited from the formation of the database to March 4, 2021. Read More

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Efficacy of cognitive behavioral therapy on mood and quality of life for patients with COVID-19: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25512

Department of Psychiatry.

Background: There is no study that has conducted a review or meta-analysis investigating a cognitive behavioral therapy (CBT) intervention to patients with COVID19, with the aim of improving their psychological health. Therefore, in order to provide new evidence-based medical evidence for clinical treatment, we undertook a systematic review and meta-analysis to assess the effectiveness of CBT in relieving patients' psychological distress and improving quality of life during the COVID-19 epidemic.

Methods: Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, Cochrane Library will be searched in April 2021 by 2 independent reviewers. Read More

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Traditional East Asian herbal medicines for the treatment of poststroke constipation: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25503

Department of Cardiology and Neurology.

Background: Post-stroke constipation is a major complication of stroke and increases the incidence of poor neurological outcomes and infectious complications and, therefore, warrants active and prompt treatment. In East Asian countries, several types of herbal medicines have been used for the treatment of post-stroke constipation because they are considered safer than existing pharmacotherapies. However, no systematic review has investigated the efficacy and safety of traditional East Asian herbal medicine in the treatment of post-stroke constipation. Read More

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Acupotomy for shoulder pain: A protocol for systematic review.

Medicine (Baltimore) 2021 Apr;100(15):e25502

Medical Community of Fenghua District Hospital of Traditional Chinese Medicine of Ningbo, Ningbo.

Background: Shoulder pain is a common musculoskeletal disorder prompting many patients to seek treatment. Acupotomy is a common treatment for shoulder which has been widely used in hospitals. But its efficiency has not been scientifically and methodically evaluated. Read More

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Cardiac rehabilitation of Baduanjin exercise in coronary heart disease after PCI: A protocol for systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Apr;100(15):e25501

Department of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine.

Background: Percutaneous coronary intervention (PCI) is an effective revascularization strategy in patients with coronary heart disease (CHD). However, recent studies had indicated that postPCI patients usually suffer from a low-quality life. Cardiac rehabilitation (CR) has been recommended by numerous guidelines in the clinic for these patients. Read More

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Effects of trimetazidine in combination with bisoprolol in patients with chronic heart failure and concomitant chronic obstructive pulmonary disease: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25491

Department of Critical Care Medicine, Yantaishan Hospital, Shandong, China.

Background: To the best of our knowledge, there is no study that has conducted a review investigating the clinical efficacy and safety of bisoprolol combined with trimetazidine on chronic heart failure (CHF) patients with chronic obstructive pulmonary disease (COPD). Therefore, in order to provide new evidence-based medical evidence for clinical treatment, we undertook a systematic review and meta-analysis to assess the effectiveness and safety of bisoprolol combined with trimetazidine on CHF patients with COPD.

Methods: Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, Cochrane Library will be searched in April 2021 by 2 independent reviewers. Read More

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A systematic review and meta-analysis on the regulation of programmed cell death-1 on T-cells in type 2 diabetes.

Medicine (Baltimore) 2021 Apr;100(15):e25488

School of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Durban.

Background: To assess T-cell exhaustion mediated by programmed cell death 1 (PD-1) pathway in patients living with type 2 diabetes (T2D).

Methods: MEDLINE and ProQuest electronic databases were searched for eligible studies from inception up to February 2020. The risk of bias and the quality of evidence were independently assessed by two reviewers using the modified Newcastle-Ottawa Scale adapted for cross-sectional studies and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool, respectively. Read More

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Risk factors of in-stent restenosis in patients with diabetes mellitus after percutaneous coronary intervention: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25484

Department of Hematology, Zhuzhou Central Hospital, Zhuzhou 412000, Hunan Province, China.

Background: Percutaneous coronary intervention (PCI) has become one of the effective methods for the treatment of coronary heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects the therapeutic effects. The incidence of ISR in diabetes mellitus (DM) patients increased by 2 to 4 times. Read More

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Effects of continuous positive airway pressure treatment in obstructive sleep apnea patients with atrial fibrillation: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25438

Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University.

Background: Obstructive sleep apnea (OSA) is correlated with atrial fibrillation (AF). Over the past decade, there has been an increasing interest in the relationship between OSA with continuous positive airway pressure (CPAP) and progression or recurrence of AF.

Methods: This investigation was an analysis of studies searched in the Cochrane Library, PubMed, EMBASE, EBSCO, OVID, and Web of Science databases from inception to July 2020 to evaluate the recurrence or progression of AF in CPAP users, CPAP nonusers, and patients without OSA. Read More

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Effects of continuous use of metformin on cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25353

Department of Emergency, Qianjiang Central Hospital of Chongqing, Chongqing, China.

Background: To our knowledge, no meta-analyses or reviews have investigated the efficacy and safety of metformin on cardiovascular outcomes after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM). We thus conduct a high-quality systematic review and meta-analysis to assess the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM.

Methods: In this systematic review and meta-analysis, we will search PUBMED, Scopus, EMBASE, and Cochrane Library databases through April, 2021. Read More

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Performance evaluation of CA242 by flow fluorescence assay.

Medicine (Baltimore) 2021 Apr;100(15):e25301

Xiamen Key Laboratory of Biomarker Translational Medicine, Center of Clinical Laboratory, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian, China.

Abstract: Carbohydrate antigen 24-2 (CA24-2) is usually used as a biomarker for the diagnosis of pancreatic cancer and colorectal cancer. Currentlly, a new quantitative assay kit for CA242 by flow fluorometry assay (FFA) was developed by Shanghai Tellgen Cooperation Co. Ltd. Read More

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The efficacy of moxibustion and acupuncture therapy for ankylosing spondylitis: A protocol for an overview of systematic reviews and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25179

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Background: Ankylosing spondylitis is a complex and progressive autoimmune inflammatory disease with a worldwide prevalence ranging up to 0.9%. Several systematic reviews and meta-analyses of traditional Chinese medicine alternative therapies, such as acupuncture or moxibustion, have demonstrated the effectiveness of moxibustion and acupuncture in the treatment of ankylosing spondylitis. Read More

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Evaluation of association between methylenetetrahydrofolate reductase and azoospermia: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e24523

Department of Andrology, Wuxi Hosptial of Traditional Chinese Medicine, Wuxi, China.

Background: Infertility affects childbearing age couples all over the world. One of the important reasons for infertility is genetic factors. Our study evaluated the association between methylenetetrahydrofolate reductase (MTHFR) and azoospermia. Read More

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Efficacy and safety of abdominal acupuncture for knee osteoarthritis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e23628

Department of Orthopaedics, The First Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangdong, China.

Background: Knee osteoarthritis (KOA) is a disease based on degenerative pathological changes. Most commonly seen in the elderly and is one of Kenn's leading causes, its symptoms include swollen knees, pain in walking up and downstairs. If left untreated, it can lead to joint deformity and disability. Read More

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Comparison of treatment results between surgical and conservative treatment of distal radius fractures in adults: A meta-analysis of randomized controlled trials.

Acta Orthop Traumatol Turc 2021 Mar;55(2):118-126

Xiamen University, Xiamen, Fujian, China.

Objective: This meta-analysis study aims to determine the efficacy and safety of surgical and conservative treatments for distal radius fractures (DRFs) in adults.

Methods: Reports of randomized controlled trials were retrieved from the Web of Science, Pubmed, Google Scholar, EMBASE, Cochrane Library, Medline, Ovid, and BIOSIS for studies that met the eligibility criteria. The search was limited to human subjects and had no language limits. Read More

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