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8-Hydroxy-2'-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis.

Psychiatry Investig 2021 Jul 22;18(7):603-618. Epub 2021 Jul 22.

Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kajang, Malaysia.

Objective: Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Read More

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Prediction of diabetic protein markers based on an ensemble method.

Front Biosci (Landmark Ed) 2021 Jul;26(7):207-221

School of Opto-electronic and Communication Engineering, Xiamen University of Technology, 361024 Xiamen, Fujian, China.

: A diabetic protein marker is a type of protein that is closely related to diabetes. This kind of protein plays an important role in the prevention and diagnosis of diabetes. Therefore, it is necessary to identify an effective method for predicting diabetic protein markers. Read More

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Current status of haemophilia inhibitor management in mainland China: a haemophilia treatment centres survey on treatment preferences and real-world clinical practices.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Laboratory of Blood Disease Gene Therapy, CAMS Key Laboratory of Gene Therapy for Blood Diseases, CAMS Center for Stem Cell Medicine, PUMC Department of Stem Cell and Regenerative Medicine, Tianjin, China.

To investigate the current experience and expertise for haemophilia inhibitor patient management in haemophilia treatment centres (HTCs) in mainland China. Questionnaires were distributed to 'tertiary tier A' hospital HTCs across China to collect information on treatment preferences for bleeding control, prophylaxis and inhibitor eradication, as well as their regimens in real-world clinical practice. Of 40 questionnaires distributed, 39 were returned. Read More

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Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes.

J Natl Compr Canc Netw 2021 Jul 28;19(7):821-828. Epub 2021 Jul 28.

5Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Read More

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Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance.

Seizure 2021 Jul 26;91:447-455. Epub 2021 Jul 26.

Unidad Mixta de Estudio de la Neuroinflamación, Instituto de Investigaciones Biomédicas (IIBO), Universidad Nacional Autónoma de México (UNAM) / Instituto Nacional de Neurología y Neurocirugía (INNN), Ciudad de México, México; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Ciudad Universitaria. Apartado Postal 70228. México DF 04510. México. Electronic address:

Neuroinflammation is probably one of the factors involved in drug resistance in people with epilepsy. Finding peripheral markers reflecting the intensity of neuroinflammation could be of great help to decide for which patients anti-inflammatory treatment might be an option. In this context, peripheral cytokines levels and lymphocyte phenotypes were assessed by ELISA and flow cytometry in 3 groups of subjects: drug resistant patients with temporal lobe epilepsy (DR-TLE), non DR-TLE patients and healthy controls. Read More

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A measure of illness awareness in alcohol use disorder-Alcohol Use Awareness and Insight Scale (AAS).

Drug Alcohol Depend 2021 Jun 18;226:108813. Epub 2021 Jun 18.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Campbell Institute Research Program, CAMH, University of Toronto, Toronto, Ontario, Canada; Geriatric Mental Health Division, CAMH, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Introduction: Impaired illness awareness in individuals with alcohol use disorder can negatively affect treatment adherence, rehabilitation, and other clinical outcomes. However, the construct of illness awareness in alcohol use disorder and its clinical implications remain to be better conceptualized and understood. The objective of this study was to develop and psychometrically test a scale designed to assess impaired illness awareness in individuals with alcohol use disorder. Read More

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Extra-axial chordoma of the thumb: Report of a rare case with clinicopathologic and molecular analysis.

Pathol Res Pract 2021 Jul 22;225:153564. Epub 2021 Jul 22.

Department of Pathology, Rigshospitalet, University Hospital of Copenhagen, Denmark. Electronic address:

Chordoma is a very rare malignant tumor, with a phenotype that recapitulates notochord, and is chiefly located in the axial skeleton with only few cases reported in the extra-axial skeleton and soft tissues. The diagnosis can be challenging for both clinicians, radiologists and pathologists because of the rarity of tumor, its unspecific radiological pattern and histomorphological similarities to other tumors like extra-skeletal myxoid chondrosarcoma, soft tissue myoepithelioma and metastatic adenocarcinomas, more so on small biopsies. We present a case of a recurrent extra-axial chordoma with a prominent soft tissue component in the left thumb around proximal phalanx of an 80-year-old man, with detailed report of the histopathological, imaging and most importantly molecular features, which are in conformity with the typical profile of notochordal neoplasms. Read More

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Reverse osmosis concentrate treatment by microbubble ozonation-biological activated carbon process: Organics removal performance and environmental impact assessment.

Sci Total Environ 2021 Jul 28;798:149289. Epub 2021 Jul 28.

National University of Singapore, Sembcorp-NUS Corporate Laboratory c/o FoE, Block E1A, #04-01, 1 Engineering Drive 2, 117576, Singapore; Department of Civil & Environmental Engineering, Faculty of Engineering, National University of Singapore, Block E1A, #07-01, 1 Engineering Drive 2, 117576, Singapore. Electronic address:

Reverse osmosis (RO) is being used in many water reclamation facilities to produce high quality water that can be reused for different purposes. As a part of the RO process, a reject stream is produced as the reverse osmosis concentrate (ROC), which contains elevated levels of contaminants compared to the source water. Effective treatment and safe disposal of ROC via cost-effective means is very challenging. Read More

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Hypochlorous acid initiated lipid chlorination at air-water interface.

Sci Total Environ 2021 Jul 29;798:149320. Epub 2021 Jul 29.

School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai, Shandong 264209, China. Electronic address:

There has been a surge of interest in interfacial hypochlorous acid (HOCl) chemistry for indoor air quality and public health. Here we combined nanoelectrospray mass spectrometry (nESI-MS) and acoustic levitation (AL) techniques to study the chlorination chemistry of three model lipids (DPPE, POPG, DOPG) mediated by HOCl at the air-water interface of levitated water droplet. For DPPE with no CC double bonds, HOCl was insensitive to the alkane chains, and showed considerable delay directing to head amino groups compared to that in aqueous environment. Read More

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Zinc concentration prediction in rice grain using back-propagation neural network based on soil properties and safe utilization of paddy soil: A large-scale field study in Guangxi, China.

Sci Total Environ 2021 Jul 24;798:149270. Epub 2021 Jul 24.

Guangxi Institute of Geological Survey, Nanning 530023, PR China.

Zn is an essential nutrient for humans, with crucial biological functions. However, Zn concentration in rice grains is generally low. Therefore, a cereal-based diet may lead to Zn deficiency in people, further leading to a series of health problems, such as immune and brain dysfunction. Read More

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Predictors of clozapine discontinuation at 2 years in treatment-resistant schizophrenia.

Schizophr Res 2021 Jul 30;235:102-108. Epub 2021 Jul 30.

Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Chile. Electronic address:

Introduction: Little is known about predictors of clinical response to clozapine treatment in treatment-resistant psychosis. Most published cohorts are small, providing inconsistent results. We aimed to identify baseline clinical predictors of future clinical response in patients who initiate clozapine treatment, mainly focusing on the effect of age, duration of illness, baseline clinical symptoms and homelessness. Read More

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Controllable organosilane monolayer density of surface bonding using silatranes for thiol functionalization of silica particles for liquid chromatography and validation of microanalytical method for elemental composition determination.

J Chromatogr A 2021 Jul 22;1653:462418. Epub 2021 Jul 22.

Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analyses, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany. Electronic address:

The present work systematically investigates a new strategy for the functionalization of silica gel using alkyl silatrane chemistry instead of alkylsilanes for synthesis of chromatographic stationary phases. In this work, silica was chemically modified for further functionalization by a thiol-ene click reaction. Thus, 3-mercaptopropylsilatrane (MPS) was used which is capable to form self-assembled monolayers (SAM) on top of silanol surfaces in a controlled manner as previously shown for silicon wafers. Read More

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Increased Relative Functional Gain and Improved Stroke Outcomes: A Linked Registry Study of the Impact of Rehabilitation.

J Stroke Cerebrovasc Dis 2021 Jul 30;30(10):106015. Epub 2021 Jul 30.

Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia; Translational Public Health and Evaluation Division, Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Level 3 Hudson Institute Building, 27-31 Wright Street, Clayton, VIC 3168, Australia. Electronic address:

Objectives: It is unclear how acute care influences patient outcomes in those who receive rehabilitation. We aimed to determine the associations between acute stroke therapies, outcomes during inpatient rehabilitation and self-reported outcomes at 90-180 days after stroke.

Materials And Methods: Patient-level data from adults with acute stroke registered in the Australian Stroke Clinical Registry (AuSCR, 2014-2017) were linked with data from the Australasian Rehabilitation Outcomes Centre (AROC). Read More

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Photochemical and photophysical properties of tetracarboxylic acid phthalocyanines from glycolic and lactic acids in homogeneous and micro heterogeneous media.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 13;263:120177. Epub 2021 Jul 13.

Federal University of ABC/Center for Natural and Human Sciences, Av. dos Estados, 5001 - Santo André, São Paulo CEP 09210-580, Brazil. Electronic address:

Glycolic acid and lactic acid substituted zinc phthalocyanines were studied concerning their photophysical and photochemical properties in eight organic solvents (homogeneous medium) and in aqueous media with the presence of CTAB and PVP 360 surfactants. Solvent effects were investigated according to several physical solvent parameters, including studies that used more than one parameter at a time, such as the E(30) scale and the Lippet-Mataga equation. Computational studies were realized and was found in good agreement with experimental data indicating J-type dimers' formation through hydrogen bonds, which may not affect the spectroscopic properties. Read More

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MIR spectroscopy versus MALDI-ToF-MS for authenticity control of honeys from different botanical origins based on soft independent modelling by class analogy (SIMCA) - A clash of techniques?

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 23;263:120225. Epub 2021 Jul 23.

Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany. Electronic address:

In this study, highly reproducible MIR spectroscopy and highly sensitive MALDI-ToF-MS data were directly compared for the metabolomic profiling of monofloral and multifloral honey samples from three different botanical origins canola, acacia, and honeydew. Subsequently, three different classification models were applied to the data of both techniques, PCA-LDA, PCA- kNN, and soft independent modelling by class analogy (SIMCA) as class modelling technique. All monofloral external test set samples were classified correctly by PCA-LDA and SIMCA with both data sets, while multifloral test set samples could only be identified as outliers by the SIMCA technique, which is a crucial aspect in the authenticity control of honey. Read More

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Diabetic foot self-care practice in women with diabetes in Iran.

Diabetes Metab Syndr 2021 Jul 26;15(5):102225. Epub 2021 Jul 26.

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: The present study was conducted to determine the situation of foot self-care practice among Iranian women with diabetes.

Methods: In this cross-sectional study, 475 women completed the Diabetic Foot Self-Care Questionnaire (DFSQ) along with other questions. The overall and three components scores including personal care, podiatric care, and foot wearing, were calculated and their relationship with other factors was analyzed. Read More

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Construction of MoS/Mxene heterostructure on stress-modulated kapok fiber for high-rate sodium-ion batteries.

J Colloid Interface Sci 2021 Jul 23;605:472-482. Epub 2021 Jul 23.

Tianjin Municipal Key Laboratory of Advanced Fiber and Energy Storage Technology, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.

Molybdenum disulfide (MoS) has possession of a layered structure and high theoretical capacity, which is a candidate anode material for sodium ion batteries. However, unmodified MoS are inflicted with a poor cycling stability and an inferior rate capability upon charge/discharge processes. Considering that the shape and size of anode materials play a key role in the performance of anode materials, this paper proposes a multi-level composite structure formed by the micro-nano materials based on self-assembled molybdenum disulfide (MoS) nanoflowers, Mxene and hollow carbonized kapok fiber (CKF). Read More

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Effect of long-term intergenerational exposure to ocean acidification on ompa and ompb transcripts expression in European seabass (Dicentrarchus labrax).

Mar Environ Res 2021 Jul 27;170:105438. Epub 2021 Jul 27.

Department of Integrative Ecophysiology, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany.

Since sensory system allows organisms to perceive and interact with their external environment, any disruption in their functioning may have detrimental consequences on their survival. Ocean acidification has been shown to potentially impair olfactory system in fish and it is therefore essential to develop biological tools contributing to better characterize such effects. The olfactory marker protein (omp) gene is involved in the maturation and the activity of olfactory sensory neurons in vertebrates. Read More

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Low-sound-level auditory processing in noise-exposed adults.

Hear Res 2021 Jul 9;409:108309. Epub 2021 Jul 9.

Manchester Centre for Audiology and Deafness, School of Health Sciences, University of Manchester, M13 9PL, UK.; Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL, UK. Electronic address:

Early signs of noise-induced hearing damage are difficult to identify, as they are often confounded by factors such as age, audiometric thresholds, or even music experience. Much previous research has focused on deficits observed at high intensity levels. In contrast, the present study was designed to test the hypothesis that noise exposure causes a degradation in low-sound-level auditory processing in humans, as a consequence of dysfunction of the inner hair cell pathway. Read More

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Pitch perception is more robust to interference and better resolved when provided by pulse rate than by modulation frequency of cochlear implant stimulation.

Hear Res 2021 Jul 24;409:108319. Epub 2021 Jul 24.

Auditory Research Center, Caruso Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States.

Cochlear implants are medical devices that have been used to restore hearing to more than half a million people worldwide. Most recipients achieve high levels of speech comprehension through these devices, but speech comprehension in background noise and music appreciation in general are markedly poor compared to normal hearing. A key aspect of hearing that is notably diminished in cochlear implant outcomes is the sense of pitch provided by these devices. Read More

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Valorization of waste cabbage leaves by postharvest photochemical treatments monitored with a non-destructive fluorescence-based sensor.

J Photochem Photobiol B 2021 Jul 20;222:112263. Epub 2021 Jul 20.

Research Institute of Horticulture, Konstytucji 3 Maja 1/3, Skierniewice, Poland.

The biosynthesis of polyphenolic compounds in cabbage waste, outer green leaves of white head cabbage (Brassica oleracea L. var. capitata subvar. Read More

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Synthesis, biological evaluation (antioxidant, antimicrobial, enzyme inhibition, and cytotoxic) and molecular docking study of hydroxy methoxy benzoin/benzil analogous.

Bioorg Chem 2021 Jul 16;115:105183. Epub 2021 Jul 16.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

In this work, due to the biological activity evaluation, a series of hydroxy methoxy benzoins (1-8), benzils (10-16) and methoxy benzoin/benzil-O-β-d-glucosides (17-28) were synthesized. Antioxidant (FRAP, CUPRAC, DPPH), antimicrobial (16 microorganisms, and two yeast), enzyme inhibition (α-amylase, α-glucosidase, AChE, BChE, and tyrosinase) of all synthesized benzoin/benzil analogs were investigated. Benzoins (1-8) showed the most effective antioxidant properties compared to all three methods. Read More

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Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study.

Neuroimage Clin 2021 Jul 24;31:102765. Epub 2021 Jul 24.

Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany; Institute for Diagnostic and Interventional Radiology, Pediatric and Neuroradiology, University Medical Centre Rostock, Rostock, Germany.

Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role of machine learning and artificial intelligence to increase detection of brain abnormalities in TLE remains inconclusive. Read More

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Reasons for rejecting hormonal contraception in Western countries: A systematic review.

Soc Sci Med 2021 Jul 20;284:114247. Epub 2021 Jul 20.

Institut National d'Études Démographiques (Ined), 9 Cours des Humanités, F-93300, Aubervilliers, France; Univ. Paris-Saclay, UVSQ, Inserm, CESP, F-94807, Villejuif, France. Electronic address:

Over the past decade, women in Western countries have taken to various social media platforms to share their dissatisfactory experiences with hormonal contraception, which may be pills, patches, rings, injectables, implants or hormonal intrauterine devices (IUDs). These online testimonials have been denounced as spreading "hormonophobia", i.e. Read More

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The role of redundant verbal labels in 8- and 10-month-olds' working memory.

Infant Behav Dev 2021 Jul 30;64:101617. Epub 2021 Jul 30.

University of Massachusetts Boston, United States.

Verbal labels have been shown to help preverbal infants' performance on various cognitive tasks, such as categorization. Redundant labels also aid adults' visual working memory (WM), but it is not known if this linguistic benefit extends to preverbal infants' WM. In two eye-tracking studies, we tested whether 8- and 10-month-old infants' WM performance would improve with the presence of redundant labels in a Delayed Match Retrieval (DMR) paradigm that tested infants' WM for object-location bindings. Read More

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Analyzing drivers' hazard recognition: Precursors to single-vehicle collisions.

Accid Anal Prev 2021 Jul 30;160:106304. Epub 2021 Jul 30.

Department of Civil & Environmental Engineering, The University of Tennessee, Knoxville, United States.

Extensive driver behavior and performance information provided by real-world video surveillance and sensor data in the SHRP2 Naturalistic Driving Study has enabled the examination of new layers and pathways leading to crash outcomes. We note that the prominence of hazards and the importance of recognizing them vary systematically across single vs. multi-vehicle crashes, and address a fundamental question about safety: why do around three-quarters of drivers involved in single-vehicle crashes not recognize, perceive, or react to the precipitating event (PE)? Using a path-analytic framework through marginal effects, this study investigates factors correlated to recognition of the PE in single-vehicle events, and how these correlations may act as crash precursors. Read More

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Osteocyte Calcium Signaling - A Potential Translator of Mechanical Load to Mechanobiology.

Authors:
Karl J Lewis

Bone 2021 Jul 30:116136. Epub 2021 Jul 30.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY. Electronic address:

Osteocytes are embedded dendritic bone cells; by virtue of their position in bone tissue, ability to coordinate bone building osteoblasts and resorbing osteoclasts, and sensitivity to tissue level mechanical loading, they serve as the resident bone mechanosensor. The mechanisms osteocytes use to change mechanical loading into biological signals that drive tissue level changes has been well studied over the last 30 years, however the ways loading parameters are encoded at the cellular level are still not fully understood. Calcium signaling is a first messenger signal exhibited by osteocytes in response to mechanical forces. Read More

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Expressive and Receptive Language in Russian Primary-School-Aged Children with Autism Spectrum Disorder.

Res Dev Disabil 2021 Jul 30;117:104042. Epub 2021 Jul 30.

Center for Language and Brain, HSE University, Moscow, Russia; Institute of Linguistics, Russian Academy of Sciences, Moscow, Russia.

Background: Abnormal language development in both expressive and receptive domains occurs in most children with Autism Spectrum Disorder (ASD), although the language deficit is not a core symptom of ASD. However, previous studies disagree on the difference in the degree of impairment between expressive and receptive language in ASD. Existing research has concentrated on vocabulary and 'global expressive and receptive language', often using parental reports for language assessment. Read More

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Transfusion Guidelines in Adult Spine Surgery: A Systematic Review and Critical Summary of Currently Available Evidence.

Spine J 2021 Jul 30. Epub 2021 Jul 30.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA 75235; University of Texas Southwestern Medical Center, Spine Center, Dallas, TX, USA 75235.

Background Context: Red blood cell transfusion can be associated with complications in medical and surgical patients. Acute anemia in ambulatory patients undergoing surgery can also impede wound healing and independent self-care. Current transfusion threshold guidelines are still based on evidence derived from critically-ill intensive care unit medical patients and may not apply to spine surgery candidates. Read More

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Risk factors for postoperative recurrence of anal fistula identified by an international, evidence-based Delphi consultation survey of surgical specialists.

Int J Surg 2021 Jul 30:106038. Epub 2021 Jul 30.

Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background: Despite the emerging knowledge about postoperative anal fistula recurrence (AFR) and the increasing number of clinical studies, there is no better understanding or consensus regarding the risk factors for AFR. The aim of this study was to generate international consensus guidance statements focusing on AFR.

Methods: A two-round modified Delphi process was conducted among international surgical specialists via an online survey delivered by email with a secure link created with Google Forms. Read More

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