163,692 results match your criteria better biological


Cancer driver gene and non-coding RNA alterations as biomarkers of brain metastasis in lung cancer: A review of the literature.

Biomed Pharmacother 2021 Sep 21;143:112190. Epub 2021 Sep 21.

Zimagene Medical Genetics Laboratory, Avicenna St., Hamedan, Iran. Electronic address:

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite multimodal treatments and advances in systemic therapies, development of BM remains one of the main factors associated with poor prognosis and mortality in patients with lung cancer. Therefore, better understanding of mechanisms involved in lung cancer brain metastasis (LCBM) is of great importance to suppress cancer cells and to improve the overall survival of patients. Read More

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September 2021

Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies.

Neuroimage Clin 2021 Sep 16;32:102830. Epub 2021 Sep 16.

Brain and Mind Research Programme, Central European Institute of Technology, Masaryk University (CEITEC MU), 5 Kamenice, Brno 62500, Czech Republic; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1L8, Canada.

Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. Read More

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September 2021

AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss.

Eur J Med Chem 2021 Sep 20;226:113849. Epub 2021 Sep 20.

Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, 68178, USA. Electronic address:

Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of hearing loss and cancer. Previously, we identified AZD5438 and AT7519-7 as potent inhibitors of CDK2, however, they also targeted additional kinases, leading to unwanted toxicities. Proteolysis Targeting Chimeras (PROTACs) are a new promising class of small molecules that can effectively direct specific proteins to proteasomal degradation. Read More

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September 2021

Insulin signaling alters antioxidant capacity in the diabetic heart.

Redox Biol 2021 Sep 20;47:102140. Epub 2021 Sep 20.

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA. Electronic address:

Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the modulation of reactive oxygen species (ROS) production and clearance must be better defined. Read More

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September 2021

Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.

Bioorg Med Chem Lett 2021 Sep 21:128375. Epub 2021 Sep 21.

Department of Pharmacy, Central University of Rajasthan, Bandarsindari, Ajmer, Rajasthan 305817, India. Electronic address:

GSK-3β directly phosphorylate tubulin binding site of tau protein, indicating its importance in tau aggregation and, therefore, in Alzheimer's disease pathology. New GSK-3β inhibitors were identified using a structure-based screening, ADMET analysis. These studies revealed that ZINC09036109, ZINC72371723, ZINC72371725, and ZINC01373165 approached optimal ADMET properties along with good MM-GBSA dG binding. Read More

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September 2021

Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells.

Chem Biol Interact 2021 Sep 21:109673. Epub 2021 Sep 21.

Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address:

2,3-Dimethyl-1,4-benzoquinones named as Plastoquinone (PQ) analogs have antiproliferative activity and are promising new members of molecules that can be used to cope with cancer. In an attempt to develop effective and potentially safe antiproliferative agents, previously reported twelve Plastoquinone analogs (PQ1-12) have been obtained to understand their antiproliferative profile. All PQ analogs have been selected by the National Cancer Institute (NCI) of Bethesda based on the NCI Developmental Therapeutics Program and tested against the panel of 60 cancer cell lines. Read More

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September 2021

Insights on microbial fuel cells for sustainable biological nitrogen removal from wastewater: A review.

Environ Res 2021 Sep 21:112095. Epub 2021 Sep 21.

School of Biochemical Engineering and Technology, Sirindhorn International Institute of Technology, Thammasat University, P.O. Box 22, Pathum Thani, 12121, Thailand. Electronic address:

Microbial fuel cells (MFCs) have emerged as a promising technology for energy-efficient wastewater treatment. The feasibility of integrating biological nitrogen removal into MFC systems has been reported. However, better pollutant removal efficiency and power production need to be achieved at a lower cost for a sustainable wastewater treatment system. Read More

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September 2021

Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer.

Mol Carcinog 2021 Sep 24. Epub 2021 Sep 24.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Cancer and the immune system share an intimate relationship. Chronic inflammation increases the risk of cancer occurrence and can also drive inflammatory mediators into the tumor microenvironment enhancing tumor growth and survival. The p38 MAPK pathway is activated both acutely and chronically by stress, inflammatory chemokines, chronic inflammatory conditions, and cancer. Read More

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September 2021

Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana.

Plant J 2021 Sep 24. Epub 2021 Sep 24.

Department of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA.

Zinc (Zn) is essential for normal plant growth and development. The ZIP (ZRT, IRT-like Protein) family members are involved in Zn transport and cellular Zn homeostasis throughout the domains of life. In this study, we have characterized four ZIP transporters from Arabidopsis thaliana (IRT3, ZIP4, ZIP6 and ZIP9) to better understand their functional roles. Read More

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September 2021

Non-malignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus.

Hepatology 2021 Sep 24. Epub 2021 Sep 24.

Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.

Background And Aim: Portal vein thrombosis (PVT) is a common complication of cirrhosis. The exact pathophysiology remains largely unknown and treatment with anticoagulants does not lead to recanalization of the portal vein in all patients. A better insight in the structure and composition of portal vein thrombi may assist in developing new strategies for the prevention and treatment of PVT. Read More

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September 2021

Effects of spray-dried animal plasma on growth performance, survival, feed utilization, immune responses, and resistance to Vibrio parahaemolyticus infection of Pacific white shrimp (Litopenaeus vannamei).

PLoS One 2021 24;16(9):e0257792. Epub 2021 Sep 24.

APC LLC, 2425 SE Oak Tree Court, Ankeny, Iowa, United States of America.

Spray-dried animal plasma (SDP) in feed for several animal species provides health benefits, but research about use of SDP in shrimp feed is very limited. The objectives of the present study were to investigate the effects of dietary SDP on growth performance, feed utilization, immune responses, and prevention of Vibrio parahaemolyticus infection in Pacific white shrimp (Litopenaeus vannamei). In Experiment 1, the post-larvae were divided into five groups (four tank/group and 80 shrimp/tank) and fed four times daily diets with porcine SDP at 0, 1. Read More

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September 2021

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.

PLoS Pathog 2021 Sep 24;17(9):e1009543. Epub 2021 Sep 24.

Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, United States of America.

Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). Here, we analyzed monoclonal antibodies (mAbs) isolated from non-human primates (NHPs) immunized with variants of a native flexibly linked (NFL) HIV-1 Env stabilized trimer derived from the tier 2 clade C 16055 strain. The antibodies displayed neutralizing activity against the autologous virus with potencies ranging from 0. Read More

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September 2021

Clinical and Radiological Outcomes of Two Modified Open-Door Laminoplasties Based on a Novel Paraspinal Approach for Treatment of Multilevel Cervical Spondylotic Myelopathy.

Spine (Phila Pa 1976) 2021 Sep 22. Epub 2021 Sep 22.

Department of Orthopedic Surgery and Biological Engineering and Regenerative Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Study Design: a case-control study.

Objectives: to evaluate the outcomes of two modified laminoplasties (LPs) based on a novel paraspinal approach for treating multilevel cervical spondylotic myelopathy.

Summary Of Background Data: no laminoplasty through a natural intermuscular plane mimicking Wiltse approach to minimize intraoperative injury to extensor muscles has ever been developed and studied. Read More

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September 2021

A Nonparametric Approach for Estimating Three-Dimensional Fiber Orientation Distribution Functions (ODFs) in Fibrous Materials.

IEEE Trans Med Imaging 2021 Sep 24;PP. Epub 2021 Sep 24.

Many biological tissues contain an underlying fibrous microstructure that is optimized to suit a physiological function. The fiber architecture dictates physical characteristics such as stiffness, diffusivity, and electrical conduction. Abnormal deviations of fiber architecture are often associated with disease. Read More

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September 2021

Assessment of Prediction Methods for Protein Structures Determined by NMR in CASP14: Impact of AlphaFold2.

Proteins 2021 Sep 24. Epub 2021 Sep 24.

Dept of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York, USA.

NMR studies can provide unique information about protein conformations in solution. In CASP14, three reference structures provided by solution NMR methods were available (T1027, T1029, and T1055), as well as a fourth data set of NMR-derived contacts for an integral membrane protein (T1088). For the three targets with NMR-based structures, the best prediction results ranged from very good (GDT_TS = 0. Read More

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September 2021

Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer.

Carcinogenesis 2021 Sep 24. Epub 2021 Sep 24.

Division of Biomedical Research & Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Iwate, Japan.

We investigated whether early circulating tumor DNA (ctDNA) changes, measured using digital PCR (dPCR), can predict later chemotherapy responses in esophageal squamous cell cancer (ESCC). We compared the dynamics of ctDNA and tumor volumes during chemotherapy in 42 ESCC. The accuracy of predictions of later chemotherapy responses were evaluated by the ratio of the variant allele frequency (VAF) of ctDNA (post-/pre-ctDNA) and the total tumor volume (post-/pre-volume) before and after an initial chemotherapy cycle using a receiver-operating characteristic curve analysis. Read More

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September 2021

Key Characteristics of Cardiovascular Toxicants.

Environ Health Perspect 2021 Sep 24;129(9):95001. Epub 2021 Sep 24.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA.

Background: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches.

Objectives: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them. Read More

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September 2021

Influence of the Amount of Fresh Specimen on the Isolation of Tumor Mesenchymal Stem-Like Cells from High-Grade Glioma.

Yonsei Med J 2021 Oct;62(10):936-942

Yonsei University College of Medicine, Seoul, Korea.

Purpose: A critical indicator of the overall survival of patients with high-grade glioma is the successful isolation of tumor mesenchymal stem-like cells (tMSLCs), which play important roles in glioma progression. However, attempts to isolate tMSLCs from surgical specimens have not always been successful, and the reasons for this remain unclear. Considering that the amount of surgical high-grade glioma specimens varies, we hypothesized that larger surgical specimens would be better for tMSLC isolation. Read More

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October 2021

A promising platform for predicting toxicity.

Elife 2021 09 24;10. Epub 2021 Sep 24.

Lausanne University Hospital, Lausanne, Switzerland.

Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy drugs. Read More

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September 2021

Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity.

Innovation (N Y) 2021 May 29;2(2):100108. Epub 2021 Apr 29.

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.

Extreme longevity has evolved multiple times during the evolution of mammals, yet its underlying molecular mechanisms remain largely underexplored. Here, we compared the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan (control group) in the hopes of better understanding the common molecular mechanisms behind longevity. We identified 16 unique positively selected genes and 23 rapidly evolving genes in long-lived species, which included nine genes involved in regulating lifespan through the insulin/IGF-1 signaling (IIS) pathway and 11 genes highly enriched in immune-response-related pathways, suggesting that the IIS pathway and immune response play a particularly important role in exceptional mammalian longevity. Read More

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Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery.

Innovation (N Y) 2020 Aug 5;1(2):100034. Epub 2020 Aug 5.

State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health. HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is no cure. In cells infected by HBV, viral DNA can be integrated into the cellular genome. Read More

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Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study.

Hum Reprod Open 2021 7;2021(4):hoab032. Epub 2021 Aug 7.

Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Study Question: Does lifestyle intervention consisting of an energy-restricted diet, enhancement of physical activity and motivational counseling prior to IVF improve embryo utilization rate (EUR) and cumulative live birth rate (CLBR) in women with obesity?

Summary Answer: A 6-month lifestyle intervention preceding IVF improved neither EUR nor CLBR in women with obesity in the first IVF treatment cycle where at least one oocyte was retrieved.

What Is Known Already: A randomized controlled trial (RCT) evaluating the efficacy of a low caloric liquid formula diet (LCD) preceding IVF in women with obesity was unable to demonstrate an effect of LCD on embryo quality and live birth rate: in this study, only one fresh embryo transfer (ET) or, in case of freeze-all strategy, the first transfer with frozen-thawed embryos was reported. We hypothesized that any effect on embryo quality of a lifestyle intervention in women with obesity undergoing IVF treatment is better revealed by EUR and CLBR after transfer of all fresh and frozen-thawed embryos. Read More

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A Network Pharmacology and Molecular Docking Strategy to Explore Potential Targets and Mechanisms Underlying the Effect of Curcumin on Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus.

Biomed Res Int 2021 13;2021:5538643. Epub 2021 Sep 13.

Department of Orthopaedic Surgery, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Background: Systemic lupus erythematosus (SLE) is a refractory immune disease, which is often complicated with osteonecrosis of the femoral head (ONFH). Curcumin, the most active ingredient of Curcuma longa with a variety of biological activities, has wide effects on the body system. The study is aimed at exploring the potential therapeutic targets underlying the effect of curcumin on SLE-ONFH by utilizing a network pharmacology approach and molecular docking strategy. Read More

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September 2021

Integrative Analysis of mA Regulator-Mediated RNA Methylation Modification Patterns and Immune Characteristics in Lupus Nephritis.

Front Cell Dev Biol 2021 7;9:724837. Epub 2021 Sep 7.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: There is growing evidence to demonstrate that the epigenetic regulation of immune characteristics, especially for N6-methyladenosine (mA) RNA methylation. However, how mA methylation is involved in lupus nephritis (LN) is still unclear. This study aimed to determine the role of mA RNA methylation and their association with the immune microenvironment in LN. Read More

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September 2021

Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma.

Front Oncol 2021 7;11:708900. Epub 2021 Sep 7.

Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, China.

Background: Kinesin superfamily of proteins (KIFs) has been broadly reported to play an indispensable role in the biological process. Recently, emerging evidence reveals its oncogenic role in various cancers. However, the prognostic, oncological, and immunological values of KIFs have not been comprehensively explored in pancreatic ductal adenocarcinoma (PDAC) patients. Read More

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September 2021

Haplotype and diversity analysis of indigenous rice for salinity tolerance in early-stage seedling using simple sequence repeat markers.

Biotechnol Rep (Amst) 2021 Sep 9;31:e00666. Epub 2021 Aug 9.

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Lin'an, Hangzhou 311300,, Zhejiang, China.

We evaluated the seedling-stage salt tolerance of a total of 50 indigenous rice genotypes from coastal Tamil Nadu. Using a hydroponic system, we studied the different agronomic characters 14 days after exposure to six different concentrations of saline solution. Shoot and root length as well as plant biomass at seedling stage decreased with increasing salinity. Read More

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September 2021

Folic Acid-Conjugated CuFeSe Nanoparticles for Targeted T2-Weighted Magnetic Resonance Imaging and Computed Tomography of Tumors In Vivo.

Int J Nanomedicine 2021 17;16:6429-6440. Epub 2021 Sep 17.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.

Background: Development of new long-circulating contrast agents for computed tomography (CT) and magnetic resonance imaging (MRI) of different biological systems still remains a great challenge. Here, we report the synthesis of folic acid (FA)-targeted CuFeSe nano-contrast agent for CT and MRI imaging in vitro and in vivo.

Methods And Results: In our study, CuFeSe was fabricated through a facile and green aqueous reaction and then further aminated through silanization. Read More

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September 2021

Clinico-radio-pathological Features and Biological Behavior of Breast Cancer in Young Indian Women: A Prospective Study.

Indian J Radiol Imaging 2021 Apr 30;31(2):323-332. Epub 2021 Jul 30.

Department of Radio-Diagnosis, Basavatarkam Indo-American Cancer Hospital and Research Centre, Hyderabad, Telangana, India.

The aim of the study is to evaluate the characteristic imaging features of breast cancer on mammogram, ultrasound, and magnetic resonance imaging (MRI) in women less than 40 years of age and to assess the degree of correlation between clinico-radio-pathological features and biological behavior. A prospective observational study on consecutive women under 40 years of age evaluated with ultrasound of breast, digital mammogram, or contrast-enhanced breast MRI, diagnosed with breast cancer on histopathology and molecular analysis done at our center between January and December 2019 were included. Patient demographics, clinical presentation, family history, BRCA mutation status, imaging, pathological findings, and molecular status were determined. Read More

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Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner.

Commun Biol 2021 Sep 23;4(1):1122. Epub 2021 Sep 23.

Graduate Program in Cancer Biology, Vanderbilt University, Nashville, TN, USA.

Hypoxia is a common feature in tumors and induces signaling that promotes tumor cell survival, invasion, and metastasis, but the impact of hypoxia inducible factor (HIF) signaling in the primary tumor on dissemination to bone in particular remains unclear. To better understand the contributions of hypoxia inducible factor 1 alpha (HIF1α), HIF2α, and general HIF pathway activation in metastasis, we employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary specific deletion of Hif1α, Hif2α, or von Hippel-Lindau factor (Vhl) using the Cre-lox system. Here we show that Hif1α or Hif2α deletion in the primary tumor decreases metastatic tumor burden in the bone marrow, while Vhl deletion increases bone tumor burden, as hypothesized. Read More

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September 2021

Computational identification of multiple lysine PTM sites by analyzing the instance hardness and feature importance.

Sci Rep 2021 Sep 23;11(1):18882. Epub 2021 Sep 23.

Computer Science and Engineering, Rajshahi University of Engineering and Technology, Rajshahi, 6204, Bangladesh.

Identification of post-translational modifications (PTM) is significant in the study of computational proteomics, cell biology, pathogenesis, and drug development due to its role in many bio-molecular mechanisms. Though there are several computational tools to identify individual PTMs, only three predictors have been established to predict multiple PTMs at the same lysine residue. Furthermore, detailed analysis and assessment on dataset balancing and the significance of different feature encoding techniques for a suitable multi-PTM prediction model are still lacking. Read More

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September 2021