164,304 results match your criteria best practices

Social media and its impact on healthcare.

Ann Allergy Asthma Immunol 2021 Sep 20. Epub 2021 Sep 20.

Nationwide Children's Hospital and The Ohio State University College of Medicine; Division of Allergy and Immunology. Electronic address:

Objective: Social media has fundamentally changed how the world shares and receives information. This review offers perspective for the practicing clinician regarding how patients are being influenced by their online interactions as well as considerations for proactively discussing medical decision making with patients.

Data Sources: Literature search of PubMed database and online published market research data surrounding social media use. Read More

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September 2021

Mitigating the COVID-19 challenges to HIV prevention efforts in Africa: A socio-behavioral perspective.

Glob Public Health 2021 Sep 23:1-4. Epub 2021 Sep 23.

Astra Consulting, Kensington, CA, USA.

In this commentary, the authors highlight how the COVID-19 pandemic has a range of negative effects on HIV prevention in Africa, both well documented HIV service interruptions and less well appreciated effects of the socio-structural context that put people at risk of HIV (e.g. loss of earnings, stigma). Read More

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September 2021

Money Talks: Pilot Financial Wellness Programs to Promote Positive Financial Planning Behaviors Among Residents.

Acad Med 2021 Sep 21. Epub 2021 Sep 21.

P. Ng is assistant professor of clinical medicine, Department of Medicine, Stony Brook University Hospital, Stony Brook, New York; ORCID: https://orcid.org/0000-0003-1900-6931. S. Raghavan was assistant professor of medicine, Department of Medicine, North Shore University Hospital, Northwell Health, Manhasset, New York, and Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York at the time of writing. She is now program director, Internal Medicine Residency Program, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, New York; ORCID: https://orcid.org/0000-0001-9645- 2463. C. Zhang is assistant professor of medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; ORCID: https://orcid.org/0000-0002-3190-9503. J.-Y. Pan is assistant professor, Department of Medicine, Montefiore Medical Center, New York, New York; ORCID: https://orcid.org/0000-0002-0522-2679. P. O'Rourke is assistant professor of medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; ORCID: https://orcid.org/0000-0002-4790-6921. R. Wong is assistant professor of clinical medicine, Department of Medicine, Stony Brook University Hospital, Stony Brook, New York; ORCID: https://orcid.org/0000-0003-3108-7324.

Problem: Graduate medical education programs and national organizations are becoming more involved in promoting trainee financial wellness. Current literature reports residents have poor financial knowledge, high debt levels, low concern about their finances, and deficits in financial preparedness, but there has been little published on best practices for implementing financial wellness programs for residents or measuring meaningful outcomes of such programs.

Approach: From June 2017-2019, the authors invited 277 internal medicine residents from the Stony Brook University Hospital, Montefiore Medical Center, and Johns Hopkins Bayview Medical Center residency programs to participate in financial wellness programs. Read More

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September 2021

A Comparative Systematic Review and Meta-Analysis of 3 Routes of Administration of Epidural Injections in Lumbar Disc Herniation.

Pain Physician 2021 Sep;24(6):425-440

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: The Best Practices in Pain Management from the U.S. Department of Health and Human Services (HHS) describes interventional techniques as part of a continuum. Read More

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September 2021

A comparative appraisal of three important oil yielding plants for their biodiesel potential.

Biol Futur 2021 Sep 6. Epub 2021 Sep 6.

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.

In the present scenario, alternative energy sources are required to achieve the future economic prosperity where shortage of fossil fuels will be a limiting factor and hamper the global economic growth. Therefore, interest in biofuel is increasing continuously. The best way of sustainable development is fossil fuel supplementation with biodiesel to reduce the fossil fuel demand. Read More

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September 2021

Temporal variations in glucose level, oxidative stress and antioxidant profile of Koi carps (Cyprinus carpio var koi) in response to hypoxic tolerance.

Proteek Dasgupta

Biol Futur 2021 Feb 2. Epub 2021 Feb 2.

Department of Zoology, Bangalore University, Jnana Bharathi Campus, Bengaluru, 560056, India.

Biochemical analyses were conducted temporally to understand the impact of prolonged hypoxic environment on gill and white muscle of juvenile Koi carps (Cyprinus carpio var koi). The 16-day study involved quantification of Glucose (GLU), oxidative stress (Lipid Peroxidation-LPO) and antioxidant profile (Catalase-CAT, Glutathione-GSH, Glutathione-S-Transferase-GST) every 96th hour to understand the physiological consequences of hypoxic environment compared to normoxia (Control). There was no mortality throughout the study period, however, fishes were physically exhausted and exhibited Aquatic Surface Respiration (ASR) after day 8. Read More

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February 2021

Policy relevance and the ethical conduct of science.

Biol Futur 2021 Jun 28;72(2):105-111. Epub 2020 Sep 28.

Department of Agricultural Economics, Extension and Rural Development, University of Pretoria, Gauteng, South Africa.

Scientific enquiry and the communication of science are essential to achieving development goals. The demand for evidence-based policy poses a challenge to maintaining the ethical conduct of science. The modern scientist faces intense competition in light of the changing nature of collaborative efforts, the quickening pace and increasing complexity of research endeavours and a growing emphasis on commercialisation of research results. Read More

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Analyzing failures in adoption of smart technologies for medical waste management systems: a type-2 neutrosophic-based approach.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Department of Industrial and Systems Engineering, Istinye University, 34010, Istanbul, Turkey.

Medical waste management (MWM) systems are considered among the most important urban systems nowadays. Cities in different countries prefer to transform their infrastructure based on sustainability guidelines and practices. Meanwhile, smart technologies such as Internet of Things (IoT) and blockchain are being recently used in different urban systems of cities that aim to transform into smart cities. Read More

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September 2021

Being the Father of a Preterm-Born Child: Contemporary Research and Recommendations for NICU Staff.

Front Pediatr 2021 6;9:724992. Epub 2021 Sep 6.

Faculty of Health, School of Nursing and Midwifery, University of Plymouth, Plymouth, United Kingdom.

Most studies on parental reactions to a preterm birth and to hospitalization of the newborn in Neonatal Intensive Care Units (NICUs) have involved mothers. However, emotional responses and behaviors of fathers are equally important. Usually, the father is the first to meet the preterm newborn, to find out information about baby's condition and to communicate to the mother and other family members. Read More

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September 2021

A multisociety organizational consensus process to define guiding principles for acute perioperative pain management.

Reg Anesth Pain Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.

The US Health and Human Services Pain Management Best Practices Inter-Agency Task Force initiated a public-private partnership which led to the publication of its report in 2019. The report emphasized the need for individualized, multimodal, and multidisciplinary approaches to pain management that decrease the over-reliance on opioids, increase access to care, and promote widespread education on pain and substance use disorders. The Task Force specifically called on specialty organizations to work together to develop evidence-based guidelines. Read More

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September 2021

Reducing opioid usage in total knee arthroplasty postoperative pain management: a literature review and future directions.

Pain Manag 2021 Sep 23. Epub 2021 Sep 23.

VA San Diego Health Care, 3350 La Jolla Village Dr, San Diego, CA 92161, USA.

Total knee arthroplasty (TKA) is a common orthopedic surgery performed with a projected 3.5 million procedures to be done by 2030. Current postoperative pain management for TKA is insufficient, as it results in extensive opioid consumption and functional decline postoperatively. Read More

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September 2021

Molecular testing in endometrial carcinoma (Joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists).

Cesk Patol 2021 ;57(3):181-187

Molecular classification of endometrial carcinoma is becoming an important part of the diagnostic process with direct therapeutic implications. Recent international guidelines, including the joint ESGO-ESTRO-ESP recommendation, include the molecular classification into standard diagnostic algorithms. Molecular testing of endometrial carcinomas is also recommended in the latest (5th) edition of the WHO classification of Female Genital Tumors. Read More

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January 2021

Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms Using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies.

J Pharm Sci 2021 Sep 19. Epub 2021 Sep 19.

Regulatory Affairs, Simulations Plus, Inc., Lancaster, CA, USA.

For oral drug products, in vitro dissolution is the most used surrogate of in vivo dissolution and absorption. In the context of drug product quality, safe space is defined as the boundaries of in vitro dissolution, and relevant quality attributes, within which drug product variants are expected to be bioequivalent to each other. It would be highly desirable if the safe space could be established via a direct link between available in vitro data and in vivo pharmacokinetics. Read More

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September 2021

In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation.

PLoS One 2021 22;16(9):e0257413. Epub 2021 Sep 22.

Agriculture Victoria, AgriBio, The Centre for AgriBioscience, Bundoora, Victoria, Australia.

Background: Cannabis has been used worldwide for centuries for industrial, recreational and medicinal use, however, to date no successful attempts at editing genes involved in cannabinoid biosynthesis have been reported. This study proposes and develops an in silico best practices approach for the design and implementation of genome editing technologies in cannabis to target all genes involved in cannabinoid biosynthesis.

Results: A large dataset of reference genomes was accessed and mined to determine copy number variation and associated SNP variants for optimum target edit sites for genotype independent editing. Read More

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September 2021

Meta-analysis of Pragmatic and Explanatory Trials.

Methods Mol Biol 2022 ;2345:147-158

Department of Cardiology, St. Michael's Hospital, Toronto, ON, Canada.

Pooling studies with different clinical and methodological features may lead to statistical heterogeneity, particularly if heterogeneity remains unexplained. One potential source of heterogeneity may be how much the included trials tend toward a pragmatic or explanatory design. Many tools have been developed to aid researchers in quantifying pragmatism in clinical trials, at both the design and appraisal stages. Read More

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January 2022

Assumptions not often assessed or satisfied in published mediation analyses in psychology and psychiatry.

Epidemiol Rev 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine.

Mediation analysis aims to investigate the "mechanisms of action" behind the effects of interventions or treatments. Originally developed in psychology, a robust set of mediation methods are now used across a range of fields. Given the history and common use of mediation in mental health research, this review aimed to understand how mediation analysis is implemented in psychology and psychiatry and whether analyses adhere to, address, or justify the key underlying assumptions of their approaches. Read More

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September 2021

Maintenance Strategies for Myeloma: Is Bigger Always Better?

Cancer J 2021 May-Jun 01;27(3):231-238

Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA.

Abstract: Over the last decade, several very important prospective randomized controlled trials have confirmed the significant survival benefit conferred by maintenance therapies. Owing to these developments, the role of continued maintenance in the optimal management strategies of newly diagnosed myeloma patients (both transplant-eligible and transplant-ineligible) has been strongly cemented. In dealing with an incurable disease such as myeloma, whether to offer maintenance is no longer as relevant a question as it was before, but which antimyeloma agent or agents to use, as maintenance remains more pertinent today. Read More

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September 2021

Health Care Providers' Views on Clinic Infrastructure and Practice Models That May Facilitate HIV Preexposure Prophylaxis (PrEP) Prescribing: A Qualitative Meta-Synthesis.

Health Promot Pract 2021 Sep 22:15248399211038364. Epub 2021 Sep 22.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

HIV (human immunodeficiency virus) preexposure prophylaxis (PrEP) is an effective biomedical HIV prevention tool. Increasing PrEP use among populations disproportionately affected by HIV is one of the key efforts in the United States' Ending the HIV Epidemic (EHE) initiative and the HIV National Strategic Plan for the United States. Given that PrEP is available only through prescription, it is important to explore structural, organizational, or environmental factors that could facilitate or impede health care provider's PrEP prescribing behavior. Read More

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September 2021

The relationship between personality, season, and wounding receipt in zoo-housed Japanese macaques (Macaca fuscata): A multi-institutional study.

Am J Primatol 2021 Sep 21:e23332. Epub 2021 Sep 21.

Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, Chicago, Illinois, USA.

It is important to those managing Japanese macaques (Macaca fuscata) in captive settings to understand predictors of wounding. While studies have demonstrated that season (breeding or nonbreeding) and sex predict rates of wounding received by zoo-housed Japanese macaques, we investigated whether individual differences in personality ratings also might explain some of the observed interindividual variance in wounding. Such patterns were previously observed in rhesus macaques (M. Read More

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September 2021

Comparing classification models-a practical tutorial.

J Comput Aided Mol Des 2021 Sep 22. Epub 2021 Sep 22.

Relay Therapeutics, 399 Binney St, Cambridge, MA, 02141, USA.

While machine learning models have become a mainstay in Cheminformatics, the field has yet to agree on standards for model evaluation and comparison. In many cases, authors compare methods by performing multiple folds of cross-validation and reporting the mean value for an evaluation metric such as the area under the receiver operating characteristic. These comparisons of mean values often lack statistical rigor and can lead to inaccurate conclusions. Read More

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September 2021

County Social Vulnerability and Influenza Vaccine Rates: National and Local Estimates for Medicare Recipients.

Am J Prev Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, Texas.

Introduction: Seasonal influenza vaccination among older adults is well below the recommendation of Healthy People 2020. Although geographic disparities in influenza vaccination are well documented, it remains unclear how community attributes correlate with influenza vaccination rates. Social vulnerability measures play an important role in interventions addressing vaccine equity; however, social vulnerability dimensions as corollaries of vaccination are poorly understood. Read More

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September 2021

Understanding public trust in water managers: Findings from the Netherlands.

J Environ Manage 2021 Sep 20;300:113749. Epub 2021 Sep 20.

Department of Environmental Sciences, Open University, PO Box 2960, 6401 DL, Heerlen, the Netherlands. Electronic address:

Public trust in water managers is often considered an important precondition for the effective implementation of sustainable water-management practices. Although it is well known that general public trust in government institutions is under pressure, much less is known in the literature on water governance whether such distrust also affects general and task-specific trust of the wider public in water managers. In addition, empirical studies on the determinants of such trust seem to be scarce. Read More

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September 2021

Parents' sources of adolescent sexual health information and their interest in resources from primary care.

Acad Pediatr 2021 Sep 18. Epub 2021 Sep 18.

Division of General Pediatrics and Adolescent Health, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota; School of Nursing, University of Minnesota, Minneapolis, Minnesota.

Objective: To examine sources of information used by parents to facilitate parent-adolescent communication about sexual and reproductive health (SRH), parents' preferences for receiving SRH information through primary care, and factors associated with parents' interest in primary-care-based SRH information (i.e., resources recommended or offered in the primary care setting). Read More

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September 2021

Changing the Care Environment for Acute Intoxication: Providing Intoxicated Adults With an Alternative to the Emergency Department and Jail.

J Stud Alcohol Drugs 2021 Sep;82(5):678-684

School of Nursing, Department of Social & Behavioral Sciences, University of California-San Francisco, San Francisco, California.

Objective: This study examines models of sobering centers throughout the United States and identifies best practices and barriers to providing care to acutely intoxicated adults.

Method: A survey was developed and distributed from June to October 2019 to leadership of sobering centers in the United States that provided short-term (<24 hour) care to adults admitted for being intoxicated in public.

Results: The author screened 53 programs: 37 met inclusion criteria and 26 (70%) responded. Read More

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September 2021

Integrating Continuous Glucose Monitoring Into Clinical Practices and Patients' Lives.

Diabetes Technol Ther 2021 Sep;23(S3):S72-S80

Diabetes and Obesity Care, Bend, Oregon, USA.

Numerous studies have demonstrated the clinical benefits of continuous glucose monitoring (CGM) in individuals with diabetes. Within ongoing innovations in CGM technology, individuals now have an expanding array of options that allow them to select the device that meets their individual needs and preferences. Although demand for CGM in primary care continues to grow, many clinicians are reluctant to prescribe this technology due to their unfamiliarity with the various devices, uncertainty about which devices are best suited to each patient and the feasibility of using CGM. Read More

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September 2021

The relevance of rock shape over mass-implications for rockfall hazard assessments.

Nat Commun 2021 Sep 20;12(1):5546. Epub 2021 Sep 20.

WSL Institute for Snow and Avalanche Research SLF, Davos, Switzerland.

The mitigation of rapid mass movements involves a subtle interplay between field surveys, numerical modelling, and experience. Hazard engineers rely on a combination of best practices and, if available, historical facts as a vital prerequisite in establishing reproducible and accurate hazard zoning. Full-scale field tests have been performed to reinforce the physical understanding of debris flows and snow avalanches. Read More

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September 2021

Role of deceased donor kidney procurement biopsies in organ allocation.

Curr Opin Nephrol Hypertens 2021 Sep 20. Epub 2021 Sep 20.

Department of Medicine, Division of Nephrology, Columbia University Medical Center The Columbia University Renal Epidemiology (CURE) Group Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Purpose Of Review: There has been an increased emphasis by the transplant community and the federal government to increase the utilization of deceased donor kidneys. Procurement biopsies during allocation are the most common reason for kidney discards. This manuscript reviews the evidence of procurement biopsies practices and utility. Read More

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September 2021

Clinical application of fetal genome-wide sequencing during pregnancy: position statement of the Canadian College of Medical Geneticists.

J Med Genet 2021 Sep 20. Epub 2021 Sep 20.

Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Purpose And Scope: The aim of this position statement is to provide recommendations for Canadian healthcare professionals regarding the use of genome-wide sequencing (GWS) in the context of diagnostic testing of the fetus during pregnancy. This statement was developed to facilitate clinical translation of GWS as a prenatal diagnostic test and the development of best practices in Canada, but the applicability of this document is broader and aims to help professionals in other healthcare systems.

Methods Of Statement Development: A multidisciplinary group was assembled to review existing literature on fetal GWS for genetic diagnosis in the context of suspected monogenic diseases and to make recommendations relevant to the Canadian context. Read More

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September 2021