153,454 results match your criteria best medical


Triformyl cholic acid and folic acid functionalized magnetic graphene oxide nanocomposites: Multiple-targeted dual-modal synergistic chemotherapy/photothermal therapy for liver cancer.

J Inorg Biochem 2021 Jul 22;223:111558. Epub 2021 Jul 22.

Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China. Electronic address:

Photo-chemotherapy (PCT) reveals great potential in hepatocellular carcinoma (HCC) treatment, therefore the construct of smart PCT nano-agents with high photothermal conversion efficiency and accurate drug delivery is of great significant. Herein, a novel hybrid nanomaterial MGO-TCA-FA has been designed and constructed by grafting the triformyl cholic acid (TCA) and folic acid (FA) on the surface of FeO modified graphene oxide (MGO). The doxorubicin hydrochloride (DOX) as a model drug could be effectively loaded on the MGO-TCA-FA via hydrogen bonding and π-π stacking (the drug loading amount was 1040 mg/g). Read More

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Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels.

J Ethnopharmacol 2021 Jul 27:114457. Epub 2021 Jul 27.

School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. Electronic address:

Ethnopharmacology Relevance: Pain often causes a series of abnormal changes in physiology and psychology, which can lead to disease and even death. Drug therapy is the most basic and commonly used method for pain relief and management. Interestingly, at present, hundreds of traditional Chinese medicines have been reported to be used for pain relief, most of which are monomer preparations, which have been developed into new painkillers. Read More

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A Predictive Model of Reintubation after Cardiac Surgery Using the Electronic Health Record.

Ann Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Biomedical Informatics, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center; Department of Quality, Safety, and Risk Prevention, Vanderbilt University Medical Center.

Background: Reintubation and prolonged intubation after cardiac surgery are associated with significant complications. Despite these competing risks, providers frequently extubate patients with limited insight into the risk of reintubation at the time of extubation. Achieving timely, successful extubation remains a significant clinical challenge. Read More

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Growth factors in the initial stage of bone formation, analysis of their expression in chondrocytes from epiphyseal cartilage of rat costochondral junction.

Folia Histochem Cytobiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.

Introduction: In endochondral ossification septoclasts and osteoclasts (also called chondroclasts) release growth factors deposited in non-calcified and calcified zones of the growth plate. They stimulate, within the metaphysis, initial stages of the bone formation. We have recently reported quantitation of several growth factors in calcified cartilage from calf costochondral junction. Read More

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Identification and characteristics of a novel aminoglycoside phosphotransferase, APH(3')-IId, from an MDR clinical isolate of Brucella intermedia.

J Antimicrob Chemother 2021 Jul 30. Epub 2021 Jul 30.

Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Objectives: To describe a novel chromosomal aminoglycoside phosphotransferase named APH(3')-IId identified in an MDR Brucella intermedia ZJ499 isolate from a cancer patient.

Methods: Species identity was determined by PCR and MALDI-TOF MS analysis. WGS was performed to determine the genetic elements conferring antimicrobial resistance. Read More

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Validation and comparison of 28 risk prediction models for coronary artery disease.

Eur J Prev Cardiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

Aims: Risk prediction models (RPMs) for coronary artery disease (CAD), using variables to calculate CAD risk, are potentially valuable tools in prevention strategies. However, their use in the clinical practice is limited by a lack of poor model description, external validation, and head-to-head comparisons.

Methods And Results: CAD RPMs were identified through Tufts PACE CPM Registry and a systematic PubMed search. Read More

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Intimal aortic atherosclerosis in cardiac surgery: surgical strategies to prevent embolic stroke.

Eur J Cardiothorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

Objectives: Although the incidence of perioperative stroke after cardiac surgery gradually decreased over the last decades, there is much variation between centres. This review aimed to create a concise overview of the evidence on possible surgical strategies to prevent embolic stroke in patients with intimal aortic atherosclerosis.

Methods: The PubMed and EMBASE databases were searched for studies on surgical management of aortic atherosclerosis and the association with perioperative stroke in cardiac surgery, including specific searches on the most common types of surgery. Read More

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Low-threshold 1150  nm single-polarization single-frequency Yb-doped DFB fiber laser.

Opt Lett 2021 Aug;46(15):3705-3708

We demonstrate a stable single-polarization single-frequency distributed feedback Bragg (DFB) fiber laser at 1150 nm based on a 5 cm long Yb-doped fiber which, to the best of our knowledge, is the first demonstration of a Yb-doped fiber-based single-frequency laser with a wavelength longer than 1120 nm. The threshold is as low as 10 mW. The measured maximum output power is 10. Read More

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Optimized synthesis of lignin sulfonate nanoparticles by solvent shifting method and their application for adsorptive removal of dye pollutant.

Chemosphere 2021 Jul 15;285:131576. Epub 2021 Jul 15.

Department of Chemical Engineering, University of Mohaghegh Ardabili, Ardabil, Iran.

Synthesis of value added products from wastes is of importance from different perspectives. Wood and paper industry produces tons of wastewaters that contains lignin. In this paper, we report a new approach, called solvent-shifting method, to synthesize lignin sulfonate nanoparticles (LS-NPs). Read More

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Targeted mesoporous silica nanoparticles for improved inhibition of disinfectant resistant Listeria monocytogenes and lower environmental pollution.

J Hazard Mater 2021 Jun 9;418:126364. Epub 2021 Jun 9.

Department of Biology, Medical School, Atilim University, 06830 Ankara, Turkey. Electronic address:

Benzalkonium chloride (BAC) is a common ingredient of disinfectants used for industrial, medical, food safety and domestic applications. It is a common pollutant detected in surface and wastewaters to induce adverse effects on Human health as well as aquatic and terrestrial life forms. Since disinfectant use is essential in combatting against microorganisms, the best approach to reduce ecotoxicity level is to restrict BAC use. Read More

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Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP).

Infect Dis Ther 2021 Jul 30. Epub 2021 Jul 30.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Introduction: The Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) constituted an expert panel for developing evidence-based guidance for the clinical management of adult patients with coronavirus disease 2019 (COVID-19) outside intensive care units.

Methods: Ten systematic literature searches were performed to answer ten different key questions. The retrieved evidence was graded according to the Grading of Recommendations Assessment, Development, and Evaluation methodology (GRADE). Read More

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Psychometric properties of the Chinese version of the Courtauld Emotional Control Scale in women newly diagnosed with breast cancer.

Qual Life Res 2021 Jul 30. Epub 2021 Jul 30.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Renmin Middle Road 139#, Furong District, Changsha, 410011, Hunan, China.

Purpose: Emotional control, the attempt to suppress the expression of negative effects, is an essential factor in the prevalence of psychological distress in women with breast cancer. The Courtauld Emotional Control Scale (CECS) is a commonly used self-report tool for assessing emotional suppression in both clinical and general groups. This study aimed to validate the Chinese version of the Courtauld Emotional Control Scale (CECS) in women newly diagnosed with breast cancer. Read More

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Improving long-term intraocular pressure and visual outcomes in eyes with aniridic glaucoma.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 30. Epub 2021 Jul 30.

Department of Bio-Statistics, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To study the long-term intraocular pressure (IOP) and visual outcomes in treated aniridic glaucoma.

Methods: A retrospective chart review of patients with aniridia and glaucoma, with ≥ 2-year follow-up, was performed. Eyes in early glaucomatous stages were medically managed, while moderate-severe stage eyes underwent a trabeculectomy with mitomycin-c (MMC). Read More

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Pre-participation Vision Screening and Comprehensive Eye Care in National Collegiate Athletic Association Athletes.

Optom Vis Sci 2021 Jul;98(7):764-770

Department of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama.

Significance: Pre-participation physical evaluation and its vision screenings have been the mainstay of medical clearance for competitive play for decades. The ability of screening to address athlete's sports-specific vision needs is unknown.

Methods: Fifty-eight intercollegiate football players consented to participate in a comprehensive, sports-specific eye examination in addition to the standard pre-participation vision screening. Read More

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Supporting Patient-Clinician Interaction in Chronic HIV Care: Design and Development of a Patient-Reported Outcomes Software Application.

J Med Internet Res 2021 Jul 30;23(7):e27861. Epub 2021 Jul 30.

Patient-Centered Outcomes Research, Health Economics Clinical Trial Unit, Hospital Hotel-Dieu, AP-HP, University de Paris, Paris, France.

Background: The consideration of health-related quality of life (HRQL) is a hallmark of best practice in HIV care. Information technology offers an opportunity to more closely engage patients with chronic HIV infection in their long-term management and support a focus on HRQL. However, the implementation of patient-reported outcome (PRO) measures, such as HRQL in routine care, is challenged by the need to synthesize data generated by questionnaires, the complexity of collecting data between patient visits, and the integration of results into clinical decision-making processes. Read More

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Predicting Depressive Symptom Severity Through Individuals' Nearby Bluetooth Device Count Data Collected by Mobile Phones: Preliminary Longitudinal Study.

JMIR Mhealth Uhealth 2021 Jul 30;9(7):e29840. Epub 2021 Jul 30.

Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: Research in mental health has found associations between depression and individuals' behaviors and statuses, such as social connections and interactions, working status, mobility, and social isolation and loneliness. These behaviors and statuses can be approximated by the nearby Bluetooth device count (NBDC) detected by Bluetooth sensors in mobile phones.

Objective: This study aimed to explore the value of the NBDC data in predicting depressive symptom severity as measured via the 8-item Patient Health Questionnaire (PHQ-8). Read More

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The Fast Health Interoperability Resources (FIHR) Standard: Systematic Literature Review of Implementations, Applications, Challenges and Opportunities.

JMIR Med Inform 2021 Jul 30;9(7):e21929. Epub 2021 Jul 30.

Department of Computer Engineering, Faculty of Computer Science, Universitas Sriwijaya, Palembang, Indonesia.

Background: Information technology has shifted paper-based documentation in the health care sector into a digital form, in which patient information is transferred electronically from one place to another. However, there remain challenges and issues to resolve in this domain owing to the lack of proper standards, the growth of new technologies (mobile devices, tablets, ubiquitous computing), and health care providers who are reluctant to share patient information. Therefore, a solid systematic literature review was performed to understand the use of this new technology in the health care sector. Read More

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lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184.

Int J Mol Med 2021 Sep 30;48(3). Epub 2021 Jul 30.

Reproductive Center of Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.

Long non‑coding RNA (lncRNA) small nucleolar RNA host gene 11 (SNHG11) has been shown to play an important role in the development and progression of numerous types of cancer. However, to the best of our knowledge, the role of SNHG11 in prostate cancer (PCa) development and metastasis remains unclear. Thus, the aim of the present study was to investigate the functional role and molecular mechanisms of SNHG11 in PCa progression. Read More

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September 2021

Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p.

Oncol Rep 2021 Sep 30;46(3). Epub 2021 Jul 30.

Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

A prevalent type of bone tumor, osteosarcoma (OS) is prone to pulmonary metastasis, which results in a high relapse risk and poor prognosis for patients. The progression of OS is significantly associated with the expression of long non‑coding (lnc)RNA H19. To the best of our knowledge, however, the exact molecular mechanism of this lncRNA has not been fully investigated. Read More

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September 2021

Prejudice between triage nurses and emergency medical technicians: is it a big deal?

Acta Biomed 2021 Jul 29;92(S2):e2021026. Epub 2021 Jul 29.

Department of Biomedical Sciences for Health, University of Milan, Milano, Italy.

The transmission of information between registered nurses (RNs) and emergency medical technicians (EMTs) in triage plays a fundamental role in patient care. Despite their common purpose is to assure patients to get the best diagnostic, therapeutic and care pathway, triage RNs and EMTs hold different perspectives during the process. One aspect that has not been investigated in the international literature concerns the possible presence of prejudice, meant as a preconceived opinion capable of causing people to adopt unjust attitudes toward EMTs by triage RNs. Read More

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Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes.

Pediatr Obes 2021 Jul 30:e12833. Epub 2021 Jul 30.

Department of Statistics, Penn State University, University Park, PA, USA.

Background: Metabolomic analysis is commonly used to understand the biological underpinning of diseases such as obesity. However, our knowledge of gut metabolites related to weight outcomes in young children is currently limited.

Objectives: To (1) explore the relationships between metabolites and child weight outcomes, (2) determine the potential effect of covariates (e. Read More

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Examining how meta-analytic methods perform in the presence of bias: A simulation study.

Res Synth Methods 2021 Jul 30. Epub 2021 Jul 30.

Population Health Sciences, Bristol Medical School, University of Bristol.

Standard meta-analysis methods are vulnerable to bias from incomplete reporting of results (both publication and outcome reporting bias) and poor study quality. Several alternative methods have been proposed as being less vulnerable to such biases. To evaluate these claims independently we simulated study results under a broad range of conditions first with no bias, then introducing simulated publication bias, outcome reporting bias, and bias from poor study quality. Read More

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Disease expression caused by different variants in the BEST1 gene: genotype and phenotype findings in bestrophinopathies.

Acta Ophthalmol 2021 Jul 29. Epub 2021 Jul 29.

Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany.

Purpose: To analyse the spectrum of clinical features and molecular genetic data in a series of patients carrying likely disease-associated variants in the BEST1 gene.

Methods: Retrospective observational analysis of clinical data extracted from the medical records of visual function, multimodal imaging and electrophysiology of 62 eyes of 31 patients. Molecular genetic analysis was performed by means of panel-based NGS or Sanger sequencing. Read More

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CT-Based Hand-crafted Radiomic Signatures Can Predict PD-L1 Expression Levels in Non-small Cell Lung Cancer: a Two-Center Study.

J Digit Imaging 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Here, we used pre-treatment CT images to develop and evaluate a radiomic signature that can predict the expression of programmed death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC). We then verified its predictive performance by cross-referencing its results with clinical characteristics. This two-center retrospective analysis included 125 patients with histologically confirmed NSCLC. Read More

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CIRSE Standards of Practice on Percutaneous Transhepatic Cholangiography, Biliary Drainage and Stenting.

Cardiovasc Intervent Radiol 2021 Jul 29. Epub 2021 Jul 29.

Interventional Radiology Unit, Department of Radiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

This CIRSE Standards of Practice document is aimed at interventional radiologists and provides best practices for performing percutaneous transhepatic cholangiography, biliary drainage and stenting. It has been developed by an expert writing group established by the CIRSE Standards of Practice Committee. Read More

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Perceptions of Spiritual Dryness in Iran During the COVID-19 Pandemic.

J Relig Health 2021 Jul 29. Epub 2021 Jul 29.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study addresses perceptions of spiritual dryness (a specific form of spiritual struggle) during the COVID-19 pandemic among Iranian Muslims (n = 362), and how these perceptions can be predicted. Spiritual dryness was perceived often to regularly by 27% and occasionally by 35%. Regression models revealed that the best predictors of spiritual dryness (SDS-7) were usage of mood-enhancing medications, loneliness/social isolation and praying as positive predictors, and being restricted in daily life concerns as negative predictor. Read More

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Probing depth reduction of laser application in periodontal therapy: a network meta-analysis.

Lasers Med Sci 2021 Jul 29. Epub 2021 Jul 29.

Department of Epidemiology and Statistics, Hebei Province Key Laboratory of Environment and Human Health, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.

The aim was to systematically evaluate the probing depth (PD) reduction of lasers in scaling and root planing (SRP) of chronic periodontitis by network meta-analysis (NMA). Randomized controlled clinical trials (RCTs) were searched through electronic-search and hand-search up to January 2020. Standard mean different (SMD) and 95% confidence interval (CI) were counted for PD reduction. Read More

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Cardiovascular risk assessment: The foundation of preventive cardiology.

Authors:
Nathan D Wong

Am J Prev Cardiol 2020 Mar 1;1:100008. Epub 2020 May 1.

Heart Disease Prevention Program, Division of Cardiology, C240 Medical Sciences, University of California, Irvine, CA, 92697-4079, USA.

The foundation of preventive cardiology begins with knowing the patient's baseline cardiovascular disease (CVD) risk from which the patient-clinician risk discussion informs on the best ways to lower risk through lifestyle management, as well as a decision about the initiation and intensity of pharmacologic therapy. Global CVD risk assessment involves estimation of cardiovascular risk using a basic panel of risk factors. The Framingham Heart Study championed the first such risk scores, followed by others around the world. Read More

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An analysis of national action plans on antimicrobial resistance in Southeast Asia using a governance framework approach.

Lancet Reg Health West Pac 2021 Feb 23;7:100084. Epub 2021 Jan 23.

Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #10-01, Singapore 117549, Singapore.

The complex problem of antimicrobial resistance (AMR) is spread across human health, animal health, and the environment. The Global Action Plan (GAP) on AMR and context-specific national action plans (NAPs) were developed to combat this problem. To date, there is no systematic content analysis of NAPs from countries of the Association of Southeast Asia Nations (ASEAN). Read More

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February 2021