25,953 results match your criteria benign prostatic

Re: Water Vapor Thermal Therapy to Alleviate Catheter-dependent Urinary Retention Secondary to Benign Prostatic Hyperplasia.

Eur Urol 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, Clinic Favoriten, Sigmund Freud Private Medical University, Vienna, Austria. Electronic address:

View Article and Full-Text PDF
September 2021

3-T MRI and clinical validation of ultrasound-guided transperineal laser ablation of benign prostatic hyperplasia.

Eur Radiol Exp 2021 Sep 17;5(1):41. Epub 2021 Sep 17.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133, Rome, Italy.

Background: Transperineal laser ablation (TPLA) of the prostate is a novel, mini-invasive option for men with lower urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH). Our aim was to assess the impact of ultrasound-guided TPLA regarding urodynamic improvement and sexual function, monitoring clinical data, postprocedural complications and imaging findings at 3-T multiparametric magnetic resonance imaging.

Methods: Forty-four patients aged ≥ 50 affected with moderate to severe LUTS (International Prostate Symptoms score ≥ 12) due to benign prostatic obstruction and refractoriness, intolerance or poor compliance to medical therapies underwent US-guided TPLA between May 2018 and February 2020. Read More

View Article and Full-Text PDF
September 2021

Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation.

Ann Transl Med 2021 Aug;9(15):1246

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common urological condition in aging men. While dihydroartemisinin (DHA) exhibits a wide range of pharmacological activities, to date, there have been no studies examining the effects of DHA on BPH.

Methods: An BPH model was constructed in rats via daily subcutaneous injection of testosterone propionate (TP) for 28 consecutive days. Read More

View Article and Full-Text PDF

Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.

Transl Androl Urol 2021 Aug;10(8):3432-3439

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: To perform a prospective, randomized, single center study to investigate the efficacy of combined use of curcumin, an anti-inflammatory agent, with the best standard management (BSM, tamsulosin and finasteride) in benign prostatic hyperplasia (BPH) patients.

Methods: One hundred and twenty-two consecutive patients were randomized to receive tamsulosin 0.2 mg, finasteride 5 mg, and curcumin 2,250 mg once a day (curcumin + BSM group, n=61) versus tamsulosin 0. Read More

View Article and Full-Text PDF

A randomized placebo-controlled study: Phellodendron Bawei tablets combined with standard management can improve storage symptoms, sleep quality, and medication compliance in patients with benign prostatic hyperplasia compared to placebo with standard management.

Transl Androl Urol 2021 Aug;10(8):3423-3431

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common micturition disorder in middle-aged and elderly males, and it is one of the most common urology-related diseases worldwide. However, standard therapeutic drugs (α1-receptor blockers + 5α reductase inhibitors) do not provide anti-inflammatory or anti-infective effects. The Phellodendron Bawei tablet is a proprietary Chinese medicine with anti-inflammatory and anti-infective effects. Read More

View Article and Full-Text PDF

Combination of transurethral resection of the prostate and flexible and rigid ureteroscopy for benign prostatic hyperplasia and ureteral calculus.

Transl Androl Urol 2021 Aug;10(8):3395-3401

Department of Urology Surgery, Hengshui People's Hospital, Hengshui, China.

Background: Combination of transurethral resection of the prostate (TURP) and flexible and rigid ureteroscopy (URS/RIRS) is a successful approach for patients with benign prostatic hyperplasia (BPH) and ureteral calculus (UC), and the sequence is URS/RIRS followed by TURP. This research aims to compare TURP followed by URS/RIRS with URS/RIRS followed by TURP in terms of clinical efficiency and safety.

Methods: From June 2009 to June 2021, 173 patients with BPH and upper urinary tract stones were recruited through the Harrison International Peace Hospital and were divided into intervention (TURP followed by URS/RIRS) and control groups (URS/RIRS followed by TURP). Read More

View Article and Full-Text PDF

N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.

Med Oncol 2021 Sep 14;38(10):127. Epub 2021 Sep 14.

Department of Pathology, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

Although patients with early localized prostate cancer can survive longer, castration-resistant prostate cancer (CRPC) has gradually emerged with the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play a vital role in the progression of several cancer types. However, the underlying mechanism of how N-Myc and TEM8 promote the progression of prostate cancer remains unclear. Read More

View Article and Full-Text PDF
September 2021

Associations Between Kidney Dysfunction and Risk Factors in Patients with Transurethral Resection of the Prostate.

Res Rep Urol 2021 7;13:665-672. Epub 2021 Sep 7.

Medical Faculty of Riau University, Pekanbaru, Riau, Indonesia.

Purpose: Benign prostate hyperplasia (BPH) with urinary retention can result in kidney dysfunction. Several risk factors might influence deterioration in kidney function. The aims of this study were to assess the association between kidney dysfunction and risk factors in patients with transurethral resection of the prostate (TURP). Read More

View Article and Full-Text PDF
September 2021

Diagnosis of "cribriform" prostatic adenocarcinoma: an interobserver reproducibility study among urologic pathologists with recommendations.

Am J Cancer Res 2021 15;11(8):3990-4001. Epub 2021 Aug 15.

Department of Pathology, Tufts Medical Center Boston, MA, USA.

Accurate diagnosis of cribriform Gleason pattern 4 (CrP4) prostate adenocarcinoma (PCa) is important due to its independent association with adverse clinical outcomes and as a growing body of evidence suggests that it impacts clinical decision making in PCa management. To identify reproducible features for diagnosis of CrP4, we assessed interobserver agreement among 27 experienced urologic pathologists of 60 digital images from 44 radical prostatectomies (RP) that represented a broad spectrum of potential CrP4. The following morphologic features were correlated with the consensus diagnosis (defined as 75% agreement) for each image: partial vs. Read More

View Article and Full-Text PDF

U-shape incision on prostate capsule: New intraperitoneal laparoscopic technique in simple prostatectomy: A case report.

Ann Med Surg (Lond) 2021 Sep 4;69:102787. Epub 2021 Sep 4.

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: and importance: Laparoscopy is a known technique for simple prostatectomy using intraperitoneal or extraperitoneal approaches. In the present study, a novel method is suggested for easier access to the whole body and even the head of the adenoma.

Case Presentation: This method was performed on 6 patients with prostate hyperplasia. Read More

View Article and Full-Text PDF
September 2021

Association of mycoplasma with prostate cancer: A systematic review and meta-analysis.

Cancer Epidemiol 2021 Sep 10;75:102021. Epub 2021 Sep 10.

Department of Pathology, Botucatu Medical School, Universidade Estadual Paulista, UNESP, Botucatu, São Paulo, Brazil; Division of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Manila, Philippines. Electronic address:

Mycoplasmas are emerging sexually transmitted pathogens usually associated with male urinary tract infection, non-gonococcal urethritis (NGU), infertility, and prostate cancer. In this study, we review the evidence linking mycoplasma infection and prostate cancer. We conducted a systematic review and meta-analysis based on PRISMA guidelines. Read More

View Article and Full-Text PDF
September 2021

The Firmicutes/Bacteroidetes ratio of the human gut microbiota is associated with prostate enlargement.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.

Background: The pathophysiology of the prostate enlargement underlying lower urinary tract symptoms is unknown. Meanwhile, the gut microbiota can contribute to various host conditions. We hypothesized that the gut microbiota plays a role in prostate enlargement. Read More

View Article and Full-Text PDF
September 2021

Lymphocyte-to-monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Department of Urology, Seoul National University Boramae Medical Center, Seoul, Korea.

Background: Inflammation plays critical roles at different stages of carcinogenesis and cancer progression. Several previous studies showed conflicting results for the predictive role of systemic inflammation markers in the detection of clinically significant prostate cancers (CSPCs). We aimed to determine the predictive roles of lymphocyte-to-monocyte (LMR) and eosinophil-to-lymphocyte ratios (ELR) in the detection of CSPC at standard 12-core transrectal ultrasound-guided prostate biopsy (12-core-TRUS-Bx) using our large-cohort database. Read More

View Article and Full-Text PDF
September 2021

What Is the Interaction between Urine C-Reactive Protein, Prostatic Inflammation, and Doxazosin Treatment in Patients with Benign Prostatic Hyperplasia? A Pilot Study.

Urol Int 2021 Sep 7:1-5. Epub 2021 Sep 7.

Department of Urology, Ankara Numune Research and Training Hospital, University of Health Sciences, Ankara, Turkey.

Introduction: It was aimed to show the relationship between benign prostatic hyperplasia and inflammation by measuring urinary C-reactive protein values before and after alpha-blocker treatment.

Methods: A total of 71 patients with a total prostate-specific antigen <3.5 ng/mL, International Prostate Symptom Score >7, and maximum urinary flow rate <15 mL/s were included in the study. Read More

View Article and Full-Text PDF
September 2021

Bioelectric Impedance Analysis Test Improves the Detection of Prostate Cancer in Biopsy Candidates: A Multifeature Decision Support System.

Front Oncol 2021 27;11:555277. Epub 2021 Aug 27.

Department of Information Engineering & Research Center "E. Piaggio", University of Pisa, Pisa, Italy.

Prostate cancer (PCa) gold-standard diagnosis relies on prostate biopsy, which is currently overly recommended since other available noninvasive tools such as prostate-specific antigen (PSA) multiparametric MRI (mMRI) showed low diagnostic accuracy or high costs, respectively. The aim of the study was to determine the accuracy of a novel Bioelectric Impedance Analysis (BIA) test endorectal probe for the selection of patients candidate to prostate biopsy and in particular the clinical value of three different parameters such as resistance (R), reactance (Xc), and phase angle (PA) degree. One-hundred twenty-three consecutive candidates to prostate biopsy and 40 healthy volunteers were enrolled. Read More

View Article and Full-Text PDF

Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study.

Biomed Opt Express 2021 Aug 15;12(8):4873-4888. Epub 2021 Jul 15.

Department of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, MI 48109, USA.

In our previous studies, we have developed a prototype interstitial needle sensing probe that can acquire broadband A-line photoacoustic (PA) signals encoding both tissue microarchitecture and histochemical information comparable to that accessible by histology. Paving the road toward clinical translation of this technology, we replaced the piezoelectric hydrophone in the needle PA probe with a fiber optic hydrophone that enabled both broader bandwidth and sufficient signal-to-noise ratio (SNR) for PA signal detection. Such an all-optical design also facilitated disposability and significantly reduced the footprint of the needle PA sensing probe. Read More

View Article and Full-Text PDF

The association of prostatic lipids with progression, racial disparity and discovery of biomarkers in prostate cancer.

Transl Oncol 2021 Sep 10;14(12):101218. Epub 2021 Sep 10.

Department of Pathology, University of Mississippi Medical Center, Jackson MS 39216, United States.

Background: It remains under-investigated whether prostatic lipid profiles are associated with pathogenesis, progression, racial disparity, and discovery of biomarkers in prostate cancer (PCa).

Methods: The electrospray ionization-tandem mass spectrometry was applied to quantitate prostatic lipids in human and mouse PCa and non-cancer prostatic tissues. Biostatistics and bioinformatics were used to compare the concentrations of prostatic lipids at levels of total lipid, group, class and individual species between PCa and benign prostatic tissues, between races, and among pathological conditions of PCa. Read More

View Article and Full-Text PDF
September 2021

Lectins applied to diagnosis and treatment of prostate cancer and benign hyperplasia: A review.

Int J Biol Macromol 2021 Sep 9;190:543-553. Epub 2021 Sep 9.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address:

Environmental factors, as well as genetic factors, contribute to the increase in prostate cancer cases (PCa), the second leading cause of cancer death in men. This fact calls for the development of more reliable, quick and low-cost early detection tests to distinguish between malignant and benign cases. Abnormal cell glycosylation pattern is a promising PCa marker for this purpose. Read More

View Article and Full-Text PDF
September 2021

Testicular infarction as a rare complication of pyogenic epididymoorchitis due to : A case report and systematic literature review.

IDCases 2021 25;26:e01258. Epub 2021 Aug 25.

Department of Infectious Diseases, St. Luke's International Hospital, Tokyo 104-0044, Japan.

Background: Testicular infarction is a known serious complication associated with epididymitis. It is known to be idiopathic in 70% of cases but the frequency, risk factors, and management are yet to be elucidated. This paper aims to report a case of testicular infarction secondary to pyogenic epididymoorchitis caused

Case Presentation: A 64-year-old male with a past medical history of benign prostate hypertrophy using intermittent self-catheterization and a recent history of culture-negative pyogenic epididymoorchitis treated with oral cefpodoxime was admitted to our hospital due to a 4-week history of fever, right scrotal pain, and swelling. Read More

View Article and Full-Text PDF

Increased Sensitivity of Detection of and DNA Fragments in Serum of Prostate Cancer Patients: Optimisation of Diagnostics Using OBBPA-ddPCR.

Cancers (Basel) 2021 Sep 4;13(17). Epub 2021 Sep 4.

Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technische Universität Dresden, Fetscherstr. 74, D-01307 Dresden, Germany.

Identification of aberrant DNA methylation is a promising tool in prostate cancer (PCa) diagnosis and treatment. In this study, we evaluated a two-step method named optimised bias-based preamplification followed by digital PCR (OBBPA-dPCR). The method was used to identify promoter hypermethylation of 2 tumour suppressor genes and in the circulating cell-free DNA (cfDNA) from serum samples of PCa patients ( = 75), benign prostatic hyperplasia (BPH, = 58), and healthy individuals (controls, = 155). Read More

View Article and Full-Text PDF
September 2021

The Relationship between PI-RADS Categories and Incidental Findings in Multiparametric Prostate MRI.

J Coll Physicians Surg Pak 2021 Sep;31(9):1030-1034

Department of Radiology, Faculty of Medicine, Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey.

Objective: To find the frequency and significance of extraprostatic incidental findings (ep-IFs) during multiparametric-magnetic prostate resonance imaging (mp-MRI), and compare them with prostate imaging reporting and data system (PI-RADS) outcomes.

Study Design: Analytical study. Place & Duration of Study: Goztepe Education and Research Hospital, Istanbul, Turkey, from June 2019 to January 2020. Read More

View Article and Full-Text PDF
September 2021

Two cases of pelvic schwannomas simultaneously resected with the prostate by robot-assisted surgery.

IJU Case Rep 2021 Sep 7;4(5):277-281. Epub 2021 Jun 7.

Department of Urology Higashinagoya National Hospital Nagoya Aichi Japan.

Introduction: Schwannoma is a rare benign tumor of peripheral nerves arising from Schwann cells of the ubiquitous nerve sheath. The operative steps and technical aspects of robotic resection of pelvic schwannoma are described herein.

Case Presentation: We describe two patients with pelvic tumors simultaneously resected with the prostate by robot-assisted surgery: a 69-year-old man with schwannoma of the right side of the pelvic floor and a 68-year-old man with schwannoma in the left pelvis. Read More

View Article and Full-Text PDF
September 2021

Benign Prostatic Hyperplasia.

Steven A Kaplan

J Urol 2021 Sep 9:101097JU0000000000002218. Epub 2021 Sep 9.

View Article and Full-Text PDF
September 2021

for the treatment of lower urinary tract symptoms due to benign prostatic enlargement: A systematic review and meta-analysis.

Investig Clin Urol 2021 Sep;62(5):520-534

Department of Health Science, Universidad Nacional de La Matanza, San Justo, Buenos Aires, Argentina.

Purpose: To assess the effects of alone or in combination with other phytotherapy compared to placebo in men with LUTS due to benign prostatic enlargement.

Materials And Methods: Following a registered protocol (CRD42021226655), we searched (December 2020) MEDLINE, CENTRAL, Embase, ClinicalTrials.gov, WHO-ICTRP trials platform and other sources with no restrictions on language, publication date or status. Read More

View Article and Full-Text PDF
September 2021

Pharmacotherapy of patients with benign prostate enlargement and storage symptoms in everyday clinical practice.

Eur Rev Med Pharmacol Sci 2021 Aug;25(16):5248-5254

Department of Urology and Oncological Urology, Wrocław Medical University, Wrocław, Poland.

Objective: Storage symptoms significantly deteriorate the quality of life in men with benign prostate enlargement (BPE). Muscarinic receptor antagonists (MRAs) and β3-adrenergic receptors agonists alone, or in combination with selective α1-alpha-antagonists, are considered the most effective medicines relieving storage symptoms. The aim of this study was to analyze the pharmacotherapy of storage symptoms in men with BPE, and their compliance with the European Association of Urology (EAU) guidelines. Read More

View Article and Full-Text PDF


Harefuah 2021 Sep;160(9):615-618

Department of Urology, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Introduction: Botulinum toxin is an accepted therapy for several urologic diseases involving the lower urinary tract system. Intravesical injection of the toxin emerged in recent decades as an evidenced-based approach for the treatment of patients with medication refractory neurogenic or idiopathic detrusor over-activity. The use of the toxin for other urologic disease such as benign prostate enlargement, detrusor-sphincter dyssynergia or premature ejaculation - still requires further research. Read More

View Article and Full-Text PDF
September 2021

Huge Coronary Aneurysm in a Morbidly Obese Man with Exertional Dyspnea and Chest Pain.

Am J Case Rep 2021 Sep 5;22:e932786. Epub 2021 Sep 5.

Department of Cardiology, Professor Kojuri Cardiology Clinic, Shiraz, Iran.

BACKGROUND Giant coronary artery aneurysm (GCAA) is a rare disease, with an incidence of 0.02% in the general population. GCAA is defined as when the diameter of the coronary artery is more than 4 times the adjacent part or more than 8 mm. Read More

View Article and Full-Text PDF
September 2021

MicroRNA-199b-3p suppresses malignant proliferation by targeting Phospholipase Cε and correlated with poor prognosis in prostate cancer.

Biochem Biophys Res Commun 2021 Oct 28;576:73-79. Epub 2021 Aug 28.

Department of Urology Surgery, The First Affiliated Hospital of Chongqing Medical University.No.1, Youyi Road, Chongqing, 400016, PR China. Electronic address:

Objectives: MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). The aim of our study was to demonstrate the function of miR-199b-3p in PCa.

Methods: Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect miR-199b-3p expression in PCa and benign prostatic hyperplasia (BPH) tissue samples. Read More

View Article and Full-Text PDF
October 2021

Automatic identification of suspicious bone metastatic lesions in bone scintigraphy using convolutional neural network.

BMC Med Imaging 2021 Sep 4;21(1):131. Epub 2021 Sep 4.

Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, China.

Background: We aimed to construct an artificial intelligence (AI) guided identification of suspicious bone metastatic lesions from the whole-body bone scintigraphy (WBS) images by convolutional neural networks (CNNs).

Methods: We retrospectively collected the Tc-MDP WBS images with confirmed bone lesions from 3352 patients with malignancy. 14,972 bone lesions were delineated manually by physicians and annotated as benign and malignant. Read More

View Article and Full-Text PDF
September 2021