36,990 results match your criteria behavior liver

Recovery trend to co-exposure of iron oxide nanoparticles (γ-FeO) and glyphosate in liver tissue of the fish Poecilia reticulata.

Chemosphere 2021 Jun 1;282:130993. Epub 2021 Jun 1.

Laboratory of Cellular Behavior, Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:

Citrate-coated iron oxide nanoparticles (IONPs) have potential use in environmental remediation, with possibilities in decontaminating aquatic environments exposed to toxic substances. This study analyzed IONPs associated to Roundup Original, a glyphosate-based herbicide (GBH), and pure glyphosate (GLY), through ultrastructural and histopathological biomarkers in liver tissue, from females of Poecilia reticulata exposed to: iron ions (0.3 mg/L) (IFe) and IONPs (0. Read More

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A valproic acid-modified platinum diimine complex as potential photosensitizer for photodynamic therapy.

J Inorg Biochem 2021 Jun 5;222:111508. Epub 2021 Jun 5.

Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address:

Histone deacetylase inhibitors have often been used in combination treatment of various types of cancers due to their non-genotoxic epigenetic potential. Valproic acid (VPA) is a well-known histone deacetylase inhibitor. Conjugate of VPA with a phtoactive platinum diimine complex through an ester bond has been fabricated to potentiate the photocytotoxicity of the photosensitizer. Read More

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Understanding the patient experience in hepatocellular carcinoma: a qualitative patient interview study.

Qual Life Res 2021 Jun 11. Epub 2021 Jun 11.

AstraZeneca, 1 Medimmune Way, Gaithersburg, MD, 20878, USA.

Purpose: This study aimed to elucidate the patient experience of hepatocellular carcinoma (HCC) to guide patient-centered outcome measurement in drug development.

Methods: Patients with HCC participated in qualitative interviews to elicit disease-related signs/symptoms and impacts, using discussion guides developed from literature searches and discussions with oncologists. Interview participants rated the disturbance of their experiences (0-10 scale). Read More

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Construction of a novel asymmetric imidazole-cored AIE probe for ratiometric imaging of endogenous leucine aminopeptidase.

Chem Commun (Camb) 2021 Jun 11. Epub 2021 Jun 11.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, P. R. China. and Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha 410078, China.

We report a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to image endogenous LAP for the first time. It offered good sensitivity and selectivity, and concomitantly, was applied successfully for real-time tracking of LAP in the cisplatin-induced liver injury zebrafish model. Read More

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Ovarian clear cell carcinoma with an immature teratoma component showing ARID1A deficiency and an identical PIK3CA mutation.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, Jichi Medical University, Tochigi, Japan.

We herein report a case of ovarian clear cell carcinoma with an immature teratoma component that exhibited aggressive behavior. A 47-year-old woman presented with abdominal distention, and computed tomography detected a cystic mass on the right ovary. The resected mass had mural nodules, most of which showed a pale-yellow appearance; some nodules had a heterogeneous cut surface with bright yellow and white areas. Read More

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Intermittent fasting therapy promotes insulin sensitivity by inhibiting NLRP3 inflammasome in rat model.

Ann Palliat Med 2021 May;10(5):5299-5309

Department of Traditional Chinese Medicine, The Affiliated Bao'an Hospital of Shenzhen, Southern Medical University, Shenzhen, China.

Background: Substantial studies have demonstrated that fasting therapy (FT) can inhibit the inflammatory response and improve insulin resistance (IR); however, the underlying mechanisms are still unclear. This study aimed to explore the related mechanisms of intermittent FT for the treatment of IR.

Methods: A rat IR model was established through collaboration of a high-fat diet with streptozotocin (STZ) injection. Read More

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[The incidence risk of elevated fasting blood glucose in people with fatty liver disease: a cohort study of 40 000 people over the past 10 years].

Zhonghua Gan Zang Bing Za Zhi 2021 May;29(5):446-450

Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China Department of Gastroenterology, PUDONG Hospital, Fudan University, Shanghai 201399, China.

To analyze the time point when patients with fatty liver disease had a significantly higher risk of elevated fasting blood glucose than those without in the physical examination group in Karamay Central Hospital, factors affecting the incidence of elevated blood glucose in patients with fatty liver disease, and the influence of the number of influencing factors on it. Physical examination data from Karamay Central Hospital during September 2008 to April 2017 were retrospectively analyzed. Combined with the survival analysis, the 1-,3-, 5-, and 7-year prevalence rates of elevated fasting glucose occurs in people with and without fatty liver disease were analyzed. Read More

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Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions.

J Pharm Pharm Sci 2021 ;24:277-291

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, USA.

Purpose: Remdesivir, a drug originally developed against Ebola virus, is currently recommended for patients hospitalized with coronavirus disease of 2019 (COVID-19). In spite of United States Food and Drug Administration's recent assent of remdesivir as the only approved agent for COVID-19, there is limited information available about the physicochemical, metabolism, transport, pharmacokinetic (PK), and drug-drug interaction (DDI) properties of this drug. The objective of this in silico simulation work was to simulate the biopharmaceutical and DDI behavior of remdesivir and characterize remdesivir PK properties in special populations which are highly affected by COVID-19. Read More

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January 2021

CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes.

Am J Physiol Cell Physiol 2021 Jun 9. Epub 2021 Jun 9.

Radiation Control Technologies, Inc., Loudonville, New York, United States.

Thrombospondin-1 (TSP1) is the prototypical member of a family of secreted proteins that modulate cell behavior by engaging with molecules in the extracellular matrix and with receptors on the cell surface. CD47 is widely displayed on many, if not all, cell types and is a high affinity TSP1 receptor. CD47 is a self-antigen that limits innate immune cell activities, a feature recently exploited to enhance cancer immunotherapy. Read More

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Molecular changes associated with migratory departure from wintering areas in obligate songbird migrants.

J Exp Biol 2021 Jun 9;224(11). Epub 2021 Jun 9.

Department of Zoology, University of Delhi, Delhi 110 007, India.

Day length regulates the development of spring migratory and subsequent reproductive phenotypes in avian migrants. This study used molecular approaches, and compared mRNA and proteome-wide expression in captive redheaded buntings that were photostimulated under long-day (LD) conditions for 4 days (early stimulated, LD-eS) or for ∼3 weeks until each bird had shown 4 successive nights of Zugunruhe (stimulated, LD-S); controls were maintained under short days. After ∼3 weeks of LD, photostimulated indices of the migratory preparedness (fattening, weight gain and Zugunruhe) were paralleled with upregulated expression of acc, dgat2 and apoa1 genes in the liver, and of cd36, fabp3 and cpt1 genes in the flight muscle, suggesting enhanced fatty acid (FA) synthesis and transport in the LD-S state. Read More

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Multi-Site Multi-Vendor Validation of a Quantitative MRI and CT Compatible Fat Phantom.

Med Phys 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, University of Wisconsin, Madison, WI, 53705, USA.

Purpose: Chemical shift-encoded magnetic resonance imaging enables accurate quantification of liver fat content though estimation of proton density fat-fraction (PDFF). Computed tomography (CT) is capable of quantifying fat, based on decreased attenuation with increased fat concentration. Current quantitative fat phantoms do not accurately mimic the CT number of human liver. Read More

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Measuring Global Alcohol Health Literacy: A Narrative Review.

J Stud Alcohol Drugs 2021 May;82(3):309-319

Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Objective: Studies assessing awareness and knowledge of alcohol-attributable causes of death and disease have been conducted across the globe to develop and evaluate public information campaigns to increase alcohol health literacy. Because of variation in measurement, the results of these studies cannot be easily compared to determine relative rates of high versus low alcohol health literacy across countries or regions. This review catalogs the samples and survey items that have been used and presents recommendations for how to improve alcohol health literacy survey research. Read More

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Nontarget Screening of Organohalogen Compounds in the Liver of Wild Birds from Osaka, Japan: Specific Accumulation of Highly Chlorinated POP Homologues in Raptors.

Environ Sci Technol 2021 Jun 8. Epub 2021 Jun 8.

Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan.

Nontarget screening studies have recently revealed the accumulation of typically unmonitored organohalogen compounds (OHCs) in various marine animals, but information for terrestrial food chains is still lacking. This study investigated the accumulation profiles of known and unknown OHCs in the liver of representative wild bird specimens from Osaka, Japan using nontarget analysis based on two-dimensional gas chromatography-time-of-flight mass spectrometry. A large number of unmonitored OHCs were identified, including anthropogenic contaminants and marine halogenated natural products (HNPs), and their accumulation profiles were considered to be influenced by terrestrial and brackish water-based diets. Read More

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Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.

Hum Genomics 2021 Jun 7;15(1):34. Epub 2021 Jun 7.

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.

Background: Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a combination of the number of mitochondria per cell and cell-type composition. Here, we studied MT-CN variation in blood-derived DNA from 19184 Finnish individuals using a combination of genome (N = 4163) and exome sequencing (N = 19034) data as well as imputed genotypes (N = 17718). Read More

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Doxorubicin Loaded Dextran-coated Superparamagnetic Iron Oxide Nanoparticles with Sustained Release Property: Intracellular Uptake, Pharmacokinetics, and Biodistribution Study.

Curr Pharm Biotechnol 2021 Jun 4. Epub 2021 Jun 4.

National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi'an, China.

Background: Due to the short biological half-life and serious side effects (especially for heart and kidney), the application of Doxorubicin (Dox) in clinical therapy is strictly limited. To overcome these shortcomings, a novel sustained release formulation of doxorubicin-loaded dextran-coated superparamagnetic iron oxide nanoparticles (Dox-DSPIONs) was prepared.

Objective: The purpose of this study was to evaluate the intracellular uptake behavior of Dox-DSPIONs and to investigate their pharmacokinetics and biodistribution properties. Read More

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Maternal genetics influences fetal neurodevelopment and postnatal autism spectrum disorder-like phenotype by modulating in-utero immunosuppression.

Transl Psychiatry 2021 Jun 5;11(1):348. Epub 2021 Jun 5.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Genetic studies in ASD have mostly focused on the proband, with no clear understanding of parental genetic contributions to fetal neurodevelopment. Among parental etiological factors, perinatal maternal inflammation secondary to autoimmunity, infections, and toxins is associated with ASD. However, the inherent impact of maternal genetics on in-utero inflammation and fetal neurodevelopment in the absence of strong external inflammatory exposures is not known. Read More

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Toxicity of CuS/CdS semiconductor nanocomposites to liver cells and mice liver.

Sci Total Environ 2021 Aug 21;784:147221. Epub 2021 Apr 21.

School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China. Electronic address:

Semiconductor nanomaterials not only bring great convenience to peoples lives but also become a potential hazard to human health. The purpose of this study was to evaluate the toxicity of CuS/CdS nanocomposites in hepatocytes and mice liver. The CuS/CdS semiconductor nanocomposites were synthesized by a biomimetic synthesis - ion exchange strategy. Read More

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Sleep disorders in Wilson's disease.

Sleep Med 2021 Jul 30;83:299-303. Epub 2020 Aug 30.

French National Reference Centre for Wilson's Disease, Foundation Rothschild Hospital, Paris, France; Neurology Department, Foundation Rothschild Hospital, Paris, France.

Background/objectives: Wilson's disease (WD) is a rare genetic disorder that leads to copper overload, mainly in the liver then, in the brain. Patients with WD often complain about sleep disorders. We aimed to explore them. Read More

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The "misfortune" of being a COVID-19 negative patient during the coronavirus pandemic.

J BUON 2021 Mar-Apr;26(2):303-305

4th Department of Surgery, Medical School, University of Athens, "Attikon" University Hospital, Athens, Greece.

COVID-19 pandemic has obviously affected patients' behavior towards seeking medical help as well as physicians' decision in the management of emergencies. Our recent experience as surgeons at a COVID-19 referral hospital revealed cases which share an alerting characteristic: the delay in appropriate management. Unfortunately for COVID-19 negative patients a "coronacentric" health system has been adopted. Read More

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Radiopharmacokinetic modelling and radiation dose assessment of Ra used for treatment of metastatic castration-resistant prostate cancer.

EJNMMI Phys 2021 Jun 2;8(1):44. Epub 2021 Jun 2.

Institute of Radiation Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Purpose: Ra-223 dichloride (Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for radium and its progeny to show their radiopharmacokinetic behaviour. Organ absorbed doses after intravenous injection of Ra were estimated and compared to clinical data and data of an earlier modelling study. Read More

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Effects of high-fat diet on the formation of depressive-like behavior in mice.

Food Funct 2021 Jun 1. Epub 2021 Jun 1.

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.

Depression is an important global health issue that is associated with serious physical and mental health consequences. The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression. Here, we aim to evaluate the effects of high-fat diet (HFD) consumption on depressive-like behaviors. Read More

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Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use.

Pharmaceuticals (Basel) 2021 May 24;14(6). Epub 2021 May 24.

Institute of Biomedical Sciences, Mackay Medical College, New Taipei City 25245, Taiwan.

The nearly simultaneous convergence of human genetics and advanced molecular technologies has led to an improved understanding of human diseases. At the same time, the demand for drug screening and gene function identification has also increased, albeit time- and labor-intensive. However, bridging the gap between in vitro evidence from cell lines and in vivo evidence, the lower vertebrate zebrafish possesses many advantages over higher vertebrates, such as low maintenance, high fecundity, light-induced spawning, transparent embryos, short generation interval, rapid embryonic development, fully sequenced genome, and some phenotypes similar to human diseases. Read More

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Effects of Tyrosine and Tryptophan Supplements on the Vital Indicators in Mice Differently Prone to Diet-Induced Obesity.

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia.

We studied the effects of the addition of large neutral amino acids, such as tyrosine (Tyr) and tryptophan (Trp), in mice DBA/2J and tetrahybrid mice DBCB receiving a high-fat, high-carbohydrate diet (HFCD) for 65 days. The locomotor activity, anxiety, muscle tone, mass of internal organs, liver morphology, adipokines, cytokines, and biochemical indices of animals were assessed. The Tyr supplementation potentiated increased anxiety in EPM and contributed to a muscle tone increase, a decrease in the AST/ALT ratio, and an increase in protein anabolism in both mice strains. Read More

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Seeds Reduce Anxiety-Like Behavior, Lipids, and Overweight in Mice.

Molecules 2021 May 27;26(11). Epub 2021 May 27.

Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, 14370 Mexico City, Mexico.

Overweight, obesity, and psychiatric disorders are serious health problems. To evidence the anxiolytic-like effects and lipid reduction in mice receiving a high-calorie diet and seeds in a nonpolar extract (SBHX, 30 and 300 mg/kg), animals were assessed in open-field, hole-board, and elevated plus-maze tests. SBHX (3 and 10 mg/kg) potentiated the pentobarbital-induced hypnosis. Read More

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Possible Role of IRS-4 in the Origin of Multifocal Hepatocellular Carcinoma.

Cancers (Basel) 2021 May 23;13(11). Epub 2021 May 23.

Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.

New evidence suggests that insulin receptor substrate 4 (IRS-4) may play an important role in the promotion of tumoral growth. In this investigation, we have evaluated the role of IRS-4 in a pilot study performed on patients with liver cancer. We used immunohistochemistry to examine IRS-4 expression in biopsies of tumoral tissue from a cohort of 31 patient suffering of hepatocellular carcinoma (HCC). Read More

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Role of Fucoidan on the Growth Behavior and Blood Metabolites and Toxic Effects of Atrazine in Nile Tilapia (Linnaeus, 1758).

Animals (Basel) 2021 May 18;11(5). Epub 2021 May 18.

Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Waterborne herbicides are stressful agents that threaten the productivity and safety of finfish species. In this study, the toxicity impacts of atrazine (ATZ) and the protective role of fucoidan were investigated on the health performance of Nile tilapia. For 40 days, the total number of 180 Nile tilapia was assigned in four groups (triplicates, 15 fish/replicate), where the first (control) and third groups were offered the control diet, while the second and fourth groups were offered a fucoidan (FCN). Read More

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Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Department of Emergency Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.

Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis, steatohepatitis, hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The progression of ALD is mainly associated with the amount and duration of alcohol usage; however, it is also influenced by genetic, epigenetic, and environmental factors. The definite diagnosis of ALD is based on a liver biopsy, although several non-invasive diagnostic tools and serum biomarkers have emerging roles in the early detection of ALD. Read More

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Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug-Drug Interaction with Rifampin and Liver Impairment.

Pharmaceutics 2021 May 22;13(6). Epub 2021 May 22.

Institute for Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.

Cabozantinib (CAB) is a receptor tyrosine kinase inhibitor approved for the treatment of several cancer types. Enterohepatic recirculation (EHC) of the substance is assumed but has not been further investigated yet. CAB is mainly metabolized via CYP3A4 and is susceptible for drug-drug interactions (DDI). Read More

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Behavioral and reproductive effects in Poecilia vivipara males from a tropical estuary affected by estrogenic contaminants.

Mar Pollut Bull 2021 May 29;169:112543. Epub 2021 May 29.

Laboratório de Ecotoxicologia Aquática, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Av. Prof. Moraes Rego, s/n, Recife, PE, 50670-920, Brazil. Electronic address:

Contamination of aquatic habitats by endocrine disruptor chemicals is a major concern globally. This study evaluated histochemical, behavioral, and reproductive effects on adult male Poecilia vivipara sampled from Capibaribe River Estuarine System (CRES), compared to laboratory control males after breeding with virgin control females. CRES is contaminated by a mixture of estrogenic contaminants estrone, 17β-estradiol, estriol, 17α-Ethinylestradiol, bisphenol A and caffeine in concentrations averaging 13. Read More

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