Circulation 2021 Apr 18;143(14):1394-1410. Epub 2020 Dec 18.
Departments of Cardiac Development and Remodeling (L.W., M.R., S.S., F.W., T.B., M.W., A.S., T.B.).
Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity, allowing acquisition of contractile or synthetic states, but critical information is missing about the physiologic signals, promoting formation, and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 (bone morphogenetic protein) are known to regulate endothelial quiescence after secretion from the liver and right atrium, whereas a direct role in the regulation of VSMCs was not investigated. We studied the role of BMP9 and BMP10 for controlling formation of contractile VSMCs. Read More