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Invisible ECG for High Throughput Screening in eSports.

Sensors (Basel) 2021 Nov 16;21(22). Epub 2021 Nov 16.

IT-Instituto de Telecomunicações, 1049-001 Lisboa, Portugal.

eSports is a rapidly growing industry with increasing investment and large-scale international tournaments offering significant prizes. This has led to an increased focus on individual and team performance with factors such as communication, concentration, and team intelligence identified as important to success. Over a similar period of time, personal physiological monitoring technologies have become commonplace with clinical grade assessment available across a range of parameters that have evidenced utility. Read More

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November 2021

A Power-Efficient Sensing Approach for Pulse Wave Palpation-Based Heart Rate Measurement.

Sensors (Basel) 2021 Nov 13;21(22). Epub 2021 Nov 13.

Institute of Engineering and Technology, Universidad Autónoma de Ciudad Juárez (UACJ), Ciudad Juárez 32310, Mexico.

Heart rate (HR) is an essential indicator of health in the human body. It measures the number of times per minute that the heart contracts or beats. An irregular heartbeat can signify a severe health condition, so monitoring heart rate periodically can help prevent heart complications. Read More

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November 2021

Wearable Device for Yogic Breathing with Real-Time Heart Rate and Posture Monitoring.

J Med Signals Sens 2021 Oct-Dec;11(4):253-261. Epub 2021 Oct 20.

Centre for Integrated Medicine and Research, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: Yogic breathing also called as "Pranayama" is practiced with inhalation (Pooraka), holding the breath for some time (Kumbhaka) and then exhalation (Rechaka). The effective methods of yogic breathing keep oneself healthy and also improves immunity power. The yogic breathing can be practiced irrespective of one's age and gender and even in the office which helps to reduce the stress. Read More

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October 2021

Diagnosis and Treatment of an Undifferentiated Embryonal Sarcoma of the Liver in a 37-Week Pregnant Woman: A Case Report.

Int J Womens Health 2021 16;13:1123-1128. Epub 2021 Nov 16.

Hanoi University of Public Health, Hanoi, Vietnam.

Purpose: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant lesion in adults. Here, we present an extremely rare case of UESL in a pregnant woman. However, this was the first case, wherein one surgery covered all the procedures needed to be performed, including delivery of the neonate, hysterectomy, and resection of the left liver lobe to ensure the safety of both the mother and the newborn. Read More

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November 2021

Increased resting heart rate and glucose metabolism in a community population.

J Int Med Res 2021 Nov;49(11):3000605211053754

Guangdong Civil Servant Health Examination Center, Guangdong Provincial People's Hospital, Guangzhou, China.

Objective: Resting heart rate (RHR) independently predicts cardiovascular death. Increased RHR is related to chronic diseases, but community-based studies are rare. We investigated this population and factors related to RHR. Read More

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November 2021

Gestational Age and Neonatal Electrocardiograms.

Pediatrics 2021 Nov 24. Epub 2021 Nov 24.

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Interpretation of the neonatal electrocardiogram (ECG) is challenging due to the profound changes of the cardiovascular system in this period. We aimed to investigate the impact of gestational age (GA) on the neonatal ECG and create GA-specific reference values.

Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of neonates. Read More

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November 2021

48-year-old with Altered Mental Status and Respiratory Failure: A Case Report.

Clin Pract Cases Emerg Med 2021 Nov;5(4):502-506

Kingman Regional Medical Center, Department of Emergency Medicine, Kingman, Arizona.

Introduction: The differential diagnosis for altered mental status and respiratory failure is broad. Careful physical examination, appropriate use of diagnostic tools, and accurate interpretation and correlation of test results are important for piecing together the puzzle of a patient with altered mental status that emergency physicians commonly face. In certain cases, such as this one, rapid diagnosis and management is crucial for improving patient morbidity and mortality. Read More

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November 2021

High Mortality During the Second Wave of the Coronavirus Disease 2019 (COVID-19) Pandemic in Uganda: Experience From a National Referral COVID-19 Treatment Unit.

Open Forum Infect Dis 2021 Nov 18;8(11):ofab530. Epub 2021 Nov 18.

Department of Internal Medicine, Mulago National Referral Hospital, Kampala, Uganda.

Background: We evaluated clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in the second wave of the pandemic in a national COVID-19 treatment unit (CTU) in Uganda.

Methods: We conducted a retrospective cohort study of COVID-19 patients hospitalized at the Mulago National Referral Hospital CTU between May 1 and July 11, 2021. We performed Kaplan-Meier analysis to evaluate all-cause in-hospital mortality. Read More

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November 2021

Diltiazem Dosing Strategies in the Management of Atrial Fibrillation With Rapid Ventricular Rate.

Cureus 2021 Oct 16;13(10):e18829. Epub 2021 Oct 16.

Emergency Medicine, Michigan State University College of Human Medicine, East Lansing, USA.

Introduction Diltiazem is commonly used for the management of atrial fibrillation (AFIB) with rapid ventricular rate (RVR) in the emergency department (ED). Conflicting studies comparing the efficacy of diltiazem have led to various dosing strategies. The objective of this study was to investigate diltiazem administration in a community ED and determine the effect of varying doses on heart rate (HR) control, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Read More

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October 2021

Impact of maternal obesity on neonatal heart rate and cardiac size.

Arch Dis Child Fetal Neonatal Ed 2021 Nov 17. Epub 2021 Nov 17.

Women's and Children's Health, King's College London, London, UK.

Background: Maternal obesity may increase offspring risk of cardiovascular disease. We assessed the impact of maternal obesity on cardiac structure and function in newborns as a marker of fetal cardiac growth.

Methods: Neonates born to mothers of healthy weight (body mass index (BMI) 20-25 kg/m, n=56) and to mothers who were obese (BMI ≥30 kg/m, n=31) underwent 25-minute continuous ECG recording and non-sedated, free-breathing cardiac MRI within 72 hours of birth. Read More

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November 2021

Left ventricular vortex analysis by high-frame rate blood speckle tracking echocardiography in healthy children and in congenital heart disease.

Int J Cardiol Heart Vasc 2021 Dec 3;37:100897. Epub 2021 Nov 3.

Taussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA.

Background: High-frame rate blood speckle tracking (BST) echocardiography is a new technique for the assessment of intracardiac flow. The purpose of this study was to evaluate the characteristics of left ventricular (LV) vortices in healthy children and in those with congenital heart disease (CHD).

Methods: Characteristics of LV vortices were analyses based on 4-chamber BST images from 118 healthy children (median age 6. Read More

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December 2021

Complete heart block in neonatal lupus: a forgotten cause of fetal bradycardia.

BMJ Case Rep 2021 Nov 16;14(11). Epub 2021 Nov 16.

Neonatal Intensive Care Unit, Calmette Hospital, Phnom Penh, Cambodia.

The most common cause of congenital heart block (CHB) is neonatal lupus, an acquired autoimmune disease caused by transplacental transfer of maternal antibodies to the fetus. A full-term female neonate was admitted to neonatal intensive care unit for severe bradycardia with stable haemodynamics. The mother, showing no clinical symptoms or any particular history, was transferred to our tertiary centre for profound fetal bradycardia. Read More

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November 2021

Acute esophageal necrosis induced by immune checkpoint inhibitors.

Rev Esp Enferm Dig 2021 Nov 16. Epub 2021 Nov 16.

Medical Oncology, Hospital Universitario de Salamanca.

A 73-year-old man with chronic obstructive pulmonary disease presented to the emergency department with a two-day history of coffee ground emesis and melena. The patient had been treated with the PD-1 inhibitor nivolumab because of a lung adenocarcinoma stage IV. On examination, he was tachycardic (130 beats per minute) and hypotensive (95/55 mm Hg). Read More

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November 2021

Label-free quantitative measurement of cardiovascular dynamics in a zebrafish embryo using frequency-comb-referenced-quantitative phase imaging.

J Biomed Opt 2021 11;26(11)

Nanyang Technological University, School of Mechanical and Aerospace Engineering, Singapore.

Significance: Real-time monitoring of the heart rate and blood flow is crucial for studying cardiovascular dysfunction, which leads to cardiovascular diseases.

Aim: This study aims at in-depth understanding of high-speed cardiovascular dynamics in a zebrafish embryo model for various biomedical applications via frequency-comb-referenced quantitative phase imaging (FCR-QPI).

Approach: Quantitative phase imaging (QPI) has emerged as a powerful technique in the field of biomedicine but has not been actively applied to the monitoring of circulatory/cardiovascular parameters, due to dynamic speckles and low frame rates. Read More

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November 2021

Troponin I phosphorylation is essential for cardiac reserve.

J Gen Physiol 2022 Sep 12;154(9). Epub 2021 Nov 12.

Dorothy M. Davis Heart and Lung Research Institute, Physiology and Cell Biology Department, Wexner Medical Center, The Ohio State University, Columbus, OH.

With an increase in the body's metabolic demand (e.g., exercise), the heart must increase its pumping performance. Read More

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September 2022

Dysautonomia in the Ehlers-Danlos syndromes and hypermobility spectrum disorders-With a focus on the postural tachycardia syndrome.

Am J Med Genet C Semin Med Genet 2021 Nov 12. Epub 2021 Nov 12.

The Wellington Hospital, London, UK.

Dysautonomia (autonomic dysfunction) occurs in the Ehlers-Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD). Symptoms include palpitations, dizziness, presyncope, and syncope, especially when standing upright. Symptoms of orthostatic intolerance are usually relieved by sitting or lying and may be exacerbated by stimuli in daily life that cause vasodilatation, such as food ingestion, exertion, and heat. Read More

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November 2021

A Rare Case of Addison's Disease Presenting With Intermittent Pancytopenia and Cardiac Tamponade.

AACE Clin Case Rep 2021 Nov-Dec;7(6):353-356. Epub 2021 May 21.

Saint Elizabeth's Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Objective: To report the first case, to our knowledge, of intermittent pancytopenia and cardiac tamponade occurring together in association with Autoimmune Addison's Disease (AAD).

Methods: A 21 year-old woman presented on three different occasions with multiple complaints. Her evaluation was significant for intermittent pancytopenia (white blood cell, 1. Read More

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Perioperative Management of Ehlers-Danlos Type III Syndrome Associated With Postural Orthostatic Tachycardia in Patients Undergoing General Anesthesia.

Cureus 2021 Nov 6;13(11):e19311. Epub 2021 Nov 6.

Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, USA.

Ehlers-Danlos syndrome (EDS) is an autosomal dominant inherited disorder of connective tissue with common clinical features of skin hyperelasticity, joint hypermobility, and easy bruising. Postural orthostatic tachycardia syndrome (POTS) refers to more than three months of a sustained increase in heart rate of more than 30 beats per minute and symptoms of orthostatic intolerance within 10 minutes of assuming a standing position without associated hypotension. These medical conditions can be associated with each other, potentially creating significant perioperative challenges. Read More

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November 2021

Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.

Int J Gen Med 2021 4;14:7699-7706. Epub 2021 Nov 4.

Orthopaedic Center of Deyang City, Department of Orthopedics, Deyang People's Hospital, Deyang, Sichuan, People's Republic of China.

Purpose: To investigate the relationship between admission resting heart rate (RHR) and all-cause mortality in elderly patients with hip fracture.

Methods: A retrospective cohort study with 837 patients based on the established hip fracture database was conducted. Admission RHR was measured via electrocardiogram, and patients were grouped by the median RHR value (beats per minute, bpm). Read More

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November 2021

Evidence for impaired chronotropic responses to and recovery from 6-minute walk test in women with post-acute COVID-19 syndrome.

Exp Physiol 2021 Nov 10. Epub 2021 Nov 10.

Department of Kinesiology, School of Public Health - Bloomington, Indiana University, Bloomington, Indiana, USA.

New Findings: What is the central question of this study? Are chronotropic responses to a 6-minute walk test different in women with post-acute coronavirus disease 2019 (COVID-19) syndrome compared with control subjects? What is the main finding and its importance? Compared with control subjects, the increase in heart rate was attenuated and recovery delayed after a 6-minute walk test in participants after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Women reporting specific symptoms at time of testing had greater impairments compared with control subjects and SARS-CoV-2 participants not actively experiencing these symptoms. Such alterations have potential to constrain not only exercise tolerance but also participation in free-living physical activity in women during post-acute recovery from COVID-19. Read More

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November 2021

Mucopolysaccharidosis patients have reduced functional capacity.

Pediatr Pulmonol 2021 Nov 6. Epub 2021 Nov 6.

Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil.

Introduction: Mucopolysaccharidoses (MPSs) are a group of rare diseases caused by an intralysosomal accumulation of glycosaminoglycans, resulting in a multisystemic clinical condition characterized by variable degrees of physical-functional impairment.

Objective: To evaluate the functional capacity (FC) of MPS patients and compare with a healthy control group.

Methods: This is a cross-sectional study of 6- to 39-year-old patients followed at a medical reference center and compared with their control peers, matched by age and sex. Read More

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November 2021

Evaluation of a contactless neonatal physiological monitor in Nairobi, Kenya.

Arch Dis Child 2021 Nov 5. Epub 2021 Nov 5.

Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.

Background: Globally, 2.5 million neonates died in 2018, accounting for 46% of under-5 deaths. Multiparameter continuous physiological monitoring (MCPM) of neonates allows for early detection and treatment of life-threatening health problems. Read More

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November 2021

Passive leg cycling increases activity of the cardiorespiratory system in people with tetraplegia.

Appl Physiol Nutr Metab 2021 Nov 5. Epub 2021 Nov 5.

University of Split School of Medicine, Department of Integrative Physiology, Split, Splitsko-dalmatinska, Croatia;

Individuals with cervical spinal cord injury (SCI) are at an increased risk for cardiovascular disease. Exercise is well-established for preventing cardiovascular disease, however, there are limited straightforward and safe exercise approaches for increasing the activity of the cardiorespiratory system after cervical SCI. The objective of this study was to investigate the cardiorespiratory response to passive leg cycling in people with cervical SCI. Read More

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November 2021

Paramedic Student Clinical Performance During High-Fidelity Simulation After a Physically Demanding Occupational Task: A Pilot Randomized Crossover Trial.

Simul Healthc 2021 Nov 3. Epub 2021 Nov 3.

From the Paramedicine Program (A.M.), Griffith University School of Medicine, Gold Coast, Queensland; Holsworth Research Initiative (J.R.H.), La Trobe University, Bendigo, Victoria; Paramedicine Program (S.S.), Charles Sturt University, Port Macquarie, New South Wales; Paramedicine Program (A.H.), Australian Catholic University, Brisbane, Queensland; Charles Sturt University (C.S.), School of Biomedical Sciences, Bathurst; and Charles Sturt University (J.W.), School of Biomedical Sciences, Orange, New South Wales, Australia.

Introduction: Paramedic duties include assessing, treating, and maneuvering patients in physically challenging environments. Whether clinical skills and patient care are affected by these occupational demands is unknown. High-fidelity simulation affords the opportunity to study this in a controlled setting. Read More

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November 2021

Intravenous Metoprolol Versus Diltiazem for Rate Control in Atrial Fibrillation.

Ann Pharmacother 2021 Nov 5:10600280211056356. Epub 2021 Nov 5.

Community Regional Medical Center, Fresno, CA, USA.

Background: Currently, it remains unclear whether β-blockers or nondihydropyridine calcium channel blockers are preferred for the acute management of atrial fibrillation (AF).

Objective: The objective of this study was to compare the efficacy and safety of intravenous (IV) metoprolol and diltiazem for rate control.

Methods: This was a single-center, retrospective cohort study of patients who presented to the emergency department between 2015 and 2019 with AF with rapid ventricular rate (RVR) and received IV metoprolol or diltiazem. Read More

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November 2021

Incidental Findings of Asystole in a Patient With Complaints of Near Syncope: A Case Report on Paroxysmal Ventricular Standstill.

Cureus 2021 Oct 2;13(10):e18438. Epub 2021 Oct 2.

Internal Medicine, Graduate Medical Education, Lewis Gale Medical Center, Salem, USA.

Paroxysmal ventricular standstill (PVS) is an unusual cardiac phenomenon in which the heart experiences episodes of absent ventricular activity despite normal atrial functioning, often leading to cardiac arrest and syncope. In this case, we report the hospital stay of a 70-year-old male who was admitted to the hospital following an episode of near syncope at home. On admission, the patient's initial electrocardiogram (ECG) showed sinus rhythm at 60 beats per minute without atrioventricular (AV) block. Read More

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October 2021

Validation of Heart Rate Extracted From Wrist-Based Photoplethysmography in the Perioperative Setting: Prospective Observational Study.

JMIR Cardio 2021 Nov 4;5(2):e27765. Epub 2021 Nov 4.

Department of Anesthesiology, Catharina Hospital Eindhoven, Eindhoven, Netherlands.

Background: Measurement of heart rate (HR) through an unobtrusive, wrist-worn optical HR monitor (OHRM) could enable earlier recognition of patient deterioration in low acuity settings and enable timely intervention.

Objective: The goal of this study was to assess the agreement between the HR extracted from the OHRM and the gold standard 5-lead electrocardiogram (ECG) connected to a patient monitor during surgery and in the recovery period.

Methods: In patients undergoing surgery requiring anesthesia, the HR reported by the patient monitor's ECG module was recorded and stored simultaneously with the photopletysmography (PPG) from the OHRM attached to the patient's wrist. Read More

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November 2021

Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice.

Front Physiol 2021 18;12:692247. Epub 2021 Oct 18.

Department of Biology, York University, Toronto, ON, Canada.

Heart rate (HR) and blood pressure as well as adverse cardiovascular events show clear circadian patterns, which are linked to interdependent daily variations in physical activity and cardiac autonomic nerve system (ANS) activity. We set out to assess the relative contributions of the ANS (alone) and physical activity to circadian HR fluctuations. To do so, we measured HR (beats per minute, bpm) in mice that were either immobilized using isoflurane anesthesia or free-moving. Read More

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October 2021

Atrial tachyarrhythmia as a presenting symptom leading to the diagnosis of pulmonary sarcoidosis treated with catheter-based ablation.

Proc (Bayl Univ Med Cent) 2021 23;34(6):712-714. Epub 2021 Jul 23.

Department of Cardiology, Baylor Scott & White The Heart Hospital , Plano , Texas.

A 55-year-old woman was referred for recurrent palpitations. A 48-hour ambulatory cardiac monitor revealed an atrial tachycardia rate up to 170 beats per minute. A subsequent electrophysiology study revealed atrial fibrillation and both typical and atypical atrial flutter. Read More

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Intact survival from severe cardiogenic shock caused by the first attack of atrial tachycardia treated with extracorporeal membrane oxygenation and surgical left atrium appendage resection: a case report.

JA Clin Rep 2021 Nov 3;7(1):81. Epub 2021 Nov 3.

Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Atrial tachycardia (AT) is rare in children and can usually be reversed to sinus rhythm with pharmacotherapy and cardioversion. We report a rare case of severe left-sided heart failure due to refractory AT.

Case Presentation: A 12-year-old boy had AT with a heart rate of 180 beats/minute, which was refractory to any medication and defibrillation despite the first attack. Read More

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November 2021