7 results match your criteria bb-based system

  • Page 1 of 1

Minimally invasive preimplantation genetic testing using blastocyst culture medium.

Hum Reprod 2019 07;34(7):1369-1379

Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Huaxiang Road, Shenyang, China.

Study Question: Is minimally invasive chromosome screening (MICS) using blastocyst culture medium (BCM) sufficiently fast and accurate for preimplantation genetic testing (PGT).

Summary Answer: A new assay for MICS, named MICS-Inst achieved high-resolution, comprehensive chromosome ploidy detection using BCM.

What Is Known Already: BCM is a viable source of genomic DNA for use in PGT. Read More

View Article and Full-Text PDF

Twenty-four-hour ambulatory blood pressure changes in older patients with essential hypertension receiving monotherapy or dual combination antihypertensive drug therapy.

J Geriatr Cardiol 2019 Apr;16(4):354-361

Department of Traditional Chinese Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To evaluate the differences in 24-hour ambulatory blood pressure (BP) in older patients with hypertension treated with the five major classes of antihypertensive drugs, as monotherapy or dual combination therapy, to improve daytime and nighttime BP control.

Methods: We enrolled 1920 Chinese community-dwelling outpatients aged ≥ 60 years and compared ambulatory BP values and ambulatory BP control (24-hour BP < 130/80 mmHg; daytime mean BP < 135/85 mmHg; and nighttime mean BP < 120/70 mmHg), as well as nighttime BP dip patterns for monotherapy and dual combination therapy groups.

Results: Patients' mean age was 71 years, and 59. Read More

View Article and Full-Text PDF

Geometric Calibration Using Line Fiducials for Cone-Beam CT with General, Non-Circular Source-Detector Trajectories.

Proc SPIE Int Soc Opt Eng 2017 Mar;10132

Department of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21205 USA.

Purpose: Traditional BB-based geometric calibration methods for cone-beam CT (CBCT) rely strongly on foreknowledge of the scan trajectory shape. This is a hindrance to the implementation of variable trajectory CBCT systems, normally requiring a dedicated calibration phantom or software algorithm for every scan orbit of interest. A more flexible method of calibration is proposed here that accommodates multiple orbit types - including strongly noncircular trajectories - with a single phantom and software routine. Read More

View Article and Full-Text PDF

We-Measure: Toward a low-cost portable posturography for patients with multiple sclerosis using the commercial Wii balance board.

J Neurol Sci 2015 Dec 14;359(1-2):440-4. Epub 2015 Oct 14.

Department of Neurology and Psychiatry, Sapienza University, Rome, Italy. Electronic address:

This study was aimed at investigating whether postural sway measures derived from a standard force platform were similar to those generated by a custom-written software ("We-Measure") acquiring and processing data from a commercial Nintendo balance board (BB). For this purpose, 90 patients with multiple sclerosis (MS) and 50 healthy controls (HC) were tested in a single-day session with a reference standard force platform and a BB-based system. Despite its acceptable between-device agreement (tested by visual evaluation of Bland-Altman plot), the low-cost BB-based system tended to overestimate postural sway when compared to the reference standard force platform in both MS and HC groups (on average +30% and +54%, respectively). Read More

View Article and Full-Text PDF
December 2015

A low-complexity 2-point step size gradient projection method with selective function evaluations for smoothed total variation based CBCT reconstructions.

Phys Med Biol 2014 Nov 16;59(21):6565-82. Epub 2014 Oct 16.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA.

The Barzilai-Borwein (BB) 2-point step size gradient method is receiving attention for accelerating Total Variation (TV) based CBCT reconstructions. In order to become truly viable for clinical applications, however, its convergence property needs to be properly addressed. We propose a novel fast converging gradient projection BB method that requires 'at most one function evaluation' in each iterative step. Read More

View Article and Full-Text PDF
November 2014

Amplified amperometric aptasensor for selective detection of protein using catalase-functional DNA-PtNPs dendrimer as a synergetic signal amplification label.

Biosens Bioelectron 2014 Oct 26;60:224-30. Epub 2014 Apr 26.

Key Laboratory of Ministry of Education of Luminescence and Real-Time Analytical Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address:

In this work, we present a new strategy to construct an electrochemical aptasensor for sensitive detection of platelet-derived growth factor BB (PDGF-BB) based on the synergetic amplification of a three-dimensional (3D) nanoscale catalase (CAT) enzyme-functional DNA-platinum nanoparticles (PtNPs) dendrimer through autonomous layer-by-layer assembly. Firstly, polyamidoaminedendrimer (PAMAM) with a hyper-branched and three-dimensional structure was served as nanocarriers to coimmobilize a large number of PDGF-BB binding aptamer (PBA II) and ssDNA 1 (S1) to form PBA II-PAMAM-S1 bioconjugate. In the presence of PDGF-BB, the bioconjugate was self-assembled on the electrode by sandwich assay. Read More

View Article and Full-Text PDF
October 2014

Electrochemical aptameric recognition system for a sensitive protein assay based on specific target binding-induced rolling circle amplification.

Anal Chem 2010 Mar;82(6):2282-9

State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.

A reusable aptameric recognition system was described for the electrochemical detection of the protein PDGF-BB based on the target binding-induced rolling circle amplification (RCA). A complementary DNA (CDNA), linear padlock probe, and primer probe were utilized to introduce a RCA process into the aptamer-target binding event while a new aptamer was elegantly designed via lengthening the original aptamer by the complement to the CDNA. The aptameric sensing system facilitates the integration of multiple functional elements into a signaling scheme: a unique electrochemical technique, an attractive RCA process, reversible DNA hybridization, and desirable aptameric target recognition. Read More

View Article and Full-Text PDF
  • Page 1 of 1