408 results match your criteria basophils oral

Anaphylaxis is a rare reaction in COVID-19 vaccination.

J Biol Regul Homeost Agents 2021 Jun 9;35(3). Epub 2021 Jun 9.

Postgraduate Medical School, University of Chieti, Chieti, Italy.

Anaphylaxis is a severe multisystem reaction that occurs rapidly after the introduction of an antigen that would otherwise be a harmless substance. It is characterized by airway and respiratory problems, cardiovascular collapse, mucosal inflammation, and other complications, all severe symptoms that can cause death. IgE-dependent anaphylaxis involves mast cells (MCs) which are the main sources of biologically active mediators that contribute to the pathological and lethal phenomena that can occur in anaphylaxis. Read More

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Linggan Wuwei Jiangxin formula ameliorates airway hyperresponsiveness through suppression of IL-1β and IL-17A expression in allergic asthmatic mice especially with diet-induced obesity.

Ann Transl Med 2021 Apr;9(8):682

Institute of Respiratory Disease, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Obese asthma represents a disease phenotype, which is associated with worse disease control and unresponsiveness to standard anti-inflammatory regimens, including inhaled corticosteroids. Obesity-related innate airway hyperresponsiveness (AHR) plays a role in this asthma phenotype via activation of the IL-1β/innate lymphoid cell 3 (ILC3)/IL-17A pathway. Linggan Wuwei Jiangxin (LGWWJX) formula may be a promising therapeutic option for obese asthma according to traditional Chinese medicine theory, clinical experience and related research. Read More

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Combinatorial advantage of Ses i 1-specific IgE and basophil activation for diagnosis of sesame food allergy.

Pediatr Allergy Immunol 2021 May 5. Epub 2021 May 5.

Yitzhak Shamir Medical Center, Institute of Allergy, Immunology and Pediatric Pulmonology, Zerifin, Israel.

Background: The prevalence of sesame food allergy (SFA) is increasing worldwide with the potential of anaphylactic reactions upon exposure. Utility of specific component IgE testing as an alternative to the oral food challenge (OFC), the diagnostic standard, is being investigated.

Methods: Patients (n = 42) with suspected SFA completed an open OFC to sesame. Read More

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Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women.

J Pharmacokinet Pharmacodyn 2021 Jun 5;48(3):411-438. Epub 2021 May 5.

School of Pharmacy and Pharmaceutical Sciences, State University of New York, University at Buffalo, Buffalo, NY, USA.

Population pharmacokinetic/pharmacodynamic (PK/PD) analysis was performed for extensive data for differing dosage forms and routes for dexamethasone (DEX) and betamethasone (BET) in 48 healthy nonpregnant Indian women in a partial and complex cross-over design. Single doses of 6 mg dexamethasone phosphate (DEX-P), betamethasone phosphate (BET-P), or 1:1 mixture of betamethasone phosphate and acetate (BET-PA) were administered orally (PO) or intramuscularly (IM) where each woman enrolled in a two-period cross-over study. Plasma concentrations collected over 96 h were described with a two-compartment model with differing PO and IM first-order absorption inputs. Read More

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Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2.

Vaccines (Basel) 2021 Apr 21;9(5). Epub 2021 Apr 21.

Laboratory of Clinical Pathology, "Buccheri La Ferla" Hospital, 90127 Palermo, Italy.

The main contraindication to the anti-SARS CoV2 vaccine is an anaphylactic reaction to a vaccine component. The need to vaccinate allergic people who are at higher risk can be of public health interest and this report shows a case of an allergic reaction to PEG of a HCW who had received the first dose of anti-SARS CoV2 vaccine. For 5 h after the administration of the vaccine, she had the appearance of erythematous spots on the face and neck, and a feeling of a slurred mouth and hoarseness. Read More

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The Use of Bruton's Tyrosine Kinase Inhibitors to Treat Allergic Disorders.

Curr Treat Options Allergy 2021 Apr 16:1-13. Epub 2021 Apr 16.

Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA.

Purpose Of Review: Studies show that inhibitors of Bruton's tyrosine kinase (BTKis), currently FDA-approved for the treatment of B cell malignancies, can prevent IgE-mediated reactions through broad inhibition of the FcεRI signaling pathway in human mast cells and basophils. This review will summarize recent data supporting the use of these drugs as novel therapies in various allergic disorders.

Recent Findings: Recent studies have shown that BTKis can prevent IgE-mediated degranulation and cytokine production in primary human mast cells and basophils. Read More

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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial.

Clin Transl Sci 2021 Apr 9. Epub 2021 Apr 9.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Safe and effective new oral therapies for autoimmune, allergic, and inflammatory conditions remain a significant therapeutic need. Here, we investigate the human pharmacokinetics, pharmacodynamics (PDs), and safety of the selective, covalent Bruton's tyrosine kinase (BTK) inhibitor, remibrutinib. Study objectives were explored in randomized single and multiple ascending dose (SAD and MAD, respectively) cohorts with daily doses up to 600 mg, and a crossover food effect (FE) cohort, in adult healthy subjects without (SAD [n =80]/FE [n =12]) or with asymptomatic atopic diathesis (MAD [n =64]). Read More

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Coenzyme Q protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice.

BMC Pharmacol Toxicol 2021 04 7;22(1):19. Epub 2021 Apr 7.

Department of Pharmaceutical Sciences and Technology, Technical University of Kenya, P. O. Box 52428, Nairobi, 00200, Kenya.

Background: Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). Read More

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The pharmacology of the prostaglandin D receptor 2 (DP) receptor antagonist, fevipiprant.

Pulm Pharmacol Ther 2021 Jun 4;68:102030. Epub 2021 Apr 4.

Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, NJ, 07936, USA.

Fevipiprant is an oral, non-steroidal, highly selective, reversible antagonist of the prostaglandin D (DP) receptor. The DP receptor is a mediator of inflammation expressed on the membrane of key inflammatory cells, including eosinophils, Th2 cells, type 2 innate lymphoid cells, CD8 cytotoxic T cells, basophils and monocytes, as well as airway smooth muscle and epithelial cells. The DP receptor pathway regulates the allergic and non-allergic asthma inflammatory cascade and is activated by the binding of prostaglandin D. Read More

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Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab.

Allergy 2021 Mar 30. Epub 2021 Mar 30.

Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.

Background: Multifood oral immunotherapy (mOIT) with adjunctive anti-IgE (omalizumab, XOLAIR ) treatment affords safe, effective, and rapid desensitization to multiple foods, although the specific immune mechanisms mediating this desensitization remain to be fully elucidated.

Methods: Participants in our phase 2 mOIT trial (NCT02643862) received omalizumab from baseline to week 16 and mOIT from week 8 to week 36. We compared the immune profile of PBMCs and plasma taken at baseline, week 8, and week 36 using high-dimensional mass cytometry, component-resolved diagnostics, the indirect basophil activation test, and Luminex. Read More

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Effects of potential probiotic strains LBKV-3 on Immune Cells responses in Malnutrite children: a double-blind, randomized, Controlled trial.

Sunil T Hajare

J Immunoassay Immunochem 2021 Mar 22:1-14. Epub 2021 Mar 22.

College of Natural and Computational Sciences, Dilla University, Ethiopia.

This study investigated the phagocytic cell response in malnourished children after oral feeding of a fermented product containing clinically proven probiotic strains of , LBKV-3. The bacterial strain is used as a probiotic for humans to test its effect on immune cell activity in undernourished children below 8 years of age. To study the immune cell activity, implantation abilities of the culture in the GI tract of malnourished children, forty-five children of 6-7 and 7-8 years were randomly selected and distributed in three groups, each comprising 15 children in each of the age group. Read More

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Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease.

J Immunol 2021 Apr 5;206(7):1454-1468. Epub 2021 Mar 5.

Principia Biopharma Inc., South San Francisco, CA 94080; and.

Bruton tyrosine kinase (BTK) is expressed in B cells and innate immune cells, acting as an essential signaling element in multiple immune cell pathways. Selective BTK inhibition has the potential to target multiple immune-mediated disease pathways. Rilzabrutinib is an oral, reversible, covalent BTK inhibitor designed for immune-mediated diseases. Read More

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Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action.

Pathogens 2021 Feb 2;10(2). Epub 2021 Feb 2.

Laboratory of Allergy and Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

Owing to the successful application of sublingual immunotherapy (SLIT), allergen immunotherapy (AIT) has become one of the leading treatments for allergic diseases. Similar to the case with other AITs, such as subcutaneous and oral immunotherapies, not only the alleviation of allergic symptoms, but also the curing of the diseases can be expected in patients undergoing SLIT. However, how and why such strong efficacy is obtained by SLIT, in which allergens are simply administered under the tongue, is not clearly known. Read More

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February 2021

Basophil Activation Test Reduces Oral Food Challenges to Nuts and Sesame.

J Allergy Clin Immunol Pract 2021 05 29;9(5):2016-2027.e6. Epub 2020 Dec 29.

Pediatric Allergy Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Background: Nut allergic patients are often IgE sensitized to other nuts/seeds and need multiple oral food challenges (OFCs) before the safe nuts can be introduced in the diet. However, OFCs are time-consuming and risky procedures.

Objective: To assess the utility of the basophil activation test (BAT) to predict the allergic status and reduce the need for an OFC in children with 1 or more nut or seed allergies. Read More

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Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy.

Front Immunol 2020 14;11:602660. Epub 2020 Dec 14.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.

Basophil activation tests (BATs) can closely monitor, , a patient's propensity to develop type I hypersensitivity reactions. Because of their high specificity and sensitivity, BATs have become promising diagnostic tools, especially in cases with equivocal clinical histories, skin prick test results, and/or levels of specific IgE to allergen extracts. BATs also are useful as tools for monitoring the effects of treatment, since oral immunotherapy (OIT) studies report a diminution in patients' basophil responsiveness over the course of OIT. Read More

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IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy.

Front Immunol 2020 11;11:603050. Epub 2020 Dec 11.

Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States.

Food allergy is a major health issue, affecting the lives of 8% of U.S. children and their families. Read More

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Traditional Chinese medicine for food allergy and eczema.

Ann Allergy Asthma Immunol 2021 Jun 10;126(6):639-654. Epub 2020 Dec 10.

Department of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, New York; Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, New York. Electronic address:

Objective: To summarize the recent evidence of traditional Chinese medicine (TCM) for food allergy and eczema.

Data Sources: Published literature from PubMed database and abstract conference presentations.

Study Selections: Studies relevant to TCM for food allergy and eczema were included. Read More

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Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study.

Allergy 2021 Jun 29;76(6):1800-1812. Epub 2020 Dec 29.

Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.

Background: Peanut and tree nut allergies are the most important causes of anaphylaxis. Co-reactivity to more than one nut is frequent, and co-sensitization in the absence of clinical data is often obtained. Confirmatory oral food challenges (OFCs) are inconsistently performed. Read More

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Two Different Composite Markers Predict Severity and Threshold Dose in Peanut Allergy.

J Allergy Clin Immunol Pract 2021 01 7;9(1):275-282.e1. Epub 2020 Oct 7.

Immunology Department, Biological Allergology Unit, Hôpital A. Trousseau, Sorbonne Université, AP-HP, Paris, France.

Background: Safe and cost-effective biological surrogate markers to evaluate the severity and threshold dose of peanut allergy (PA) reactions during an oral food challenge (OFC) are lacking.

Objective: To evaluate biological markers associated with the severity and threshold dose of an allergic reaction during an OFC in a population of children with PA.

Methods: Demographic and biological parameters of children with peanut OFC and basophil activation test (BAT) results were collected. Read More

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January 2021

Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice.

Int Immunol 2021 Mar;33(3):183-189

Polpharma Biologics B.V., Utrecht, The Netherlands.

Food allergy is a common disease caused by intake of allergen-containing foods, such as milk, eggs, peanuts and wheat. Systemic anaphylaxis is a severe hypersensitive allergic reaction resulting from degranulation of mast cells or basophils after cross-linking of surface high-affinity IgE receptors (Fcε-RI) with allergen-specific IgE and allergens. In this study, we developed a novel human mast cell/basophil-engrafted mouse model that recapitulates systemic anaphylaxis triggered by β-lactoglobulin (BLG), a major allergen found in cow's milk. Read More

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A Case of Anaphylaxis in Which a Basophil Activation Test Was Used to Identify the Suspected Agent.

Anesth Prog 2020 09;67(3):172-173

Department of Dental Anesthesiology, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry, Gifu, Japan.

This is a case report of anaphylaxis in which the basophil activation test (BAT) was used to identify the etiological agent. Although skin tests are considered the most effective methods for identifying anaphylactic triggers, the test itself presents a risk of inducing anaphylaxis. The BAT is advantageous because of its inherent lack of risk, high sensitivity and specificity to identify the suspected anaphylactic agents, and diagnostic accuracy comparable to conventional skin testing. Read More

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September 2020

Hydrogen sulfide: An endogenous regulator of the immune system.

Pharmacol Res 2020 11 8;161:105119. Epub 2020 Aug 8.

Chair of Pharmacology, Section of Medicine, University of Fribourg, Switzerland; Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

Hydrogen sulfide (HS) is now recognized as an endogenous signaling gasotransmitter in mammals. It is produced by mammalian cells and tissues by various enzymes - predominantly cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) - but part of the HS is produced by the intestinal microbiota (colonic HS-producing bacteria). Here we summarize the available information on the production and functional role of HS in the various cell types typically associated with innate immunity (neutrophils, macrophages, dendritic cells, natural killer cells, mast cells, basophils, eosinophils) and adaptive immunity (T and B lymphocytes) under normal conditions and as it relates to the development of various inflammatory and immune diseases. Read More

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November 2020

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson's Disease Patients: Data from the NHANES 2011-2012.

J Pers Med 2020 Jul 25;10(3). Epub 2020 Jul 25.

Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Almada, Portugal.

People with Parkinson's Disease (PD) are associated with the presence of periodontitis. We aimed to compare blood and standard biochemical surrogates of PD patients diagnosed with periodontitis with PD individuals without periodontitis. This retrospective cohort study used a sample from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 that underwent periodontal diagnosis ( = 3669). Read More

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Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

J Clin Invest 2020 09;130(9):4759-4770

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

No known therapies can prevent anaphylaxis. Bruton's tyrosine kinase (BTK) is an enzyme thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells. We tested the hypothesis that FDA-approved BTK inhibitors (BTKis) would prevent IgE-mediated responses including anaphylaxis. Read More

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September 2020

Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats.

Toxicol Rep 2020 8;7:610-623. Epub 2020 May 8.

Department of Anatomy and Developmental Biology, Monash University, Melbourne, 3168, Australia.

Background: Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity study has not been performed. The objective of this study was to determine the long-term toxic effect of UA on clinical chemistry, haematology, coagulation, pathology/morphology, behaviour and motor skills in rats. Read More

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Effectiveness and safety of benralizumab for severe asthma in clinical practice (J-BEST): a prospective study.

Ann Transl Med 2020 Apr;8(7):438

Department of Respiratory Medicine, Japanese Red Cross Medical Center, Tokyo, Japan.

Background: Benralizumab is a humanized, fucosylated, monoclonal antibody that targets the interleukin 5 (IL-5) α receptor. Several phase III trials have shown that benralizumab can significantly reduce the incidence of acute exacerbations and improve lung function in patients with severe asthma. However, there is a paucity of data from clinical practice. Read More

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Biomarkers of severity and threshold of allergic reactions during oral peanut challenges.

J Allergy Clin Immunol 2020 08 18;146(2):344-355. Epub 2020 Apr 18.

Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Children's Allergy Service, Evelina London Children's Hospital, Guy's and St Thomas' Hospital, London, United Kingdom; Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

Background: Oral food challenge (OFC) is the criterion standard to assess peanut allergy (PA), but it involves a risk of allergic reactions of unpredictable severity.

Objective: Our aim was to identify biomarkers for risk of severe reactions or low dose threshold during OFC to peanut.

Methods: We assessed Learning Early about Peanut Allergy study, Persistance of Oral Tolerance to Peanut study, and Peanut Allergy Sensitization study participants by administering the basophil activation test (BAT) and the skin prick test (SPT) and measuring the levels of peanut-specific IgE, Arachis hypogaea 2-specific IgE, and peanut-specific IgG4, and we analyzed the utility of the different biomarkers in relation to PA status, severity, and threshold dose of allergic reactions to peanut during OFC. Read More

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Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death.

PLoS One 2020 17;15(4):e0231101. Epub 2020 Apr 17.

Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Mast cells and basophils are central players in allergic reactions triggered by immunoglobulin E (IgE). They have intracellular granules containing allergic mediators (e.g. Read More

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In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development.

Pediatr Allergy Immunol 2020 08 3;31(6):686-694. Epub 2020 May 3.

Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.

Background: Low vitamin D levels have been associated with allergic diseases. Vitamin D has potent immunomodulatory properties, but the mechanisms remain unclear. We have investigated the effect of oral vitamin D supplementation on circulating immune cell phenotypes in infants. Read More

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