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Genomic basis of high-altitude adaptation in Tibetan Prunus fruit trees.

Curr Biol 2021 Jul 22. Epub 2021 Jul 22.

Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China; Key Laboratory of Horticultural Crop (Fruit trees) Biology and Genetic Improvement (Ministry of Agriculture and Rural Affairs), Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

The Great Himalayan Mountains and their foothills are believed to be the place of origin and development of many plant species. The genetic basis of adaptation to high plateaus is a fascinating topic that is poorly understood at the population level. We comprehensively collected and sequenced 377 accessions of Prunus germplasm along altitude gradients ranging from 2,067 to 4,492 m in the Himalayas. Read More

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Dynamics of carbon stocks of different pools in Huzhong National Nature Reserve, Northeast China under the disturbance of various severity fires.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2325-2334

Chinese Academy of Sciences Key Laboratory of Forest Ecology and Management, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

In this study, the FireBGCv2 model was used to simulate the dynamics of forest carbon pools of Huzhong Nature Reserve within the next 100 years under various forest fire severity scena-rios. The aim of this study was to explore the responses of different forest carbon pools to fire disturbance, and to provide scientific basis for forest fuel management. The results showed that forest fire significantly reduced forest carbon storage, with the greatest reduction under the scenario of high-severity forest fire. Read More

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Sustainable production of benzene from lignin.

Nat Commun 2021 07 26;12(1):4534. Epub 2021 Jul 26.

Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

Benzene is a widely used commodity chemical, which is currently produced from fossil resources. Lignin, a waste from lignocellulosic biomass industry, is the most abundant renewable source of benzene ring in nature. Efficient production of benzene from lignin, which requires total transformation of C-C/C-O into C-H bonds without side hydrogenation, is of great importance, but has not been realized. Read More

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Biofilm associated genotypes of multiple antibiotic resistant Pseudomonas aeruginosa.

BMC Genomics 2021 Jul 26;22(1):572. Epub 2021 Jul 26.

Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester, United Kingdom.

Background: Pseudomonas aeruginosa is a ubiquitous environmental microorganism and also a common cause of infection. Its ability to survive in many different environments and persistently colonize humans is linked to its presence in biofilms formed on indwelling device surfaces. Biofilm promotes adhesion to, and survival on surfaces, protects from desiccation and the actions of antibiotics and disinfectants. Read More

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Construction of Robust Cadmium-Free Cu-In-Zn-S Nanocrystals and Polyfluorene Derivatives Hybrid Emissive Layer for Stable Electroluminescent White Light-Emitting Devices.

J Phys Chem Lett 2021 Jul 23:7113-7119. Epub 2021 Jul 23.

Key Laboratory of Luminescence and Optical Information, Ministry of Education, School of Science, Beijing JiaoTong University, Beijing 100044, China.

Combination of the merit of inorganic nanocrystals (NCs) and solution-processed conjugated polymer is a convenient strategy to obtain stable and efficient electroluminescent white-light-emitting diodes (el-WLEDs). In this work, an el-WLED was fabricated on the basis of Cd-free Cu-In-Zn-S (CIZS)/ZnS NCs blending with polyfluorene derivative poly[4-(octyloxy)-9,9-diphenylfluoren-2,7-diyl]--[5-(octyloxy)-9,9-diphenylfluoren-2,7-diyl] (PODPF), which exhibited a stable white light emission with a color rendering index value of 85. Meanwhile, it had a stable spectrum under high voltage due to the extremely weak energy transfer between PODPF and CIZS/ZnS NCs. Read More

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Application of Machine Learning for eutrophication analysis and algal bloom prediction in an urban river: A 10-year study of the Han River, South Korea.

Sci Total Environ 2021 Jul 17;797:149040. Epub 2021 Jul 17.

Department of Environment and Energy, Sejong University, Seoul 05006, South Korea. Electronic address:

The increasing release of nutrients to aquatic environments has led to great concern regarding eutrophication and the risk of unwanted algal blooms. Based on observational data of 20 water quality parameters measured on a monthly basis at 40 stations from 2011 to 2020, this study applied different Machine Learning (ML) algorithms to suggest the best option for algal bloom prediction in the Han River, a large river in South Korea. Eight different ML algorithms were categorized into several groups of statistical learning, regression family, and deep learning, and were then compared for their suitability to predict the chlorophyll-derived trophic index (TSI-Chla). Read More

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Engineering of an Upconversion Luminescence Sensing Platform Based on the Competition Effect for Mercury-Ion Monitoring in Green Tea.

J Agric Food Chem 2021 Jul 26. Epub 2021 Jul 26.

School of Food & Biological Engineering, Key Laboratory for Agricultural Products Processing of Anhui Province, Hefei University of Technology, Hefei 230009, China.

Accurately monitoring mercury ions (Hg) in food and agriculture-related matrixes (e.g., green tea) is of great significance to safeguard food safety. Read More

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Identification of in vitro angiotensin-converting enzyme and dipeptidyl peptidase IV inhibitory peptides from draft beer by virtual screening and molecular docking.

J Sci Food Agric 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory of Biological Fermentation Engineering of Beer.

Background: Hypertension and diabetes are two kinds of senile diseases which often occur simultaneously. The commonly used drugs in clinic may produce certain side effects. Food-derived polypeptide is a kind of polypeptide with great development potential, which has many functions of regulating human physiological function. Read More

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The Attitude-Behavior Relationship Revisited.

Psychol Sci 2021 Jul 26:956797621995206. Epub 2021 Jul 26.

Marketing Department, Kellogg School of Management, Northwestern University.

The attitude-behavior relationship is of great import to many areas of psychology. Indeed, psychologists across disciplines have published thousands of articles on the topic. The majority of this research implies that the attitude-behavior relationship is linear. Read More

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Self-Healable, High-Strength Hydrogel Electrode for Flexible Sensors and Supercapacitors.

ACS Appl Mater Interfaces 2021 Jul 26. Epub 2021 Jul 26.

School of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.

Flexible energy storage materials and sensors have become the key equipment of human-machine interface technology. For the preparation of these devices, hydrogel electrodes are relevant because of their unique porous structure, high capacitance, flexibility, small size, and lightweight. In this paper, regular polypyrrole (PPy) is synthesized on a heat-induced phase-separated gel (H-Gel/AS) by the template degradation method, and a gelatin-based PPy hydrogel with high strength, high strain rate, and high conductivity is prepared. Read More

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[Temporal and Spatial Evolution of Non-point Source Pollution Load of Total Nitrogen in Tuojiang River Basin].

Huan Jing Ke Xue 2021 Aug;42(8):3773-3784

School of Environment and Resource, Southwest University of Science and Technology, Mianyang 621010, China.

Currently, the aquatic environment of the Tuojiang River basin in Sichuan Province is severely polluted by non-point sources of total nitrogen (TN). This study adopts the pollution discharge coefficient method to estimate the TN pollution load of non-point sources in this watershed during 2007-2017. The temporal and spatial distribution and transfer trends of the TN pollution load in the Tuojiang River basin were examined, based on center-of-gravity statistical and spatial analysis technology. Read More

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SILAR Deposition of Metal Oxide Nanostructured Films.

Small 2021 Jul 26:e2101666. Epub 2021 Jul 26.

RMIT University, School of Science, Melbourne, VIC, 3001, Australia.

Methods for the fabrication of thin films with well controlled structure and properties are of great importance for the development of functional devices for a large range of applications. SILAR, the acronym for Successive Ionic Layer Adsorption and Reaction, is an evolution and combination of two other deposition methods, the Atomic Layer Deposition and Chemical Bath Deposition. Due to a relative simplicity and low cost, this method has gained increasing interest in the scientific community. Read More

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Tailoring Highly Ordered Graphene Framework in Epoxy for High-Performance Polymer-Based Heat Dissipation Plates.

ACS Nano 2021 Jul 26. Epub 2021 Jul 26.

Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, People's Republic of China.

As the power density and integration level of electronic devices increase, there are growing demands to improve the thermal conductivity of polymers for addressing the thermal management issues. On the basis of the ultrahigh intrinsic thermal conductivity, graphene has exhibited great potential as reinforcing fillers to develop polymer composites, but the resultant thermal conductivity of reported graphene-based composites is still limited. Here, an interconnected and highly ordered graphene framework (HOGF) composed of high-quality and horizontally aligned graphene sheets was developed by a porous film-templated assembly strategy, followed by a stress-induced orientation process and graphitization post-treatment. Read More

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Individual Resilience Interventions: A Systematic Review in Adult Population Samples over the Last Decade.

Int J Environ Res Public Health 2021 Jul 16;18(14). Epub 2021 Jul 16.

Psychosocial Rehabilitation Laboratory, Center for Rehabilitation Research, School of Health, Polytechnic Institute of Porto, 4200 Porto, Portugal.

Resilience interventions have been gaining importance among researchers due to their potential to provide well-being and reduce the prevalence of mental disorders that are becoming an increasing concern, especially in Western countries, because of the costs associated. The purpose of this systematic review is to identify the intervention studies carried out in the last decade in adult population samples, evaluate their methodological quality and highlight the trends of these types of interventions. This review was performed using systematic literature searches in the following electronic databases: B-on, PubMed, PsycNet and Science Direct. Read More

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The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum, 91054 Erlangen, Germany.

Immune-mediated inflammatory diseases (IMIDs), such as inflammatory bowel diseases and inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis), are marked by increasing worldwide incidence rates. Read More

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Next-Generation Biomarkers in Multiple Myeloma: Understanding the Molecular Basis for Potential Use in Diagnosis and Prognosis.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur 56000, Malaysia.

Multiple myeloma (MM) is considered to be the second most common blood malignancy and it is characterized by abnormal proliferation and an accumulation of malignant plasma cells in the bone marrow. Although the currently utilized markers in the diagnosis and assessment of MM are showing promising results, the incidence and mortality rate of the disease are still high. Therefore, exploring and developing better diagnostic or prognostic biomarkers have drawn global interest. Read More

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Molecular Basis of Late-Life Depression.

Int J Mol Sci 2021 Jul 10;22(14). Epub 2021 Jul 10.

Department of Psychiatry, China Medical University Hospital, Taichung 40402, Taiwan.

Late-life depression (LLD), compared to depression at a young age, is more likely to have poor prognosis and high risk of progression to dementia. A recent systemic review and meta-analysis of the present antidepressants for LLD showed that the treatment response rate was 48% and the remission rate was only 33.7%, thus implying the need to improve the treatment with other approaches in the future. Read More

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The characterisation and provenance of crude oils stranded on the South Australian coastline. Part II: Potential parent petroleum systems.

Mar Pollut Bull 2021 Jul 20;171:112709. Epub 2021 Jul 20.

Energy, CSIRO, Kensington, WA 6151, Australia.

In 2014-2016 more than 600 specimens of semi-solid crude oil were recovered from 30 ocean beaches along the coastline of South Australia, as part of the recently completed Great Australian Bight Research Program. All are believed to be products of submarine oil seepage. Their source-specific biomarker signatures provide the basis for their assignment to sixteen oil families, some previously unrecognised. Read More

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[Prediction of Q-markers of Astragali Radix based on network pharmacology and fingerprint].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2691-2698

Gansu University of Chinese Medicine Lanzhou 730000,China Key Laboratory of Standard and Quality Research of Chinese Medicine of Gansu Province Lanzhou 730000,China.

Astragali Radix is one of the most commonly used medicinal materials. In recent years, its cultivated varieties and a variety of adulterants have flooded the market, which makes its quality uneven, and the development of quality control methods has become a research hotspot. Therefore, figuring out the quality markers of Astragali Radix is of great significance for its comprehensive evaluation. Read More

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CAM-DR: Mechanisms, Roles and Clinical Application in Tumors.

Front Cell Dev Biol 2021 6;9:698047. Epub 2021 Jul 6.

Medical School, Nantong University, Nantong, China.

Despite the continuous improvement of various therapeutic techniques, the overall prognosis of tumors has been significantly improved, but malignant tumors in the middle and advanced stages still cannot be completely cured. It is now evident that cell adhesion-mediated resistance (CAM-DR) limits the success of cancer therapies and is a great obstacle to overcome in the clinic. The interactions between tumor cells and extracellular matrix (ECM) molecules or adjacent cells may play a significant role in initiating the intracellular signaling pathways that are associated with cell proliferation, survival upon binding to their ligands. Read More

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Health risk assessment of As due to rice ingestion based on iAs distribution and actual consumption patterns for the residents in Beijing: a cross-sectional study.

Environ Geochem Health 2021 Jul 21. Epub 2021 Jul 21.

Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China.

As a well-known human carcinogen, arsenic (As) could pose various detrimental health effects to humans mainly through the exposure pathway of food ingestion. In comparison with other foods, rice can accumulate more arsenic due to its tissue specificity. Thus, it is of great significance to assess the health risk of As due to rice ingestion. Read More

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Single-Molecule Real-Time and Illumina-Based RNA Sequencing Data Identified Vernalization-Responsive Candidate Genes in Faba Bean ( L.).

Front Genet 2021 5;12:656137. Epub 2021 Jul 5.

Institute of Industrial Crops, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Faba bean ( L.) is one of the most widely grown cool season legume crops in the world. Winter faba bean normally has a vernalization requirement, which promotes an earlier flowering and pod setting than unvernalized plants. Read More

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Optimization of diosgenin extraction from Dioscorea deltoidea tubers using response surface methodology and artificial neural network modelling.

PLoS One 2021 21;16(7):e0253617. Epub 2021 Jul 21.

Department of Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Dioscorea deltoidea var. deltoidea (Dioscoreaceae) is a valuable endangered plant of great medicinal and economic importance due to the presence of the bioactive compound diosgenin. In the present study, response surface methodology (RSM) and artificial neural network (ANN) modelling have been implemented to evaluate the diosgenin content from D. Read More

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Orf virus ORF120 protein positively regulates the NF-κB pathway by interacting with G3BP1.

J Virol 2021 Jul 21:JVI0015321. Epub 2021 Jul 21.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

Orf virus (ORFV) is a highly epitheliotropic parapoxvirus with zoonotic significance that induces proliferative lesions in the skin of sheep, goats and humans. Several viral proteins encoded by ORFV, including NF-κB inhibitors, play important roles in hijacking host-associated proteins for viral evasion of the host innate immune response. However, the roles of proteins with unknown functions in viral replication and latent infection remain to be explored. Read More

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Keeping the ICRP recommendations fit for purpose.

J Radiol Prot 2021 Jul 20. Epub 2021 Jul 20.

Southern Urals Biophysics Institute, Ozersk, RUSSIAN FEDERATION.

The International Commission on Radiological Protection (ICRP) has embarked on a review and revision of the System of Radiological Protection that will update the 2007 General Recommendations in ICRP Publication 103. This is the beginning of a process that will take several years, involving open and transparent engagement with organisations and individuals around the world. While the System is robust and has performed well, it must adapt to address changes in science and society to remain fit for purpose. Read More

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Histological changes after pulmonary artery banding for retraining of subpulmonary left ventricle.

Ann Thorac Surg 2021 Jul 17. Epub 2021 Jul 17.

Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children's Hospital, Boston, MA; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) with intact ventricular septum (IVS) or d-looped transposition of the great arteries (DTGA) with IVS post atrial switch operation often develop left ventricular dysfunction after anatomical repair despite prior retraining of the morphologically left ventricle (mLV) using pulmonary artery banding (PAB). We examined histopathological changes in such mLV.

Methods: Capillary density, myocyte diameter, and interstitial fibrous area in the mLV were retrospectively evaluated in postmortem or explanted heart specimens obtained from patients with ccTGA/IVS or DTGA/IVS post atrial switch operation after PAB for retraining and compared with those of patients with normal cardiac anatomy, ccTGA/IVS or DTGA/IVS without PAB, and ccTGA or DTGA with high mLV pressure using generalized estimating equations models. Read More

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Neuroplastin in human cognition: review of literature and future perspectives.

Transl Psychiatry 2021 Jul 16;11(1):394. Epub 2021 Jul 16.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Šalata12, 10000, Zagreb, Croatia.

Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it was found that some of the effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Read More

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Molecular Characterization of TRPA Subfamily Genes and Function in Temperature Preference in (Meyrick) (Lepidoptera: Gelechiidae).

Int J Mol Sci 2021 Jul 2;22(13). Epub 2021 Jul 2.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

To reveal the mechanism of temperature preference in , one of the top 20 plant pests in the world, we cloned and identified , , and genes by RACE and bioinformatic analysis, and clarified their expression profiles during different development stages using real-time PCR, and revealed their function in preference temperature by RNAi. The full-length cDNA of was 3136 bp, with a 2865-bp open reading frame encoding a 259.89-kDa protein; and the partial length cDNA of was 2326-bp, with a 2025-bp open reading frame encoding a 193. Read More

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Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment.

ACS Nano 2021 Jul 19. Epub 2021 Jul 19.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization in the perifollicular microenvironment is the leading cause of AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress and promote angiogenesis simultaneously to reshape the perifollicular microenvironment for AGA treatment. Read More

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Manganese oxide nanomaterials boost cancer immunotherapy.

J Mater Chem B 2021 Jul 19. Epub 2021 Jul 19.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. and University of Science and Technology of China, Hefei, 230026, China.

Immunotherapy, a strategy that leverages the host immune function to fight against cancer, plays an increasingly important role in clinical tumor therapy. In spite of the great success achieved in not only clinical treatment but also basic research, cancer immunotherapy still faces many huge challenges. Manganese oxide nanomaterials (MONs), as ideal tumor microenvironment (TME)-responsive biomaterials, are able to dramatically elicit anti-tumor immune responses in multiple ways, indicating great prospects for immunotherapy. Read More

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