35,114 results match your criteria basic knowledge


Connecting research and teaching introductory cell and molecular biology using an Arabidopsis mutant screen.

Biochem Mol Biol Educ 2021 Sep 24. Epub 2021 Sep 24.

MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, Michigan, USA.

A complex research project was translated into a Course-based Undergraduate Research Experience (CURE), which was implemented in sections of an introductory Cell and Molecular Biology laboratory course. The research laboratory generated an engineered plant line producing a growth-inhibiting, lipid-derived plant hormone and mutagenized this line. Students in the CURE cultured the mutagenized plant population and selected and characterized suppressor mutants. Read More

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September 2021

Prognostic significance of platelet lymphocyte ratio in patients with melanoma: A meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27223

Department of Medical Oncology, Chongqing University Cancer Hospital & Chongqing Cancer Institute, Chongqing, PR China.

Background: The aim of this study was to systematically evaluate the prognostic role of platelet lymphocyte ratio (PLR) in patients with melanoma through performing a meta-analysis.

Methods: PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched for potential studies. The basic characteristics and relevant data were extracted. Read More

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September 2021

Temperature affects growth, geosmin/2-methylisoborneol production, and gene expression in two cyanobacterial species.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, Japan.

Cyanobacterial blooms accompanied by taste and odor (T&O) compounds affect the recreational function and safe use of drinking water. Geosmin and 2-methylisoborneol (2-MIB) are the most common T&O compounds. In this study, we investigated the effect of temperature on geosmin and 2-MIB production in Dolichospermum smithii and Pseudanabaena foetida var. Read More

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September 2021

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data.

Innovation (N Y) 2021 Aug 1;2(3):100141. Epub 2021 Jul 1.

Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Functional enrichment analysis is pivotal for interpreting high-throughput omics data in life science. It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible. To meet these requirements, we present here an updated version of our popular Bioconductor package, clusterProfiler 4. Read More

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Oncofertility Knowledge and Communication: Comparison Between Medical and Surgical Oncologists and Breast Cancer Patients in Academic Chinese Centers.

Front Surg 2021 7;8:681614. Epub 2021 Sep 7.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

As cancer has become a major public health issue in China, fertility preservation remains limited despite the wide application of Assisted Reproductive Technology (ART) throughout the country. This study aimed to identify gaps in knowledge and communication as well as referrals in the previous year regarding oncofertility among medical and surgical oncologists and breast cancer patients (BCPs) in Chinese academic settings to target areas of needed improvement. A WeChat online questionnaire was designed, distributed, and compared between medical and surgical oncology specialists and reproductive age BCPs in academic teaching settings in Shanghai. Read More

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September 2021

The pattern of health insurance economic resilience in the Covid 19 pandemic shock.

BMC Res Notes 2021 Sep 23;14(1):371. Epub 2021 Sep 23.

Health Economic, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Health insurance is based on people's significant risks in receiving health services that they cannot afford alone. Since the outbreak of the corona epidemic, the health insurance system has suffered many economic problems. Designing a model of a health insurance system based on the requirements of a resilient economy can improve the functions of this system in the corona crisis. Read More

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September 2021

Physiological and histopathological effects of electroporation pulse on stomach of rats.

BMC Gastroenterol 2021 Sep 23;21(1):351. Epub 2021 Sep 23.

National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta District, Xi'an, 710061, China.

Background: Irreversible electroporation (IRE) is an emerging tissue ablation technique with widespread potential, especially for cancer treatment. Although the safety and efficacy of IRE for gastric tissue ablation have been demonstrated, there is a gap of knowledge regarding the effect of electroporation pulse (EP) on the physiology and histopathology of the stomach. This study applied EP to the stomach of healthy rats and investigated the digestive function, serum marker levels, and gastric tissue structure of EP-treated rats. Read More

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September 2021

Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives.

Expert Rev Mol Diagn 2021 Sep 23. Epub 2021 Sep 23.

Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Infertility is a major health problem, worldwide, which affects 10-15% of couples. About half percent of infertility cases are related to male-related factors. Male infertility is a complex disease that is the result of various insults as lifestyle issues, genetics, and epigenetic factors. Read More

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September 2021

Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China.

Genomics 2021 Sep 20. Epub 2021 Sep 20.

BGI-Shenzhen, Shenzhen 518083, China; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen 518083, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address:

Persistent infections of high-risk human papillomaviruses (HPVs) are the leading cause of cervical cancers. We collected cervical exfoliated cell samples from females in Changsha city, Hunan Province and obtained 358 viral genomes of four major HPV types, including HPV 16 (n = 82), 18 (n = 35), 52 (n = 121) and 58 (n = 100). The lineage/sublineage distribution of the four HPVs confirmed previous epidemiological reports, with the predominant prevailing sublineage as A4 (50%), A1 (37%) and A3 (13%) for HPV16, A1 (83%) for HPV18, B2 (86%) for HPV52 and A1 (65%), A3 (19%) and A2 (12%) for HPV58. Read More

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September 2021

Conceptions of university students on microplastics in Germany.

PLoS One 2021 23;16(9):e0257734. Epub 2021 Sep 23.

Department of Biology Education, Centre of Maths and Science Education (Z-MNU), University of Bayreuth, Bayreuth, Germany.

Microplastics are a global challenge and a frequently studied environmental issue. Hence, the knowledge body about microplastics within the scientific community is growing fast and challenges an elaborated knowledge transfer from science to the general public. Just as well-informed people are the basis for reducing microplastics' impact on the environment, knowledge of the audience's conceptions is the basis for an accurate and successful dissemination of scientific findings. Read More

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September 2021

Writing a strong scientific paper in medicine and the biomedical sciences: a checklist and recommendations for early career researchers.

Biol Futur 2021 Jul 28. Epub 2021 Jul 28.

Institute of Medical Microbiology, Faculty of Medicine, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.

Scientific writing is an important skill in both academia and clinical practice. The skills for writing a strong scientific paper are necessary for researchers (comprising academic staff and health-care professionals). The process of a scientific research will be completed by reporting the obtained results in the form of a strong scholarly publication. Read More

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Cervical cancer knowledge and screening uptake by marginalized population of women in inner-city Durban, South Africa: Insights into the need for increased health literacy.

Womens Health (Lond) 2021 Jan-Dec;17:17455065211047141

Department of Basic Medical Sciences, Durban University of Technology, Durban, South Africa.

Background: Cervical cancer in South Africa accounts for 15.85% of all female cancers and 30.29% of African female cancers, resulting in over 5000 deaths annually. Read More

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September 2021

Different perceptions of thorax anatomy and hand placement for chest compressions among healthcare professionals and laypersons: Implications for cardiopulmonary resuscitation.

Resusc Plus 2021 Sep 29;7:100138. Epub 2021 Jun 29.

Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

Aim: The European Resuscitation Council guidelines recommend that the hand position for chest compressions is obtained by "placing the heel of your hand in the centre of the chest". Importantly, guidelines are based on a study on healthcare professionals being extrapolated to laypersons. This study explored whether healthcare professionals and laypersons differ in anatomical knowledge necessary for obtaining the correct hand position for chest compressions and understanding of European Resuscitation Council guideline recommendations in the absence of a demonstration. Read More

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September 2021

Pushing the methodological envelope in understanding the photo/electrosynthetic materials-microorganism interface.

iScience 2021 Sep 28;24(9):103049. Epub 2021 Aug 28.

Department of Chemistry, Université de Montréal, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, QC H2V 0B3 Canada.

Biohybrid photo/electrosynthetic systems synergize microbial metabolic pathways and inorganic materials to generate the fuels and chemicals to power our society. They aim to combine the strengths of product selectivity from biological cells and efficient charge generation and light absorption of inorganic materials. However crucial mechanistic questions still remain. Read More

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September 2021

Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome.

Front Med (Lausanne) 2021 6;8:730161. Epub 2021 Sep 6.

Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in the cardiomyocyte electrophysiology, primarily ion channels (autoimmune cardiac channelopathies). Specifically, some of these autoantibodies can prolong the action potential duration leading to acquired long-QT syndrome (LQTS), a condition known to increase the risk of life-threatening ventricular arrhythmias, particularly Torsades de Pointes (TdP). Read More

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September 2021

Research on Influencing Factors and Dimensions of Health Literacy in Different Age Groups: Before and After the COVID-19 Era in Chongqing, China.

Front Public Health 2021 6;9:690525. Epub 2021 Sep 6.

School of Public Health and Management, Chongqing Medical University, Chongqing, China.

Understanding the levels of health literacy among different groups is essential for better public health interventions targeting specific subgroups of the population. Additionally, this article explores the prevalence and influencing factors of the health literacy levels of different age groups during the COVID-19 epidemic. Multistage stratified cluster random sampling and the Probability Proportion to Size (PPS) method were used to select permanent residents aged 15-69 in Chongqing (54,706) for the questionnaire survey. Read More

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September 2021

Evaluating Deep Neural Network Architectures with Transfer Learning for Pneumonitis Diagnosis.

Comput Math Methods Med 2021 12;2021:8036304. Epub 2021 Sep 12.

Department of Computer Science and Information Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan.

Pneumonitis is an infectious disease that causes the inflammation of the air sac. It can be life-threatening to the very young and elderly. Detection of pneumonitis from X-ray images is a significant challenge. Read More

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September 2021

Persuasive Features of Scientific Explanations: Explanatory Schemata of Physical and Psychosocial Phenomena.

Front Psychol 2021 6;12:644809. Epub 2021 Sep 6.

Behavioral Sciences and Leadership Department, United States Military Academy, Highlands, NY, United States.

Explanations are central to understanding the causal relationships between entities within the environment. Instead of examining basic heuristics and schemata that inform the acceptance or rejection of scientific explanations, recent studies have predominantly examined complex explanatory models. In the present study, we examined which essential features of explanatory schemata can account for phenomena that are attributed to domain-specific knowledge. Read More

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September 2021

Formative Feedback with In-Class Question Bank Utilization Improves Resident Satisfaction with General Surgery Didactics.

Adv Med Educ Pract 2021 15;12:1033-1041. Epub 2021 Sep 15.

Department of Surgery, Mayo Clinic, Phoenix, AZ, USA.

Background: Formative feedback provides low-stakes opportunities for educational improvement. To enrich our basic science didactics, formative feedback measures were incorporated into our didactics using mobile devices.

Materials And Methods: Lecture changes included institutional paid access to a commercial question bank, a 5-item in-class pre-didactic quiz curated from the question bank and taken on the resident's mobile device, and group discussion of quiz topics. Read More

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September 2021

Synthesis and antiviral activity of diverse heterocyclic scaffolds.

Chem Biol Drug Des 2021 Sep 22. Epub 2021 Sep 22.

Department of Chemistry, College of Basic Sciences and Humanities, Punjab Agricultural University, Ludhiana, 141004, Punjab, India.

Heterocyclic moieties form a major part of organic chemistry as they are widely distributed in nature and have wide scale practical applications ranging from extensive clinical use to diverse fields such as medicine, agriculture, photochemistry, biocidal formulations and polymer science. By virtue of their therapeutic properties, they could be employed in combating many infectious diseases. Among the common infectious diseases, viral infections are of great public health importance worldwide. Read More

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September 2021

A natural history museum visitor survey of perception, attitude and knowledge (PAK) of microbes and antibiotics.

PLoS One 2021 22;16(9):e0257085. Epub 2021 Sep 22.

American Museum of Natural History, Sackler Institute for Comparative Genomics, New York, NY, United States of America.

A kiosk-based survey at the American Museum of Natural History in New York City in 2016-2018 allowed us to assess public knowledge of antibiotics and public attitudes toward microbes in museum goers. Over 22,000 visitors from 172 countries and territories answered several carefully designed questions about microbes and antibiotics. These visitors also entered age, gender, and country demographic data that allowed for stratification along these demographic and geographic divisions. Read More

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September 2021

Nano Spray-Dried Drugs for Oral Administration: A Review.

Assay Drug Dev Technol 2021 Sep 21. Epub 2021 Sep 21.

Institute for Energy Systems, Eastern Switzerland University of Applied Sciences of Technology, Buchs, Switzerland.

Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. Read More

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September 2021

Challenges in Comparative Meta-Analysis of the Accuracy of Multiple Diagnostic Tests.

Methods Mol Biol 2022 ;2345:299-316

Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

The rapid increase in diagnostic and screening techniques has urged the need to choose among multiple diagnostic tests. For the majority of diseases, there is more than a single test available, and studies usually compare a subset of these tests. In such cases, a separate meta-analysis of each test cannot provide a reliable answer on the relative accuracy of the multiple available tests. Read More

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January 2022

On the optimal control of SIR model with Erlang-distributed infectious period: isolation strategies.

J Math Biol 2021 Sep 22;83(4):36. Epub 2021 Sep 22.

Department of Mathematical, Physical and Computer Sciences, University of Parma, Parco Area delle Scienze 53/A, 43124, Parma, Italy.

Mathematical models are formal and simplified representations of the knowledge related to a phenomenon. In classical epidemic models, a major simplification consists in assuming that the infectious period is exponentially distributed, then implying that the chance of recovery is independent on the time since infection. Here, we first attempt to investigate the consequences of relaxing this assumption on the performances of time-variant disease control strategies by using optimal control theory. Read More

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September 2021

Curriculum of Gross Anatomy Education in Korean Dental Hygiene Programs: Perceptions of Clinical Dental Hygienists.

Anat Sci Educ 2021 Sep 21. Epub 2021 Sep 21.

Department of Health Administration, Division of Health Science, Dongseo University, Busan, South Korea.

It is essential for dental hygienists to have basic knowledge of gross anatomy to provide efficient treatment. However, gross anatomy course is relatively neglected due to their disparity from actual clinical dental practice. This study aimed to propose an effective dental hygiene gross anatomy curriculum that reflects the opinions of professional clinical dental hygienists. Read More

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September 2021

Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial.

Fam Pract 2021 Sep 21. Epub 2021 Sep 21.

School of Medicine, Keele University, Keele, Staffordshire ST5 5BG, UK.

Background: Multimorbidity is increasingly the norm; however, primary care remains focused on single diseases. Osteoarthritis, anxiety, and depression are frequently comorbid with other long-term conditions (LTCs), but rarely prioritized by clinicians.

Objectives: To test the feasibility of a randomized controlled trial (RCT) of an intervention integrating case-finding and management for osteoarthritis, anxiety, and depression within LTC reviews. Read More

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September 2021

Decision making about genetic health information among family dyads: A systematic literature review.

Health Psychol Rev 2021 Sep 21:1-41. Epub 2021 Sep 21.

The Discipline of Genetic Counselling, The University of Technology Sydney, Ultimo, NSW, Australia.

Decisions involving two individuals (i.e., dyadic decision making)have been increasingly studied in healthcare research. Read More

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September 2021

Genomic Stability and Genetic Defense Systems in , a Candidate Beneficial Bacterium from the Human Microbiome.

mSystems 2021 Sep 21:e0042521. Epub 2021 Sep 21.

The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.

Dolosigranulum pigrum is positively associated with indicators of health in multiple epidemiological studies of human nasal microbiota. Knowledge of the basic biology of is a prerequisite for evaluating its potential for future therapeutic use; however, such data are very limited. To gain insight into 's chromosomal structure, pangenome, and genomic stability, we compared the genomes of 28 strains that were collected across 20 years. Read More

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September 2021

Mapping Orbital-Resolved Magnetism in Single Lanthanide Atoms.

ACS Nano 2021 Sep 21. Epub 2021 Sep 21.

Center for Quantum Nanoscience, Institute for Basic Science (IBS), Seoul 03760, Republic of Korea.

Single lanthanide atoms and molecules are promising candidates for atomic data storage and quantum logic due to the long lifetime of their magnetic quantum states. Accessing and controlling these states through electrical transport requires precise knowledge of their electronic configuration at the level of individual atomic orbitals, especially of the outer shells involved in transport. However, no experimental techniques have so far shown the required sensitivity to probe single atoms with orbital selectivity. Read More

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September 2021