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Repetitive Transcranial Magnetic Stimulation of the Contralesional Dorsal Premotor Cortex for Upper Extremity Motor Improvement in Severe Stroke: Study Protocol for a Pilot Randomized Clinical Trial.

Cerebrovasc Dis 2022 Jan 20:1-8. Epub 2022 Jan 20.

Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.

Up to 50% of stroke survivors have persistent, severe upper extremity paresis even after receiving rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) can augment the effects of rehabilitation by modulating corticomotor excitability, but the conventional approach of facilitating excitability of the ipsilesional primary motor cortex (iM1) fails to produce motor improvement in stroke survivors with severe loss of ipsilesional substrate. Instead, the undamaged, contralesional dorsal premotor cortex (cPMd) may be a more suitable target. Read More

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January 2022

Effectiveness of an Internet-Based Self-Help Intervention versus Public Mental Health Advice to Reduce Worry during the COVID-19 Pandemic: A Pragmatic, Parallel-Group, Randomized Controlled Trial.

Psychother Psychosom 2022 Jan 20:1-13. Epub 2022 Jan 20.

Department of Health Psychology and Applied Biological Psychology, Institute of Psychology, Leuphana University of Lüneburg, Lüneburg, Germany.

Introduction: The mental health burden for the general population due to the COVID-19 pandemic has been highlighted. Evidence on effective, easily accessible public health interventions to reduce worry, a major transdiagnostic risk-factor for, e.g. Read More

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January 2022

Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive decline.

Parkinsonism Relat Disord 2022 Jan 8;95:70-76. Epub 2022 Jan 8.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China; Advanced Innovation Center for Human Brain Projection, Capital Medical University, Beijing, China. Electronic address:

Objective: Whether perivascular space (PVS) visible on magnetic resonance imaging (MRI) represents glymphatic dysfunction and whether this imaging marker is pathologic in Parkinson's disease (PD) have been controversial. The objective was to determine whether PVS visible on MRI is independently associated with cognitive decline in patients with PD, and to test whether pathologic proteins in the CSF (such as Aβ) mediate the pathologic role of PVS.

Methods: A total of 341 patients with Parkinson's disease from Parkinson's Progression Marker Initiative (PPMI) cohort was included in the present study. Read More

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January 2022

Nodule net: A centralized prospective lung nodule tracking and safety-net program.

Respir Med 2022 Jan 13;192:106737. Epub 2022 Jan 13.

Department of Pulmonary and Critical Care, Mount Auburn Hospital, Beth Israel Lahey Health, Cambridge, MA, USA; Department of Medicine, Mount Auburn Hospital, Beth Israel Lahey Health, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA.

Background: Inadequate follow-up of suspicious lung nodules can result in diagnostic delays and potential progression to advanced lung cancer. In 2015, a multidisciplinary lung nodule management program, Nodule Net, was implemented to increase the timely follow-up rate. In this study, we sought to evaluate the effectiveness of the program. Read More

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January 2022

The Fluency Trust Residential Course for young people who stutter: A pragmatic feasibility study.

J Commun Disord 2022 Jan 17;95:106181. Epub 2022 Jan 17.

Bristol Speech and Language Therapy Research Unit, North Bristol NHS Trust, Pines and Steps, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, United Kingdom.

Introduction: A feasibility study of The Fluency Trust Residential Course (FTRC) for adolescents who stutter was conducted. The study aimed to measure key areas of a feasibility trial, for example, recruitment and retention, outcome measure completion, outcome measure reliability, and acceptability of the intervention to inform future research into the FTRC.

Methods: Quantitative and qualitative methods were used. Read More

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January 2022

Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism.

Thromb Res 2022 Jan 14;211:10-18. Epub 2022 Jan 14.

Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Universidad Autónoma de Barcelona, Spain.

Background: Bleeding is the most dreaded complication of anticoagulant therapy for acute venous thromboembolism (VTE). Limited data exist about patient characteristics, time course and outcomes of major bleeding, according to the bleeding site.

Methods: We used the data from the Registro Informatizado Enfermedad TromboEmbólica (RIETE) registry (03/2001-07/2018) and identified patients who suffered from major bleeding during anticoagulation. Read More

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January 2022

Pattern of changes in cross sectional area of arterial branches after jailing with pipeline embolization device: beyond parent neck artery patency.

Clin Imaging 2022 Jan 10;83:159-165. Epub 2022 Jan 10.

Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Objective: The Pipeline-Embolization-Device (PED) has been used increasingly for intracranial-aneurysms. Despite the high-patency-rate of jailed branches following PED deployment, little is known about changes in these vessels size. This study measured change in size after PED. Read More

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January 2022

Efficacy of antimicrobial photodynamic therapy in reducing oral yeasts carriage among individuals using electronic nicotine delivery systems.

Photodiagnosis Photodyn Ther 2022 Jan 17:102724. Epub 2022 Jan 17.

Department of Oral Medicine and Radiology, Sharavathi Dental College and Hospital, Shivamogga, Karnataka 577204, India.; Department of Oral Medicine and Radiology, Faculty of Dentistry, Levy Mwanawasa Medical University (LMMU), Ministry of Health, Lusaka 10101, Zambia. Electronic address:

Objective: The aim was to assess the efficacy of antimicrobial photodynamic therapy (aPDT) in reducing oral yeasts carriage among individuals using electronic nicotine delivery systems (ENDS).

Methods: Self-reported ENDS users and non-users (individuals that reported to have never used any nicotinic product) were included. Demographic data was collected using a questionnaire. Read More

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January 2022

An overview of the Connect through PLAY trial to increase physical activity in underserved adolescents.

Contemp Clin Trials 2022 Jan 17:106677. Epub 2022 Jan 17.

Boys and Girls Clubs of the Midlands, Lexington, SC, USA. Electronic address:

Background: The Connect through Positive Leisure Activities for Youth (Connect through PLAY) trial is a prospective, randomized controlled trial implemented within pre-existing afterschool programs (ASPs) comparing a staff-based social development physical activity (PA) program to a health curriculum active control. The efficacy trial aims to improve staff capacity for implementing effective physical activity (PA) programming within ASPs serving underserved youth (minority, low-income) through enhancing the influence of ASP staff as key change agents and addressing the social development needs of adolescents.

Design And Setting: The 5-year cluster randomized trial will involve 30 ASPs that are randomized to either the Connect through PLAY intervention or the active health curriculum control. Read More

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January 2022

Differences in Patient-Reported Outcomes between Anterior and Posterior Approaches for Treatment of Cervical Spondylotic Myelopathy: A Quality Outcomes Database Analysis.

World Neurosurg 2022 Jan 17. Epub 2022 Jan 17.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah. Electronic address:

Objective: Surgery for cervical spondylotic myelopathy (CSM) may use anterior or posterior approaches. Our objective was to compare baseline differences and validated postoperative patient-reported outcome measures between anterior and posterior approaches.

Methods: The NeuroPoint Quality Outcomes Database was queried retrospectively to identify patients with symptomatic CSM treated at 14 high-volume sites. Read More

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January 2022

Effect of charcoal dentifrices on tooth whitening and enamel surface roughness.

Am J Dent 2021 Dec;34(6):295-299

Student Research Program, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA,

Purpose: To evaluate tooth color change and surface roughness after the use of charcoal dentifrices.

Methods: Bovine teeth (n= 64) used for color measurements were stained in tea solution and embedded in acrylic resin. Specimens were randomized into four groups of 16 specimens each. Read More

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December 2021

Cemented versus screw-retained zirconia-based single implant restorations: 5-year results of a randomized controlled clinical trial.

Clin Oral Implants Res 2022 Jan 20. Epub 2022 Jan 20.

Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.

Objectives: to compare cemented and screw-retained one-piece zirconia-based restorations in terms of clinical, radiographic and technical outcomes 5 years after insertion.

Materials And Methods: Thirty-four patients with single-tooth implants were randomly restored with either a cemented lithium disilicate crown on a one-piece customized zirconia abutment (CEM, 17 patients) or a screw-retained crown based on a directly veneered one-piece customized zirconia abutment (SCREW, 16 patients). All patients were recalled for a baseline examination (7 to 10 days after crown insertion) and then annually up 5 years. Read More

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January 2022

Phenotypic and genotypic assessment of antimicrobial resistance in Escherichia coli from Australian cattle populations at slaughter.

J Food Prot 2022 Jan 20. Epub 2022 Jan 20.

CSIRO: Commonwealth Scientific and Industrial Research Organisation 39 Kessels Rd Coopers Plains AUSTRALIA Brisbane 4108.

Australia relies on periodic antimicrobial resistance (AMR) surveys to determine trends and changes in AMR in animal production systems. This study is a follow-up to a survey of E. coli from healthy cattle at slaughter conducted in 2013 which provided baseline data on AMR prevalence across cattle groups and production practices. Read More

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January 2022

Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes.

Diabetes Care 2022 Jan 20. Epub 2022 Jan 20.

Phoenix Veterans Affairs Health Care System, Phoenix, AZ.

Objective: To evaluate the association of a multicomponent advanced glycation end product (AGE) panel with decline in kidney function and its utility in predicting renal function loss (RFL) when added to routine clinical measures in type 2 diabetes.

Research Design And Methods: Carboxymethyl and carboxyethyl lysine and methylglyoxal, 3-deoxyglucosone, and glyoxal hydroimidazolones were measured in baseline serum and plasma samples, respectively, from Action to Control Cardiovascular Risk in Diabetes (ACCORD) (n = 1,150) and Veterans Affairs Diabetes Trial (VADT) (n = 447) participants. A composite AGE score was calculated from individual AGE z scores. Read More

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January 2022

Pain-Free Survival After Endoscopic Rhizotomy Versus Radiofrequency for Lumbar Facet Joint Pain: A Real-World Comparison Study.

Pain Physician 2022 Jan;25(1):E87-E94

Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China.

Background: Endoscopic rhizotomy (ER) of the medial branch has been recently developed for the treatment of lumbar facet joint pain (LFJP). However, there are no studies comparing the pain-free duration after ER and radiofrequency (RF).

Objectives: To evaluate the long-term outcomes for pain and physical function in patients who underwent ER versus RF for LFJP and compare their pain-free survival. Read More

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January 2022

Outcomes of Cervical Therapeutic Medial Branch Blocks and Radiofrequency Neurotomy: Clinical Outcomes and Cost Utility are Equivalent.

Pain Physician 2022 Jan;25(1):35-47

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: Cervical facet joint pain is often managed with either cervical radiofrequency neurotomy, cervical medial branch blocks, or cervical intraarticular injections. However, the effectiveness of each modality continues to be debated. Further, there is no agreement in reference to superiority or inferiority of facet joint nerve blocks compared to radiofrequency neurotomy, even though cervical facet joint radiofrequency neurotomy has been preferred by many and in fact, has been mandated by the Centers for Medicare and Medicaid Services (CMS), except when radiofrequency cannot be confirmed. Read More

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January 2022

Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study.

Pain Physician 2022 Jan;25(1):29-34

Neurological Associates - The Interventional Group, USA, Los Angeles, CA; Department of Neurology, University of California, Los Angeles, CA.

Background: Interventions for chronic discogenic spine pain are currently insufficient in lowering individual patient suffering and global disease burden. A 2016 study of platelet rich plasma (PRP) for chronic discogenic pain previously demonstrated clinically significant response among active group patients compared with controls.

Objectives: To replicate the previous research to move this intervention forward as a viable option for patient care. Read More

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January 2022

Snakebite Associated Thrombotic Microangiopathy and Recommendations for Clinical Practice.

Toxins (Basel) 2022 Jan 14;14(1). Epub 2022 Jan 14.

Clinical Toxicology Research Group, University of Newcastle, Newcastle 2308, Australia.

Snakebite is a significant and under-resourced global public health issue. Snake venoms cause a variety of potentially fatal clinical toxin syndromes, including venom-induced consumption coagulopathy (VICC) which is associated with major haemorrhage. A subset of patients with VICC develop a thrombotic microangiopathy (TMA). Read More

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January 2022

Botulinum Toxin-A Injection in Chronic Pelvic Pain Syndrome Treatment: A Systematic Review and Pooled Meta-Analysis.

Toxins (Basel) 2022 Jan 1;14(1). Epub 2022 Jan 1.

Department of Urology, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona, Piazzale Aristide Stefani 1, 37126 Verona, Italy.

Introduction: Pain management of patients with chronic pelvic pain syndrome (CPPS) is challenging, because pain is often refractory to conventional treatments. Botulinum toxin A (BTX-A) may represent a promising therapeutic strategy for these patients. The aim of this systematic review was to investigate the role of BTX-A in CPPS treatment. Read More

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January 2022

Intermittent Fasting in Weight Loss and Cardiometabolic Risk Reduction: A Randomized Controlled Trial.

J Nurs Res 2022 Feb;30(1):e185

MSc, Clinical Psychologist, Social Services Department, Po Leung Kuk, Fo Tan, Shatin, N.T., Hong Kong SAR, China.

Background: Intermittent fasting is an effective approach to promote weight loss. The optimal model of intermittent fasting in achieving weight management and cardiometabolic risk reduction is an underexplored but important issue.

Purpose: This study was designed to examine the effects of alternate-day fasting (ADF) and 16/8 time-restricted fasting (16/8 TRF) on weight loss, blood glucose, and lipid profile in overweight and obese adults with prediabetes. Read More

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February 2022

A Two-Stage Diabetic Foot Salvage Using Synthetic Bone Void Filler and Lesser Toe Fillet Flap: A Case Report.

JBJS Case Connect 2022 Jan 20;12(1). Epub 2022 Jan 20.

Unity Health, St. Michael's Hospital, Division of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada.

Case: A 54-year-old type 2 diabetic man with a diabetic forefoot ulcer and osteomyelitis successfully underwent a staged reconstruction to salvage his foot. An antibiotic-carrying bone void filler was used to decrease the infection burden after initial debridement. The fifth toe fillet flap was performed to cover the large soft-tissue defect. Read More

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January 2022

Comparison of co-administration of amiodarone and rivaroxaban to co-administration of dronedarone and rivaroxaban for hemorrhage risks after atrial fibrillation ablation.

J Interv Card Electrophysiol 2022 Jan 20. Epub 2022 Jan 20.

Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao , 266000, Shandong, China.

Purpose: To investigate whether co-administration of antiarrhythmic dronedarone and anticoagulant rivaroxaban would increase the risks of hemorrhage after atrial fibrillation (AF) ablation.

Methods: A total of 100 patients with AF who underwent radiofrequency catheter ablation (CA) in the Department of Cardiology, the Affiliated Hospital of Qingdao University from 2019-12 to 2020-11 were included. Patients were divided into an oral dronedarone and rivaroxaban group (D-R group, N = 50) and an oral amiodarone and rivaroxaban group (A-R group, N = 50) according to the postoperative antiarrhythmic and anticoagulation strategies. Read More

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January 2022

Impact of tolvaptan on improvement of tricuspid regurgitation and right ventricular dimension in patients with right-sided heart failure.

Heart Vessels 2022 Jan 20. Epub 2022 Jan 20.

Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Managing right-sided chronic heart failure (CHF) due to tricuspid regurgitation (TR) remains a clinical challenge. Tolvaptan (TLV), a vasopressin V2 receptor inhibitor, is effective in controlling decompensated HF. However, its effects on right-sided CHF caused by TR are unclear. Read More

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January 2022

A GEE model for predicting axial length after cataract surgery in children younger than 2 years of age.

Graefes Arch Clin Exp Ophthalmol 2022 Jan 20. Epub 2022 Jan 20.

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Xueyuan Road, WenZhou, 325102, Zhejiang, China.

Purpose: To develop a model for predicting postoperative axial length (AL) in children undergoing cataract surgery younger than 2 years of age.

Setting: The Eye Hospital of Wenzhou Medical University, Hangzhou, China DESIGN: Retrospective study.

Methods: Children were included only if AL data were available before surgery and at least 1 year after surgery. Read More

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January 2022

Evaluation of Substantial Reduction in Elective Radiotherapy Dose and Field in Patients With Human Papillomavirus-Associated Oropharyngeal Carcinoma Treated With Definitive Chemoradiotherapy.

JAMA Oncol 2022 Jan 20. Epub 2022 Jan 20.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Several de-escalation strategies for human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) have focused on deintensifying gross disease treatment. Reduction of radiotherapy dose and target volume to subclinical regions may achieve good clinical outcomes with favorable patient quality of life (QOL).

Objective: To determine outcomes from a systematic approach of reducing radiotherapy dose and target volume to the elective treatment regions in patients with HPV-associated OPC undergoing concurrent chemoradiotherapy (CCRT). Read More

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January 2022

Early Readout on Overall Survival of Patients With Melanoma Treated With Immunotherapy Using a Novel Imaging Analysis.

JAMA Oncol 2022 Jan 20. Epub 2022 Jan 20.

Department of Radiology, Columbia University Medical Center, New York, New York.

Importance: Existing criteria to estimate the benefit of a therapy in patients with cancer rely almost exclusively on tumor size, an approach that was not designed to estimate survival benefit and is challenged by the unique properties of immunotherapy. More accurate prediction of survival by treatment could enhance treatment decisions.

Objective: To validate, using radiomics and machine learning, the performance of a signature of quantitative computed tomography (CT) imaging features for estimating overall survival (OS) in patients with advanced melanoma treated with immunotherapy. Read More

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January 2022

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

JAMA Oncol 2022 Jan 20. Epub 2022 Jan 20.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Extramammary Paget disease (EMPD) is a frequently recurring malignant neoplasm with metastatic potential that presents in older adults on the genital, perianal, and axillary skin. Extramammary Paget disease can precede or occur along with internal malignant neoplasms.

Objective: To develop recommendations for the care of adults with EMPD. Read More

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January 2022

[Case of endovenectomy and stenting with functioning arteriovenous fistula in extended post-thrombotic occlusion of deep veins].

Angiol Sosud Khir 2021 ;27(4):146-151

Department of Vascular Surgery, Interregional Clinical Diagnostic Centre, Kazan, Russia.

We describe herein a case of surgical treatment of a 32-year-old female patient presenting with multilevel post-thrombotic occlusion of deep veins of the left lower limb. Laboratory study revealed high-risk hereditary thrombophilia (homozygous mutation of PAI-1, MTR, heterozygous mutation of MTHFR, MTRR, ITGA2). The first stage included endovenectomy from the common femoral vein with creation of an arteriovenous fistula between femoral vessels. Read More

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January 2021

Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy.

J Cardiovasc Dev Dis 2022 Jan 11;9(1). Epub 2022 Jan 11.

Advanced Heart Failure Unit, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

Aims: Non-ischaemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular (LV) chamber enlargement and systolic dysfunction in the absence of coronary artery disease. Left ventricular reverse remodelling (LVRR) is the ability of a dilated ventricle to restore its normal size, shape and function. We sought to determine the frequency, clinical predictors and prognostic implications of LVRR, in a cohort of heart failure (HF) patients with NIDCM. Read More

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January 2022