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The Natural History of Insomnia: Predisposing, precipitating, coping and perpetuating factors over the early developmental course of insomnia.

Sleep 2021 Apr 13. Epub 2021 Apr 13.

School of Psychology, University of Glasgow, Glasgow, UK.

While there is an extensive literature on predisposing, precipitating, coping and perpetuating factors in those with chronic insomnia, very little work has been undertaken to evaluate these factors over the early developmental course of insomnia. The present aim was to determine whether several hypothesized factors in each domain (predisposing, precipitating, coping and perpetuating), assessed during an episode of acute insomnia, are related to its persistence or remission to normal sleep. Participants comprised n = 140 people with acute insomnia and n = 737 normal sleepers recruited from the general public. Read More

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Estimating population lung cancer risk from radon using a resource efficient stratified population weighted sample survey protocol - Lessons and results from Ireland.

J Environ Radioact 2021 Apr 10;233:106582. Epub 2021 Apr 10.

Environmental Protection Agency, McCumiskey House, Richview, Clonskeagh, Dublin 14, Ireland.

A 2018 estimate indicates that there were 226,057 radon-attributable lung cancer deaths in 66 countries that had representative radon surveys. This is a shocking figure, and as it comes from only 66 countries it underestimates the worldwide death toll. Any research that enables countries to conduct representative radon surveys and to understand better the risk to citizens from radon is surely welcome. Read More

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C5 Palsy after Cervical Laminectomy: Natural History in a 10 year Series.

Spine J 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurosurgery, Loyola University Medical Center, 2160 S 1(st) Ave Maywood, IL, USA. Electronic address:

Background Context: C5 palsy is a well-known complication following cervical laminectomy, however the cause of this complication remains elusive, with many studies providing conflicting reports on prognosis and the impact of specific risk factors.

Purpose: To describe the natural history of and risk factors for C5 palsy after first time cervical laminectomy involving C4 and/or C5, in a large series with a high rate of postoperative palsy.

Study Design/setting: This is a retrospective case series. Read More

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The risks of recurrent small for gestational age infants at term is dependent on the number of previous affected births.

Am J Obstet Gynecol 2021 Apr 10. Epub 2021 Apr 10.

Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Faculty of Medicine, The University of Queensland, Australia,. Electronic address:

Background: Small-for-gestational age (SGA) infants are at significantly increased risk of perinatal complications, but the risk of recurrent SGA is not well known, particularly as there are many demographic and obstetric factors that interact and modify this risk. We investigated the relationship between previous SGA births and the risk of recurrence at term in a large Australian cohort.

Objective(s): We aimed to identify key demographic and obstetric variables that influence the risk of recurrence of an SGA infant at term. Read More

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The effect of plaque control in the treatment of Oral Lichen Planus with gingival manifestations: a Systematic Review.

Community Dent Health 2021 Apr 9. Epub 2021 Apr 9.

Centre for Host Microbiome Interactions, Kings College, London.

Background: Oral lichen planus (OLP) is a chronic autoimmune disease that frequently affects the oral mucosa. Patients with OLP tend to present with plaque accumulation which may further exacerbate the lichenoid lesion, thus plaque control may improve the quality of life of patients. The aim of this review was to test the effect of plaque control on OLP with gingival manifestations. Read More

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Telerehabilitation During the Covid-19 Pandemic in Outpatient Rehabilitation Settings: A Descriptive Study.

Phys Ther 2021 Apr 13. Epub 2021 Apr 13.

Net Health Systems, Inc., Pittsburgh PA, USA.

Objective: COVID-19 has widely affected delivery of health care. In response, telerehabilitation (TR) has emerged as alternative care model. Aims were: (1) describe baseline patient characteristics and available unadjusted outcomes for episodes of care administered during COVID-19 using TR vs. Read More

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Comparative Efficacy and Safety of Ozanimod and Dimethyl Fumarate for Relapsing-Remitting Multiple Sclerosis Using Matching-Adjusted Indirect Comparison.

CNS Drugs 2021 Apr 13. Epub 2021 Apr 13.

Bristol Myers Squibb, Princeton, NJ, USA.

Background: Patients with multiple sclerosis (MS) experience relapses and sustained disability progression. Since 2004, the number of disease-modifying therapies (DMTs) for MS has grown substantially. As a result, patients, healthcare providers, and insurers are increasingly interested in comparative efficacy and safety evaluations to distinguish between treatment options, but head-to-head studies between DMTs are limited. Read More

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