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Enhanced arm swing improves Parkinsonian gait with EEG power modulations resembling healthy gait.

Parkinsonism Relat Disord 2021 Sep 15;91:96-101. Epub 2021 Sep 15.

Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, POB 30.001, Groningen, the Netherlands. Electronic address:

Background: The supplementary motor area (SMA) is implicated in stereotypic multi-limb movements such as walking with arm swing. Gait difficulties in Parkinson's Disease (PD) include reduced arm swing, which is associated with reduced SMA activity.

Objective: To test whether enhanced arm swing improves Parkinsonian gait and explore the role of the SMA in such an improvement. Read More

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September 2021

Bone and fat hormonal crosstalk with antiretroviral initiation.

Bone 2021 Sep 18:116208. Epub 2021 Sep 18.

Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, IL. Electronic address:

Background: Bone mineral density (BMD) loss and fat gain is common in people living with HIV (PLWH), particularly after initiating combination antiretroviral therapy (cART). Given the close metabolic interaction between bone and fat, we tested the hypotheses that changes in bone-derived hormones are associated with fat accumulation and changes in fat-derived hormones are associated with BMD loss following cART initiation.

Methods: HIV-seropositive subjects (n=15) initiating fixed dose cART of tenofovir disoproxil fumarate/emtricitabine/efavirenz (TDF/FTC/EFV) underwent dual x-ray absorptiometry (DXA) assessment pre-cART and again 12-months post-cART initiation. Read More

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September 2021

Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: a ten-year follow-up study.

Diabetes Metab 2021 Sep 18:101282. Epub 2021 Sep 18.

Dpt.Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address:

Aims: To assess the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) at 10 years of follow-up and analyze predictive factors.

Materials And Methods: Eighty-eight obese subjects undergoing Roux-en-Y gastric bypass (RYGB) and 25 subjects assigned to medical therapy (MT) were evaluated every year for 10 years. T2DM remission was defined by the American Diabetes Association criteria. Read More

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September 2021

Effect of adding clonidine to lidocaine on ocular hemodynamics during sub-tenon's anesthesia: randomized double-blind study.

Braz J Anesthesiol 2021 Sep 18. Epub 2021 Sep 18.

Universidade Federal de Minas Gerais, Departamento de Cirurgia, Belo Horizonte, MG, Brazil. Electronic address:

Introduction And Objectives: Different regional anesthesia techniques for ophthalmology can have hemodynamic effects on the eye. We assessed the effects of adding clonidine to lidocaine on Intraocular Pressure (IOP), Ocular Pulse Amplitude (OPA) and Ocular Perfusion Pressure (OPP) after the sub-Tenon's technique for cataract surgery.

Methods: The study included 40 patients randomly allocated into two groups -sub-Tenon's blockade with Lidocaine plus Saline Solution (LS) or Lidocaine plus Clonidine (LC). Read More

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September 2021

Aberrant Lumbopelvic Movements Predict Prospective Functional Decline in Older Adults with Chronic Low Back Pain.

Arch Phys Med Rehabil 2021 Sep 18. Epub 2021 Sep 18.

Department of Physical Therapy, University of Delaware, Newark, DE. Electronic address:

Objective: To investigate if clinically observable aberrant lumbopelvic movements are associated with physical function at 12-month follow-up in older adults with chronic low back pain (CLBP), both directly and indirectly through baseline physical function.

Design: Secondary analysis of a yearlong prospective cohort study.

Setting: Clinical Research Laboratory. Read More

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September 2021

Comparison of kinesio taping and manual therapy in treatment of patients with bruxism using shear wave ultrasonography-a randomized clinical trial.

Int J Clin Pract 2021 Sep 21:e14902. Epub 2021 Sep 21.

Ankara University, Faculty of Dentistry, Ankara, Turkey.

Background: Bruxism is significantly associated with craniofacial pain, feeling of stiffness or fatigue of the jaw and neck pain. Various physiotherapeutic strategies are used in the treatment of bruxism; however, it is not clear which method leads to greater decrease in pain.

Objective: The aim of this study is to compare the effects of two physiotherapy methods (manual therapy (MT) and Kinesio taping with manual therapy (KTMT)) in patients with bruxism. Read More

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September 2021

Long term follow-up of SARS-CoV-2 recovered renal transplant recipients: A single-centre experience from India.

Transpl Infect Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, India.

Introduction: Follow-up studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in kidney transplant recipients (KTR) are scarcely reported.

Methods: We studied 142 hospitalized KTR for a median (interquartile range) follow-up of 9(8-11) months who recovered from SARS-CoV-2 during May 2020 to Dec 2020.The outcomes were to assess persistent symptoms post-discharge; EuroQoL visual analogue score (EQ-VAS); EuroQoL 5-dimension score (E5-QD-5L) score and modified medical research Dyspnea score (mMRC) at 1-month, 3-month and beyond 6 months. Read More

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September 2021

Mean Versus Variability: Disentangling Stress Effects on Alcohol Lapses Among Individuals in the First Year of Alcohol Use Disorder Recovery.

J Stud Alcohol Drugs 2021 Sep;82(5):623-628

Department of Psychology, Colorado State University, Fort Collins, Colorado.

Objective: Although stress is a well-known predictor of alcohol use lapses among individuals seeking recovery from alcohol use disorder (AUD), most research has relied on retrospective self-report using conventional questionnaires that explore stress effects at the level of the mean. Ecological momentary assessment (EMA) overcomes many of the shortcomings of questionnaire-based, retrospective self-report by using real-time, in-the-environment evaluations for the acquisition of ecologically valid data that can also capture stress variability. The present investigation used EMA to disentangle stress effects on alcohol lapses among individuals in the first year of an AUD recovery attempt by exploring associations between mean-level stress, stress variability, and subsequent alcohol use. Read More

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September 2021

Predictors of visual outcome in post-fever retinitis: a retrospective analysis.

Int Ophthalmol 2021 Sep 21. Epub 2021 Sep 21.

Department of Vitreo-Retina, Sankara Eye Hospital, Harakere, Shimoga, Karnataka, 577202, India.

Purpose: To identify the predictors of final visual outcome in cases with post-fever retinitis (PFR).

Methods: This is a retrospective study of cases with diagnosis of post-fever retinitis. Colour fundus photograph and optical coherence tomography (OCT) parameters at presentation and final visit were analysed. Read More

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September 2021

Impact of renin-angiotensin system inhibitors on long-term clinical outcomes of patients with rheumatic heart disease.

ESC Heart Fail 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Aims: Rheumatic heart disease (RHD) remains a major global health problem. Renin-angiotensin-aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role in RHD patients is still limited. We performed a retrospective study to determine the effect of RAASi on long-term outcomes for RHD patients. Read More

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September 2021

Inhaled Beta2-Agonists Increase In-Hospital Mortality in ICU Patients with Heart Failure.

Int Heart J 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiovascular Medicine, The Third Affiliated Hospital, Sun Yat-sen University.

The impact of beta2-agonists (B2As) on heart failure (HF) remains controversial. This study aimed to investigate whether inhaled B2As increased in-hospital mortality in ICU patients with HF.The Multiparameter Intelligent Monitoring in Intensive Care III database was initially searched to identify adult patients (≥ 18 years old) with HF in ICU. Read More

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September 2021

Improving documentation of prescriptions for as-required medications in hospital inpatients.

BMJ Open Qual 2021 Sep;10(3)

School of Medicine, University of Dundee, Dundee, UK.

It is estimated that 1 in 10 hospital inpatients in Scotland have experienced a medication error. In our unit, an audit in 2019 identified documentation of as-required prescriptions on drug Kardexes as an important target for improvement. This project aimed to reduce the percentage of these errors to <5% in the ward in 6 months. Read More

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September 2021

Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study.

Lipids Health Dis 2021 Sep 20;20(1):109. Epub 2021 Sep 20.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Medical Oncology, Guangdong Esophageal Cancer Institute, Sun Yat- sen University Cancer Center, 510060, Guangzhou, People's Republic of China.

Background: Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown.

Methods: NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy. Read More

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September 2021

Antioxidant enzymes and weight gain in drug-naive first episode schizophrenia patients treated with risperidone for 12 weeks: a prospective longitudinal study.

Curr Neuropharmacol 2021 Sep 19. Epub 2021 Sep 19.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing. China.

Oxidative stress plays an important role in weight gain induced by antipsychotics in schizophrenia (SCZ). However, little is known about how antioxidant enzymes are involved in weight gain caused by risperidone monotherapy in antipsychotics-naïve first-episode (ANFE) patients with SCZ. Therefore, the main purpose of this study was to investigate the effects of risperidone on several antioxidant enzymes in patients with ANFE SCZ and the relationship between weight gain and changes in antioxidant enzyme activities. Read More

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September 2021

Reboxetine plus Oxybutynin for Obstructed Sleep Apnea Treatment A 1-week Randomized, Placebo-controlled, Double-Blind Crossover Trial.

Chest 2021 Sep 17. Epub 2021 Sep 17.

Istituto Auxologico Italiano, IRCCS, Sleep Disorders Center & Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Background: The recent discovery that a combination of noradrenergic and antimuscarinic drugs improved upper airway muscle function during sleep and reduced obstructive sleep apnea (OSA) severity has revitalized interest in pharmacological therapies for OSA.

Research Question: Would 1-week of reboxetine plus oxybutynin be effective on OSA severity?

Study Design And Methods: We performed a randomized, placebo-controlled, double-blind, crossover trial comparing 4 mg reboxetine plus 5 mg oxybutynin (reb-oxy) to placebo in OSA subjects. After a baseline in-lab polysomnogram (PSG), patients performed PSGs after 7 nights of reb-oxy and 7 nights of placebo to compare apnea-hypopnea index (AHI, primary outcome). Read More

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September 2021

Physical Resilience in Daily Functioning Among Acutely Ill Hospitalized Older Adults: The Hospital-ADL Study.

J Am Med Dir Assoc 2021 Sep 17. Epub 2021 Sep 17.

Amsterdam UMC, University of Amsterdam, Internal Medicine, Section of Geriatric Medicine, Amsterdam Public Health Research Institute, Amsterdam, Netherlands; ACHIEVE - Centre of Applied Research, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, Netherlands.

Objectives: Insight into older adults' physical resilience is needed to predict functional recovery after hospitalization. We assessed functional trajectories in response to acute illness and subsequent hospitalization and investigated baseline variables and dynamic variables associated with these trajectories.

Design: Prospective observational cohort study (Hospitalization-Associated Disability and impact on daily Life Study). Read More

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September 2021

Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models.

PLoS One 2021 20;16(9):e0257694. Epub 2021 Sep 20.

Comparative Medicine, Pfizer Worldwide Research, Development & Medical, San Diego, California, United States of America.

In oncology research, while xenograft tumor models are easily visualized and humane endpoints can be clearly defined, metastatic tumor models are often based on more subjective clinical observations as endpoints. This study aimed at identifying objective non-invasive criteria for predicting imminent distress and mortality in metastatic lung tumor-bearing mice. BALB/c and C57BL/6 mice were inoculated with CT26 or B16F10 cells, respectively. Read More

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September 2021

Case 294: Catastrophic Antiphospholipid Syndrome.

Radiology 2021 Oct;301(1):242-246

From the Departments of Radiology (M.G., M.B., M.P.R.) and Internal Medicine (N.C.C.), Cochin Hospital, APHP.Centre, 27 Rue du Fg St Jacques, Paris 75014, France; and Université de Paris, Paris, France (M.B., N.C.C., M.P.R.).

History A 50-year-old woman presented to the emergency department of our hospital with a 2-day history of lower limb pain associated with unusual asthenia and diffuse arthralgia over the past 3 weeks. She was a native of Guinea and had lived in France for most of her life, working as a personal care assistant. Her only medical history of note was an occurrence of fetal death at 12 weeks gestation when she was 35 years old. Read More

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October 2021

Reevaluating clinical assessment outcomes after unrestricted return to play following sport-related concussion.

Brain Inj 2021 Sep 20:1-7. Epub 2021 Sep 20.

UVA Department of Kinesiology, The University of Virginia, Charlottesville, Virginia, USA.

Primary Objective: The objective of this study was to examine neurocognition, postural control, and symptomology at multiple timepoints following concussion. We hypothesized that collegiate athletes would perform similar to or better than their baseline in terms of each outcome at both timepoints.

Research Design: This was a retrospective study of 71 collegiate athletes (18. Read More

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September 2021

Prevention of work-related stress, fatigue, loss of cognitive function, attention and recovery of stamina with Robuvit® in professionals with increased oxidative stress.

Minerva Med 2021 Sep 20. Epub 2021 Sep 20.

RADIOLOGY INSTITUTE Dpt. Sc Med or Biotec, Ch-Pe University, Pescara, Italy.

Aim: The aim of this open, pilot supplement registry study was to evaluate the protective, preventive effects of Robuvit® on professional-related fatigue symptoms and on aspects of cognitive functions, professional attitudes and decision-making in healthy nurses under professional stress and with increased oxidative stress.

Results: In total, 40 subjects, aged 30 - 37, completed the 4-week registry study. A control group of 20 subjects used only the standard management (SM) and one group of 20 subjects took 300 mg Robuvit®. Read More

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September 2021

Quality of Care Before and After Mergers and Acquisitions of Rural Hospitals.

JAMA Netw Open 2021 Sep 1;4(9):e2124662. Epub 2021 Sep 1.

IBM Watson Health, Rochester, New York.

Importance: Rural hospitals are increasingly merging with other hospitals. The associations of hospital mergers with quality of care need further investigation.

Objectives: To examine changes in quality of care for patients at rural hospitals that merged compared with those that remained independent. Read More

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September 2021

The impact of experimental pain on shoulder movement during an arm elevated reaching task in a virtual reality environment.

Physiol Rep 2021 Sep;9(18):e15025

Faculty of Medicine, Université Laval, Quebec City, Canada.

Background: People with chronic shoulder pain have been shown to present with motor adaptations during arm movements. These adaptations may create abnormal physical stress on shoulder tendons and muscles. However, how and why these adaptations develop from the acute stage of pain is still not well-understood. Read More

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September 2021

The Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Cardiovascular Risk Biomarkers in Patients with Type 2 Diabetes: a Post-Hoc Analysis.

Diabetes Obes Metab 2021 Sep 20. Epub 2021 Sep 20.

Eli Lilly and Company, Indianapolis, Indiana, USA.

In a phase 2 trial of once-weekly tirzepatide (1, 5, 10, or 15 mg), dulaglutide (1.5 mg), or placebo, the dual GIP and GLP-1 receptor agonist tirzepatide dose-dependently reduced HbA1c and body weight in patients with type 2 diabetes. In this post-hoc analysis, inflammation, endothelial dysfunction, and cellular stress biomarkers were measured at baseline, 4, 12, and 26 weeks to evaluate additional effects of tirzepatide on cardiovascular risk factors. Read More

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September 2021

The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging.

Ther Adv Respir Dis 2021 Jan-Dec;15:17534666211046774

Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Background: Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cystic fibrosis (CF) lung remain unclear. This study aims to offer novel information on the mode of action of the cystic fibrosis transmembrane conductance regulator (CFTR)-modulating drug by assessing lung structure and function using functional respiratory imaging (FRI).

Methods: CF patients aged ⩾12 years homozygous for were recruited in an open-label study. Read More

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September 2021

Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.

Hum Psychopharmacol 2021 Sep 20:e2818. Epub 2021 Sep 20.

Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Nagoya, Japan.

Objective: The aim of this study was evaluation of the association between severity of pain and expression of total or ubiquitinated serotonin transporter (SERT) protein in patients with burning mouth syndrome and atypical odontalgia (BMS/AO), who were treated by duloxetine.

Methods: Patients with BMS/AO were assessed for severity of pain using the visual analog scale (VAS), and expression of total and ubiquitinated SERT protein in platelets before (baseline) and 12 weeks after duloxetine-treatment.

Results: The expression of total and ubiquitinated SERT protein at baseline in all patients (n = 33) were higher and lower, respectively, compared to those in healthy controls. Read More

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September 2021

Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomised, double-blinded, placebo-controlled clinical trial.

EClinicalMedicine 2021 Oct 11;40:101124. Epub 2021 Sep 11.

Universidad San Francisco de Quito (USFQ), Quito, Ecuador.

Background: Androgenetic alopecia (AGA) is the most common hair loss disorder seen in men. It can have an early onset but has also been associated with ageing and senescence. It often induces pronounced psychological impact. Read More

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October 2021

Is analysis of inflammatory biomarkers and lymphocyte subpopulations useful in prediction of tuberculosis treatment outcomes?

J Clin Tuberc Other Mycobact Dis 2021 Dec 8;25:100275. Epub 2021 Sep 8.

Department of Internal Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 Kaunas, Lithuania.

Analysis of inflammatory biomarkers and lymphocytes during the treatment of tuberculosis (TB) could yield findings that influence the routine clinical practice and use of new anti-TB drugs. This study aimed to evaluate whether the selected biomarkers-soluble intercellular adhesion molecule type 1, soluble urokinase-type plasminogen activator receptor (suPAR), and C-reactive protein (CRP)-and T-cell subpopulations are useful for predicting culture conversion, treatment outcomes, and the extent of radiological lesions (calculated using X-ray score) in patients with drug-sensitive pulmonary TB. This study included 62 patients with drug-sensitive pulmonary TB. Read More

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December 2021

Denosumab versus zoledronate for the treatment of low bone mineral density in male HIV-infected patients.

Bone Rep 2021 Dec 10;15:101128. Epub 2021 Sep 10.

Endocrinology Unit, 1 Department of Propedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, LAIKO General Hospital of Athens, Greece.

Introduction: We aimed to compare annual changes in the bone mineral density (BMD) at the lumbar spine (LS) and the femoral neck (FN) in males with HIV-associated osteoporosis treated with either zoledronate (ZOL) or denosumab (Dmab).

Methods: In this open label, 12-month, prospective, multicenter, cohort study, 23 male people living with HIV (PLWH) under (ART) with low BMD were administered either a single iv infusion of ZOL 5 mg ( = 10) or Dmab 60 mg sc injections biannually ( = 13). Fourteen age-matched male PLWH with normal BMD served as controls. Read More

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December 2021

Peripheral Blood Biomarkers Associated With Improved Functional Outcome in Patients With Chronic Left Ventricular Dysfunction: A Biorepository Evaluation of the FOCUS-CCTRN Trial.

Front Cardiovasc Med 2021 3;8:698088. Epub 2021 Sep 3.

Regenerative Medicine Department, Texas Heart Institute, Houston, TX, United States.

Cell therapy trials for heart failure (HF) have shown modest improvement; however, the mechanisms underlying improvement in some patients but not others are not well understood. Although immune cells are important in the course of HF, our understanding of the immune processes in HF is limited. The objective of this study was to evaluate associations between temporal changes in peripheral blood (PB) cell subpopulations and improved outcome in patients with chronic ischemic cardiomyopathy after bone marrow-derived mononuclear cell therapy or placebo in the FOCUS-CCTRN trial. Read More

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September 2021

Analogs of microgravity: the function of Schlemm's canal, intraocular pressure and autonomic nervous during the head-down tilt test in healthy subjects.

Int J Ophthalmol 2021 18;14(9):1419-1423. Epub 2021 Sep 18.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.

Aim: To evaluate the ocular outcomes and to elucidate possible mechanisms underlying intraocular pressure (IOP) change following the head-down tilt (HDT) test.

Methods: The study included 21 participants at the Department of Ophthalmology of Tongji Hospital. Subjects received the test of I-care tonometry, enhanced depth imaging optical coherence tomography and heart rate variability (HRV) analysis before and after 15min HDT test. Read More

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September 2021