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Evaluation of an mHealth-enabled hierarchical diabetes management intervention in primary care in China (ROADMAP): A cluster randomized trial.

PLoS Med 2021 Sep 21;18(9):e1003754. Epub 2021 Sep 21.

The George Institute for Global Health at Peking University Health Science Center, Beijing, China.

Background: Glycemic control remains suboptimal in developing countries due to critical system deficiencies. An innovative mobile health (mHealth)-enabled hierarchical diabetes management intervention was introduced and evaluated in China with the purpose of achieving better control of type 2 diabetes in primary care.

Methods And Findings: A community-based cluster randomized controlled trial was conducted among registered patients with type 2 diabetes in primary care from June 2017 to July 2019. Read More

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September 2021

Impact of COVID-19 on gastroenterology fellowship training: a multicenter analysis of endoscopy volumes.

Endosc Int Open 2021 Oct 16;9(10):E1572-E1578. Epub 2021 Sep 16.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.

The COVID-19 pandemic has had a profound impact on gastroenterology training programs. We aimed to objectively evaluate procedural training volume and impact of COVID-19 on gastroenterology fellowship programs in the United States. This was a retrospective, multicenter study. Read More

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October 2021

Climate change, extreme events, and increased risk of salmonellosis: foodborne diseases active surveillance network (FoodNet), 2004-2014.

Environ Health 2021 09 18;20(1):105. Epub 2021 Sep 18.

Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, 2234F SPH Building #255, College Park, MD, 20742, USA.

Background: Infections with nontyphoidal Salmonella cause an estimated 19,336 hospitalizations each year in the United States. Sources of infection can vary by state and include animal and plant-based foods, as well as environmental reservoirs. Several studies have recognized the importance of increased ambient temperature and precipitation in the spread and persistence of Salmonella in soil and food. Read More

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September 2021

Influence of white matter lesions on the prognosis of acute cardioembolic stroke without reperfusion therapy.

BMC Neurol 2021 Sep 18;21(1):364. Epub 2021 Sep 18.

Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, 321# Middle Zhongshan Road, Jiangsu Province, 210008, Nanjing, China.

Background: Few studies have investigated the influence of white matter lesions (WMLs) on the prognosis of acute cardioembolic stroke (CES). We aimed to explore the role of WMLs in predicting 3-month prognosis of CES without reperfusion therapy.

Methods: A number of 251 acute CES patients without reperfusion therapy at a single center were retrospectively recruited. Read More

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September 2021

The cognitive anxiety sensitivity treatment (CAST) in anxiety prevention - Focus on separation anxiety and interoception.

Eur Neuropsychopharmacol 2021 Sep 15;53:104-113. Epub 2021 Sep 15.

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Given the high prevalence and considerable clinical and societal burden of anxiety disorders, preventive measures are urgently warranted to reduce their incidence and overall healthcare impact. Anxiety sensitivity (AS) - a key element in learning theories of anxiety disorders in the context of interoceptive conditioning - constitutes a malleable risk factor of particularly panic disorder and separation anxiety, which share developmental, nosological, epidemiological and pathomechanistic characteristics. The computer-assisted 'Cognitive Anxiety Sensitivity Treatment' (CAST) targeting interoceptive anxiety symptoms (cf. Read More

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September 2021

Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.

Theriogenology 2021 Aug 15;175:100-110. Epub 2021 Aug 15.

Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary.

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model of gonadotropin-dependent infertility. Serum testosterone and AMH concentrations were studied in five adult male Beagles implanted (day 0) with 4. Read More

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Randomized Controlled Trial of a Dichoptic Digital Therapeutic for Amblyopia.

Ophthalmology 2021 Sep 14. Epub 2021 Sep 14.

Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.

Purpose: Digital therapeutics are a new class of interventions that are software-driven and intended to treat various conditions. We developed and evaluated a dichoptic digital therapeutic for amblyopia, a neurodevelopmental disorder for which current treatments may be limited by poor adherence and residual vision deficits.

Design: Randomized controlled trial. Read More

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September 2021

The Association Between Service Connection and Treatment Outcome in Veterans Undergoing Residential PTSD Treatment.

Psychiatr Q 2021 Sep 17. Epub 2021 Sep 17.

VA Center for Clinical Management Research, VA Ann Arbor Healthcare System/Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

The Department of Veterans Affairs has invested significant time and resources into the treatment of posttraumatic stress disorder (PTSD). Despite concerted efforts, a significant portion of patients do not respond optimally to trauma-focused treatment. One of the factors that has been hypothesized to be associated with treatment response is participation in the Veterans Benefits Administration service-connected disability process. Read More

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September 2021

A randomized placebo-controlled study: Phellodendron Bawei tablets combined with standard management can improve storage symptoms, sleep quality, and medication compliance in patients with benign prostatic hyperplasia compared to placebo with standard management.

Transl Androl Urol 2021 Aug;10(8):3423-3431

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common micturition disorder in middle-aged and elderly males, and it is one of the most common urology-related diseases worldwide. However, standard therapeutic drugs (α1-receptor blockers + 5α reductase inhibitors) do not provide anti-inflammatory or anti-infective effects. The Phellodendron Bawei tablet is a proprietary Chinese medicine with anti-inflammatory and anti-infective effects. Read More

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Long term dual antiplatelet therapy after myocardial infarction: retrospective analysis in an outpatient population.

Monaldi Arch Chest Dis 2021 Sep 16. Epub 2021 Sep 16.

Cardiology/ICU Department, S. Gennaro Hospital, Naples.

Long term treatment with ticagrelor 60 mg and low-dose aspirin are indicated after acute coronary syndrome (ACS). We retrospectively reviewed aggregate data of 187 patients (155 M and 38 F) (mean age 63.8±9 years) in follow up after ACS with at least one high risk condition (Multivessel disease, diabetes, GFR<60 mL/min, history of prior myocardial infarction, age >65 years) treated with ticagrelor 60 mg twice daily (after 90 mg twice daily for 12 months). Read More

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September 2021

Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans.

mSystems 2021 Sep 14:e0096421. Epub 2021 Sep 14.

Institute for Systems Biologygrid.64212.33, Seattle, Washington, USA.

Recent human feeding studies have shown how the baseline taxonomic composition of the gut microbiome can determine responses to weight loss interventions. However, the functional determinants underlying this phenomenon remain unclear. We report a weight loss response analysis on a cohort of 105 individuals selected from a larger population enrolled in a commercial wellness program, which included healthy lifestyle coaching. Read More

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September 2021

Association of Quality of Life Measures and Otolaryngologic Care in Cystic Fibrosis Patients.

Ann Otol Rhinol Laryngol 2021 Sep 11:34894211045636. Epub 2021 Sep 11.

Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Objectives: Appropriate management of chronic rhinosinusitis (CRS) among patients with cystic fibrosis (CF) is important in improving quality of life. Otolaryngologists play a critical role in reducing CRS symptom burden. This study seeks to evaluate the role of patient-reported quality-of-life measures in guiding interventions for CF-related sinus disease. Read More

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September 2021

Hyperreflective foci as important prognostic indicators of progression of retinitis pigmentosa.

Retina 2021 Sep 6. Epub 2021 Sep 6.

Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.

Purpose: To investigate the presence and clinical relevance of hyperreflective foci (HRFs) in retinitis pigmentosa (RP).

Methods: Seventy-seven RP cases were retrospectively reviewed. The 10-mm wide cross-line macular scans in optical coherent tomography (OCT) were acquired. Read More

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September 2021

Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England.

BMJ Open 2021 09 8;11(9):e042483. Epub 2021 Sep 8.

William Harvey Research Institute, Queen Mary University of London, London, UK

Objectives: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high.

Design: We developed a Bayesian model to infer incident cases and reproduction number () in England, from incident death data. We then used this to forecast excess cases and deaths in multiple plausible scenarios in which increases at one or more time points. Read More

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September 2021

CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater.

J Headache Pain 2021 Sep 8;22(1):105. Epub 2021 Sep 8.

Institute of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nürnberg, Universitätsstr. 17, D-91054, Erlangen, Germany.

Background: Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks. Increased CGRP levels have been observed in different extracellular fluid compartments during primary headaches such as migraine but it is not entirely clear how CGRP is drained from the meninges.

Methods: We have used an in vivo preparation of the rat to examine after which time and at which concentration CGRP applied onto the exposed parietal dura mater appears in the jugular venous blood and the cerebrospinal fluid (CSF) collected from the cisterna magna. Read More

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September 2021

Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients.

Hematology 2021 Dec;26(1):684-690

National Orthopedic Hospital Enugu, Enugu, Nigeria.

Background: Sickle cell anaemia affects about 4 million people across the globe, making it an inherited disorder of public health importance. Red cell lysis consequent upon haemoglobin crystallization and repeated sickling leads to anaemia and a baseline strain on haemopoiesis. Vaso-occlusion and haemolysis underlies majority of the chronic complications of sickle cell. Read More

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December 2021

Working memory training for adult glioma patients: a proof-of-concept study.

J Neurooncol 2021 Sep 7. Epub 2021 Sep 7.

Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA.

Background: CogMed Working Memory Training (CWMT) is a computer-based program shown to improve working memory (WM) among those with cognitive impairments. No study to date has investigated its feasibility, acceptability, and satisfaction in adult patients with glioma, despite the well-documented incidence of WM impairment in this population.

Methods: Twenty patients with glioma and objective and/or perceived WM deficits enrolled in the study: 52% high-grade, 60% female, Mage = 47 (range = 21-72 years). Read More

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September 2021

Identifying the Phenotypic and Temporal Heterogeneity of Knee Osteoarthritis: Data From the Osteoarthritis Initiative.

Front Public Health 2021 19;9:726140. Epub 2021 Aug 19.

School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, United States.

Previous studies discussing phenotypic and temporal heterogeneity of knee osteoarthritis (KOA) separately have fatal limitations that either clustering patients with similar severity or assuming all knees have a single common progression pattern, which are unreliable. This study tried to uncover more reliable information on phenotypic and temporal heterogeneity of KOA. Data were from Osteoarthritis Initiative database. Read More

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Cross-education and detraining effects of eccentric vs. concentric resistance training of the elbow flexors.

BMC Sports Sci Med Rehabil 2021 Sep 6;13(1):105. Epub 2021 Sep 6.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Niigata, Japan.

Background: Unilateral resistance training increases the strength of the contralateral non-trained homologous muscles known as the cross-education effect. We tested the hypothesis that unilateral eccentric resistance training (ET) would induce greater and longer-lasting cross-education effect when compared with concentric resistance training (CT).

Methods: Young (20-23 y) participants were allocated to ET (5 males, 4 females) or CT (5 males, 4 females) group that performed unilateral progressive ET or CT of the elbow flexors, twice a week for 5 weeks (10 sessions) followed by a 5-week detraining, and control group (7 males, 6 females) that did not perform any training. Read More

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September 2021

The impact of Technetium-99m dimercapto-succinic acid scintigraphy on DNA damage and oxidative stress in children.

Int J Clin Pract 2021 Sep 6:e14810. Epub 2021 Sep 6.

Urology Department, Medical Faculty Alanya Practice and Research Center, Başkent University, Antalya, Turkey.

Background: Technetium-99m-dimercapto succinic acid (Tc-99m DMSA) scintigraphy is a commonly used imaging modality in children with urological abnormalities. The radiopharmaceuticals, which have the effects of ionising radiation, are used in this method. This study aimed to investigate the impact of the Tc-99m DMSA scan on renal oxidative stress and mononuclear leukocyte (MNL) DNA damage. Read More

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September 2021

RCT of a Telehealth Group-Based Intervention to Increase Physical Activity in Multiple Sclerosis: eFIT.

Neurol Clin Pract 2021 Aug;11(4):291-297

Translational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.

Objective: To conduct a pilot randomized controlled trial to determine whether participation in a group-based structured telehealth intervention increases physical activity in people with multiple sclerosis (MS).

Methods: In this parallel-arms trial, all study procedures were administered remotely. Adults diagnosed with MS (any subtype) were randomized to one of two 12-week (1 h/wk) active conditions: eFIT, online moderated structured groups; or eJournal, online independent journaling. Read More

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The impact of preoperative pelvic pain on outcomes after vaginal reconstructive surgery.

Am J Obstet Gynecol 2021 Sep 1. Epub 2021 Sep 1.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Hartford Hospital, Hartford, CT.

Background: Pelvic pain is a debilitating condition that is common among women with pelvic floor disorders. Limited information is known about the impact of preoperative pelvic pain on outcomes after vaginal reconstructive surgery.

Objective: This study aimed to compare the outcomes after vaginal reconstructive surgery between women with and without preoperative pelvic pain. Read More

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September 2021

Severe Perampanel Toxicity in a Pediatric Patient With Prolonged Symptoms.

J Emerg Med 2021 Aug 31. Epub 2021 Aug 31.

Division of Medical Toxicology, Department of Emergency Medicine, University of California at San Diego Medical Center, San Diego, CA.

Background: Perampanel is a new antiepileptic used to treat partial-onset seizures and generalized tonic-clonic seizures in people older than 12 years old. Perampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, with a prolonged half-life of approximately 105 hours. Few cases of significant toxicity have been reported, and effects in overdose are poorly understood. Read More

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Follitropin alpha versus beta in a first GnRH antagonist ICSI cycle: a retrospective cohort study.

Reprod Biomed Online 2021 Jul 24. Epub 2021 Jul 24.

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Department of Obstetrics and Gynaecology, University of Zagreb, Zagreb, Croatia. Electronic address:

Research Question: Are cumulative live birth rates (CLBR) after follitropin alpha (Ovaleap®) and follitropin beta (Puregon®) similar when used for ovarian stimulation with ICSI (intracytoplasmic sperm injection) in a first-rank gonadotrophin-releasing hormone (GnRH) antagonist protocol?

Design: Retrospective single-centre cohort study including 832 infertile patients undergoing ovarian stimulation with a daily dose of 150-225 IU FSH in their first ICSI cycle at a tertiary referral centre between July 2016 and July 2019. Of those, 349 patients used Ovaleap and 483 patients received Puregon.

Results: Baseline characteristics were not statistically different between the groups. Read More

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Validation of Hindi version of the Pittsburg Sleep Quality Index.

J Assoc Physicians India 2021 Apr;69(4):11-12

Consultant, Department of Rheumatology, Indraprastha Apollo Hospital, New Delhi.

Background: Sleep quality is poorly understood in the Indian population. Lack of a suitable tool to assess sleep quality in Hindi language is the main reason behind this. Pittsburg sleep quality index (PSQI) is widely used in different population groups to assess subjective sleep quality over last one month. Read More

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The impact of obstructive sleep apnea on endothelial function during weight loss in an obese pediatric population.

Sleep Med 2021 Aug 12;86:48-55. Epub 2021 Aug 12.

Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium; Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. Electronic address:

Background: Childhood obesity is an increasing problem with substantial comorbidities such as obstructive sleep apnea (OSA) and increased cardiovascular morbidity. Endothelial dysfunction is an underlying mechanism related to both obesity and OSA.

Research Question: To investigate the effect of weight loss on endothelial function and OSA in obese children and to determine whether a change in endothelial function can be linked to an improvement in OSA. Read More

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Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis.

Authors:

Lancet 2021 Sep 27;398(10305):1053-1064. Epub 2021 Aug 27.

Background: The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-pressure-lowering treatment on the risk of major cardiovascular events in groups of patients stratified by age and blood pressure at baseline.

Methods: We did a meta-analysis using individual participant-level data from randomised controlled trials of pharmacological blood-pressure-lowering versus placebo or other classes of blood-pressure-lowering medications, or between more versus less intensive treatment strategies, which had at least 1000 persons-years of follow-up in each treatment group. Read More

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September 2021

Integrated analysis of pain, health-related quality of life, and analgesic use in patients with metastatic castration-resistant prostate cancer treated with Radium-223.

Prostate Cancer Prostatic Dis 2021 Aug 26. Epub 2021 Aug 26.

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: Radium-223 (Ra-223), an alpha-emitting radiopharmaceutical, established an improved overall survival and health-related quality of life (HRQoL) in symptomatic metastatic castration-resistant prostate cancer (mCRPC) patients. However, effects on pain were not specifically evaluated. Here we assess integrated HRQoL, pain, and opioid use in a contemporary, more extensively pretreated, symptomatic and asymptomatic mCRPC population. Read More

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Daily Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and DNA Damage.

Nutrients 2021 Aug 14;13(8). Epub 2021 Aug 14.

Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy.

Chronic obstructive pulmonary disease (COPD) is a respiratory disease associated with airways inflammation and lung parenchyma fibrosis. The primary goals of COPD treatment are to reduce symptoms and risk of exacerbations, therefore pulmonary rehabilitation is considered the key component of managing COPD patients. Oxidative airway damage, inflammation and reduction of endogenous antioxidant enzymes are known to play a crucial role in the pathogenesis of COPD. Read More

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Comparison of Mechanical Support with Impella or Extracorporeal Life Support in Post-Cardiac Arrest Cardiogenic Shock: A Propensity Scoring Matching Analysis.

J Clin Med 2021 Aug 14;10(16). Epub 2021 Aug 14.

Department of Cardiology, Angiology and Intensive Care, Philipps University Marburg, 35043 Marburg, Germany.

Our aim was to compare the outcomes of Impella with extracorporeal life support (ECLS) in patients with post-cardiac arrest cardiogenic shock (CS) complicating acute myocardial infarction (AMI). This was a retrospective study of patients resuscitated from out of hospital cardiac arrest (OHCA) with post-cardiac arrest CS following AMI (May 2015 to May 2020). Patients were supported either with Impella 2. Read More

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