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Left Atrial Enlargement on Non-Gated CT Is Associated with Large Vessel Occlusion in Acute Ischaemic Stroke.

Cerebrovasc Dis Extra 2021 Sep 22;11(3):87-91. Epub 2021 Sep 22.

Cardiothoracic Radiology Department, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.

Background: Recent reports have suggested that atrial fibrillation (AF) is more prevalent in the large vessel occlusion (LVO) subgroup of acute ischaemic stroke patients. Given the association between left atrial enlargement (LAE) and AF, we sought to evaluate the feasibility of assessing LAE on non-gated CT and its association with LVO in the hyperacute stroke setting.

Methods: We analysed our prospectively collected database that included all stroke patients referred for consideration of endovascular treatment between April 14, 2020, and May 21, 2020. Read More

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September 2021

Microablative Erbium: YAG Laser Therapy for Vulvodynia - A Report on Efficacy, Safety, and Treatment Satisfaction.

Sex Med 2021 Sep 19;9(6):100432. Epub 2021 Sep 19.

Department of Obstetrics and Gynecology, Medical University of Graz, Austria.

Introduction: Treatment for vulvodynia is challenging and a multidisciplinary approach is recommended.

Aim: To examine the effectiveness, safety and treatment satisfaction of vulvovaginal microablative laser treatment for vulvodynia.

Methods: Case study of women who received laser treatment as part of a multidisciplinary treatment program for vulvodynia. Read More

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September 2021

Liraglutide reduces plasma PCSK9 in patients with type 2 diabetes not treated with statins.

Diabetes Metab 2021 Sep 19:101284. Epub 2021 Sep 19.

University of Burgundy, INSERM LNC UMR1231, Dijon, France; CHU Dijon, Department of Biochemistry, Dijon, France.

Aim: Dyslipidaemia in type 2 diabetes mellitus (T2DM), which increases cardiovascular risk, includes abnormal metabolism of low-density lipoproteins (LDL). Our group has recently shown that liraglutide increases LDL catabolism in patients with T2DM and that it reduces the expression of PCSK9 (a major inhibitor of LDL-receptor expression) in vitro and in mice. This prompted us to study the effect of liraglutide on plasma PCSK9 level in patients with T2DM. Read More

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September 2021

Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males.

Behav Brain Res 2021 Sep 19:113590. Epub 2021 Sep 19.

Psychology Department, University of Florida, Gainesville, FL; Center for Addiction Research and Education, University of Florida, Gainesville, FL.

Oxytocin attenuates cocaine-seeking when administered both systemically and directly into the nucleus accumbens core. This effect is blocked by intra-accumbens antagonism of mGlu2/3 and, together with our finding that intra-accumbens oxytocin increases glutamate concentrations in this brain region, indicates that pre-synaptic regulation of glutamate release by oxytocin influences cocaine relapse. However, mGlu2/3 receptors also regulate dopamine release in the nucleus accumbens. Read More

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September 2021

Safety and heart rate changes in Covid-19 patients treated with Remdesivir.

Int J Infect Dis 2021 Sep 19. Epub 2021 Sep 19.

1Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Foggia, Italy. Electronic address:

Objectives Limited data are available regarding the occurrence and the extent of cardiac rhythm disturbances in patients with COVID-19 treated with Remdesivir. Methods Here we present a case series of 52 patients who underwent daily electrocardiogram (ECG) examination after Remdesivir administration. Results Compared to baseline, a significant heart rate reduction was observed after initiation of Remdesivir; no case of severe bradycardia or arrhythmias leading to significant clinical complications or Remdesivir discontinuation however occurred. Read More

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September 2021

SARS-CoV-2 positivity rates in asymptomatic workers at a cancer referral center in Mexico City: a prospective observational study in the context of adapting hospitals back to regular practice.

Am J Infect Control 2021 Sep 19. Epub 2021 Sep 19.

Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.

Background: Healthcare workers are at increased risk of SARS-CoV-2 infection. The positivity rates in hospitals that do not receive patients with COVID-19, such as the National Cancer Institute (INCan) in Mexico, and the associated factors are unknown.

Objective: To assess the incidence and factors associated with SARS-CoV-2 infection in health workers at INCan. Read More

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September 2021

20% ALA-PDT pre-treated by fire needle in patients with dissecting cellulitis of the scalp: an interim analysis.

Photodiagnosis Photodyn Ther 2021 Sep 19:102544. Epub 2021 Sep 19.

Department of Dermatology, First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Background: Dissecting cellulitis of the scalp (DCS) is a rare but distinctive, chronic suppurative condition, and the treatment is a real therapeutic challenge. Recently, treatment of DCS with 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has been considered as a useful alternative treatment.

Objective: To evaluate the efficacy and safety of 20% ALA-PDT pre-treated by fire needle in the treatment of DCS. Read More

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September 2021

Effects of a Health Promotion Intervention on Physical Activity in African American Men Living with HIV: Randomized Controlled Trial.

AIDS Patient Care STDS 2021 Sep 22. Epub 2021 Sep 22.

Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.

HIV and its treatment with antiretroviral therapy increase the risk of noncommunicable diseases (NCDs) tied to physical inactivity. Older African American men are also at high risk for NCDs. We tested the efficacy of a theory-based intervention to increase adherence to federal aerobic and muscle-strengthening physical activity (PA) guidelines among African American men aged 40 years and older living with HIV. Read More

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September 2021

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase.

N Engl J Med 2021 Sep 22. Epub 2021 Sep 22.

From Baylor College of Medicine, Houston (H.M.E.S.), and Javara, The Woodlands (C.K.) - both in Texas; Brigham and Women's Hospital, Boston (L.R.B.), and Moderna, Cambridge (A.A., H.C., W.D., S.H., B.L., D.M., R.P., F.S., J.E.T., H.Z., J.M.) - both in Massachusetts; Meridian Clinical Research, Baton Rouge, LA (B.E., F.E.); University of Miami, Miami (S.D.-L.), and DeLand Clinical Research Unit, DeLand (B.R.) - both in Florida; University of Pittsburgh School of Medicine, Pittsburgh (J.M.M.); Emory University School of Medicine, Atlanta (E.J.A.); University of Colorado School of Medicine, Aurora (T.B.C.); University of California, Los Angeles (J.C.), and Wake Research-Medical Center for Clinical Research, San Diego (L.H.-C.) - both in California; Kaiser Permanente Washington Health Research Institute (L.A.J.), and Fred Hutchinson Cancer Research Center (L.C., P.G., H.J.) - both in Seattle; University of Cincinnati, Cincinnati (C.J.F.); Henry Ford Health System, Detroit (M.Z.); Vitalink Research, Greenville, SC (G.F.); Clinical Research Center of Nevada, Wake Research, Las Vegas (M.L.); and the University of Maryland, College Park (K.M.N.), and the Vaccine Research Center (J.R.M., J.E.L., B.S.G.), National Institute of Allergy and Infectious Diseases (D.F., M.M., L.P.), National Institutes of Health, Bethesda - both in Maryland.

Background: At interim analysis in a phase 3, observer-blinded, placebo-controlled clinical trial, the mRNA-1273 vaccine showed 94.1% efficacy in preventing coronavirus disease 2019 (Covid-19). After emergency use of the vaccine was authorized, the protocol was amended to include an open-label phase. Read More

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September 2021

PANSS Individual Item and Marder Dimension Analyses From a Pivotal Trial of RBP-7000 (Monthly Extended-Release Risperidone) in Schizophrenia Patients.

J Clin Psychiatry 2021 Sep 21;82(5). Epub 2021 Sep 21.

Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California.

Positive and Negative Syndrome Scale (PANSS) data from a pivotal phase 3 study in participants with schizophrenia of RBP-7000, a recently marketed long-acting subcutaneous injectable risperidone formulation, were examined to determine if dose-response relationships existed for different items of the PANSS.

Changes in the 30 PANSS items were analyzed individually and using the 5 factor-analysis-derived dimensions defined by Marder and colleagues. Subgroups of patients who could benefit from the RBP-7000 120 mg dose were investigated. Read More

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September 2021

Factors Associated With Variation in Pediatric Systemic Lupus Erythematosus Care Delivery.

ACR Open Rheumatol 2021 Sep 22. Epub 2021 Sep 22.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Objective: Patients with pediatric systemic lupus erythematosus (pSLE) and mixed connective tissue disease (MCTD) receive only a fraction of recommended care. Using published quality indicators and guidelines, we developed a 13-item pediatric lupus care index (p-LuCI) to quantify the proportion of recommended clinical evaluations and comorbidity prevention interventions completed and the timeliness of follow-up. Our objective was to assess baseline index performance and identify sources of p-LuCI variation. Read More

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September 2021

Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring.

Am J Transplant 2021 Sep 22. Epub 2021 Sep 22.

Department of Nephrology, Hospital del Mar, Barcelona, Spain.

Studies are urgently needed to characterize immunogenicity, efficacy, and safety of SARS-CoV-2 mRNA vaccines in kidney transplant (KT) recipients, excluded from major clinical trials. Complex ELISPOT and other cellular response techniques have been applied, but simpler tools are needed. An easy-to-use real-world monitoring of SARS-CoV-2 IgG antibodies against the Spike protein and QuantiFERON SARS-CoV-2 IFNγ release assay (IGRA) were performed at baseline and 28 days after the second dose in KT recipients and controls (dialysis patients and healthy ones). Read More

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September 2021

Complimentary effects on glycemic and non-glycemic parameters between responder and non-responders treated with pioglitazone and canagliflozin in drug naïve subjects with type 2 diabetes.

Int J Clin Pract 2021 Sep 22:e14914. Epub 2021 Sep 22.

Division of Diabetes and Endocrinology, Department of Internal Medicine, Gyoda General Hospital, Saitama, Japan.

Objectives: The aim of this study is to investigate the differential regulation of metabolic parameters between pioglitazone and canagliflozin in relation to their glycemic efficacies.

Methods: Drugs naïve subjects with T2DM received pioglitazone 15-30 mg/day or canagliflozin 50-100 mg/day monotherapy for 3 months. Those who had ≥1% reduction in HbA1c were defined as responders and others who had <1% reduction as non-responders. Read More

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September 2021

Safety and efficacy of alirocumab in real life setting: analysis of the Belgian cohort of the ODYSSEY APPRISE trial with review of current lipid treatment guidelines and its implementation in clinical practice.

Int J Clin Pract 2021 Sep 22:e14916. Epub 2021 Sep 22.

Department of Diabetes and Endocrinology, University Hospitals of Leuven, Leuven, Belgium.

Background: As lipid targets became more stringent in the latest ESC/EAS guidelines, many patients on statin monotherapy are left above their risk-based target, increasing the need for lipid lowering therapies. The results of the ODYSSEY APPRISE study were recently published by Gaudet et al. In this trial alirocumab (a PCSK9 inhibitor) was investigated in high cardiovascular risk patients in a real-life setting. Read More

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September 2021

Immediate implant placement combining socket seal abutment and peri-implant socket filling. A prospective case series.

Clin Oral Implants Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Periodontology and Oral Surgery, Faculty of Medicine, University of Liege, Belgium.

Objectives: The aim of this prospective case series was to assess the implant outcomes as well as hard and soft tissue dimensional changes of immediate implant placement in posterior sites using a custom-made sealing socket abutment (SSA) combined to peri-implant socket filling (PISF).

Material And Methods: Twenty patients were considered for single extraction and immediate implant in upper or lower posterior regions. The remaining peri-implant sockets were filled with Deproteinized Bovine Bone Mineral. Read More

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September 2021

Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication-overuse headache.

Headache 2021 Sep 22. Epub 2021 Sep 22.

Lundbeck La Jolla Research Center, San Diego, California, USA.

Objective: This post hoc analysis in patients medically diagnosed with chronic migraine (CM) and medication-overuse headache (MOH) evaluated reductions in the use of acute headache medication (AHM) and sustained changes in the diagnostic status of CM and MOH following eptinezumab treatment in the PROMISE-2 study.

Background: Eptinezumab, a monoclonal antibody that inhibits calcitonin gene-related peptide, is approved in the United States for the preventive treatment of migraine. A previous analysis showed that eptinezumab reduced monthly migraine days and was well tolerated in the subgroup of PROMISE-2 patients diagnosed with both CM and MOH. Read More

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September 2021

Growth After Adenotonsillectomy for Obstructive Sleep Apnea: Revisited.

Laryngoscope 2021 Sep 22. Epub 2021 Sep 22.

Department of Otolaryngology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, U.S.A.

Objectives/hypothesis: To reanalyze the growth trajectory and assess longitudinal changes of children undergoing adenotonsillectomy (AT) versus watchful waiting (WW) enrolled in the Childhood Adenotonsillectomy Trial (CHAT) study and to determine if an AT increases the risk of obesity in children.

Study Design: Reanalysis of prospective cohort investigation.

Methods: The study analyzed publicly available data from CHAT, including 3 months visit data not previously included in a prior publication. Read More

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September 2021

Phase and amplitude EEG correlations change with disease progression in people with idiopathic rapid eye-movement sleep behavior disorder.

Sleep 2021 Sep 22. Epub 2021 Sep 22.

Department of Informatics, Bioengineering, Robotics and System engineering (DIBRIS), University of Genoa, Genoa, Italy.

Study Objectives: Increased phase synchronization in electroencephalography (EEG) bands might reflect the activation of compensatory mechanisms of cognitive decline in people with neurodegenerative diseases. Here, we investigated whether altered large-scale couplings of brain oscillations could be linked to the balancing of cognitive decline in a longitudinal cohort of people with idiopathic rapid eye-movement sleep behavior disorder (iRBD).

Methods: We analyzed 18 patients (17 males, 69. Read More

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September 2021

Effect of Online Palliative Care Training on Knowledge and Self-Efficacy of Direct Care Workers.

Intellect Dev Disabil 2021 Oct;59(5):392-404

Jinsook Kim and Jennifer A. Gray, Northern Illinois University.

We evaluated the effectiveness of an online training on palliative care knowledge and self-efficacy among staff working with people with intellectual and developmental disabilities (IDD) using a one-group pretest-posttest design. Staff from four nonprofit residential and day services organizations in a U.S. Read More

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October 2021

MIND Diet and Cognitive Function over Eight Years in Puerto Rican Older Adults.

J Gerontol A Biol Sci Med Sci 2021 Sep 22. Epub 2021 Sep 22.

Department of Public Health, University of Massachusetts Lowell.

Background: Healthy diets have been associated with better cognitive function. Socio-economic factors including education, poverty and job complexity may modify the relationship between diet and cognition.

Methods: We used adjusted linear mixed models to examine the association between long-term adherence to the Mediterranean-Dietary Approaches to Stop Hypertension - Intervention for Neurodegenerative Delay (MIND) diet and cognitive function over 8 years of follow-up in Puerto Rican adults residing in the Boston, MA area (aged 45 to 75 years at baseline). Read More

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September 2021

Residential greenness and increased physical activity in patients after coronary artery bypass graft surgery.

Eur J Prev Cardiol 2021 Sep;28(11):1184-1191

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Israel.

Aims: Physical activity is a fundamental component of rehabilitation following coronary artery bypass (CABG) surgery. Proximity to neighbourhood green spaces may encourage physical activity. We investigated the association between residential greenness and exercise-related physical activity post-CABG surgery. Read More

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September 2021

The effects of transitions in metabolic health and obesity status on incident cardiovascular disease: Insights from a general Chinese population.

Eur J Prev Cardiol 2021 Sep;28(11):1250-1258

Department of Cardiology, The First Hospital of China Medical University, China.

Background: Recent studies have investigated the association of transitions in metabolic health and obesity status over time with the risk of cardiovascular disease, focusing on the subgroup demonstrating metabolically healthy obesity. However, these studies have produced inconsistent results. This study evaluates the relation in a general Chinese population. Read More

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September 2021

Cardiorespiratory fitness and survival following cancer diagnosis.

Eur J Prev Cardiol 2021 Sep;28(11):1242-1249

Sackler School of Medicine, Tel-Aviv University, Israel.

Aims: Data on the association of cardiorespiratory fitness with survival of cancer patients are limited. This study aimed to evaluate the association between midlife cardiorespiratory fitness and survival after a subsequent cancer diagnosis.

Methods: We evaluated 19,134 asymptomatic self-referred adults who were screened in preventive healthcare settings. Read More

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September 2021

Non-adherence to established dietary guidelines associated with increased mortality: the Copenhagen General Population Study.

Eur J Prev Cardiol 2021 Sep;28(11):1259-1268

Department of Internal Medicine, Zealand University Hospital, Denmark.

Aims: The relevance of adherence to established dietary guidelines is repeatedly challenged. We hypothesised that non-adherence to established dietary guidelines is associated with an excess risk of cardiovascular, non-cardiovascular and all-cause mortality.

Methods: We studied 100,191 white adult Danes aged 20-100 years recruited in 2003-2015 and followed up until December 2018. Read More

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September 2021

Effect of Yoga on Performance and Physical Fitness in Cricket Bowlers.

Int J Yoga Therap 2021 Sep 22. Epub 2021 Sep 22.

MGM School of Physiotherapy, MGM Institute of Health Sciences, Kamothe, Navi Mumbai, India.

Cricket-bowling performance is known to be influenced by speed of ball release and accuracy. Currently, training sessions typically involve fielding-specific drills and conditioning exercises. Scientific evidence for inclusion of a comprehensive yoga intervention in daily training and exercise sessions remains unexplored. Read More

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September 2021

Computational Fluid Dynamics Modeling of Nasal Obstruction and Associations with Patient-Reported Outcomes.

Plast Reconstr Surg 2021 Oct;148(4):592e-600e

From the Department of Otolaryngology-Head and Neck Surgery and Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary; ISC-CNR, Consiglio Nazionale delle Ricerche; Lexma Technology; Max Planck Institute for Dynamics and Self-Organization; and John A. Paulson School of Engineering and Applied Sciences, Harvard University.

Background: Nasal obstruction is a common problem, with significant impact on quality of life. Accurate diagnosis may be challenging because of the complex and dynamic nature of the involved anatomy. Computational fluid dynamics modeling has the ability to identify specific anatomical defects, allowing for a targeted surgical approach. Read More

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October 2021

A Matched Comparison of the Benefits of Breast Reduction on Health-Related Quality of Life.

Plast Reconstr Surg 2021 Oct;148(4):729-735

From the Division of Plastic Surgery, Department of Surgery, University of Pennsylvania.

Background: Breast reduction surgery has consistently fallen within the top 10 surgical procedures performed by plastic surgeons. This is because of its capability to relieve the physical and psychological impact of macromastia. Although numerous women pursue consultation, many never undergo the procedure. Read More

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October 2021

Sugar Habit Hacker: Initial evidence that a planning intervention reduces sugar intake.

J Behav Addict 2021 Sep 22. Epub 2021 Sep 22.

3School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Background And Aims: Sugar is a potentially addictive substance that is consumed in such high levels the World Health Organisation has set recommended consumption limits. To date there are no empirically tested brief interventions for reducing sugar consumption in adult populations. The current study aimed to preliminarily assess the feasibility of recruitment, retention, and intervention engagement and impact of a brief intervention. Read More

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September 2021

Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity.

Neurology 2021 Jun;96(22):e2673-e2684

From the Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC (R.J.J., S.A.M.S., W.M.V.d.F., P.S., P.J.V., B.M.T.), and Clinical Developmental Psychology & Clinical Neuropsychology (S.A.M.S.), VU University; Alzheimer Center Limburg, School for Mental Health and Neuroscience (P.J.V.), Maastricht University, the Netherlands; and Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics (P.J.V.), Karolinska Institutet, Stockholm, Sweden.

Objective: To investigate the influence of heterogeneity in disease progression for detecting treatment effects in Alzheimer disease (AD) trials, using a simulation study.

Methods: Individuals with an abnormal amyloid PET scan, diagnosis of mild cognitive impairment or dementia, baseline Mini-Mental State Examination (MMSE) score ≥24, global Clinical Dementia Rating (CDR) score of 0.5, and ≥1 follow-up cognitive assessment were selected from the Alzheimer's Disease Neuroimaging Initiative database (n = 302, age 73 ± 6. Read More

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Spatiotemporal Sequence Prediction With Point Processes and Self-Organizing Decision Trees.

IEEE Trans Neural Netw Learn Syst 2021 Sep 22;PP. Epub 2021 Sep 22.

We study the spatiotemporal prediction problem and introduce a novel point-process-based prediction algorithm. Spatiotemporal prediction is extensively studied in machine learning literature due to its critical real-life applications, such as crime, earthquake, and social event prediction. Despite these thorough studies, specific problems inherent to the application domain are not yet fully explored. Read More

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September 2021