184,773 results match your criteria based types


Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids.

Authors:
Robert G Hahn

J Basic Clin Physiol Pharmacol 2021 Sep 27. Epub 2021 Sep 27.

Research Unit, Södertälje Hospital, Södertälje, Sweden.

Objectives: Systemic absorption of the irrigating fluid used to flush the operating site is a potentially serious complication in several types of endoscopic operations. To increase safety, many surgeons have changed from a monopolar to a bipolar resection technique because 0.9% saline can then be used instead of electrolyte-free fluid for irrigation. Read More

View Article and Full-Text PDF
September 2021

The Language of Dreams: Application of Linguistics-Based Approaches for the Automated Analysis of Dream Experiences.

Clocks Sleep 2021 Sep 19;3(3):495-514. Epub 2021 Sep 19.

MoMiLab Research Unit, IMT School for Advanced Studies Lucca, 55100 Lucca, Italy.

The study of dreams represents a crucial intersection between philosophical, psychological, neuroscientific, and clinical interests. Importantly, one of the main sources of insight into dreaming activity are the (oral or written) reports provided by dreamers upon awakening from their sleep. Classically, two main types of information are commonly extracted from dream reports: structural and semantic, content-related information. Read More

View Article and Full-Text PDF
September 2021

Advancement in Detection Methods: From Conventional to Electrochemical-Based Sensing Detection.

Biosensors (Basel) 2021 Sep 18;11(9). Epub 2021 Sep 18.

Collaborative Microelectronic Design Excellence Centre (CEDEC), [email protected], Universiti Sains Malaysia, Level 1, Block C, No. 10 Persiaran Bukit Jambul, Bayan Lepas 11900, Malaysia.

Large-scale food-borne outbreaks caused by are rarely seen nowadays, thanks to the advanced nature of the medical system. However, small, localised outbreaks in certain regions still exist and could possess a huge threat to the public health if eradication measure is not initiated. This review discusses the progress of detection approaches covering their basic principles, characteristics, applications, and performances. Read More

View Article and Full-Text PDF
September 2021

Usability of smart infusion pumps: A heuristic evaluation.

Appl Ergon 2021 Sep 22;98:103584. Epub 2021 Sep 22.

Department of Industrial and Systems Engineering, University of Iowa, Iowa City, 52242, USA; Department of Internal Medicine, University of Iowa, Iowa City, 52242, USA. Electronic address:

Although smart infusion pumps were built to eliminate medication errors, new types of usability errors have arisen. The purposes of this study were to determine potential risks when using smart pumps during secondary medication administration and to identify opportunities for design improvements. We observed and analyzed nurses when they interacted with smart pumps and heuristically evaluated the smart pump to identify usability problems. Read More

View Article and Full-Text PDF
September 2021

SuFEx modification of silk fibroin silicon aerogel and its adsorption behavior and antibacterial performance.

Chemosphere 2021 Sep 20;287(Pt 3):132291. Epub 2021 Sep 20.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address:

A silk fibroin silicon-based composite aerogel (SSA) has been modified via a SuFEx reaction for application in the adsorption of anionic pollutants and antimicrobials in water. The tyrosine fragment in the silk fibroin was modified by a high yielding SuFEx click reaction. A quaternary ammonium salt functionality was introduced into the silk fibroin protein and the modified silk fibroin protein was crosslinked with tetraethyl orthosilicate. Read More

View Article and Full-Text PDF
September 2021

Parenting styles and types: Breastfeeding attitudes in a large sample of mothers.

Midwifery 2021 Sep 14;103:103142. Epub 2021 Sep 14.

School of Psychology, University of Lincoln, Lincoln, United Kingdom.

Objective: The importance of breastfeeding for both maternal and infant health is well established. However, it remains the case that only a small percentage of infants are breastfed after the first six months of life. Maternal negative breastfeeding attitudes are associated with a reduced likelihood of breastfeeding an infant, but they are a malleable target for practitioner interventions. Read More

View Article and Full-Text PDF
September 2021

A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations.

J Clin Epidemiol 2021 Sep 22. Epub 2021 Sep 22.

Public Health Agency of Canada, Canada.

Objectives: To propose a taxonomy and framework that identifies and presents actionable statements in guidelines.

Study Design And Setting: We took an iterative approach reviewing case studies of guidelines produced by the World Health Organization and the American Society of Hematology to develop an initial conceptual framework. We then tested it using randomly selected recommendations from published guidelines addressing COVID-19 from different organizations, evaluated its results, and refined it before retesting. Read More

View Article and Full-Text PDF
September 2021

Vicariance and Dispersal Events Inferred from Mitochondrial Genomes and Nuclear Genes (18S, 28S) Shaped Global Cryptocercus Distributions.

Mol Phylogenet Evol 2021 Sep 22:107318. Epub 2021 Sep 22.

College of Plant Protection, Southwest University, Beibei, Chongqing 400716, P. R. China. Electronic address:

Cryptocercus Scudder, a genus of wingless, subsocial cockroaches, has low vagility but exhibits a disjunct distribution in eastern and western North America, and in China, South Korea and the Russian Far East. This distribution provides an ideal model for testing hypotheses of vicariance through plate tectonics or other natural barriers versus transoceanic dispersal or across other natural barriers. We sequenced 45 Cryptocercus mitochondrial genomes to resolve phylogenetic relationships among members of the genus worldwide. Read More

View Article and Full-Text PDF
September 2021

Digital Twin of Low Dosage Continuous Powder Blending - Artificial Neural Networks and Residence Time Distribution Models.

Eur J Pharm Biopharm 2021 Sep 22. Epub 2021 Sep 22.

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rakpart 3, Budapest H-1111, Hungary. Electronic address:

In this paper we present a thorough description of the digital twin development for a continuous pharmaceutical powder blending process in accordance with the Process Analytical Technologies (PAT) and Quality by Design (QbD) guidelines. A low-dosage system of caffeine active pharmaceutical ingredient (API) and dextrose excipient was examined via continuous blending experiments. Near infrared (NIR) spectroscopy-based process analytics were applied; quantitative evaluation of spectra was achieved using multivariate data analysis. Read More

View Article and Full-Text PDF
September 2021

Protective effect of oligosaccharides isolated from Panax ginseng C. A. Meyer against UVB-induced skin barrier damage in BALB/c hairless mice and human keratinocytes.

J Ethnopharmacol 2021 Sep 22:114677. Epub 2021 Sep 22.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin Province, China; Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Changchun University of Chinese Medicine, Changchun, Jilin Province, China. Electronic address:

Ethnopharmacological Relevance: Skin barrier dysfunction can lead to water and electrolyte loss, triggering homeostatic imbalances that can trigger atopic dermatitis and anaphylaxis. Panax ginseng C.A. Read More

View Article and Full-Text PDF
September 2021

Improving process understanding in roll compaction.

J Pharm Sci 2021 Sep 22. Epub 2021 Sep 22.

Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany. Electronic address:

Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. Read More

View Article and Full-Text PDF
September 2021

Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy.

Adv Sci (Weinh) 2021 Sep 24:e2102587. Epub 2021 Sep 24.

State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P.R. China.

Inorganic nanomaterials with intrinsic singlet oxygen ( O ) generation capacity, are emerged yet dynamically developing materials as nano-photosensitizers (NPSs) for photodynamic therapy (PDT). Compared to previously reported nanomaterials that have been used as either carriers to load organic PSs or energy donors to excite the attached organic PSs through a Foster resonance energy transfer process, these NPSs possess intrinsic O generation capacity with extremely high O quantum yield (e.g. Read More

View Article and Full-Text PDF
September 2021

Individual differences in proactive interference in rats (Rattus Norvegicus).

Psychon Bull Rev 2021 Sep 24. Epub 2021 Sep 24.

Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.

Individual differences in behaviors are seen across many species, and investigations have focused on traits linked to aggression, risk taking, emotionality, coping styles, and differences in cognitive systems. The current study investigated whether there were individual differences in proactive interference tasks in rats (Rattus Norvegicus), and tested hypotheses suggesting that these tasks should load onto a single factor and there should be clusters of rats who perform well or poorly on these tasks. The performance of 39 rats was tested across three learning tasks that all involved disengagement from an irrelevant previously learned stimulus to a relevant stimulus: latent inhibition (LI), partial reinforcement extinction effect (PREE), and reversal learning (RL). Read More

View Article and Full-Text PDF
September 2021

: An R Package for performing kernel change point detection on the running statistics of multivariate time series.

Behav Res Methods 2021 Sep 24. Epub 2021 Sep 24.

Research Group of Quantitative Psychology and Individual Differences, KU Leuven - University of Leuven, Tiensestraat 102, Box 3713, 3000, Leuven, Belgium.

In many scientific disciplines, researchers are interested in discovering when complex systems such as stock markets, the weather or the human body display abrupt changes. Essentially, this often comes down to detecting whether a multivariate time series contains abrupt changes in one or more statistics, such as means, variances or pairwise correlations. To assist researchers in this endeavor, this paper presents the package for performing kernel change point (KCP) detection on user-selected running statistics of multivariate time series. Read More

View Article and Full-Text PDF
September 2021

Transopercular Insular Approach, Overcoming the Training Curve Using a Cadaveric Simulation Model: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurological Surgery and Spine Unit, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Transopercular approach to the insula is indicated for resection of insular low-grade gliomas, particularly for Yasargil's 3B, 5A, and 5B types. Nevertheless, the infrequent location and its challenging approach make it difficult to master the surgery. Consequently, a realistic laboratory training model might help to acquire key surgical skills. Read More

View Article and Full-Text PDF
September 2021

Brain regions susceptible to alpha-synuclein spreading.

Mol Psychiatry 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD pathologies. In animal models, the spreading of α-syn has been associated with motor dysfunction and neuronal death. However, variability in both susceptible brain regions and cellular populations limits our understanding of the consequences of α-syn spreading and the development of associated therapies. Read More

View Article and Full-Text PDF
September 2021

Controlling for human population stratification in rare variant association studies.

Sci Rep 2021 Sep 24;11(1):19015. Epub 2021 Sep 24.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.

Population stratification is a confounder of genetic association studies. In analyses of rare variants, corrections based on principal components (PCs) and linear mixed models (LMMs) yield conflicting conclusions. Studies evaluating these approaches generally focused on limited types of structure and large sample sizes. Read More

View Article and Full-Text PDF
September 2021

Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review.

Chin J Nat Med 2021 Sep;19(9):641-647

Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Natural products are one of the important sources for the discovery of new drugs. Betulinic acid (BA), a pentacyclic triterpenoid widely distributed in the plant kingdom, exhibits powerful biological effects, including antitumor activity against various types of cancer cells. A considerable number of BA derivatives have been designed and prepared to remove their disadvantages, such as poor water solubility and low bioavailability. Read More

View Article and Full-Text PDF
September 2021

A review on the use of chitosan and chitosan derivatives as the bio-adsorbents for the water treatment: Removal of nitrogen-containing pollutants.

Carbohydr Polym 2021 Dec 1;273:118625. Epub 2021 Sep 1.

Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Xincun West Road 266, Zibo 255000, China. Electronic address:

Chitosan and its derivatives have been widely used as the adsorbents for different types of water pollutants. This review paper lists various physically and chemically modified chitosan-based adsorbents such as chitosan beads, cross-linked chitosan, chitosan-polymer composites, chitosan-inorganic material composites, and chitosan-metal complexes for the removal of nitrogen-containing pollutants (nitrate, nitrite, ammonia, and ammonium ions) from aqueous solutions. It covers preparation strategies, the effect of modification on adsorbent structure, and the impact of adsorption variables using batch and fixed-bed column studies. Read More

View Article and Full-Text PDF
December 2021

Clinical neurorestorative cell therapies for stroke.

Prog Brain Res 2021 13;265:231-247. Epub 2021 Aug 13.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Clinical neurorestorative cell therapies for stroke have been explored for over 20 years. Majority cell therapies have shown neurorestorative effects for stroke on non-double-blind studies. In this review, we summarize types of cell transplantation, transplanted routes, therapeutic time windows, dosage, results of exploring trials or clinical studies, results of multicenter, double-blind or observing-blind, randomized, placebo-controlled clinical trials. Read More

View Article and Full-Text PDF

Patient involvement at the managerial level: the effectiveness of a patient and family advisory council at a regional cancer centre in Sweden.

BMC Health Serv Res 2021 Sep 25;21(1):1011. Epub 2021 Sep 25.

Department of Public Health and Caring Sciences, Uppsala University, Box 564, 751 22, Uppsala, Sweden.

Background: In cancer care as well as other types of treatment and care, little is known about the contribution of Patient and Family Advisory Councils (PFACs) operating at the managerial level in healthcare organizations. The aim of the study was to investigate the effectiveness of a Swedish PFAC operating at the managerial level at one of Sweden's six regional cancer centres.

Methods: This was a qualitative, single-case study based on interviews with PFAC participants and meeting minutes from PFAC meetings. Read More

View Article and Full-Text PDF
September 2021

Identification of driver genes based on gene mutational effects and network centrality.

BMC Bioinformatics 2021 Sep 24;22(Suppl 3):457. Epub 2021 Sep 24.

Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, College of Computer Science and Technology, Anhui University, Hefei, China.

Background: As one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority of somatic mutations did not affect the occurrence and development of cancer; thus, identifying the mutations responsible for tumor occurrence and development is one of the main targets of current cancer treatments.

Results: To effectively identify driver genes, we adopted a semi-local centrality measure and gene mutation effect function to assess the effect of gene mutations on changes in gene expression patterns. Read More

View Article and Full-Text PDF
September 2021

[Dissemination of National Physical Activity Recommendations: Participatory Development of Dissemination Strategies in Germany].

Gesundheitswesen 2021 Sep 24. Epub 2021 Sep 24.

Department für Sportwissenschaft und Sport Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.

Background: In 2016, the first evidence-based National Recommendations for Physical Activity and Physical Activity Promotion were published in Germany. These recommendations are primarily intended for experts, decision makers and stakeholders.

Objectives: This study aims to describe the development of dissemination strategies for these recommendations. Read More

View Article and Full-Text PDF
September 2021

Power Profile of Top 5 Results in World Tour Cycling Races.

Int J Sports Physiol Perform 2021 Sep 24:1-7. Epub 2021 Sep 24.

Purpose: This study evaluated the power profile of a top 5 result achieved in World Tour cycling races of varying types, namely: flat sprint finish, semi-mountain race with a sprint finish, semi-mountain race with uphill finish, and mountain races (MT).

Methods: Power output data from 33 professional cyclists were collected between 2012 and 2019. This large data set was filtered so that it only included top 5 finishes in World Tour races (18 participants and 177 races). Read More

View Article and Full-Text PDF
September 2021

Microbial community coalescence: does it matter in the Three Gorges Reservoir?

Water Res 2021 Sep 8;205:117638. Epub 2021 Sep 8.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, PR China. Electronic address:

The microbial community coalescence describes the mixing of microbial communities and the merging of their surrounding environments. Despite its prevalence in natural ecosystems and its potential influence on ecological processes, little research focused on the extent of coalescence between aquatic microbial communities. In this research, we analyzed the microbial communities in the Three Gorges Reservoir, a typical deep-water reservoir on the Yangtze River. Read More

View Article and Full-Text PDF
September 2021

Laryngeal disorders in people living with HIV.

Am J Otolaryngol 2021 Sep 20;43(1):103234. Epub 2021 Sep 20.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States of America.

Objectives: Several studies have shown that HIV infected individuals are at higher risk compared to the general population of developing non-AIDS defining conditions such as some types of cancer, kidney disease, liver disease and others. In this case-control study, we compared the incidence of laryngeal disorders between a treatment-seeking HIV-positive population and uninfected controls. We aimed to investigate whether there are any laryngeal disorders that are overrepresented in HIV-positive individuals. Read More

View Article and Full-Text PDF
September 2021

Techno-economic analysis of livestock urine and manure as a microalgal growth medium.

Waste Manag 2021 Sep 21;135:276-286. Epub 2021 Sep 21.

School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan 44919, Republic of Korea. Electronic address:

Microalgae have the potential to utilize the nutrients in livestock urine and manure (LUM) for the production of useful biomass, which can be used as a source of bioindustry. This study aims to evaluate the economic benefits of LUM feedstock that have not been clearly discussed before. Two types of photobioreactors were designed with a capacity of 200 m d. Read More

View Article and Full-Text PDF
September 2021

Effect of surfactants on phosphorus release and acidogenic fermentation of waste activated sludge containing different aluminium phosphate forms.

Chemosphere 2021 Sep 10;287(Pt 3):132213. Epub 2021 Sep 10.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China. Electronic address:

The effects of different surfactants (rhamnolipid, trehalolipid and citrate) on phosphorus (P) release and acidogenic fermentation of waste activated sludge (WAS) containing different aluminium phosphate forms (AlPO, Al(PO)) were investigated. Results showed that rhamnolipid was the most effective surfactant to release P from aluminum phosphates (AlPs)-rich sludge. Al(PO) was easier to release P than AlPO in WAS due to their different crystal structures. Read More

View Article and Full-Text PDF
September 2021

Sex-based differences in timely emergency department evaluations for patients with drug poisoning.

Public Health 2021 Sep 21;199:57-64. Epub 2021 Sep 21.

Center for Populations Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Center for Emergency Medicine, Emergency Services Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: Unintentional poisoning was the leading cause of injury-related death in the United States in 2017. Prescribed and illicit drugs are the most common cause of poisoning, and timely management in the emergency department (ED) is important. Our aim was to identify any disparities in wait times associated with sex for drug poisoning-related ED visits. Read More

View Article and Full-Text PDF
September 2021